Society for Immunotherapy of Cancer: updates and best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) image analysis and data sharing by Ignacio I Wistuba, Michael T Tetzlaff, Carlo B Bifulco, Benjamin Green, Sacha Gnjatic, Scott J Rodig, Joel C Sunshine, Janis M Taube, Keith E Steele, Marlon C Rebelatto, David L Rimm, Ana Lako, Edwin R Parra, Guray Akturk, Michael Angelo, Shirley Greenbaum, Noah F Greenwald, Cyrus V Hedvat, Travis J Hollmann, Kurt A Schalper, Cláudia S Ferreira, Konstanty Korski, Emanuel Schenck, Michael J Surace, Jennifer H Yearley, Jeffrey S Roskes, Margaret Eminizer, Logan L Engle, Daniel Jiménez-Sánchez, Jamie Rodriguez-Canales, Alexander S Szalay

“…Objectives Multiplex immunohistochemistry and immunofluorescence (mIHC/IF) are emerging technologies that can be used to help define complex immunophenotypes in tissue, quantify immune cell subsets, and assess the spatial arrangement of marker expression. mIHC/IF assays require concerted efforts to optimize and validate the multiplex staining protocols prior to their application on slides. …”
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Effect of Zhuanggu Jianxi Decoction on Synovitis in Knee Osteoarthritis Rabbits via LXRs/NF-κB Pathway by CHEN Peng, GUO Jiemei, XIAO Yan, WANG Jianhui, SU Youxin

“…Compared with the Zhuanggu Jianxi decoction group, the protein expression of LXRα and N-CoR in both the LXRα and N-CoR inhibitor groups were significantly decreased (<italic>P</italic>&lt;0.05), and the protein expression of P50 and P65 were significantly increased (<italic>P</italic>&lt;0.05).ConclusionZhuanggu Jianxi decoction could improve the pathological manifestations of synovial lining cell hyperplasia and the disorder arrangement, inflammatory cell infiltration and fibrous tissue hyperplasia, reduce the content of inflammatory related indexes in tissues, so as to reduce the inflammatory response of KOA synovial tissue in rabbits, which may be related to the up-regulation of LXRα and N-CoR protein expression in synovial cells via LXRs/NF-κB pathway in synovial tissue, thereby down-regulating P50 and P65 protein to reduce IL-1β, TNF-α, MMP-3 and MMP-13.…”
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Crack of a helicopter main rotor actuator attachment: failure analysis and lessons learned by L. Allegrucci, F. De Paolis, A. Coletta, M. Bernabei

“…This condition is mainly related to the presence of coarse-grained and aligned CuAl2 precipitates. This arrangement is due to an overheating (more than 507°C) or to a cooling process carried out too slowly.Microstructural analysis was carried out on three items: 1) a large portion of the broken actuator attachment; 2) on a servoactuator coming from the same production batch; 3) on a servo actuator coming from a different production batch.The microstructure from the broken actuator attachment showed a great amount of precipitates (second phases) lengthwise aligned to the boundary grain, pores, and also cavities and dendritic globular formations.Analysis results, morphology evidences and reference images available on scientific literature were found to be in excellent agreement and validated the embrittlement and subsequent SCC mechanism hypotesis (intergranular failure propagation). …”
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Neuroprotective Effect of Crocin on Rats with Focal Cerebral Ischemia-Reperfusion Injury Based on TLR4/NF-κB Pathway by LI Xiaolei, ZHU Haisheng, MA Ruijuan, HU Ke, FENG Lina, WANG Xudong

