Immunoinformatics design of a novel multiepitope vaccine candidate against non-typhoidal salmonellosis caused by Salmonella Kentucky using outer membrane proteins A, C, and F. by Elayoni E Igomu, Paul H Mamman, Jibril Adamu, Maryam Muhammad, Abubarkar O Woziri, Manasa Y Sugun, John A Benshak, Kingsley C Anyika, Rhoda Sam-Gyang, David O Ehizibolo

“…Immune simulation results showed that the MEV elicited significant responses, including IgG, IgM, CD8+ T-cells, CD4+ T-cells, and various cytokines (IFN-γ, TGF-β, IL-2, IL-10, and IL-12), along with a noticeable reduction in antigen levels. Despite these promising in-silico findings, further validation through preclinical and clinical trials is required to confirm the vaccine's efficacy and safety.…”
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Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs by Lily Wan, Tian Tu, Qi-Lei Zhang, Juan Jiang, Xiao-Xin Yan

“…Time-pregnant primigravidas (3-5 months old) and age-matched nonpregnant females were examined, with neurogenic potential evaluated via immunolabeling of Ki67, Sp8, doublecortin (DCX), and neuron-specific nuclear antigen (NeuN) combined with bromodeoxyuridine (BrdU) birth-dating. …”
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Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells by Samanta Melgar-Rodríguez, Emilio A. Cafferata, Nicolás I. Díaz, Miguel A. Peña, Luis González-Osuna, Carolina Rojas, Alfredo Sierra-Cristancho, Angélica M. Cárdenas, Jaime Díaz-Zúñiga, Rolando Vernal

“…Natural killer T (NKT) cells constitute a unique subset of T lymphocytes characterized by specifically interacting with antigenic glycolipids conjugated to the CD1d receptor on antigen-presenting cells. …”
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Investigation of the Protective Effect of Probiotic Lactobacillus plantarum Ep-M17 on the Hepatopancreas of Penaeus vannamei by Xiaoman Hu, Wenlong Xu, Hao Li, Bowen Lu, Yang Du, Jiong Chen

“…Furthermore, Ep-M17 stimulated gene transcription in crucial immune response-related signalling pathways like the mitogen-activated protein kinase signaling pathway and the antigen processing and presentation pathway. Moreover, the incorporation of Ep-M17 into shrimp diets increased the levels of β-alanine, and histidine in the hepatopancreas, enhancing anti-inflammatory capacity and improving the shrimp’s immune response. …”
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Disseminated Histoplasmosis as an AIDS-Defining Illness Presenting as Fever of Unknown Origin in an 11-Year-Old Female by Kathryn E. Kalata, Christina Osborne, Amy Willis, Kacey Navarro, Laura Z. Fenton, Christiana Smith

“…This case also considers the utility of antigen testing as a sensitive diagnostic test in immunocompromised patients.…”
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Disulfidptosis-related immune patterns predict prognosis and characterize the tumor microenvironment in oral squamous cell carcinoma by Xuechen Wu, Boxin Liu, Shi-Zhou Deng, Tengteng Xiong, Lin Dai, Bo Cheng

“…The analysis results showed that disulfidptosis was tightly related to immune cells, immunological-related pathways, the tumor microenvironment (TME), immune checkpoints, human leukocyte antigen (HLA), and tumor mutational burden (TMB). …”
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Effect of HLA-G5 Immune Checkpoint Molecule on the Expression of ILT-2, CD27, and CD38 in Splenic B cells by Hana Rohn, Cordula Lang, Sabine Schramm, Falko M. Heinemann, Mirko Trilling, Anja Gäckler, Oliver Witzke, Peter A. Horn, Vera Rebmann

“…The human leukocyte antigen G (HLA-G) is an immune checkpoint molecule with a complex network of interactions with several inhibitory receptors. …”
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Roles of retinoic acid-related orphan receptor α in high glucose-induced cardiac fibroblasts proliferation by Wenqing San, Qianyou Zhou, Danning Shen, Danyi Cao, Yun Chen, Guoliang Meng

“…Expressions of Collagen I, Collagen III, proliferating cell nuclear antigen (PCNA), α-smooth muscle actin (α-SMA), receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3) were evaluated. …”
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Integrative analysis of Ewing’s sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy by Fangzhou He, Jiuhui Xu, Fanwei Zeng, Boyang Wang, Yi Yang, Jie Xu, Xin Sun, Tingting Ren, Xiaodong Tang

“…A comparative analysis of paired samples revealed that in tumors with a good chemotherapeutic response, macrophages presented increased antigen presentation and reduced release of protumor cytokines, whereas CD8+ T cells presented increased cytotoxicity and reduced exhaustion. …”
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Rapid isolation and recovery of Salmonella using hollow glass microspheres coated with multilayered nanofilms by Rutwik Joshi, Hesaneh Ahmadi, Md Nayeem Hasan Kashem, Fariha Afnan, Siva Parameswaran, Chau-Chyun Chen, Gizem Levent, Wei Li

