A Microfluidic Biosensor for Quantitative Detection of <i>Salmonella</i> in Traditional Chinese Medicine by Yutong Wu, Yang Liu, Jinchen Ma, Shanxi Zhu, Xiaojun Zhao, Huawei Mou, Xuanqi Ke, Zhisheng Wu, Yifei Wang, Sheng Lin, Wuzhen Qi

“…The immune MNBs, immune Au@PtNCs, and bacterial samples were introduced into a novel passive microfluidic micromixer for full mixing, resulting in the formation of a double-antibody sandwich structure due to antigen–antibody immune reactions. Subsequently, the mixture flowed into the reaction cell, where the MNBs-<i>Salmonella</i>-Au@PtNCs complex was captured by the magnetic field. …”
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Effect of RAS mutations and related immune characteristics on the prognosis of patients with MSI-H/dMMR colorectal cancer by Yupeng Jiang, Yuyao Liu, Hong Huang, Tiantian Zhao, Zengyi Zhao, Yawen Gao

“…In MSI-H/dMMR CRC patients: (1) the high CD11c + , CD4 +,  and CD8 +  cells infiltration group had longer DFS than the low-infiltration group, and Foxp3 + cells infiltration was not significantly correlated with DFS; (2) the RAS mutation status, number of CD11c+ cells infiltrated, and carbohydrate antigen 19–9 (CA19–9) level were the potential prognostic factors. …”
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A New Way for Beta Cell Neogenesis: Transdifferentiation from Alpha Cells Induced by Glucagon-Like Peptide 1 by Zhen Zhang, Yinghui Hu, Ningning Xu, Wenjun Zhou, Lei Yang, Rongping Chen, Rui Yang, Jia Sun, Hong Chen

“…The GLP1 receptor antagonist exendin (9-39) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) family inhibitor LY294002 not only suppressed protein kinase B (Akt), pancreatic and duodenal homeobox 1 (Pdx1), forkhead box O 1 (FoxO1), and mast cell function-associated antigen A (MafA) mRNA expression but also increased MAFB expression. …”
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Population- and Gender-Based Investigation for Prevalence of Helicobacter pylori in Dhamar, Yemen by Dhary A. Almashhadany, Sara M. Mayas, Hero I. Mohammed, Abdulwahed A. Hassan, Izhar U. H. Khan

“…Of the total 460, 215 rural (male: n = 120 and female: n = 95) and 245 urban (male: n = 130 and female: n = 115) specimens were investigated for identification of H. pylori by serological test using Helicobacter pylori stool antigen (HpSA) test. In addition, for comparing an improved recovery of H. pylori, conventional culture-based isolation was also carried out using three selective media. …”
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Interleukin-12p70 Expression by Dendritic Cells of HIV-1-Infected Patients Fails to Stimulate gag-Specific Immune Responses by Ellen Van Gulck, Nathalie Cools, Derek Atkinson, Lotte Bracke, Katleen Vereecken, Marc Vekemans, Viggo F. I. Van Tendeloo, Zwi N. Berneman, Guido Vanham

“…Since dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique capability to stimulate naïve T cells into effector T cells, their use for the induction of HIV-specific immune responses has been studied intensively. …”
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The expression and clinical significance of serum exosomal-long non-coding RNA DLEU1 in patients with cervical cancer by Yu Chen, Facai Cui, Xiaoyu Wu, Weifeng Zhao, Qingxin Xia

“…The combined detection of DLEU1, carbohydrate antigen 125 (CA-125) and squamous cell carcinoma (SCC) exhibited significantly higher diagnostic efficiency (p < .01). …”
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Insights from Dysregulated mRNA Expression Profile of β-Cells in Response to Proinflammatory Cytokines by Zhen Wang, Kunlin Huang, Jing Xu, Jia Liu, Ying Zheng

“…KEGG analysis showed that these differentially expressed genes were involved with “antigen processing and presentation,” “TNF signaling pathway” and “type 1 diabetes,” “cell cycle,” “necroptosis,” and “Rap1 signaling pathway.” …”
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Capsular polysaccarides of probiotics and their immunomodulatory roles by Jing Li, Saisai Feng, Leilei Yu, Jianxin Zhao, Fengwei Tian, Wei Chen, Qixiao Zhai

“…In turn, they also exhibit immunomodulatory activities, such as strengthening the functions of macrophages, promoting the maturation of antigen-presenting cells, and inducing regulatory T cells. …”
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TLR7/8/9 agonists and low-dose cisplatin synergistically promotes tertiary lymphatic structure formation and antitumor immunity by Shuting Wu, Rong Xiang, Yiwei Zhong, Shushu Zhao, Zhiyu Zhang, Zhihua Kou, Shijie Zhang, Yi Zhao, Cheng Zu, Gan Zhao, Yanling Xiao, Sulin Ren, Xiaoming Gao, Bin Wang

“…Abstract In situ vaccination (ISV) triggers antitumor immune responses using the patient’s own cancer antigens, yet limited neoantigen release hampers its efficacy. …”
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Detection of Dengue Virus-Specific IgM and IgG Antibodies through Peptide Sequences of Envelope and NS1 Proteins for Serological Identification by Pradeep Kumar Nagar, Deepali Savargaonkar, Anupkumar R. Anvikar

