A Label-Free Colorimetric Aptasensor for Flavokavain B Detection by Sisi Ke, Ningrui Wang, Xingyu Chen, Jiangwei Tian, Jiwei Li, Boyang Yu

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Targeting Brain Drug Delivery with Macromolecules Through Receptor-Mediated Transcytosis by Yuanke Li, Ruiying Liu, Zhen Zhao

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A Novel Aggregation-Induced Emission-Based Electrochemiluminescence Aptamer Sensor Utilizing Red-Emissive Sulfur Quantum Dots for Rapid and Sensitive Malathion Detection by Yajun Wu, Dongxiao Ma, Xiaoli Zhu, Fangquan Xia

“…Here, we constructed a novel aggregation-induced emission (AIE) electrochemical aptamer (Apt) sensor based on red-emissive sulfur quantum dots (SQDs), which aimed at the rapid screening and quantitative detection of malathion. …”
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Sensitive ratiometric detection of Fumonisin B1 using a reusable Ag-pSi SERS platform by Narsingh R. Nirala, Sudharsan Sadhasivam, Rohit Kumar Singh, Edward Sionov, Giorgi Shtenberg

Subjects: “…Aptamer…”
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A Truncated Multi-Thiol Aptamer-Based SARS-CoV-2 Electrochemical Biosensor: Towards Variant-Specific Point-of-Care Detection with Optimized Fabrication by Sergio Roberto Molina Ramirez, Nafiseh Samiseresht, Mateo Alejandro Martínez-Roque, Ferdinando Catania, Kevin Graef, Martin Rabe, Andreas Offenhäusser, Dirk Mayer, Gabriela Figueroa-Miranda

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Nanozyme-based aptasensors for the detection of tumor biomarkers by Ke Wang, Xiaogang Lin, Xiao Lv, Mingna Xie, Jinyu Wu, Jie Jayne Wu, Yang Luo

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Dual targeting of breast cancer by chitosan/poly lactic-co-glycolic acid nanodelivery systems: Surface activation with folic acid/aptamers, and co-encapsulated with Sorafenib and quercetin by Asghar Narmani, Saeid Ganji, Maryam Amirishoar, Fatemeh Hajikarimi, Aynaz Mazandarani, Mahya Karimi, Ali Mohammadinejad, Azin Azadpour, Roghayyeh Jahedi, Elham Assadpour, Seid Mahdi Jafari

“…Therefore, a breakthrough aptamer (Apt)- and folic acid (FA)-targeted chitosan (CS)-poly lactic-co-glycolic acid (PLGA) nanocarrier was developed for co-delivery of sorafenib (So) and quercetin (Qu) to MCF-7 and MDA-MB-231 breast cancer cells. …”
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Assessing traditional Chinese medicine from a molecular perspective by Minhui Su, Wenxi Wang, Xudong Sun, Lihong Li, Weihong Tan

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Microenvironment-confined kinetic elucidation and implementation of a DNA nano-phage with a shielded internal computing layer by Decui Tang, Shuoyao He, Yani Yang, Yuqi Zeng, Mengyi Xiong, Ding Ding, Weijun Wei, Yifan Lyu, Xiao-Bing Zhang, Weihong Tan

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Carbon Material Hybrid Construction on an Aptasensor for Monitoring Surgical Tumors by Renyuan Ma, Subash C. B. Gopinath, Thangavel Lakshmipriya, Yeng Chen

“…Carbon-based material was used to attach a higher anti-CEA capture aptamer onto the sensor surface through a chemical linker, and then, CEA was quantified by the aptamer. …”
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Scaffold-enabled high-resolution cryo-EM structure determination of RNA by Daniel B. Haack, Boris Rudolfs, Shouhong Jin, Alexandra Khitun, Kevin M. Weeks, Navtej Toor

“…In the case of the TPP riboswitch aptamer domain, the scaffolding approach allowed visualization of the riboswitch ligand binding pocket at 2.5 Å resolution. …”
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A Sensitive and Selective Electrochemical Aptasensor for Carbendazim Detection by Suthira Pushparajah, Mahnaz Shafiei, Aimin Yu

