Impact of COPD and asthma on in-hospital mortality and management of patients with heart failure in England and Wales: an observational analysis by Claudia Gulea, Rosita Zakeri, Jennifer K Quint, Constantinos Kallis

“…Objective To evaluate the association between having concomitant chronic obstructive pulmonary disease (COPD) or asthma, and in-patient mortality and post-discharge management among patients hospitalised for acute heart failure (HF).Setting Data were obtained from patients enrolled in the National Heart Failure Audit.Participants 217 329 patients hospitalised for HF in England–Wales between March 2012 and 2018.Outcomes In-hospital mortality, referrals to cardiology follow-up and prescriptions for HF medications were compared between patients with comorbid COPD (COPD-HF) or asthma (asthma-HF) versus HF-alone using mixed-effects logistic regression.Results Patients with COPD-HF were more likely to die during hospitalisation, and those with asthma-HF had a reduced likelihood of death, compared with patients who had HF-alone ((adjusted)ORadj, 95% CI: 1.10, 1.06 to 1.14 and ORadj, 95% CI: 0.84, 0.79 to 0.88). …”
Get full text

Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma: A Longitudinal Analysis by Jason D. Pole, Cameron A. Mustard, Teresa To, Joseph Beyene, Alexander C. Allen

“…This study was designed to test the hypothesis that fetal exposure to corticosteroids in the antenatal period is an independent risk factor for the development of asthma in early childhood with little or no effect in later childhood. …”
Get full text

Empowering Family Physicians to Impart Proper Inhaler Teaching to Patients with Chronic Obstructive Pulmonary Disease and Asthma by Janice M Leung, Mohit Bhutani, Richard Leigh, Dan Pelletier, Cathy Good, Don D Sin

“…BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) and asthma depend on inhalers for management, but critical errors committed during inhaler use can limit drug effectiveness. …”
Get full text

Artificial intelligence-assisted clinical decision support for childhood asthma management: A randomized clinical trial. by Hee Yun Seol, Pragya Shrestha, Joy Fladager Muth, Chung-Il Wi, Sunghwan Sohn, Euijung Ryu, Miguel Park, Kathy Ihrke, Sungrim Moon, Katherine King, Philip Wheeler, Bijan Borah, James Moriarty, Jordan Rosedahl, Hongfang Liu, Deborah B McWilliams, Young J Juhn

“…Study subjects were stratified into three strata (based on asthma severity, asthma care status, and asthma diagnosis) and were blinded to the assigned groups.…”
Get full text

Spirometry in Primary Care: An Analysis of Spirometry Test Quality in a Regional Primary Care Asthma Program by Christopher J Licskai, Todd W Sands, Lisa Paolatto, Ivan Nicoletti, Madonna Ferrone

“…BACKGROUND: Primary care office spirometry can improve access to testing and concordance between clinical practice and asthma guidelines. Compliance with test quality standards is essential to implementation.…”
Get full text

Association of multiple environmental exposures with rhinitis and asthma symptoms in preschool children: Identifying critical risk factor by Shuang Du, Hao Tang, Han Chen, Yang Shen, Zhiping Niu, Tianyi Chen, Jing Wei, Xia Meng, Wen Su, Qun Wu, Yongqiang Tan, Jing Cai, Zhuohui Zhao

“…Background: The concept “one airway, one disease” for childhood rhinitis and asthma has been challenged in recent years. This study aimed to evaluate associations of environmental exposures with alone and co-morbid symptoms of rhinitis and asthma and identify critical risk factor. …”
Get full text

A systematic review and meta-analysis of correlation between cough variant asthma and mycoplasma pneumonia in children by Luyan Jiao, Guoqing Zhang, Yi Yuan, Ling Cao

Subjects: “…cough variant asthma…”
Get full text

Elevated Proportions of Circulating CXCR5+ Follicular Helper T Cells Reflect the Presence of Airway Obstruction in Asthma by Tsukie Kin Tsukuda, Kimiko Tsuji, Akari Nishimori, Takehiko Ito, Yuka Kobayashi, Taro Suzuki, Akihito Yokoyama

