Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents by Frank Mazza, Alexandre Guet-McCreight, Thomas D. Prevot, Taufik Valiante, Etienne Sibille, Etay Hay

“…Background: Reduced cortical inhibition mediated by GABA (gamma-aminobutyric acid) is reported in depression, anxiety disorders, and aging. A novel positive allosteric modulator that specifically targets the α5-GABAA receptor subunit (α5-PAM), ligand GL-II-73 shows anxiolytic, antidepressant, and procognitive effects without the common side effects associated with nonspecific modulation by benzodiazepines such as diazepam, thus suggesting novel therapeutic potential. …”
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Self-administered active versus sham acupressure for diarrhea predominant irritable bowel syndrome: a nurse-led randomized clinical trial by Maha Gamal Ramadan Asal, Ahmed Abdelwahab Ibrahim El-Sayed, Samira Ahmed Alsenany, Zahraa Hassan Ramzy, Rasha Fathy Ahmed Dawood

“…Psychological outcomes, including anxiety and depression, also improved significantly in the active group. …”
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Status of sleeping habits and its influence on growth and metabolism of children in Beijing: a population-based cross-sectional study by Yiren Chen, Lijun Wu, Zijun Liao, Yiying Huang, Qin Liu, Shaoli Li, Junting Liu, Xinnan Zong, Jun Tai, Fangfang Chen

“…Results Girls had a greater rate of sleep anxiety, while boys had a greater rate of sleep-disordered breathing (SDB) across all age groups. …”
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Structured follow-up pathway to support people after transient ischaemic attack and minor stroke (SUPPORT TIA): protocol for a feasibility study and process evaluation by Grace M Turner, Melanie Calvert, Sue Jowett, Robbie Foy, Jonathan Mant, Sarah Tearne, Lou Atkins, Rachael Jones, Smitaa Patel, Phillip Collis

“…Follow-up questionnaires will measure anxiety, depression, fatigue, health related quality of life, self-efficacy and medication adherence. …”
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Development and internal validation of the Edmonton Obesity Staging System-2 Risk screening Tool (EOSS-2 Risk Tool) for weight-related health complications: a case-control study in... by Evan Atlantis, P Fahey, Kathryn Williams, Paul Dugdale, James Rufus John, SL Hocking, Kath Peters

“…Three variables were retained in the final multivariate model (age, self-assessed health and history of depression/anxiety). The EOSS-2 Risk Tool (index test) classified 89% of those at ‘extremely high risk’ (≥25 points), 67% of those at ‘very high risk’ (7–24 points) and 42% of those at ‘high risk’ (<7 points) of meeting diagnostic criteria for EOSS≥2 (reference).Conclusion The EOSS-2 Risk Tool is a simple, safe and accurate screening tool for diagnostic criteria for clinically significant weight-related complications for potential application in general practice. …”
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Procedural sedative effect of remimazolam in ICU patients on invasive mechanical ventilation: a randomised, prospective study by Youli Tian, Jintong Li, Minggen Jin, YiHua Piao, Jisheng Sheng, Zhixiong Mei, Qingsong Cui, Lilin Li

“…Abstract Background Invasive procedures and environmental factors in the intensive care unit (ICU) may cause anxiety and discomfort in patients, who often require sedation therapy. …”
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Improving diagnostics and surveillance of malaria among displaced people in Africa by Toufik Abdul-Rahman, Oyinbolaji Akinwande Ajetunmobi, Gafar Babatunde Bamigbade, Innocent Ayesiga, Muhammad Hamza Shah, Tolulope Sharon Rumide, Abdurahman Babatunde Adesina, Ganiyat Adekemi Adeshina, Oluwabusola Elizabeth Oni, Bet-ini Nsikak Christian, Abdullahi Tunde Aborode, Andrew Awuah Wireko, Hala Ibrahim Thaalibi, Iman Mustafa Abdalla, Sewar Basheer Banimusa, Justice Ndubuisi Jonathan, Isreal Ayobami Onifade, Md Ariful Haque

