Aptamers as new promising entities for therapeutics: our experience from the neurological diseases by Macarena Hernández-Jiménez, Fernando de Castro

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Serum assisted PD-L1 aptamer screening for improving its stability by Yu Zhou, Haozhe Zhang, Yujing Ding, Changyuan Yu, Hao Li

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Determination of L-Argininamide Based on Water-Soluble Fluorescent Conjugated Polymer-Aptamer by Hongliang Guan, Zhike He

“…In this paper, a simple label-free DNA sensor, which consisted of a poly(3-alkoxy-4-methylthiophene) and an aptamer, was used to detect L-argininamide (L-Arm). …”
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Application of PS2M Aptamer as Receptor Layer for Electrochemical Detection of Lead Ions by Izabela Zaras, Olga Kujawa, Marcin Olszewski, Marta Jarczewska

Subjects: “…aptamer-sensing layer…”
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Aptamer-Conjugated Multi-Quantum Dot-Embedded Silica Nanoparticles for Lateral Flow Immunoassay by Kwanghee Yoo, Hye-Seong Cho, Jaehi Kim, Minsup Shin, Jun-Sik Chu, Sohyeon Jang, Han-Joo Bae, Heung Su Jung, Homan Kang, Bong-Hyun Jun

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The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman  Pinschers of efficacy and outcomes by Sabine Werner, Gerd Wallukat, Niels‐Peter Becker, Katrin Wenzel, Johannes Müller, Ingolf Schimke, Gerhard Wess

“…Abstract Aims Aptamer BC 007, a 15‐mer single‐strand DNA oligonucleotide (5'‐GGTTGGTGTGGTTGG‐3'), was developed to neutralize functional autoantibodies that bind to the extracellular domains of G protein‐coupled receptors (GPCR‐AAB), leading to the modulation of receptor‐mediated signalling cascades that induce pathophysiological states. …”
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Recognition mechanism and sequence optimization of organophosphorus pesticides aptamers for better monitoring contaminations in food by Pengfei Chen, Chaoqiong Hu, Xuan Tao, Zheng Zhou, Lijun Wang, Xiao Yang, Zhenming Che, Xianggui Chen, Yukun Huang

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CRISPR-Hybrid: A CRISPR-Mediated Intracellular Directed Evolution Platform for RNA Aptamers by Qiwen Su-Tobon, Jiayi Fan, Michael Goldstein, Kevin Feeney, Hongyuan Ren, Patrick Autissier, Peiyi Wang, Yingzi Huang, Udayan Mohanty, Jia Niu

“…Here, we report an intracellular directed evolution platform for RNA aptamers against intracellularly expressed RBPs. We optimize a bacterial CRISPR-hybrid system coupled with FACS, and identified high affinity RNA aptamers orthogonal to existing aptamer-RBP pairs. …”
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Aptamers as the Agent in Decontamination Assays (Apta-Decontamination Assays): From the Environment to the Potential Application In Vivo by Mawethu Pascoe Bilibana, Marimuthu Citartan, Tzi Shien Yeoh, Timofey S. Rozhdestvensky, Thean-Hock Tang

“…The binding specificity and affinity of aptamers have long been harnessed as the key elements in the development of aptamer-based assays, particularly aptasensing application. …”
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Direct Detection of Thrombin Binding to 8-Bromodeoxyguanosine-Modified Aptamer: Effects of Modification on Affinity and Kinetics by Shou Goji, Jun Matsui

“…The affinity of an 8-bromodeoxyguanosine- (8-BrdG-) substituted thrombin-binding aptamer (TBA-Br), which has the 1st and 10th guanosine residues replaced with 8-BrdG, was estimated using reflectometric interference spectroscopy (RIfS). …”
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A Label-Free Aptasensor for the Detection of Sulfaquinoxaline Using AuNPs and Aptamer in Water Environment by Zhaoyang Zhou, Xingyue Chen, Shuang Jiang, Zhuoer Chen, Sixian Wang, Yueyang Ren, Xiaodong Fan, Tao Le