“…Such peptides together can be used to construct the multiple antigen peptides (MAP) or multiplexed microbeads for designing a precise, cost-effective, and easy-to-make peptide-based immunodiagnostic kit for DENV detection.…”
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In silico design of an epitope-based vaccine ensemble for fasliolopsiasis by Ruchishree Konhar, Ruchishree Konhar, Kanhu Charan Das, Kanhu Charan Das, Aiboklang Nongrum, Rohan Raj Samal, Shailesh Kumar Sarangi, Devendra Kumar Biswal, Devendra Kumar Biswal

“…Finding successful vaccination antigen combinations from these huge number of genes/proteins in the available omics datasets is the key in combating these neglected tropical diseases. …”
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High-Intensity Focused Ultrasound Ablation for Primary or Salvage Prostate Cancer Therapy: Initial Outcomes in the Veteran Healthcare Setting by Sagar Patel, Ali Antar, Aly Alrabaa, Gal Saffati, Broderick Fleming, Neel Srikishen, Jeremy Slawin, Jennifer Taylor, Jeffrey Jones

“…Primary endpoints included prostate-specific antigen (PSA) reduction and local recurrence rates. …”
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Helicobacter pylori infection diagnostics and choice of eradication treatment: results of inquiry of doctors from different regions of Russian Federation by N. N. Dekhnich, R. S. Kozlov, O. A. Sablin, Ye. A. Prischepova

“…Noninvasive diagnostic methods for H. pylori infection: 13C urea breath test, stool test for H. pylori antigens and serological method were applied by 29.5%; 32.2% and 34.4% of respondents respectively. …”
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Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs by Elias A. Said, Sumaya Al-Dughaishi, Wadha Al-Hatmi, Iman Al-Reesi, Mohammed S. Al-Balushi, Atika Al-Bimani, Juma Z. Al-Busaidi, Marwa Al-Riyami, Murtadha Al-Khabori, Salam Al-Kindi, Francesco A. Procopio, Shadia Al-Sinawi, Aliyaa Al-Ansari, Crystal Y. Koh, Khalid Al-Naamani, Ali A. Al-Jabri

“…We have recently demonstrated MK production by some human innate antigen-presenting cells (iAPCs), i.e., monocyte-derived dendritic cells (MDDCs) and macrophages stimulated through Toll-like receptor (TLR)-4, and plasmacytoid dendritic cells (pDCs) stimulated through TLR 7. …”
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Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer by Manoj Amrutkar, Sander Johannes Thorbjørnsen Guttorm, Anette Vefferstad Finstadsveen, Knut Jørgen Labori, Lars Eide, Helge Rootwelt, Katja Benedikte Prestø Elgstøen, Ivar P. Gladhaug, Caroline S. Verbeke

“…A strong positive correlation was observed between serum carbohydrate 19‐9 antigen (CA 19‐9) and tissue carnitines (C12, C18, C18:2) and N8‐acetylspermidine. …”
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HLA-G Expression on Blasts and Tolerogenic Cells in Patients Affected by Acute Myeloid Leukemia by Grazia Locafaro, Giada Amodio, Daniela Tomasoni, Cristina Tresoldi, Fabio Ciceri, Silvia Gregori

“…Human Leukocyte Antigen-G (HLA-G) contributes to cancer cell immune escape from host antitumor responses. …”
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Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhibiting the TGF-β1/Smad signaling pathway by Jiangtao Wang, Lina Guan, Jian Yu, Bohua Ma, Huihua Shen, Guozhu Xing, Yawei Xu, Qiufang Li, Juan Liu, Qin Xu, Wenhui Shi, Jia He, Yixuan Huang, Dongfeng Yin, Wu Li, Rui Wang

“…We further detected the expression levels of inflammatory factors interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α) and proliferative/antiproliferative indicators proliferating cell nuclear antigen (PCNA), cyclin-dependent kinase 6 (CDK6), Cyclin D1, p21 in lung tissue, and found that HF could attenuate the lung tissue inflammatory response and proliferative response in HAPH rats. …”
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At what cycle threshold level are dogs able to detect SARS-CoV-2 in humans? by Víctor M Vidal-Martínez, Juan Manuel Mancilla-Tapia, Lilia C Soler-Jiménez, Iván Velázquez-Abunader, Matilde Jiménez-Coello, Antonio Ortega-Pacheco, David Hernández-Mena

“…These performance values concur well with those reported for commercial rapid antigen tests for detecting SARS-CoV-2. Consequently, it is considered that using properly trained animals could offer a viable option to supplement existing diagnostic methods, allowing for rapid diagnosis while optimizing time and economic resources. …”
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Aggressive Recurrence of Primary Hepatic Epithelioid Haemangioendothelioma after Liver Transplantation by Qusay A. Abdoh, Asma M. Alnajjar, Faisal A. Abaalkhail, Mohammed Al Sebayel, Hussa F. Al-Hussaini, Waleed K. Al-Hamoudi, Hazem Helmy, Mohamad Almansour, Hussien A. Elsiesy

“…Liver biopsy was consistent with HEHE, with positive endothelial markers (CD31, CD34, and factor VIII-related antigen). She underwent living related liver transplantation on June 2013 and was discharged after 20 days with normal liver enzymes. …”
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Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes by Amina Lazrek, Sebastiano Finocchi Ghersi, Adeline Petre, Sarah Houabes, Anne-Agathe Serre, Frederic Gassa, Magali Sandt, Cecile Laude, Camille Roukoz, Salvatore Cozzi

“…Despite initial remission, the patient experienced a rise in prostate-specific antigen (PSA) levels indicative of local recurrence in 2022. …”
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