The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation by David W. Pittman, Alexandra M. Brantly, Alexandra L. Drobonick, Hannah T. King, Daniel C. Mesta, Caroline G. Richards, Manjari Lal, Manshun Lai

“…Negative hedonic sensory qualities of HIV antiretroviral drugs often reduce patient adherence particularly in pediatric populations requiring oral consumption. …”
Get full text

Modelling the immunopathogenesis of HIV-1 infection and the effect of multidrug therapy: The role of fusion inhibitors in HAART by Gesham Magombedze, Winston Garira, Eddie Mwenje

“…In this study, we develop a new mathematical model ofthe immuno-pathogenesis of HIV-1 infection, which we use to assess virologicalresponses to both intracellular and extracellular antiretroviral drugs. We firstdevelop a basic mathematical model of the immuno-pathogenesis of HIV-1infection that incorporates three distinct stages in the infection cycle of HIV-1:entry of HIV-1 into the cytoplasm of CD4+ T cells, transcription of HIV-1RNA to DNA within CD4+ T cells, and production of HIV-1 viral particleswithin CD4+ T cells. …”
Get full text

Efficacy and safety of an Albuvirtide-based regimen for preventing mother-to-child transmission of multidrug-resistant HIV: a case report by Na Li, Shifei Wen, Fangfang Zhu, Guirong Liu, Daqing Zhu

“…Abstract Background Antiretroviral drugs are essential for preventing mother-to-child transmission (MTCT) of HIV in HIV-infected pregnant women. …”
Get full text

Prevalence and factors associated with xerostomia in patients hospitalized due AIDS-related complications by Jhonatan Yukio Naka, Adryano Arana Kamei, Vanessa C. Klamas, Mateus A. Ventura, Marcelo Morato, Rafael Z. Mobile, Antonio A. S. D. Lima

“…This fact may be associated with low salivary flow and the use of various drugs, including antiretroviral drugs.…”
Get full text

Impaired Urine Dilution Capability in HIV Stable Patients by Waldo H. Belloso, Mariana de Paz Sierra, Matilde Navarro, Marisa L. Sanchez, Ariel G. Perelsztein, Carlos G. Musso

“…Viral infection itself and the use of some antiretroviral drugs contribute to this condition. The thick ascending limb of Henle’s loop (TALH) is the tubule segment where free water clearance is generated, determining along with glomerular filtration rate the kidney’s ability to dilute urine. …”
Get full text

The impact of COVID-19 pandemic on HIV and AIDS care provision in South Africa: an integrative literature review by James R. Seretlo, Thifhelimbilu I. Ramavhoya, Fhumulani M. Mulaudzi, Rodwell Gundo, Tintswalo V. Nesengani, Mamoeng N. Kgatla, Mmapheko D. Peu

“…COVID-19 had a negative impact in the uptake, HIV monitoring, and adherence to antiretroviral drugs by people living with HIV. The use of telehealth, de-centralization, online classes, and call centers can be some of the innovative strategies that South Africa can adapt, which will help in the prevention of care and avoidance of negative impacts of future pandemics on the health of South Africans.…”
Get full text

Sexual maturity staging and affecting immune-hormonal factors in children aged 6-18 years living with HIV: experience from tertiary care center in North India by Ashwini Shivannavar, Alok Hemal, Hema Gupta Mittal

“…No statistically significant association was observed with CD4 categories (p = 0.3), viral load categories (p = 0.2), age at ART initiation, and BMI categories with pubertal stages. Among antiretroviral drugs, less than 50% of children on abacavir, zidovudine, and lopinavir/ritonavir had attained pubertal onset (in girls, breast stage ≥ 2; in boys, testicular volume (TV) stage ≥ 2). …”
Get full text

A global review of national guidelines of post‐exposure prophylaxis for the prevention of HIV by Marcus Maisano, Daniel Tran, Virginia Macdonald, Rachel C. Baggaley, Nathan Ford, Cheryl C. Johnson, Ying Zhang, Jason J. Ong

“…Abstract Introduction The World Health Organization (WHO) recommends the use of antiretroviral drugs as post‐exposure prophylaxis (PEP) for preventing HIV acquisition for occupational and non‐occupational exposures. …”
Get full text

¿La combinación dolutegravir y rifampicina en los pacientes no incluidos en los ensayos clínicos es también eficaz y segura en el binomio VIH-infección micobacteriana? Casos de la... by Sara Fontserè Recuenco, Rafael Luque-Márquez

“…Rifampicin complicates antiretroviral drugs management, influencing the prognostic of both conditions. …”
Get full text

