-
1401
Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes
Published 2019-01-01“…Dysregulation of multiple microRNAs widely takes place during rheumatoid arthritis (RA) and experimental arthritides. This study is performed to explore the possible mechanism underlying DICER1 deficiency-mediated inflammation in human synoviocytes SW982. …”
Get full text
Article -
1402
Development of quality indicators for hand osteoarthritis care – Results from an European consensus study
Published 2025-03-01Get full text
Article -
1403
Nature and prevalence of long-term conditions in people with intellectual disability: retrospective longitudinal population-based study
Published 2025-01-01“…Conditions which may usually be expected to emerge later in life are present in younger age groups, such as diabetes, hypertension and chronic arthritis. When hospital episodes were analysed, epilepsy, diabetes, chronic airway disease and mental illness were commonly treated conditions during hospital admission across both sexes. …”
Get full text
Article -
1404
Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation
Published 2025-01-01“…We aimed to investigate the relationship between circulating apoCIII levels and subclinical inflammation markers across different cohorts with distinctive inflammatory patterns: patients with metabolic disorders (MDs), patients with rheumatoid arthritis (RA), and controls. Specifically, we assessed the associations of apoCIII with acute inflammation biomarkers (e.g., high sensitivity C-reactive protein (hsCRP)) and novel systemic inflammation biomarkers (e.g., glycosylated proteins: Glyc-A, Glyc-B, Glyc-F), aiming to understand the role of apoCIII beyond its traditional function in TG metabolism. …”
Get full text
Article -
1405
Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassip...
Published 2025-02-01“…Background: Diabetes Mellitus is a chronic metabolic disorder caused by genetic disorders and other factors such as the use of certain medications, pancreatic injury, and autoimmune diseases such as rheumatoid arthritis and high blood pressure. However, several therapeutic agents are currently used to manage blood sugar levels, thus reducing the risk of complications. …”
Get full text
Article -
1406
Biomimetic bioreactor for potentiated uricase replacement therapy in hyperuricemia and gout
Published 2025-01-01“…It also targeted inflamed joints, reducing swelling and inflammation in gouty arthritis models.DiscussionThis study presents RBC@SeMSN@Uri as a novel biomimetic strategy for enzyme replacement therapy in hyperuricemia and gout. …”
Get full text
Article -
1407
3D-printed constructs deliver bioactive cargos to expedite cartilage regeneration
Published 2024-12-01Get full text
Article -
1408
Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study
Published 2025-01-01“…Age at disease onset (OR 1.02), axial symptom (OR 16.25), peripheral arthritis (OR 6.81), decade at disease onset (OR 3.80) and extra-musculoskeletal manifestation (OR 2.89) were associated with an early diagnosis, while female gender (OR 0.66) was inversely associated.Conclusions The proportion of patients with early SpA diagnosis improve from 15% before 1980 to 88% when first symptoms occurred after 2010. …”
Get full text
Article -
1409
-
1410
Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts
Published 2025-01-01“…Hypertension was prominent across clusters in all ages, while depression featured in younger groups and painful conditions/arthritis were common in clusters from middle-age onwards. …”
Get full text
Article -
1411
-
1412
Efficacy and safety of jaktinib hydrochloride tablets in active axial spondyloarthritis: a multicentre, randomised, double-blind, placebo-controlled phase II clinical trial
Published 2025-01-01“…The primary and key secondary endpoints were Assessment of SpondyloArthritis international Society 20 (ASAS 20) and ASAS 40 responses, respectively, at week 16. …”
Get full text
Article -
1413
-
1414
COVID-19 on patients with immune-mediated rheumatic disease: a comparative study of disease activity, fatigue, and psychological distress over six months
Published 2025-01-01“…Although the mean activity scores did not differ significantly, some patients reported worsened disease activity post-COVID-19, particularly in rheumatoid arthritis (RA) (32.2%) and systemic lupus erythematosus (SLE) patients (23.3%). …”
Get full text
Article -
1415
-
1416
The Knee-SCHOOL: a brief patient-centered multidisciplinary educational program for knee osteoarthritis
Published 2025-01-01“…BackgroundKnee osteoarthritis (KOA) is the most common form of arthritis in adults and a leading cause of years lived with disability, representing a significant burden on healthcare worldwide.ObjectiveDescribe the structure and educational elements of the Knee-SCHOOL, a brief patient-centered multidisciplinary educational program for patients with KOA.DesignObservational prospective study.SettingAcademically affiliated rehabilitation outpatient center in Brazil.MethodsThe program consisted of three in-person educational sessions (4.5 hr each) for 55 community dwelling adults, aged ≥50 years, with primary KOA-related pain. …”
Get full text
Article -
1417
Microbial metabolites and immune modulation
Published 2024-12-01“…AhR agonists derived from tryptophan metabolism enhance mucosal barrier functions, reducing disease severity. In rheumatoid arthritis, butyrate suppresses Th17-mediated joint inflammation, highlighting its systemic immunomodulatory capabilities. …”
Get full text
Article -
1418
Invasive fungal diseases in patients with autoimmune diseases: a case series from the French RESSIF network
Published 2023-08-01“…We analysed total lymphocyte and CD4-T cell counts in patients with Pneumocystis jirovecii pneumonia (PCP).Results From 2012 to 2018, 549 individuals with IFD and AID were included, mainly with PCP (n=227, 41.3%), fungemia (n=167, 30.4%) and invasive aspergillosis (n=84, 15.5%). Rheumatoid arthritis (RA) and anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) were the most frequent AID in PCP (n=55 and 25, respectively) and invasive aspergillosis (n=15 and 10, respectively), inflammatory bowel diseases (IBDs) were predominant in fungemia (n=36). …”
Get full text
Article -
1419
A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care dataResearch in context
Published 2025-03-01“…., iron deficiency anaemia and peripheral arterial disease: genetic correlation Rg = 0.45 [95% Confidence Intervals 0.27:0.64]). 33 pairs displayed negative genetic correlations, such as skin cancer and rheumatoid arthritis (Rg = −0.14 [−0.21:−0.06]), due to potential adverse drug effects. …”
Get full text
Article -
1420