“….); western blot was used to detect the expression of toll-like receptor 4 (TLR4), nuclear factor-κB p65 (NF-κB p65), p-NF-κB p65, IκBα, p-IκBα, Cleved Caspase-3, B-lymphoma-2 gene (Bcl-2), Bcl-2-related X protein (Bax).Results(1) Neurological function, cerebral infarction rate and cerebral water content: compared with the sham operation group, the mNSS score, cerebral infarction rate, cerebral water content in the model group increased significantly (<italic>P</italic>&lt;0.05); compared with the model group, the mNSS score, cerebral infarction rate, cerebral water content in the crocin group and the crocin + lipopolysaccharide group decreased significantly (<italic>P</italic>&lt;0.05); compared with the crocin group, the mNSS score, cerebral infarction rate, cerebral water content in the crocin + lipopolysaccharide group increased significantly (<italic>P</italic>&lt;0.05). (2) Pathological changes and apoptosis of cortical neurons: the cortical neurons in the sham operation group showed normal morphology and complete structure; the pathological changes of cortical neurons such as disordered arrangement, decreased number, vacuolar degeneration, hyperchromatic cytoplasmic pyknosis, unclear nuclear membrane boundary, inflammatory cell infiltration were observed in the model group; the pathological changes of cortical neurons in the crocin group were significantly improved. …”
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Protective mechanism of safflower yellow injection on myocardial ischemia-reperfusion injury in rats by activating NLRP3 inflammasome by Lingmei Li, Ce Cao, Hao Guo, Li Lin, Lei Li, Yehao Zhang, Gaojie Xin, Zixin Liu, Shujuan Xu, Xiao Han, Qiong Zhang, Jianhua Fu

“…Results In vivo, compared with sham group, the percentage of myocardial infarction area was increased and myocardial tissue arrangement was disordered in I/R group. In addition, the activities of myocardial enzymes, the contents of inflammatory factors, the expressions of inflammatory-related proteins, autophagy-related proteins, autophagosome-related proteins, Bax and Caspase-3 were increased, while Bcl-2 and Bcl-2/Bax were decreased. …”
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Suitable Sowing Date Method of Winter Wheat at the County Level Based on ECMWF Long-Term Reanalysis Data by LIU Ruixuan, ZHANG Fangzhao, ZHANG Jibo, LI Zhenhai, YANG Juntao

“…The research results can not only provide decision-making reference for winter wheat yield assessment in Qihe county, but also provide an important theoretical basis for scientifically arrangement of agricultural production.…”
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E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration by Michela Tozzi, Alessia Fiore, Sara Travaglione, Francesca Marcon, Gabriella Rainaldi, Elena Angela Pia Germinario, Ilenia Laterza, Simona Donati, Daniele Macchia, Massimo Spada, Omar Leoni, Maria Cristina Quattrini, Donatella Pietraforte, Sofia Tomasoni, Filippo Torrigiani, Ranieri Verin, Paola Matarrese, Lucrezia Gambardella, Francesca Spadaro, Maria Carollo, Agostina Pietrantoni, Francesca Carlini, Concetta Panebianco, Valerio Pazienza, Filomena Colella, Donatella Lucchetti, Alessandro Sgambato, Antonella Sistigu, Federica Moschella, Marco Guidotti, Olimpia Vincentini, Zaira Maroccia, Mauro Biffoni, Roberta De Angelis, Laura Bracci, Alessia Fabbri

“…In addition, CNF1 modifies intestinal permeability by directly altering tight junctions’ distribution in 2D Caco-2 monolayers, and by hindering the differentiation of 3D Caco-2 spheroids with an irregular arrangement of these junctions. In vivo, repeated intrarectal administration of CNF1 induces the formation of dysplastic aberrant crypt foci (ACF), and produces the formation of colorectal adenomas in an IBD model. …”
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Julius Kruopis – the pioneer of applied statistics in Lithuania by Vilijandas Bagdonavičius, Vydas Čekanavičius, Rūta Levulienė, Pranas Vaitkus

“…Under his supervision Vanda Bikelienė (Asymptotic distribution of sums of samples from finite populations, 1981) and  Natalja Kosareva  (Asymptotic analysis of statistics distributions in the scheme of sets of particles arrangement with equal probabilities, 1986) defended their doctoral theses in mathematics. …”
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Les textiles dans les tombes gauloises à dépôt de crémation en vase métallique : usages pratiques, mises en scène et perspectives anthropologiques (seconde moitié du vie s.-ve s. a... by Elsa Desplanques

“…A review was necessary in order to quantify and qualify the fragments (number, nature, arrangement) in relation to the ossuary and burnt bone assemblages, as well as to then attempt to understand the way in which these fabrics were used within funerary ritual. …”
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Dépôts et pratiques symboliques dans l’établissement aristocratique gaulois de Varennes-sur-Seine, la Justice (Seine-et-Marne) by Jean-Marc Séguier, Ginette Auxiette, Fabien Pilon

