Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway by Li Wang, Chaofan Zhang, Muhammad Azhar Memon, Qianting Shi, Le Lu, Xishuai Tong, Yonggang Ma, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan

“…Chlorogenic acid (CGA) is a dietary polyphenol exhibit various biological activities such as antioxidant, anti-inflammatory, and autophagy regulation. …”
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Lipoxin A4 levels correlate with severity in a Spanish COVID-19 cohort: potential use of endogenous pro-resolving mediators as biomarkers by Sergio Sánchez-García, Rafael I. Jaén, Roberto Lozano-Rodríguez, José Avendaño-Ortiz, Alejandro Pascual‐Iglesias, Laura Hurtado-Navarro, Eduardo López-Collazo, Eduardo López-Collazo, Lisardo Boscá, Lisardo Boscá, Patricia Prieto, Patricia Prieto, Patricia Prieto

“…These lipids have pro-resolving actions in several pathological models, including reducing NF-κB-mediated inflammation, and inducing the antioxidant response through the Nrf-2 pathway. Thus, although a potential relationship has already been suggested between low levels of SPMs and COVID-19 severity, their true role as a predictive biomarker is still unknown.Methods and resultsIn this study, we have analyzed by ELISA the serum levels of lipoxin A4 (LXA4) in a representative Spanish cohort. …”
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Quality Evaluation of Fresh Cayenne Pepper for Chili Sauce from Different Origins by Jinge XU, Zhuoqi ZHENG, Pengjie HOU, Gaoxing MA, Yandi XIONG, Zhuang MA, Meng LIU, Liang ZHAO, Xiaojun LIAO

“…On the other hand, cayenne pepper from Inner Mongolia exhibited higher acid content and antioxidant capacity, and a more abundant profile of non-volatile compounds, including umbelliferone, quercetin, phytosphingosine and so on. …”
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Novel organophosphate esters and their transformation products in offshore sediment from Eastern China: Occurrence, temporal trend, and risk assessment by Meng Gao, Yu Wang, Liman Wei, Siyuan Li, Qiuyue Zhang, Zhongkang Yang, Mohan Bai, Yiming Yao, Lei Wang, Hongwen Sun

“…Notably, a concentration peak of bis(2,4-di-tert-butylphenyl) phosphate (B2,4DtBPP) was dating back to 1940s, indicating the early usage of antioxidant tris(2,4-di-tert-butylphenyl) phosphite. …”
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Optimal dietary vitamin E level facilitates ovarian development of female largemouth bass (Micropterus salmoides) broodstock by Qiuyu Gao, Qiao Feng, Dong Zhou, Zhili Ding, Changle Qi, Youqin Kong, Qiyou Xu

“…Additionally, 209.31 mg/kg of vitamin E also significantly increasing the immunity by reducing the activities of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in the serum, while increased the activities of alkaline phosphatase and acid phosphatase when compared to the 78.25 and 915.49 mg/kg groups (P < 0.05). 209.31 and 437.77 mg/kg of vitamin E significantly enhanced the antioxidant capacity of fish (P < 0.05). The optimal dietary vitamin E requirement was determined as 255.10–292.72 mg/kg based on GSI, absolute fecundity, and the expression levels of vg and vgr. …”
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Universal antibacterial and anti-inflammatory treatment using chitosan-prussian blue nanozyme by Jian Wang, Jiayi Wang, Huayuan Zhou, Rui Ma, Zhou Fang, Jiawei Zhu, Zhejie Chen, Xinfeng Dai, Dali Wei, Jiabei Li, Yiting Jiang, Qian Xia, Xueliang Liu, Yu Yang

“…Moreover, these nanozymes exhibited potent antioxidant and anti-inflammatory properties, promoting macrophage polarization toward the M2-like phenotype, reducing oxidative stress, and alleviating inflammation. …”
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Evaluation of the effects of Keratinase-treated feather meal as a replacement for fishmeal on growth performance, liver function, and intestinal health in juvenile largemouth bass... by Yi-Huan Xu, Li-Han Zhang, Min Liu, Mei-Yan Li, Xue-Dan Fang, Hui Xia, Ran Guo, Fazhan Hanafiah, Waiho Khor, Guang Chen, Xin Hao