“…The progressive decline in lung function observed in asthma is attributed to persistent type 2 airway inflammation and associated airway remodeling. …”
Get full text

Asthma-associated prostate enlargement and bladder smooth muscle hypercontractility: unveiling a potential link to LUTS by Peibin Cen, Ming Chen, Xin Qiu, Wenbin Guo, Hongyu Lan, Xingyu Zhou, Ming Lei, Guohua Zeng, Qingfeng Yu

Subjects: “…Asthma…”
Get full text

Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation by Marianne Nuijsink, Wim C. J. Hop, Peter J. Sterk, Eric J. Duiverman, Johan C. De Jongste

“…The aim of this study was to assess cross-sectional and longitudinal correlations between uEPX and other markers of asthma control and eosinophilic airway inflammation. …”
Get full text

OK-432 Acts as Adjuvant to Modulate T Helper 2 Inflammatory Responses in a Murine Model of Asthma by Cheng-Jang Wu, Pin-Hsun Tseng, Cheng-Chi Chan, Sara Quon, Li-Chen Chen, Ming-Ling Kuo

Get full text

Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma by G. Di Lorenzo, P. Mansueto, M. Melluso, G. Morici, F. Norrito, D. Cigna, G. Candore, C. Caruso

“…The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were found in patients with asthma compared with the control group. …”
Get full text

Childhood Asthma Surveillance using Administrative Data: Consistency between Medical Billing and Hospital Discharge Diagnoses by France Labrèche, Tom Kosatsky, Raymond Przybysz

“…BACKGROUND: The absence of ongoing surveillance for childhood asthma in Montreal, Quebec, prompted the present investigation to assess the validity and practicality of administrative databases as a foundation for surveillance.…”
Get full text

The interaction between genetic predicted gut microbiome abundance and particulate matter on the risk of incident asthma in adults by Hehua Zhang, Yong Feng, Honghao Yang, Yuqian Li, Zheng Ma, Liuxin Li, Liangkai Chen, Yuhong Zhao, Lishen Shan, Yang Xia

Subjects: Get full text

Efficacy and Cost Benefit of Inhaled Corticosteroids in Patients Considered to Have Mild Asthma in Primary Care Practice by Paul O'Byrne, Lauren Cuddy, D Wayne Taylor, Stephen Birch, Joanne Morris, Jerry Syrotuik

“…OBJECTIVE: Inhaled corticosteroids are infrequently used as asthma therapy in patients considered to have mild asthma in primary care practice. …”
Get full text

Non-invasive management of severe subcutaneous emphysema in a pediatric asthma exacerbation: a case report and review by Amal H. Aljohani, Hamdi Alsufiani, Ghousia Ahmed

Subjects: Get full text

Evaluation of Real-Life Investigational Use of Enoximone in Asthma, the Third Step in Drug Repurposing: A Preliminary Report by Jan Beute, Pieter Boermans, Alex KleinJan

“…The population of uncontrolled asthma patients represents a large therapeutic burden. …”
Get full text

K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma. by Joanne Van Der Velden, Grace Sum, Donna Barker, Emmanuel Koumoundouros, Garry Barcham, Heike Wulff, Neil Castle, Peter Bradding, Kenneth Snibson

“…<h4>Background</h4>The Ca(2+)-activated K(+) channel K(Ca)3.1 is expressed in several structural and inflammatory airway cell types and is proposed to play an important role in the pathophysiology of asthma. The aim of the current study was to determine whether inhibition of K(Ca)3.1 modifies experimental asthma in sheep.…”
Get full text

Inhaling arsenic aggravates airway hyperreactivity by upregulating PNEC-sourced 5-HT in OVA-induced allergic asthma by Xue Lu, Zhu-Xia Tan, Ya-Xin Yao, Ze-Yan Li, Yan-Yan Zhu, Qian-Qun Yang, Zhao Li, Kun Peng, Yan Wang, De-Xiang Xu

Subjects: Get full text

Do United States’ Teachers Know and Adhere to the National Guidelines on Asthma Management in the Classroom? A Systematic Review by Yudilyn Jaramillo, Marina Reznik

“…Proper asthma management in schools is important in achieving optimum asthma control in children with asthma. …”
Get full text