“…Furthermore, the psychological impact of malaria, which is marked by feelings of anxiety and uncertainty, is particularly severe in vulnerable populations such as displaced children and pregnant women, aggravating the overall burden. …”
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Life in green: Associations between greenspace availability and mental health over the lifecourse – A 40-year prospective birth cohort study by B. Deng, J. Boden, N. Ye, J. Morgenroth, M. Campbell, P. Eggleton, G. McLeod, M. Hobbs

“…Mental health outcomes including depressive symptoms, anxiety disorders and suicidal ideation were assessed in adolescence (16 years), and in adulthood (18–40 years). …”
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FEAR OF SOCIAL ALIENATION OF LOVE AS GENDER CHARACTERISTICS by V. V. Melnyk, L. І. Моzhovyi, I. A. Reshetova

“…The article establishes that gender identity under the conditions of modern socio-psychological crisis is associated with forming a special "picture of fear, anxiety, loneliness" as a part of that internal and external world, generated by alienation from society. …”
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Prevalence of and factors associated with symptoms consistent with a diagnosis of irritable bowel syndrome among resident physicians in standardised training in China: a cross-sect... by Xin Wang, Ning Li, Xia Li, Zhigang Li, Jun Zhao, Xuefei Wang, Xin Hao, Jiayi Yang, Junjian Tian

“…Univariate and multivariate logistic regression models were constructed to assess the associations of age, sex, body mass index, stress, depression, anxiety, sleep quality and IBS.Results Of the included resident doctors, 77.2% were female, 20.4% were obese or underweight and 8.6% had symptoms consistent with a diagnosis of IBS. …”
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Understanding the educational inequalities in suicide attempts and their mediators: a Mendelian randomisation study by Jing Wang, Ye Yang, Rui Gao, Lilu Ding, Jiahao Zhu, Dan Zhou, Yingjun Li, Houpu Liu

“…The respective proportions of mediation were 47% (95% CI: 29% to 66%) for smoking behaviour, 36% (95% CI: 0% to 84%) for chronic pain, 49% (95% CI: 36% to 61%) for depression, 35% (95% CI: 12% to 59%) for anxiety and 26% (95% CI: 18% to 34%) for insomnia. …”
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Patients with Multiple Functional Gastrointestinal Disorders (FGIDs) Show Increased Illness Severity: A Cross-Sectional Study in a Tertiary Care FGID Specialty Clinic by Sabrina Berens, Felicitas Engel, Annika Gauss, Jonas Tesarz, Wolfgang Herzog, Beate Niesler, Esther Stroe-Kunold, Rainer Schaefert

“…Furthermore, patients with >1 FGIDs had higher general somatic symptom severity, higher illness anxiety, lower quality of life, and more work-related impairment. …”
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Identification of Critical Signature in Post‐Traumatic Stress Disorder Using Bioinformatics Analysis and in Vitro Analyses by Lifen Liu, Yang Liu, Rui Li, Yue Teng, Shuyang Zhao, Jinhong Chen, Changjiang Li, Xinyu Hu, Lin Sun

“…The MCODE plugin in Cytoscape software was utilized to analyze the protein–protein interaction (PPI) network. Anxiety and depression in a mice stress model were assessed using the open‐field test (OFT), elevated plus maze test (EPMT), and forced swimming test (FST). …”
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Benefits and harms of pregabalin in the management of neuropathic pain: a rapid review and meta-analysis of randomised clinical trials by Igho J Onakpoya, Elizabeth T Thomas, Joseph J Lee, Ben Goldacre, Carl J Heneghan

“…Our secondary outcomes were sleep disturbance, quality of life, Patient Global Impression of Change, Clinician Global Impression scale, anxiety and depression scores, overall discontinuations and discontinuations because of adverse events.Results We included 28 trials comprising 6087 participants. …”
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Cognitive and Emotional Empathy in Individuals with Spinal Cord Injury by Veronica Guadagni, Marco Sarà, Massimiliano Conson, Antonio Carolei, Simona Sacco, Silvia Vadini, Caterina Pistarini, Arcangelo Barbonetti, Giuseppe Iaria, Francesca Pistoia