“…Furthermore, there was a significant enhancement of antioxidant capacity along with oxidative stress in liver of largemouth bass with the increasing KFM concentration (P < 0.05). …”
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Integrative transcriptomic and metabolomic reveals squalene alleviating the inflammatory response and enhancing immunity of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lance... by Xiaobo Yan, Simiao Pan, Xiangxiang Suo, Weibin Huang, Tao Li, Shuang Zhang, Yuanzhi Yang, Beiping Tan, Xiaohui Dong

“…As a vital active ingredient in olive oil, squalene has been widely studied for its antioxidant and anti-inflammatory properties. Therefore, the present study was designed to use corn oil as the main lipid source to create a model of inflammation or low immunity and investigate the regulatory effect of squalene on the immunity of grouper, and to perform hepatic transcriptomic and metabolomic assays of grouper using omics technology, with the aim of providing basic data for the study of the mechanism of squalene. …”
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Bioactive Molecules from the Invasive Blue Crab <i>Callinectes sapidus</i> Exoskeleton: Evaluation of Reducing, Radical Scavenging, and Antitumor Activities by Francesco Longo, Alessandro Attanzio, Laura Marretta, Claudio Luparello, Serena Indelicato, David Bongiorno, Giampaolo Barone, Luisa Tesoriere, Ilenia Concetta Giardina, Giulia Abruscato, Manuela Perlotti, Lucie Branwen Hornsby, Vincenzo Arizza, Mirella Vazzana, Aiti Vizzini, Chiara Martino, Angelica Listro, Vinicius Queiroz, Antonio Fabbrizio, Paolo Salvatore Francesco Ciaccio, Stella Maria Cascioferro, Francesca Di Gaudio, Manuela Mauro

“…The ferric ion reducing antioxidant power (FRAP) and the free radical scavenging activity against radical 2,2-Diphenyl-1-picrylhydrazyl (DPPH) were significantly higher for chitosan (3.16 ± 0.10 mg AAE/g and 8.1 ± 0.10 µmol TE/g). …”
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Metabolomic profiling and antibacterial efficacy of probiotic-derived cell-free supernatant encapsulated in nanostructured lipid carriers against canine multidrug-resistant bacteri... by Nay Zin Myo, Nay Zin Myo, Ratchnida Kamwa, Ratchnida Kamwa, Thitirat Jamnong, Busaba Swasdipisal, Papavarin Somrak, Phanchompoo Rattanamalakorn, Vipada Neatsawang, Prasert Apiwatsiri, Teerapong Yata, David J. Hampson, Nuvee Prapasarakul, Nuvee Prapasarakul

“…Other beneficial compounds such as Pyroglutamylleucine, Trigoneoside VIII and 18-Nor-4(19),8,11,13-abietatetraene which are likely to have anti-inflammatory, antimicrobial and antioxidant activities, were also detected in the CFS. …”
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Thermoresponsive Gels with Rosemary Essential Oil: A Novel Topical Carrier for Antimicrobial Therapy and Drug Delivery Applications by Ludovic Everard Bejenaru, Adina-Elena Segneanu, Cornelia Bejenaru, Ionela Amalia Bradu, Titus Vlase, Dumitru-Daniel Herea, Marius Ciprian Văruţ, Roxana Maria Bălăşoiu, Andrei Biţă, Antonia Radu, George Dan Mogoşanu, Maria Viorica Ciocîlteu

“…RoEO, renowned for its robust antimicrobial, antioxidant, and wound-healing properties, was subjected to detailed chemical profiling using gas chromatography-mass spectrometry (GC–MS), which identified oxygenated monoterpenes as its dominant constituents. …”
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Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease by Junpeng Xu, Peng Dai, Chen Zhang, Na Dong, Caiyan Li, Chonghui Tang, Zhihao Jin, Shih‐Ho Lin, Luyang Ye, Tianmiao Sun, Yukai Jin, Fenzan Wu, Lihua Luo, Ping Wu, Shengcun Li, Xiaokun Li, Shan‐hui Hsu, Dawei Jiang, Zhouguang Wang

“…The hydrogel with caffeic acid‐grafted polymer main chain is crosslinked using a micellar nanocrosslinker, with sufficient modulus (≈167 Pa), antioxidant activity (> 50%), injectability (30‐gauge syringe needle), and shape‐adaptability. …”
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Approaches to modulate buffalo gut microbiome for efficient feed utilization and reduced environmental pollution by Vijit Dey, Puran C. Lailer, Tirtha K. Datta

