Demographic clinical trial diversity assessment methods: Use of real-world data by Hua Chen, Nnadozie Emechebe, Sudeep Karve, Leon Raskin, Jailene Leal, Ning Cheng, Wendy Sebby, Kim Ribeiro, Samuel Crawford

“…We present two examples of application of this framework to illustrate the results in the case of two disease states, rheumatoid arthritis and stroke.…”
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Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice by Ning Song, Hang Gao, Jianhao Li, Yi Liu, Mingze Wang, Zhiming Ma, Naisheng Zhang, Wenlong Zhang

“…Gout is a prevalent form of inflammatory arthritis that occurs due to high levels of uric acid in the blood leading to the formation of urate crystals in and around the joints, particularly affecting the elderly. …”
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A nested case-control study evaluating the relationship between adverse childhood experiences and immune-mediated inflammatory disease in the Canadian Longitudinal Study on Aging by Charles N Bernstein, Ruth Ann Marrie, Julia O'Mahony

“…We evaluated whether the association of ACE with disease differs between IMID and other chronic diseases.Design Nested retrospective case-control study.Setting We used data from the Canadian Longitudinal Study on Aging (CLSA), which recruited participants aged 45–85 years between 2010 and 2015.Participants We included 12 627 CLSA participants: 2 102 who reported diagnoses of IMID (258 multiple sclerosis (MS), 1 692 rheumatoid arthritis (RA) and 160 inflammatory bowel disease (IBD)), 5 519 with diabetes, 170 with epilepsy, 3 889 with asthma and 1 125 with no chronic diseases. …”
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Emicizumab in two patients with acquired haemophilia A – case report by Zhao Milly, Kartika Thomas, Witenko Corey, Snead Jessica, DeSancho Maria T, Ciolek Alana

“…The first patient, an 82-year-old man with rheumatoid arthritis (RA), presented with acquired haemophilia A (AHA) and spontaneous left tibia hematoma complicated by a persistent wound and infections. …”
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Coccoloba uvifera (L.) (Polygonaceae) Fruit: Phytochemical Screening and Potential Antioxidant Activity by Maira Rubi Segura Campos, Jorge Ruiz Ruiz, Luis Chel-Guerrero, David Betancur Ancona

“…Antioxidant compounds are now of considerable interest due to their effect of preventing or delaying aging and their apparent involvement in prevention of numerous human diseases, including cancer, atherosclerosis, Alzheimer’s disease, inflammation, and rheumatoid arthritis. In this work, the fruit of Coccoloba uvifera (L.) was investigated for their in vitro antioxidant capacity using two assays based on reactions with a relatively stable single reagent radical (Trolox equivalent antioxidant capacity, TEAC; and DPPH free radical scavenging assay, DPPH), two assays based on chelating of metallic cations, and one based on the reduction of oxidized species. …”
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Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci by Xingling Tan, MD, Zhouyouyou Xiao, MB, Yao Wen, MD, Han Liu, MD, Wei Yu, MD

“…Additionally, potential associations were observed with ulcerative colitis, psoriasis, chalazion, pernicious anemia, glaucoma, multiple sclerosis, arthritis, prostate cancer, varicose veins of lower extremities, and heart attack. …”
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Varied Presentations Of Patients With Systemic Lupus Erythematosus – What Makes Pakistani Lupus Patients Different by Muhammad Shahzad Manzoor, Shamaila Mumtaz, Faran Maqbool, Darakhshaan Samar, Muhammad Hammas Adil, Javaria Malik

“…Methods: This prospective, cross-sectional study was undertaken at the Clinic for Arthritis and Rheumatic Diseases, Rawalpindi Teaching Hospital, Rawalpindi, Pakistan between January 2020 and June 2023, involving adult patients with SLE (classified based on 1997 revised ACR criteria). …”
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Lived experiences of social support in Paralympic swimmers: A protocol for a qualitative study by Paul Martin, Alison Rushton, Nicola R Heneghan, Andrew Soundy, Beth Aitchison

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Mucosal Epithelial Jak Kinases in Health and Diseases by Narendra Kumar, Longxiang Kuang, Ryan Villa, Priyam Kumar, Jayshree Mishra

“…A selective Jak3 inhibitor CP-690550 (Xeljanz) approved by the FDA for certain chronic inflammatory conditions demonstrates immunosuppressive activity in rheumatoid arthritis, psoriasis, and organ transplant rejection. …”
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Simultaneous Inhibition of PGE2 and PGI2 Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models by Ryusuke Sugita, Harumi Kuwabara, Kazufumi Kubota, Kotaro Sugimoto, Toshihiro Kiho, Atsushi Tengeiji, Katsuhiro Kawakami, Kohei Shimada