A Case of Undiagnosed HIV Infection in a 57-Year-Old Woman with Multiple Myeloma: Consequences on Chemotherapy Efficiency and Safety by I. Poizot-Martin, S. Brégigeon, C. Tamalet, R. Bouabdallah, O. Zaegel-Faucher, V. Obry-Roguet, A. Ivanova, C.E. Cano, C. Solas

“…A multidisciplinary approach including oncologists/hematologists, virologists, and pharmacists is recommended in order to avoid drug interactions between chemotherapy and antiretroviral drugs. Moreover, prophylactic medication is recommended in these patients regardless of CD4+ cell count at the initiation of chemotherapy.…”
Get full text

Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1+ Puerto Ricans: 2006–2010 by Lycely del C. Sepúlveda-Torres, Alexandra De La Rosa, Luz Cumba, Nawal Boukli, Eddy Ríos-Olivares, Luis A. Cubano

“…This is a continuation of our efforts to maintain a record of the evolution of HIV-1 infection in Puerto Rico by monitoring the expression levels of antiretroviral drug-resistance-associated mutations. Samples from 2,500 patients from 2006–2010 were analyzed using the TruGene HIV-1 genotyping kit and the OpenGene DNA sequencing system. …”
Get full text

Patient Care and Support Measures Overcome Reluctance to Initiate New Regimen Containing Enfuvirtide by Benoit Trottier

“…In the present patient, who showed resistance to all three of the major antiretroviral drug classes, enfuvirtide was successfully introduced with clinic and peer support group assistance. …”
Get full text

Challenges in Initiating Antiretroviral Therapy in 2010 by Cécile L Tremblay, Jean-Guy Baril, David Fletcher, Donald Kilby, Paul MacPherson, Stephen D Shafran, Mark W Tyndall

“…Reducing the pill burden through the use of fixed-dose antiretroviral drug combinations can facilitate adherence.…”
Get full text

Microencapsulation Techniques in HIV Pediatric Formulations: Advances and Future Outlook by Nnamdi Ikemefuna Okafor

“…Due to the dearth of clinically licensed pediatric antiretroviral drug (ARVD) therapy, children with HIV worldwide are prescribed unlicensed drugs each year. …”
Get full text

Analytical Performances of Human Immunodeficiency Virus Type 1 RNA-Based Amplix® Real-Time PCR Platform for HIV-1 RNA Quantification by Christian Diamant Mossoro-Kpinde, Ralph-Sydney Mboumba Bouassa, Mohammad-Ali Jenabian, Serge Tonen Wolyec, Leman Robin, Mathieu Matta, Jean de Dieu Longo, Gérard Grésenguet, Laurent Andreoletti, Laurent Bélec

“…The Amplix assay showed 100% sensitivity and 99.6% specificity to diagnose virological failure in clinical samples from antiretroviral drug-experienced patients. Conclusions. The HIV-1 RNA-based Amplix real-time PCR platform constitutes sensitive and reliable system for clinical monitoring of HIV-1 RNA load in HIV-1-infected children and adults, particularly adapted to intermediate laboratory facilities in sub-Saharan Africa.…”
Get full text

Silver Nanoparticles Conjugate Attenuates Highly Active Antiretroviral Therapy-Induced Hippocampal Nissl Substance and Cognitive Deficits in Diabetic Rats by Sodiq Kolawole Lawal, Samuel Oluwaseun Olojede, Ayobami Dare, Oluwaseun Samuel Faborode, Edwin Coleridge S. Naidu, Carmen Olivia Rennie, Onyemaechi Okpara Azu

“…The application of nanomedicine to antiretroviral drug delivery holds promise in reducing the comorbidities related to long-term systemic exposure to highly active antiretroviral therapy (HAART). …”
Get full text

Steatotic liver disease in people with HIV at Tshepong Hospital: A post-mortem analysis by Aqeela Moosa, Ebrahim Variava, Alistair D. Calver, Gajendra Chita, Nadia Sabet, Sharol Ngwenya, Maria Papathanasopoulos, Tanvier Omar

“…Virological suppression and duration of antiretroviral drug use were not associated with steatosis. …”
Get full text

Applying implementation science frameworks to understand why fisherfolk continue or discontinue pre-exposure prophylaxis for HIV prevention in Uganda: a qualitative analysis by Simon Mwima, Rhoda Kitti Wanyenze, Rose Naigino, Laura M Bogart, William Musoke, Semei C Mukama, Stella Allupo, Herbert Kadama, Barbara Mukasa

“…In the outer setting, high HIV prevalence motivated PrEP initiation, but stigma, particularly the misconception that PrEP is an antiretroviral drug used by people living with HIV, led to discontinuation.Conclusion Fisherfolk in Uganda encounter multiple barriers to PrEP continuation, with women facing more significant challenges. …”
Get full text