“…In this study, we demonstrate that Salmonella can be captured due to antigen-antibody interactions on the surface of HGMS, allowing them to float to the top. …”
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The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression by Yu-Lei Gao, Bin Lu, Jian-Hua Zhai, Yan-Cun Liu, Hai-Xia Qi, Ying Yao, Yan-Fen Chai, Song-Tao Shou

“…The negative immunoregulation of Tregs was inhibited, mainly including inhibiting the expression of forkhead helix transcription factor- (Foxp-) 3, cytotoxic T lymphocyte associated antigen- (CTLA-) 4, membrane associated transforming growth factor-β (TGF-βm+), and the secretion of inhibitory cytokines [including TGF-β and interleukin- (IL-) 10], as well as CD4+ T cells-mediated cellular immunosuppression which was improved by parenteral Vit C in WT and Gulo−/− septic mice. …”
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Vaccinomics Approach for Designing Potential Peptide Vaccine by Targeting Shigella spp. Serine Protease Autotransporter Subfamily Protein SigA by Arafat Rahman Oany, Tahmina Pervin, Mamun Mia, Motaher Hossain, Mohammad Shahnaij, Shahin Mahmud, K. M. Kaderi Kibria

“…At first, 44 SigA proteins from different variants of S. flexneri, S. dysenteriae, S. boydii, and S. sonnei were assessed to find the most antigenic protein. We retrieved 12 peptides based on the highest score for human leukocyte antigen (HLA) supertypes analysed by NetCTL. …”
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Host-pathogen interaction in invasive Salmonellosis. by Hanna K de Jong, Chris M Parry, Tom van der Poll, W Joost Wiersinga

“…Virulence factors, most notably, type III secretion systems, Vi antigen, lipopolysaccharide and other surface polysaccharides, flagella, and various factors essential for the intracellular life cycle of S. enterica have been characterized. …”
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Global progress, challenges and strategies in eliminating public threat of viral hepatitis by Sihui Zhang, Fuqiang Cui

“…Main text The updated World Health Organization guidelines for the prevention, diagnosis, care and treatment for people with chronic hepatitis B infection (2024 edition) and Chinese guidelines for the prevention and treatment of chronic hepatitis B (version 2022) simplify clinical algorithms for the diagnosis, treatment, and monitoring of hepatitis B, expand treatment eligibility criteria, and provide alternative treatment options, which will cover a higher proportion of all hepatitis B surface antigen positive populations. These actions promote the global goal of eliminating the public health hazards of viral hepatitis by 2030. …”
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Exploring the functional and immune landscape of E-β thalassemia patients through RNA sequencing of peripheral blood mononuclear cells by Nibedita Mitra, Prosanto Chowdhury, Anupam Basu

“…Additionally, we conducted gene set enrichment analysis (GSEA) to explore underlying immune conditions.The gene expression profile, along with GSEA, revealed a marked decrease in MHC-II-mediated antigen presentation. Notably, we identified, for the first time, the activation of reactive oxygen species (ROS) through NK cell-mediated eosinophil chemotaxis, suggesting a link to disease severity. …”
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Immune-Mediated Cytotoxicity in Inflammatory Bowel Disease by Stephan R Targan, Richard L Deem, Fergus Shanahan

“…One is that the destruction of target cells is mediated by direct recognition of target antigens by cytotoxic cells which in turn triggers lysis. …”
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Epidemiology of dengue fever in Somaliland: clinical features, and serological patterns from a retrospective study by Dek Kahin Yosef, Ahmed Saeed Ismail, Barwaqo Saleban Awil, Halima Ahmed Hassan, Mohamed Ahmed Hassan

“…Demographic data, clinical symptoms, and results of rapid diagnostic tests for dengue NS1 antigen and IgM antibodies were analyzed. Results Of the 1,410 suspected cases, 175 (12.41%) tested positive for dengue. …”
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Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity by Jiaqi Ma, Cory M. Ayres, Chad A. Brambley, Smita S. Chandran, Tatiana J. Rosales, W. W. J. Gihan Perera, Bassant Eldaly, William T. Murray, Steven A. Corcelli, Evgenii L. Kovrigin, Christopher A. Klebanoff, Brian M. Baker

“…Abstract The inherent antigen cross-reactivity of the T cell receptor (TCR) is balanced by high specificity. …”
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Sp17 Protein Expression and Major Histocompatibility Class I and II Epitope Presentation in Diffuse Large B Cell Lymphoma Patients by Kamel Ait-Tahar, Amanda P. Anderson, Martin Barnardo, Graham P. Collins, Chris S. R. Hatton, Alison H. Banham, Karen Pulford

“…Success using immune checkpoint inhibitors and chimeric antigen receptor T cell technology has fuelled demand for validated cancer epitopes. …”
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Primary liver lymphoma: review of the literature and clinical case presentation by A. K. Smolyaninova, A. V. Gubkin, Ye. Ye. Zvonkov, Yu. A. Kucheryavy

“…Laboratory tests revealed progressive signs of liver failure at normal level of alpha-fetoprotein and carcino-embryonic antigen; clinical signs included progressive manifestations of liver encephalopathy, skin hemorrhages, severe edema, ascites, pruritis and excoriations. …”
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