“…Participants were investigated using the State-Trait Anxiety Inventory (Form Y) (STAI-Y), the Beck Depression Scale, and the Toronto Alexithymia Scale. …”
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Ethical attitudes of the future Russian officials and businessmen: Comparative analysis by A. A. Maksimenko, O. S. Deyneka, D. V. Krylova, E. V. Zabelina, E. A. Bulgakova

“…In addition, future civil servants have more uncertainty about whether they will be able to take place in life, fears about possible collisions with life crises and difficulties, as well as anxiety for their future. Existing university ethics training programmes often only strengthen relativistic views and form deviant behaviour in the future.Scientific novelty. …”
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Risk factors for fear of falling in stroke patients: a systematic review and meta-analysis by Li Ma, Qi Xie, Juhong Pei, Ling Gou, Yabin Zhang, Juanping Zhong, Yujie Su, Xinglei Wang, Xinman Dou

“…The risk factors for FoF in patients with stroke were women (OR=2.13, 95% CI 1.47 to 3.09), impaired balance ability (OR=5.54; 95% CI 3.48 to 8.81), lower mobility (OR=1.12; 95% CI 1.05 to 1.19), history of falls (OR=2.33; 95% CI 1.54 to 3.53) and walking aid (OR=1.98; 95% CI 1.37 to 2.88), anxiety (OR=2.29; 95% CI 1.43 to 3.67), depression (OR=1.80; 95% CI 1.22 to 2.67), poor lower limb motor function (OR=1.14; 95% CI 1.00 to 1.29) and physically inactiveness (OR=2.04; 95% CI 1.01 to 4.12). …”
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Nursing Skill Assessment of Hospital Nurses in Management of Critically Ill Patients by Lingli Xu, Qiyu Sun, Jiayi Feng, Li Jing Huang, Chunjing Xu, Weihong Shen, Jian Ding, Yongmei Jin

“…The application of the standardized nursing process in the nursing of critically ill patients can not only effectively reduce the self-rating anxiety scale (SAS) and sarcoidosis diagnostic score (SDS) of patients but also reduce the incidence of complications and improve the nursing satisfaction of patients.…”
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Neuropsychological features of patients of reproductive age diagnosed with breast cancer at the stage of surgical treatment using xenon-oxygen therapy by D. A. Rozenko, A. I. Shikhlyarova, L. N. Vaschenko, N. N. Popova, Yu. Yu. Arapova, A. Yu. Ardzha, A. A. Korobov

“…During the study, statistically significant differences were found in the assessment of subjective indicators, so in the group of patients using xenon-oxygen therapy, there was an improvement in well-being by 2.6 times, a decrease in depression by 2.3 times, a decrease in symptoms of nausea by 3 times, anxiety 1.9 times (p < 0.05). Against the background of an improvement in the psychophysiological state, the EEG showed a significant increase in the power of slow delta and theta rhythms, an increase in the power of the alpha rhythm and a decrease in the power of the beta rhythm, while in the patients of the control group only a decrease in the power of the beta rhythm was noted.Conclusion. …”
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Efficacy, efficiency and safety of a cardiac telerehabilitation programme using wearable sensors in patients with coronary heart disease: the TELEWEAR-CR study protocol by Andrew Xanthopoulos, Eleni Kapreli, Garyfallia Pepera, Konstantinos I Gourgoulianis, Varsamo Antoniou, Gregory Giamouzis, Constantinos Davos, Ladislav Batalik, Vasileios Stavrou, John Skoularigis

“…Secondary outcomes will be the physical activity, the safety of the exercise intervention (number of adverse events that may occur during the exercise), the quality of life, the training adherence, the anxiety and depression levels, the nicotine dependence and cost-effectiveness. …”
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