Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions by Kerry J. Welsh, Semyon A. Risin, Jeffrey K. Actor, Robert L. Hunter

“…Sections of characteristic lesions of caseating granulomas, lipid pneumonia, and cavitary stages of postprimary disease were selected for immunohistochemical studies of macrophages, lymphocytes, endothelial cells, and mycobacterial antigens. A higher percentage of cells in lipid pneumonia (36.1%) and cavitary lesions (27.8%) were positive for the dendritic cell marker DEC-205, compared to granulomas (9.0%, P<.05). …”
Get full text

Optimization of amino acid-stabilized erythropoietin parenteral formulation: In vitro and in vivo assessment by Fayed Bahgat E., Tawfik Abdulkader F., Yassin Alaa Eldeen B.

“…The aim of this study was to optimize the formulation of erythropoietin (EPO) using amino acids instead of human serum albumin (HSA) and to evaluate its in vivo stability in order to avoid the risk of viral contamination and antigenicity. Different EPO formulations were developed in such a way as to allow studying the effects of amino acids and surfactants on the EPO stability profile. …”
Get full text

A Case of Rituximab Use as an Induction and Maintenance of Remission in ANCA-Associated Vasculitis by Neveen Awad, Shahd Hafiz, Abdurahman Albeity, Hani Almoallim

“…Antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is a multisystem autoimmune disease affecting mainly microscopic blood vessels due to circulating autoantibodies against neutrophil cytoplasmic antigens. We report a case of a 57-year-old female patient presenting with hemoptysis, sinusitis, and conjunctivitis. …”
Get full text

Leukoreduction in a dog with acute leukemia by Brenna Hanratty, Anna Hauck, Amanda Foskett, J. D. Foster

“…Flow cytometry identified CD34+ leukocytosis with cells that did not express lineage antigens, suggesting the most likely diagnosis of either acute lymphoid or myeloid leukemia. …”
Get full text

Revolutionizing acute myeloid leukemia treatment: a systematic review of immune-based therapies by Ugochi Ebinama, Binsah George

“…The review focuses on targeting specific antigens in AML, including FLT3/CD125, CLL-1, CD33, CD38, CD47, CD70, and CD123.…”
Get full text

Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor... by Christopher L. Felten, Joel A. Chan, Dulce R. DeCastro, Jean Lopategui, Swapnil P. Rajurkar

“…Expression of multiple aberrant antigens and concurrent lymphomas of different classifications can cause a diagnostic challenge. …”
Get full text

Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I by Pan Qiong-Hua, Zheng Zhong-Yi, Yang Jun, Wen Yan, Yuan Lian-Chao, Li Huan-Ying, Steven G. Reed, Malcolm S. Duthie

“…Our data confirm that Chinese multibacillary (MB) leprosy patients have strong antibody responses against Mycobacterium leprae antigens ND-O-BSA and LID-1. Contacts of clinically diagnosed patients were then monitored at regular intervals by both physical examinations and the laboratory determination of antibody responses in sera collected during these examinations. …”
Get full text

Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis by Miao-Yan Xu, Jie Zeng, Xin-Hao Han, Duo-Duo Wei, Bing Fan, Xin‑Hui Qu, Shaorong Huang, Xiao-Jian Han

“…Moreover, JNC NPs + Laser can induce immunogenic cell death (ICD) to improve the maturation of dendritic cells (DCs) and present antigens to T cells, which high-effectively eliminate tumor lung metastasis. …”
Get full text

Peyer's Patches: The Immune Sensors of the Intestine by Camille Jung, Jean-Pierre Hugot, Frédérick Barreau

“…By their ability to transport luminal antigens and bacteria, PPs can be considered as the immune sensors of the intestine. …”
Get full text

A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists by Yu‐an Li, Yi Feng, Wenjing Li, Yuqin Zhang, Yanni Sun, Shifeng Wang, Roy Curtiss III, Huoying Shi

“…By leveraging the comprehensive biosynthetic capabilities of bacterial cells, this system can efficiently combine various adjuvant‐active modular components and antigenic cargo, thereby providing a highly diversified and potent vaccine platform.…”
Get full text