“…A composite feed additive formulated to reduce the methanogenic archaeal population without affecting fibrolytic rumen microbes has been demonstrated to increase milk production, antioxidant status, and immunity with abatement of enteric methane production in Murrah buffaloes. …”
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Mechanism of Delaying Cartilage Degeneration in Knee Osteoarthritis with Rongjin Niantong Recipe Based on lncRNA NEAT1 and Nrf2/ARE Pathway by FU Changlong, XIE Xinyu, QIU Zhiwei, HUANG Yanfeng, JIN Linglu, LI Xihai

“…The mechanism may be related to the down-regulation of lncRNA NEAT1 level, up-regulation of Nrf2 signal and antioxidant signal molecules expressions, and down-regulation of pro-oxidation signal molecules and inhibition of oxidative stress level.…”
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Production of Arthrospira platensis algae to increase production efficiency and enhance immune system of grass carp, Ctenopharyngodon idella against Aeromonas hydrophila by Hossein Adineh

“…At the end of the test period, growth and nutritional performance, digestive enzyme activities, blood serum antibacterial activity against Aeromonas hydrophila bacteria, immune and antioxidant factors, and blood indices were measured. …”
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Oxidative damage to DNA, expression of Mt-1, and activation of repair mechanisms induced by vanadium trioxide in cultures of human lymphocytes by V.A. Alcántara-Mejía, A.A. Beltrán-Flores, R.A. Mateos-Nava, L. Álvarez-Barrera, I.U. Bahena-Ocampo, E. Santiago-Osorio, E. Bonilla-González, J.J. Rodríguez-Mercado

“…In conclusion, one mechanism of action of V2O3 involves the oxidation of nitrogenous bases in DNA, the activation of damage sensors (such as ATMs), and the overexpression of Mt-1 as part of the antioxidant response to mitigate the effects of V and facilitate DNA repair pathways (including BER and NHEJ).…”
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Canopy humidity and irrigation regimes interactively affect rice physiology, grain filling and yield during grain filling period by Le Chen, Xueyun Deng, Hongxia Duan, Xueming Tan, Xiaobing Xie, Xiaohua Pan, Lin Guo, Tao Luo, Xinbiao Chen, Hui Gao, Haiyan Wei, Hongcheng Zhang, Yongjun Zeng

“…The HH decreased the soil plant analysis development (SPAD) parameter and net photosynthetic rate while leaf surface temperature, antioxidant enzyme activity and malondialdehyde (MDA) level got increased. …”
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hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation by Mengyuan Chang, Ruiqi Liu, Bingqian Chen, Jin Xu, Wei Wang, Yanan Ji, Zihui Gao, Boya Liu, Xinlei Yao, Hualin Sun, Feng Xu, Yuntian Shen

“…Extracellular vesicles derived from bone marrow mesenchymal stem cells (BMSC-EVs) possess anti-inflammatory and antioxidant properties, offering a potential strategy for combating weightless muscular atrophy. …”
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Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress... by Ágnes Szabó, Zsolt Galla, Eleonóra Spekker, Mónika Szűcs, Diána Martos, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, József Toldi, Etsuro Ono, László Vécsei, Masaru Tanaka

“…Plasma metabolite levels are generally consistent with those of urine: antioxidant KYNs, 5-hydroxyindoleacetic acid, and indole-3-acetic acid levels were lower; enzyme activities in KATs, kynureninase, and monoamine oxidase/aldehyde dehydrogenase were lower, but kynurenine 3-monooxygenase was higher; and oxidative stress and excitotoxicity indices were higher. …”
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Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway by Yongnan Piao, Nuoya Wang, Mingji Jin, Jianyu Piao, Mingfeng Han, Zifei Wang, Chunhua Quan, Jishan Yin, Zhonggao Gao, Wenxiang Cui, Shuangqing Wang, Xiuquan Quan

“…FD increased the activities of antioxidant factors (T-SOD, GSH, CAT, and IL-10), and decreased the inflammatory factors levels (TNF-α, IL-6, MDA, COX-2, and iNOS) by promoting the HGF/c-Met/STAT3 pathway. …”
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