“…Considered together, this evidence testifies to the plurality of structures and arrangements therein, as well as of gestures involved in practices with symbolic connotations, of a private nature, within a rural settlement. …”
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Call for Papers: Constitutions and Intergenerational Justice by IF and FRFG

“…Madison disagreed and referred to the uncertainty that would emerge from such an arrangement. Thomas Paine sided with Jefferson and formulated the following famous sentence: ‘Every age and generation must be as free to act for itself in all cases as the ages and generations which preceded it.’ …”
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Designing a Digital Branding Pattern in Healthy Agricultural Products by Abolghasem Mohammadnezhad Ali Zamini, Arezo Ahmadi danyali, Mahmoud Ahmadi Sharif

“…The country of Iran is proficient in the production of agricultural products, and produces all kinds of agricultural and garden products every year; all Iranian products have a high capacity to be branded due to Iran's special climatic conditions and the country's four season, but unfortunately, many products that are at a high level in terms of quality are bought in bulk and exported to other countries and sold under the brand of these companies; therefore, the lack of a suitable brand is one of the weaknesses of Iran's agriculture, which demands that this sector be given a proper arrangement. Producers of healthy agricultural products should understand the potential of the Internet as a branding tool in the agricultural sector because the Internet can be a powerful branding tool for healthy agricultural products beyond labels and brochures. …”
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Iwolefu Funeral Insurance and the Socioeconomics of Burial Ceremony in Ikorodu area of Lagos State by Faruq Idowu Boge

“…Human beings have evolved the custom of honouring the deceased with organized burial arrangements. Each society, therefore, has a different tradition for funeral arrangements and burial ceremonies. …”
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Shared governance increases marine protected area effectiveness. by Andrea Mast, David Gill, Gabby N Ahmadia, Emily S Darling, Dominic A Andradi-Brown, Jonas Geldman, Graham Epstein, M Aaron MacNeil

“…Protected areas are governed by a variety of institutional arrangements, yet little is known concerning the relative performance of different governance approaches. …”
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Local level institutional complementarities in contemporary China by Alexandre De Podestá Gomes

“…This paper has the objective of bringing to light and comparing two different types of institutional arrangements existing in two different prefecture-level cities in China: Nanjing and Suzhou. …”
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“Kyrie paschale” in Polish Organ Tablatures from the First Half of the 16th Century – Problems of Style and Attribution by Grzegorz Kos

“…The intabulations are arrangements of consecutive sections of the plainchant melody Kyrie ‘Lux et origo’ and constitute sequences of segments (or modules) of a Mass in which organ music alternates with plainchant. …”
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Managing agricultural water use in the Western United States: A search for efficient climate adaptation institutions by Frank A. Ward, Nicholas A. Potter, R. Aaron Hrozencik

“…These findings suggest that water trading arrangements have an important role play in adapting to water supply changes. …”
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Changes in workplace accommodations among employed Canadians with disabilities, 2017 to 2022 by Christoph Schimmele, Sung-Hee Jeon, Rubab Arim

“…Work arrangements changed during the COVID-19 pandemic, as organizations switched to working from home on a large scale and used digital technologies to adapt to physical distancing mandates (Deng et al., 2020; Fuentes & Lindsay, 2023). …”
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Evolution and diversity of institutions: Using institutional grammar to analyze governance changes in traditional crop-livestock systems by Irene Pérez-Ibarra, Alicia Tenza-Peral, Diego Soler-Navarro, Diego Arahuetes-de la Iglesia, Carmen Garate-Marín

“…Our objective was to analyze the institutional arrangements used over the last few decades relative to sharing common resources (pastures and water) and maintaining public infrastructures. …”
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Associativismo e desenho institucional no Orçamento Participativo da região metropolitana do Espírito Santo by Euzeneia Carlos

“…The study affirms the relevance of the variables, associativism and institutional design for the understanding of participation in the institutionalized arrangements. The analysis demonstrates that associativism encourages the actors' participation in the institutionalized channels, whereas the perception of authority by the social representatives correlates with the institutional design of the participatory arrangements.…”
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