Pharmacokinetics of antisense oligonucleotide drugs by M. R. Khaitov, V. V. Smirnov

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Tofersen and other antisense oligonucleotides in ALS by Albert Ludolph, Maximilian Wiesenfarth

“…The advent of antisense oligonucleotide (ASO) therapies in neurodegenerative disorders is associated with enormous hope. …”
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LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGY by O. I. Afanasieva, S. N. Pokrovsky

Subjects: “…antisense therapy…”
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Landscape of antisense genes in the human genome and identification of new human hepatic antisense RNAs by long-read sequencing by Juan Jose Rojo-Carrillo, Pedro Garrido-Rodríguez, Maria Llamas-López, Rosa Cifuentes-Riquelme, Jose Padilla, Bruno Ramos-Molina, Maria Luisa Lozano, Belen de la Morena-Barrio, Maria Eugenia de la Morena-Barrio, Javier Corral

Subjects: “…Antisense gene…”
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PERSPECTIVES OF ANTISENSE GENE THERAPY IN ORGAN TRANSPLANTATION by O. N. Reznik, A. E. Skvortsov, D. O. Kuzmin, A. P. Tutin, A. O. Reznik

Subjects: “…antisense gene therapy…”
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Antisense oligonucleotides for the arterial hypertension mechanisms study and therapy by L. O. Klimov, A. A. Seryapina, V. F. Zarytova, A. S. Levina, A. L. Markel

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Antisense oligonucleotides targeting IRF4 alleviate psoriasis by Yanxia Yu, Yirui Wang, Weiwei Chen, Chang Zhang, Zhuo li, Jing Yu, Minhao Wang, Can Song, Sihao Yan, Jiayi Lu, Liangdan Sun

“…The alleviation of imiquimod (IMQ)-induced psoriatic-like symptoms was achieved through the creation of a Irf4−/− gene deletion mouse model and pharmacological inhibition using antisense oligonucleotides targeted for Irf4. This amelioration was accompanied by a decreased number of IL-17A-producing CD4+ T cells in the skin. …”
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Rethinking antisense oligonucleotide therapeutics for amyotrophic lateral sclerosis by Daisuke Ito, Kensuke Okada

“…Abstract Antisense oligonucleotides, which are used to silence target genes, are gaining attention as a novel drug discovery modality for proteinopathies. …”
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Superior Silencing by 2′,4′-BNANC-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors by Tsuyoshi Yamamoto, Hidenori Yasuhara, Fumito Wada, Mariko Harada-Shiba, Takeshi Imanishi, Satoshi Obika

“…Melting temperatures of duplexes formed between 2′,4′-BNANC-based antisense oligonucleotides and the target mRNA surpassed those of 2′,4′-BNA/LNA-based counterparts at all lengths. …”
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Halloysite clay nanotubes as platforms for loading of aptamers and antisense oligonucleotides by Maria Rita Caruso, Martina Maria Calvino, Giuseppe Cavallaro, Jussara Amato, Simona Marzano, Federica D'Aria, Concetta Giancola, Giuseppe Lazzara, Stefana Milioto, Bruno Pagano

“…In this study, halloysite clay nanotubes have been investigated as a platform for the encapsulation of an antisense oligonucleotide (ASO1) and a DNA aptamer (D12) with potential in the treatment of prion diseases. …”
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Design and Binding Affinity of Antisense Peptides for Snake Venom Neutralization by Ivan Biruš, Tino Šeba, Marin Marić, Mario Gabričević, Tin Weitner

“…We selected two sense oligopeptides to represent critical neurotoxic regions of AtxA as targets for inhibition by complementary antisense peptides. Utilizing a heuristic antisense peptide design based on the molecular recognition theory, we modeled two antisense oligopeptides as complementary counterparts for each sense oligopeptide. …”
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Clinically relevant pseudoexons of the GALNS gene and their antisense-based correction by Igor Bychkov, Elza Shchukina, Ekaterina Zakharova

Subjects: “…Antisense oligonucleotides…”
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Programmable Single-Stranded Circular Antisense Oligonucleotides for Multitarget Gene Therapy by Yufan Pan, Xin Li, Chenyou Zhu, Mingyan Wang, Yuanyuan Wu, Rui Xu, Jun Wu, Ruofan Chen, Yifan Jiang, Baolei Tian, Yuanchen Dong, Dongsheng Liu

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Targeting FANCM using the antisense oligonucleotides to treat the ALT-positive cancers by Shakir Naji, Christopher Tong, Ashwin Ragupathi, Ming Xiao, Dong Zhang

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Identifying antisense oligonucleotides for targeted inhibition of insulin receptor isoform A by Christopher A. Galifi, Ryan J. Dikdan, Divyangi Kantak, Joseph J. Bulatowicz, Krystopher Maingrette, Samuel I. Gunderson, Teresa L. Wood

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Evidence for a major role of antisense RNAs in cyanobacterial gene regulation by Jens Georg, Björn Voß, Ingeborg Scholz, Jan Mitschke, Annegret Wilde, Wolfgang R Hess

Subjects: “…antisense RNA…”
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The influence of HIV sense and antisense transcripts on stochastic HIV transcription and reactivation by Kamil Więcek, Janusz Wiśniewski, Heng-Chang Chen

Subjects: “…HIV antisense transcripts…”
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Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster. by Christine M Williamson, Simon T Ball, Claire Dawson, Stuti Mehta, Colin V Beechey, Martin Fray, Lydia Teboul, T Neil Dear, Gavin Kelsey, Jo Peters

“…Within the imprinted Gnas cluster on mouse chromosome 2, Nespas is a paternally expressed macroRNA that arises from an imprinting control region and runs antisense to Nesp, a paternally repressed protein coding transcript. …”
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Personalized allele-specific antisense oligonucleotides for GNAO1-neurodevelopmental disorder by Inna Shomer, Nofar Mor, Shaul Raviv, Noga Budick-Harmelin, Tanya Matchevich, Sharon Avkin-Nachum, Yoach Rais, Rebecca Haffner-Krausz, Ariela Haimovich, Aviv Ziv, Reut Fluss, Bruria Ben-Ze’ev, Gali Heimer, Denis N. Silachev, Vladimir L. Katanaev, Dan Dominissini

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Development of Antisense Tools to Study Bodo saltans and Its Intracellular Symbiont by Mastaneh Ahrar, Lorna Glenn, Marie Held, Andrew Jackson, Krzysztof Kus, Gregory D. D. Hurst, Ewa Chrostek

“…We focused on the kinetoplastid host Bodo saltans and its bacterial symbiont, Candidatus Bodocaedibacter vickermanii, a member of Rickettsiales. We conclude that antisense inhibition is not feasible in the Bodo saltans and its symbiont, as the holobiont feeds on the antisense molecules—and increases in numbers—upon treatment with the antisense construct. …”
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