A Case-Control Study of the Role of Cold Symptoms and other Historical Triggering Factors in Asthma Exacerbations by Susan M Tarlo, Irvin Broder, Paul Corey, Moira Chan-Yeung, Alexander Ferguson, Allan Becker, Peter Warren, F Estelle R Simons, Christopher Sherlock, Marilyn Okada, Jure Manfreda

“…BACKGROUND: Asthma exacerbations can be provoked by many triggers such as allergens, respiratory irritants and viral infections. …”
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The Relationship among the Inspiratory Muscle Strength, the Perception of Dyspnea and Inhaled Beta2-Agonists in Patients with Asthma by Paltiel Weiner, Rasmi Magadle, Marinella Beckerman, Noa Berar-Yanay

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Oral administration of Limosilactobacillus reuteri VHProbi® M07 alleviates ovalbumin-induced allergic asthma in mice by Guoqing Meng, Hongchang Cui, Congrui Feng, Chaoqun Guo, Lei Song, Zhi Duan

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The Effect of Serine Protease Inhibitors on Airway Inflammation in a Chronic Allergen-Induced Asthma Mouse Model by Chih-Che Lin, Li-Jen Lin, Shulhn-Der Wang, Chung-Jen Chiang, Yun-Peng Chao, Joseph Lin, Shung-Te Kao

“…The serine protease inhibitors FUT, FOY, and UTI have potential therapeutic benefits for treating asthma by downregulating Th2 cytokines and Th17 cell function and inhibiting NF-κB activation in lung tissue.…”
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Impact of Clinical Factors on Generic and Disease-Specific Quality of Life in COPD and Asthma-COPD Overlap with Exacerbations by Zsófia Lázár, Alpár Horváth, Gábor Tomisa, Lilla Tamási, Veronika Müller

“…The health-related quality of life (HRQL) in chronic obstructive pulmonary disease (COPD) is worsened by frequent exacerbations, and it can be affected by the concomitant presence of bronchial asthma (asthma-COPD overlap (ACO)). The impacts of clinical factors associated with HRQL have not been compared in patients with COPD and ACO experiencing exacerbations. …”
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Taxonomic composition and biodiversity of the gut microbiome from patients with irritable bowel syndrome, ulcerative colitis, and asthma by A. Y. Tikunov, A. N. Shvalov, V. V. Morozov, I. V. Babkin, G. V. Seledtsova, I. O. Voloshina, I. P. Ivanova, A. V. Bardasheva, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

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The association between type 2 diabetes and asthma incidence: a longitudinal analysis considering genetic susceptibility by Fei Chen, Ying Yang, Liping Yu, Lulu Song, Cong Zhang, Yifan He, Lili Wu, Wanlu Ma, Bo Zhang

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Epithelial and immune transcriptomic characteristics and possible regulatory mechanisms in asthma exacerbation: insights from integrated studies by Ye Liu, Yue Li, Ruhao Wu, Yu Wang, Pengfei Li, Tianci Jiang, Ke Wang, Yize Liu, Zhe Cheng

Subjects: “…asthma exacerbation…”
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Association between Family Structure, Parental Smoking, Friends Who Smoke, and Smoking Behavior in Adolescents with Asthma by Francisco Vázquez-Nava, José María Peinado-Herreros, Atenógenes H. Saldívar-Gonzalez, Ma Del Carmen Barrientos-Gómez, Francisco J. Beltrán-Guzmán, Jesus Perez-Martin, José A. Cordóva-Fernández, Carlos F. Vázquez-Rodríguez

“…It is important that parents who have children with asthma be made aware that the presence of smokers in the home and adolescent fraternization with smoking friends not only favor the worsening of asthma, but also induce the habit of smoking.…”
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Effects of biologic therapy on novel indices of lung inhomogeneity in patients with severe type-2 high asthma by Nayia Petousi, Nick P Talbot, Ian Pavord, Peter A Robbins, Nicholas M J Smith, Graham Richmond, Asma Alamoudi, Lorenzo Petralia, Haopeng Xu, Dominic Sandhu, Grant AD Ritchie

“…Here, we assessed changes in lung inhomogeneity in patients with type-2 high asthma treated with biological therapy and explored the relationship between inhomogeneity measures and conventional asthma disease markers.Methods This was an observational study of 91 severe type-2 high asthma patients recruited from a tertiary asthma clinic, of whom 67 subsequently started anti-IL5 or anti-IL5R biologics. …”
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Impact of COPD and asthma on in-hospital mortality and management of patients with heart failure in England and Wales: an observational analysis by Claudia Gulea, Rosita Zakeri, Jennifer K Quint, Constantinos Kallis