“…Then, a CBZ-specific aptamer was attached via Pt-sulfur bonds. Upon combining CBZ with the aptamer on the electrode surface, the redox reaction of the electrochemical probe K₄[Fe(CN)₆] is hindered, resulting in a current drop. …”
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Extraordinary tunable dynamic range of electrochemical aptasensor for accurate detection of ochratoxin A in food samples by Lin Cheng, Hao Qu, Jun Teng, Li Yao, Feng Xue, Wei Chen

“…This electrochemical aptasensor is constructed based on the target induced aptamer-folding detection mechanism and the recognition between OTA and its aptamers results in the conformational change of the aptamer probe and thus signal changes for measurement. …”
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RNA folding kinetics control riboswitch sensitivity in vivo by David Z. Bushhouse, Jiayu Fu, Julius B. Lucks

“…Understanding how riboswitch sensitivity to ligand (EC50) is controlled is critical to explain how highly conserved aptamer domains are deployed in a variety of contexts with different sensitivity demands. …”
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An antifouling polydopamine-based fluorescent aptasensor for determination of arginine kinase by Yanbo Wang, Huan Li, Jinru Zhou, Fangting Wang, Yifan Qian, Linglin Fu

“…With the presence of AK, the PDA-based aptasensor exhibited elevated fluorescent signals as the FAM-labeled aptamer bound to AK and detached from the PDA particles. …”
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Nanoarchitectonics of Biofunctionalized Hydrogen‐Terminated 2D‐Germanane Heterostructures as Highly Sensitive Biorecognition Transducers: The Case Study of Cocaine Drug by Yiming Lei, Ángel Campos‐Lendínez, Xavier Sala, Jordi García‐Antón, Jose Muñoz

“…Interestingly, the aptamer–cocaine interactions hinder the interfacial electron‐transfer process of the benchmark [Fe(CN)6]3−/4− redox marker with increasing concentration of the cocaine target, leading to a detection limit as low as 4.9 ± 0.1 aM, the lowest one reported in literature by far. …”
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Preparation, characterisation, and in vitro cancer‐suppression function of RNA nanoparticles carrying miR‐301b‐3p Inhibitor by Junjie Zhao, Niu Niu, Fan Yang, Haitao Liu, Weibo Qi

“…Methods The NPs were composed of miR‐301b‐3p, A549 aptamer (A549apt), and Cyanine 5 in a bottom‐up manner with a 3‐way‐junction (3WJ) structure. …”
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Tenascin C-Guided Nanosystem for Precision Delivery of Obeticholic Acid in Liver Fibrosis Therapy by Yawen Wang, Lei Yang, Qing Xu, Taiyu Liu, Hongliang He, Lisha Liu, Lifang Yin

“…<b>Methods:</b> We designed a liposomal delivery system functionalized with the GBI-10 aptamer and encapsulating obeticholic acid (OCA lips@Apt) to enhance selective delivery to fibrotic liver tissue while minimizing systemic toxicity. …”
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Detection of Quadruplex DNA by Gold Nanoparticles by Heather F. Crouse, Alex Doudt, Cassie Zerbe, Swarna Basu

“…Enhancement of PRLS signals greater than 50% was observed at nanomolar DNA concentration, and a lower limit of detection of 2.1 nM was established for three different quadruplex DNA sequences, including the thrombin-inhibiting single-stranded 15 mer aptamer DNA, d(GGTTGGTGTGGTTGG), and the double-stranded 12 mer DNA, d(G4T4G4). …”
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A critical review of the limitations of current diagnostic techniques for schistosomiasis by Ilemobayo Victor Fasogbon, Erick Nyakundi Ondari, Deusdedit Tusubira, Egwu Chinedu Ogbonnia, Jon Ashley, Swamiappan Sasikumar, Patrick Maduabuchi Aja

“…This review summarizes the published literature on the diagnostics of schistosomiasis based on the techniques of microscopy, serology, molecular, antigen-based and aptamer-based assays. The limitations of each technique were summarized to encourage future research. …”
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