“…Prostaglandin E2 (PGE2) is well known as a mediator of inflammatory symptoms such as fever, arthritis, and inflammatory pain. In the present study, we evaluated the analgesic effect of our selective PGE2 synthesis inhibitor, compound I, 2-methyl-2-[cis-4-([1-(6-methyl-3-phenylquinolin-2-yl)piperidin-4-yl]carbonyl amino)cyclohexyl] propanoic acid, in rat yeast-induced acute and adjuvant-induced chronic inflammatory pain models. …”
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Cataract Surgery with or without Intraocular Lens Implantation in Pediatric Uveitis: A Systematic Review with Meta-Analyses by Diana Chabané Schmidt, Moug Al-Bakri, Asrin Rasul, Regitze Bangsgaard, Yousif Subhi, Daniella Bach-Holm, Line Kessel

“…Ten studies of 288 eyes were eligible for review of which the majority were eyes with juvenile idiopathic arthritis-associated uveitis. Summary estimates revealed that the BCVA was better in pseudophakic eyes vs. aphakic eyes (1-year postoperative: −0.23 logMAR, 95% CI: −0.43 to −0.03 logMAR, P=0.027; 5-year postoperative: −0.35 logMAR, 95% CI: −0.51 to −0.18 logMAR, P=0.000036). …”
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Immune Toxicity with Checkpoint Inhibition for Metastatic Melanoma: Case Series and Clinical Management by Anna J. Lomax, Jennifer Lim, Robert Cheng, Arianne Sweeting, Patricia Lowe, Neil McGill, Nicholas Shackel, Elizabeth L. Chua, Catriona McNeil

“…Management algorithms for thyroiditis, hypophysitis, arthralgia/arthritis, colitis, steroid-refractory hepatitis, and skin toxicity are discussed.…”
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A comprehensive analysis of trends in the burden of gout in China and globally from 1990 to 2021 by Shiwei Xie, Heng Xiao, Lei Xu, Gengwu Li, Fan Zhang, Mingwei Luo

“…Abstract Gout is a prevalent metabolic disorder characterized by urate crystal accumulation in joints, leading to acute arthritis and tophi formation. Despite advancements in management, the incidence and prevalence of gout have been increasing globally, particularly in China. …”
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Clinical profile and treatment outcome in chronic recurrent multifocal osteomyelitis: Experience from a tertiary care center in Southern India by Sandeep Surendran, Suma Balan

“…The initial diagnosis made were either of infection related osteomyelitis or juvenile arthritis. Nine of the 20 children had undergone bone biopsies. …”
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Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease by José L. Reyes, Danielle T. Vannan, Bertus Eksteen, Imelda Juárez Avelar, Tonathiu Rodríguez, Marisol Ibet González, Alicia Vázquez Mendoza

“…In its secondary form, DED is often associated with autoimmune diseases such as Sjögren’s syndrome and rheumatoid arthritis. Current treatment strategies for DED are limited to anti-inflammatory medications that target the immune system as the source of deleterious inflammation and tissue injury. …”
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Annexin I and dexamethasone effects on phospholipase and cyclooxygenase activity in human synoviocytes by Annaleise V. Sampey, Paul Hutchinson, Eric F. Morand

“…Annexin I is a glucocorticoid-induced mediator with anti-inflammatory activity in animal models of arthritis. We studied the effects of a bioactive annexin I peptide, ac 2–26, dexamethasone (DEX), and interleukin-1β (IL-1β) on phospholipase A2 (PLA2) and cyclooxygenase (COX) activities and prostaglandin E2 (PGE2) release in cultured human fibroblast-like synoviocytes (FLS). …”
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Patients’ and physiotherapists’ perspectives on implementing a tailored stratified treatment approach for low back pain in Nigeria: a qualitative study by Kay Stevenson, Mishael Adje, Jost Steinhäuser, Chidozie Emmanuel Mbada, Sven Karstens

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Unmasking health determinants and health outcomes for urban First Nations using respondent-driven sampling by J Smylie, M Firestone, S Maracle, M Spiller, P O'Campo

“…Common chronic diseases included arthritis, hypertension, diabetes and chronic obstructive pulmonary disease and rates of emergency room access were elevated.Conclusions RDS is an effective sampling method in urban Aboriginal contexts as it builds on existing social networks and successfully identified a population-based cohort. …”
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A comparative analysis of the health monitoring process using deep learning methods for brain tumour by N. Manjunathan, N. Gomathi

“…This model has a number of sensors, including sensors for arthritis, body temperature, skin response, and pulse. …”
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A proliferation-inducing ligand (APRIL) level among risk factors of ocular involvement in patients with Behçet’s disease by Rasha M. Ghaleb, Hanan S. Gad, Mohamed I. Abdallah, Zaki M. Zaki, Jehan A. Mahmoud

“…Cutaneous lesions and arthritis were strong independent predictors for ocular involvement in BD patients. …”
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