“…Objective To evaluate the association between having concomitant chronic obstructive pulmonary disease (COPD) or asthma, and in-patient mortality and post-discharge management among patients hospitalised for acute heart failure (HF).Setting Data were obtained from patients enrolled in the National Heart Failure Audit.Participants 217 329 patients hospitalised for HF in England–Wales between March 2012 and 2018.Outcomes In-hospital mortality, referrals to cardiology follow-up and prescriptions for HF medications were compared between patients with comorbid COPD (COPD-HF) or asthma (asthma-HF) versus HF-alone using mixed-effects logistic regression.Results Patients with COPD-HF were more likely to die during hospitalisation, and those with asthma-HF had a reduced likelihood of death, compared with patients who had HF-alone ((adjusted)ORadj, 95% CI: 1.10, 1.06 to 1.14 and ORadj, 95% CI: 0.84, 0.79 to 0.88). …”
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Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma: A Longitudinal Analysis by Jason D. Pole, Cameron A. Mustard, Teresa To, Joseph Beyene, Alexander C. Allen

“…This study was designed to test the hypothesis that fetal exposure to corticosteroids in the antenatal period is an independent risk factor for the development of asthma in early childhood with little or no effect in later childhood. …”
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Empowering Family Physicians to Impart Proper Inhaler Teaching to Patients with Chronic Obstructive Pulmonary Disease and Asthma by Janice M Leung, Mohit Bhutani, Richard Leigh, Dan Pelletier, Cathy Good, Don D Sin

“…BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) and asthma depend on inhalers for management, but critical errors committed during inhaler use can limit drug effectiveness. …”
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Artificial intelligence-assisted clinical decision support for childhood asthma management: A randomized clinical trial. by Hee Yun Seol, Pragya Shrestha, Joy Fladager Muth, Chung-Il Wi, Sunghwan Sohn, Euijung Ryu, Miguel Park, Kathy Ihrke, Sungrim Moon, Katherine King, Philip Wheeler, Bijan Borah, James Moriarty, Jordan Rosedahl, Hongfang Liu, Deborah B McWilliams, Young J Juhn

“…Study subjects were stratified into three strata (based on asthma severity, asthma care status, and asthma diagnosis) and were blinded to the assigned groups.…”
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Association of multiple environmental exposures with rhinitis and asthma symptoms in preschool children: Identifying critical risk factor by Shuang Du, Hao Tang, Han Chen, Yang Shen, Zhiping Niu, Tianyi Chen, Jing Wei, Xia Meng, Wen Su, Qun Wu, Yongqiang Tan, Jing Cai, Zhuohui Zhao

“…Background: The concept “one airway, one disease” for childhood rhinitis and asthma has been challenged in recent years. This study aimed to evaluate associations of environmental exposures with alone and co-morbid symptoms of rhinitis and asthma and identify critical risk factor. …”
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A systematic review and meta-analysis of correlation between cough variant asthma and mycoplasma pneumonia in children by Luyan Jiao, Guoqing Zhang, Yi Yuan, Ling Cao

Subjects: “…cough variant asthma…”
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Elevated Proportions of Circulating CXCR5+ Follicular Helper T Cells Reflect the Presence of Airway Obstruction in Asthma by Tsukie Kin Tsukuda, Kimiko Tsuji, Akari Nishimori, Takehiko Ito, Yuka Kobayashi, Taro Suzuki, Akihito Yokoyama

“…The progressive decline in lung function observed in asthma is attributed to persistent type 2 airway inflammation and associated airway remodeling. …”
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Asthma-associated prostate enlargement and bladder smooth muscle hypercontractility: unveiling a potential link to LUTS by Peibin Cen, Ming Chen, Xin Qiu, Wenbin Guo, Hongyu Lan, Xingyu Zhou, Ming Lei, Guohua Zeng, Qingfeng Yu

Subjects: “…Asthma…”
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Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation by Marianne Nuijsink, Wim C. J. Hop, Peter J. Sterk, Eric J. Duiverman, Johan C. De Jongste

“…The aim of this study was to assess cross-sectional and longitudinal correlations between uEPX and other markers of asthma control and eosinophilic airway inflammation. …”
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OK-432 Acts as Adjuvant to Modulate T Helper 2 Inflammatory Responses in a Murine Model of Asthma by Cheng-Jang Wu, Pin-Hsun Tseng, Cheng-Chi Chan, Sara Quon, Li-Chen Chen, Ming-Ling Kuo

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