Exploring Glypican-3 targeted CAR-NK treatment and potential therapy resistance in hepatocellular carcinoma. by Lei Yang, Kien Pham, Yibo Xi, Qunfeng Wu, Dongfang Liu, Keith D Robertson, Chen Liu

“…Therefore, developing novel treatment options for patients with HCC is urgently needed. Chimeric antigen receptor (CAR)-modified natural killer (NK) cells have demonstrated potent anti-tumor effects, making them as a promising immunotherapy strategy for cancer treatment. …”
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Real-world outcomes with tisagenlecleucel in aggressive B-cell lymphoma: subgroup analyses from the CIBMTR registry by Frederick L Locke, Grant Schofield, Marcelo Pasquini, Matthew J Frigault, Cameron J Turtle, Stephen Lim, Brian Hill, Samantha Jaglowski, Caron A Jacobson, Gunjan Shah, Daniel J Landsburg, Michael Heim, Stephen Ronan Foley, Ron Ram, Peter A Riedell, Leslie L Popplewell, Ranjan Tiwari, Marta Majdan, Aisha Masood

“…Background Tisagenlecleucel, a CD19 chimeric antigen receptor T-cell therapy, is approved for adults with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) or high-grade B-cell lymphoma (HGBCL) after ≥2 lines of therapy. …”
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Development and validation of a predictive model for lymph node metastases in peripheral non-small cell lung cancer with a tumor diameter ≤ 2.0 cm and a consolidation-to-tumor rati... by Dongyu Li, Dongyu Li, Shaolei Li, Hongbing Zhang, Chunqiu Xia, Xiaoyong Nan, Hongyu Liu, Jun Chen, Jun Chen

“…A prediction model was then developed and externally validated using a validation cohort at another institution.ResultsFour independent predictors (tumor size, CTR, pleural indentation, and carcinoembryonic antigen (CEA) values) were identified and entered into the model. …”
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Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies by Mathieu Ferrari, Matteo Righi, Vania Baldan, Patrycja Wawrzyniecka, Anna Bulek, Alexander Kinna, Biao Ma, Reyisa Bughda, Zulaikha Akbar, Saket Srivastava, Isaac Gannon, Mathew Robson, James Sillibourne, Ram Jha, Mohamed El-Kholy, Oliver Muhammad Amin, Evangelia Kokalaki, Mohammed Amin Banani, Rehan Hussain, William Day, Wen Chean Lim, Priyanka Ghongane, Jade R. Hopkins, Dennis Jungherz, Marco Herling, Martin Welin, Sachin Surade, Michael Dyson, John McCafferty, Derek Logan, Shaun Cordoba, Simon Thomas, Andrew Sewell, Paul Maciocia, Shimobi Onuoha, Martin Pule

“…Unlike other hematologic malignancies, the lack of target antigens to discriminate healthy from malignant cells limits the efficacy of immunotherapeutic approaches. …”
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Interleukin-1 signaling and CD4+ T cells control B cell recruitment to the lungs in chronic beryllium disease by Joseph M. Gaballa, Caley Valdez, Douglas G. Mack, Faiz Minhajuddin, Masoom Raza, Tabrez A. Mohammad, Allison K. Martin, Andrew Getahun, Charles A. Dinarello, Andrew P. Fontenot, Shaikh M. Atif

“…Further, RNA sequencing of pulmonary tissue-specific B cells in CBD revealed distinct gene signatures compared to splenic B cells, with increased expression of pathways involved in antigen presentation, tight junction interactions, and interferon signaling. …”
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High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma by Bo Wu, Haihua Yang, Shenpeng Ying, Hongsheng Lu, Wei Wang, Jiaming Lv, Huacai Xiong, Wei Hu

“…The nasopharynx is an important lymphoid tissue, and NPC tumourigenesis and development are partly attributed to immune system disorders. Human leukocyte antigen F (HLA-F) has shown a close correlation with NPC in many genome-wide association studies (GWASs). …”
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Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challenges by George Awuku Asare, Perpetua Dagadu, Samuel Adjei, Bernice Asiedu, Samkeliso Takaidza, Vivash Naidoo, Brodrick Amoah, Ifeoma Celestina Orabueze, Kwasi Bugyei

“…However, a significant reduction in prostate specific antigen (PSA) levels was seen in the RVARE-treated groups (Model vs Gp 3, p = 0.001; Model vs Gp 4, p = 0.000; Model vs Gp 5, p = 0.001). …”
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A Primary Pulmonary Glomus Tumor: A Case Report and Review of the Literature by Yasushi Ariizumi, Hirotaka Koizumi, Masahiro Hoshikawa, Takuo Shinmyo, Kouji Ando, Atsushi Mochizuki, Ayako Tateishi, Masatomo Doi, Mieko Funatsu, Ichirou Maeda, Masayuki Takagi