“…As a new recognition molecule, the aptamer can be recognized with SQX with high affinity and specificity, and the aptamer is no longer adsorbed to AuNPs after binding to SQX, which weakens the catalytic effect of AuNPs. …”
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High-Affinity Detection of Alpha-Synuclein by Aptamer-Gold Conjugates on an Amine-Modified Dielectric Surface by Xuemei You, Subash C. B. Gopinath, Thangavel Lakshmipriya, Dingan Li

“…In addition, a gold nanoparticle-conjugated aptamer was used to enhance the detection limit. The limit of detection for the binding between alpha-synuclein and aptamer was found to be 10 pM. …”
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Non-Invasive Point-of-Care Detection of Methamphetamine and Cocaine via Aptamer-Based Lateral Flow Test by Bilge Erkocyigit, Ezgi Man, Ece Efecan, Ozge Ozufuklar, Deniz Devecioglu, Basak Bagci, Ebru Aldemir, Hakan Coskunol, Serap Evran, Emine Guler Celik

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A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer by Xue Zheng, Ying Wang, Huaiyu Duan, Junqi Hou, Shiming He

“…Here, we designed and prepared a novel aptamer-conjugated drug targeting NCL by AS1411 aptamer-human serum albumin (HSA)-the apoprotein of lidamycin (LDP)-active enediyne chromophore (AE), in order to achieve targeted treatment of esophageal cancer. …”
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Selective Phenome Growth Adapted NK Model: A Novel Landscape to Represent Aptamer Ligand Binding by Andrew Brian Kinghorn, Julian Alexander Tanner

“…A complete empirical characterisation of an aptamer selection experiment is not feasible due to the vast complexity of aptamer selection. …”
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Aptamer-conjugated gold nanoparticles enable oligonucleotide delivery into muscle stem cells to promote regeneration of dystrophic muscles by Francesco Millozzi, Paula Milán-Rois, Arghya Sett, Giovanni Delli Carpini, Marco De Bardi, Miguel Gisbert-Garzarán, Martina Sandonà, Ciro Rodríguez-Díaz, Mario Martínez-Mingo, Irene Pardo, Federica Esposito, Maria Teresa Viscomi, Marina Bouché, Ornella Parolini, Valentina Saccone, Jean-Jacques Toulmé, Álvaro Somoza, Daniela Palacios

“…We demonstrate that AuNPs conjugation to an aptamer against α7/β1 integrin dimers directs either local or systemic delivery of microRNA-206 to MuSCs, thereby promoting muscle regeneration and improving muscle functionality, in a mouse model of Duchenne Muscular Dystrophy. …”
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Mapping Surface Potential in DNA Aptamer–Neurochemical and Membrane–Ion Interactions on the SOS Substrate Using Terahertz Microscopy by Kosei Morita, Yuta Mitsuda, Sota Yoshida, Toshihiko Kiwa, Jin Wang

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Selection of DNA Aptamers for Ovarian Cancer Biomarker CA125 Using One-Pot SELEX and High-Throughput Sequencing by Delia J. Scoville, Tae Kyu Brian Uhm, Jamie A. Shallcross, Rebecca J. Whelan

“…We suggest that powerful new diagnostic tools may be enabled by the development of nucleic acid aptamers with affinity for CA125. Here, we report on our use of One-Pot SELEX to isolate single-stranded DNA aptamers with affinity for CA125, followed by high-throughput sequencing of the selected oligonucleotides. …”
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Low-Cost and Portable Biosensor Based on Monitoring Impedance Changes in Aptamer-Functionalized Nanoporous Anodized Aluminum Oxide Membrane by Nianyu Jiang, Pranav Shrotriya

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An Aptamer Sensor Based on Alendronic Acid-Modified Upconversion Nanoparticles Combined with Magnetic Separation for Rapid and Sensitive Detection of Thiamethoxam by Qian Huang, Lu Han, Hui Ma, Weijie Lan, Kang Tu, Jing Peng, Jing Su, Leiqing Pan

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