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells by Ignacio Melero, Ruth Conde-Garrosa, David Sancho, Santos Mañes, Alfonso R Sanchez-Paulete, Francisco J Cueto, Carlos del Fresno, Paola Brandi, Alexis J. Combes, Elena Hernández-García, Michel Enamorado, Christian P Bromley, Manuel J Gomez, Santiago Zelenay, Salvador Iborra, Matthew F. Krummel

“…To characterize the immune response, we performed flow cytometry and RNA-Seq of tumor-infiltrating cDC1s.Results Here, we found that cross-presentation of tumor antigens in the steady state was DNGR-1-independent. …”
Get full text

Joint fluid multi-omics improves diagnostic confidence during evaluation of children with presumed septic arthritis by Yolanda Peña-López, Naureen G. Tareen, Bo Zhang, Indu Raman, Carlos A. Arana, Chengsong Zhu, Yang Liu, Pratibha Selvakumar, Nicolai S. C. van Oers, Simrat Morris, Lora V. Hooper, Lawson A. B. Copley, Prithvi Raj

“…The children without any bacteremia had autoantibodies (IgGs) in the joint-fluid targeting several nuclear antigens (i.e., dsDNA, histones, Jo-1, scl-70, Ro/SS-A, SmDs, CENP-A along with non-nuclear antigens i.e. …”
Get full text

Delay of innate immune responses following influenza B virus infection affects the development of a robust antibody response in ferrets by Thomas Rowe, Ashley Fletcher, Melissa Lange, Yasuko Hatta, Gabriela Jasso, David E. Wentworth, Ted M. Ross

“…Antibodies generated following infection of ferrets with human influenza viruses are used in surveillance to detect antigenic drift and cross-reactivity with vaccine viruses and circulating strains. …”
Get full text

PHYSIOLOGICAL EFFICACY OF MELANIN AS A FOOD INGREDIENT by N. Cherno, A. Kapustian, K. Naumenko, L. Gural, S. Osolina

“…It does not show cytotoxicity, side effects or antigenic responses. The various physiological effects of melanin, combined with its biocompatibility and physiological properties as a component of traditional food sources, determine the prospects for the use of melanin as a physiologically functional food ingredient that can play a significant role in human nutrition.…”
Get full text

Susceptibility Genes in Thyroid Autoimmunity by Yoshiyuki Ban, Yaron Tomer

“…Genetic susceptibility in combination with external factors (e.g. dietary iodine) is believed to initiate the autoimmune response to thyroid antigens. Abundant epidemiological data, including family and twin studies, point to a strong genetic influence on the development of AITD. …”
Get full text

Contribution of Gut Bacteria to Liver Pathobiology by Gakuhei Son, Michael Kremer, Ian N. Hines

“…Receiving approximately 70% of its blood supply from the intestinal venous outflow, the liver represents the first line of defense against gut-derived antigens and is equipped with a broad array of immune cells (i.e., macrophages, lymphocytes, natural killer cells, and dendritic cells) to accomplish this function. …”
Get full text

A Mathematical Model of Tumor-Immune and Host Cells Interactions with Chemotherapy and Optimal Control by Tarekegn Dinku, Boka Kumsa, Jyotirmoy Rana, Aiyappan Srinivasan

“…Reduction in tumor cell growth has been observed due to the increase in recruitment of immune cells activated by tumor cell antigenicity and the rate of conversion of resting immune cells into active immune cells. …”
Get full text

MODERN ASPECTS OF LYSSAVIRUS CLASSIFICATION by A. Ye. Metlin

“…Updated information on taxonomy and phylogenetic and antigenic relationship of lyssaviruses are given in the review. …”
Get full text

The compositional behavior of the human T cell receptor repertoire in ovarian cancer compared to healthy donors by Miriam Zuckerbrot-Schuldenfrei, Alona Zilberberg, Sol Efroni

“…Abstract The distinctive characteristics of an individual’s T cell receptor repertoire are crucial in recognizing and responding to a diverse array of antigens, contributing to immune specificity and adaptability. …”
Get full text

The Opportunistic Pathogen Listeria monocytogenes: Pathogenicity and Interaction with the Mucosal Immune System by Markus Schuppler, Martin J. Loessner

“…The mucosal surfaces of the gastrointestinal tract are permanently exposed to an enormous antigenic load derived from the gastrointestinal microbiota present in the human bowel. …”
Get full text