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61
Ocular Findings in COVID-19 Patients: A Review of Direct Manifestations and Indirect Effects on the Eye
Published 2020-01-01“…However, the risk of retinal toxicity with short-term high-dose use of antimalarials is still unknown. Ocular side effects have also been reported with other investigational drugs like lopinavir-ritonavir, interferons, and interleukin-1 and interleukin-6 inhibitors. …”
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62
Assessing the efficacy of iso-mukaadial acetate and betulinic acid against selected Plasmodium falciparum glycolytic pathway proteins: in silico and in vitro studies
Published 2025-01-01“…Parasite inhibition studies confirmed potent antimalarial activity against the P. falciparum NF54 strains, with BA and IMA showing IC50 values of 1.27 µg/ml and 1.03 µg/ml against the asexual stage of P. falciparum, respectively. …”
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63
The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice
Published 2013-01-01“…Xylopic acid therefore possesses prophylactic and curative antimalarial as well as antipyretic properties which makes it an ideal antimalarial agent.…”
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64
Exploring the Infectious Drug Target Glutathione S-Transferase in Plasmodium falciparum with the Inhibitory Potential of Azadirachta indica Phytocompounds
Published 2024-01-01“…Neem compounds are being studied for their potential as new and effective antimalarial drugs, and there is mounting evidence that they may help treat malaria. …”
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65
Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract of Cassia spectabilis DC on Liver and Kidney Function of Plasmodium berghei-Infected Mice
Published 2022-01-01“…Currently, the presence of antimalarial drug resistance has become a major obstacle in the treatment of malaria. …”
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66
Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum
Published 2014-01-01“…For more comprehensive analysis, antimalarial drug-protein interaction has been covered.…”
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67
Effect of Allicin and Artesunate Combination Treatment on Experimental Mice Infected with Plasmodium berghei
Published 2022-01-01“…Malaria is still a significant health problem in endemic countries and increases Plasmodium resistance to the available antimalarial drugs. Hence, this study aimed to investigate the antimalarial activity of allicin and its combination with artesunate (ART) against rodent malaria Plasmodium berghei ANKA (PbANKA) infected mice. …”
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68
Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives
Published 2015-01-01“…Artemisinin and its derivatives are widely used in the world as the first-line antimalarial drug. Recently, growing evidences reveal that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. …”
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69
In Vivo Antiplasmodial, Anti-Inflammatory, and Analgesic Properties, and Safety Profile of Root Extracts of Haematostaphis barteri Hook F. (Anacardiaceae)
Published 2015-01-01“…Malaria is an endemic disease globally and the conundrum of drug resistance has led to the search for newer antimalarial agents. The root extract of H. barteri was evaluated for antimalarial, analgesic, and anti-inflammatory properties. …”
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70
New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation
Published 2021-01-01“…The biological evaluation of all target compounds as potential antimalarial, antileishmanial, antitrypanosomal, and antimicrobial agents was performed by various well-established cell-based methods. …”
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71
A Study of Synergy of Combination of Eosin B with Chloroquine, Artemisinin, and Sulphadoxine-Pyrimethamine on Plasmodium falciparum In Vitro and Plasmodium berghei In Vivo
Published 2020-01-01“…Artemisinin is the popular antimalarial medication, but it has to be used in combination with other drugs as its monotherapy causes resistance. …”
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72
Antiplasmodial and Cytotoxic Activities of Extracts of Selected Medicinal Plants Used to Treat Malaria in Embu County, Kenya
Published 2020-01-01“…The currently prescribed antimalarial drugs have been associated with adverse side effects ranging from intolerance to toxicity. …”
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73
YAT2150 is irresistible in Plasmodium falciparum and active against Plasmodium vivax and Leishmania clinical isolates
Published 2025-01-01“…Using single-dose and ramping methods, assays were done to select Plasmodium falciparum parasites resistant to YAT2150 concentrations ranging from 3× to 0.25× the in vitro IC50 of the compound (in the two-digit nM range) and performed a cross-resistance assessment in P. falciparum lines harboring mutations that make them resistant to a variety of antimalarial drugs. Resistant parasites did not emerge in vitro after 60 days of incubation, which postulates YAT2150 as an ‘irresistible’ antimalarial. …”
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74
Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (Mâncio Lima, Acre, Brazil)
Published 2015-01-01“…Side effects of antimalarial drug can overlap with malaria symptoms. …”
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75
A narrative review on inhibitory effects of edible mushrooms against malaria and tuberculosis-the world’s deadliest diseases
Published 2023-07-01“…The isolated secondary metabolites from 39 edible mushrooms are reported, among which 107 compounds were active, 61 demonstrated antitubercular activities with IC50 range of 0.2–50 µg/mL and 46 manifested antimalarial effects with IC50 range of 0.061–36 µg/mL. …”
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76
Attributable risk factors for asymptomatic malaria and anaemia and their association with cognitive and psychomotor functions in schoolchildren of north-eastern Tanzania.
Published 2022-01-01“…We explored the prevalence of antimalarial drug resistance as well as the association of asymptomatic malaria infection and anaemia on cognitive and psychomotor functions in school-aged children living in high endemic areas. …”
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77
Efficacy of Hydroxychloroquine for Improving Pregnancy Outcomes in a Female with Systemic Lupus Erythematosus and Antiphospholipid Syndrome
Published 2022-01-01“…Recently, the addition of a novel antimalarial, hydroxychloroquine (HCQ), to the conventional treatment has shown the potential to prevent obstetric complications. …”
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78
A Child with Severe Malaria Presenting with Acute Surgical Abdomen (Duodenal Perforation)
Published 2016-01-01“…Here, we report a case of a 5-year-old male child with falciparum malaria complicated by a duodenal perforation that was successively managed with appropriate antimalarial drugs and early surgical repair.…”
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79
Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria Staphylococcus aureus and Pseudomonas aeruginosa
Published 2020-01-01“…The drugs used in this study were amodiaquine an antimalarial drug, probenecid used to prevent gout, ibuprofen a painkiller, 2-amino-5-chlorobenzaxazole used as a tool for assessing hepatic cytochrome P450 activity in rodents, ellargic acid an antioxidant, quercetin an antioxidant and anti-inflammatory drug, N–N diacryloylpiperazine used to crosslink polyacrylamide gel in 2D-protein electrophoresis, epicatechin an antioxidant and antiviral drug, curcumin an anticancer drug, and quinine an antimalarial drug. …”
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In Vivo Antiplasmodial Activity of Terminalia mantaly Stem Bark Aqueous Extract in Mice Infected by Plasmodium berghei
Published 2020-01-01“…The results suggest that the stem bark extract of T. mantaly possesses antimalarial activity.…”
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