“…Immunostaining further revealed that the tumor cells expressed smooth muscle actin, h-caldesmon, muscle specific actin (HHF-35), but not cytokeratin, epithelial membrane antigen, synaptophysin, or chromogranin A. Based on these findings, a diagnosis of primary pulmonary glomus tumor was established. …”
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Evaluation of the Frequency of HLA-DQ2/DQ8 Genes Among Patients with Celiac Disease and Those on a Gluten-Free Diet by Marek K. Kowalski, Danuta Domżał-Magrowska, Ewa Małecka-Wojciesko

“…Background: Celiac disease (CD) is a chronic, permanent, gluten-dependent disease that manifests itself with inflammation of the small intestine and malabsorption in genetically predisposed individuals with HLA-DQ2 and -DQ8 (human leukocyte antigen) histocompatibility antigens. Objective: The diagnostic criteria for celiac disease have undergone numerous modifications over the years. …”
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The Influence of Ouabain on Human Dendritic Cells Maturation by C. R. Nascimento, R. C. Valente, J. Echevarria-Lima, C. F. L. Fontes, L. de Araujo-Martins, E. G. Araujo, V. M. Rumjanek

“…Nevertheless, TNF-α-induced antigen capture downregulation, another maturation marker, occurred even in the presence of Ouabain. …”
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MMP9-Associated Tumor Stem Cells, CCL1-Silenced Dendritic Cells, and Cytokine-Induced Killer Cells Have a Remarkable Therapeutic Efficacy for Acute Myeloid Leukemia by Activating T... by Min Dong, Guozhen Zhang, Jie Meng, Biou Liu, Duanfeng Jiang, Feng Liu

“…Dendritic cells (DC) are specialized antigen-presenting cells, and cytokine-induced killer (CIK) cells have a specific killing activity to a variety of tumors. …”
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Association between Interferon-Inducible Protein 6 () Polymorphisms and Hepatitis B Virus Clearance by Geun-Hee Park, Kyoung-Yeon Kim, Sung Won Cho, Jae Youn Cheong, Gyeong Im Yu, Dong Hoon Shin, Kyu Bum Kwack

“…However, these cells are killed through HBV-induced apoptosis during the antigen-presenting period in HBV-induced chronic liver disease (CLD) patients. …”
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Adverse Events of the BCG (Bacillus Calmette–Guérin) and Rotavirus Vaccines in a Young Infant with Inborn Error of Immunity by Suleiman Al-Hammadi, Najla S. Alkuwaiti, Ghassan A. Ghatasheh, Huda Al Dhanhani, Hiba M. Shendi, Abdulghani S. Elomami, Farida Almarzooqi, Abdul-Kader Souid

“…This variant creates premature stop-gain in CD3D (CD3 antigen, delta subunit, autosomal recessive; MIM#186790), resulting in loss-of-function. …”
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Generation and characterization of chicken monocyte-derived dendritic cells by Elie Ngantcha Tatchou, Elie Ngantcha Tatchou, Romane Milcamps, Romane Milcamps, Guillaume Oldenhove, Bénédicte Lambrecht, Fiona Ingrao

“…In chicken, DCs have mainly been derived from bone marrow cell cultures, with limited characterization from blood monocytes.MethodsThe present study takes advantage of newly available chicken immunological tools to further characterize chicken monocyte-derived dendritic cells (MoDCs), focusing on their phenotype, and functions, including antigen capture and T-cell stimulation, and response to live Newcastle disease virus (NDV) stimulation.ResultsAdherent chicken PBMCs were cultured with recombinant chicken granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4), for 5 days, leading to the upregulation of putative CD11c and MHCII, markers of DC differentiation. …”
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Selective JAK2 pathway inhibition enhances anti-leukemic functionality in CD19 CAR-T cells by Kohei Mitsuno, Masaya Suematsu, Yuki Naito, Azusa Mayumi, Hideki Yoshida, Shinya Osone, Toshihiko Imamura, Yozo Nakazawa, Shigeki Yagyu, Tomoko Iehara

“…Abstract The integration of molecular targeted therapeutics with chimeric antigen receptor T (CAR-T) cell therapy represents a novel strategy to amplify the anti-tumor efficacy of immunotherapy. …”
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Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection by Nadine Rujeni, Norman Nausch, Nicholas Midzi, Graeme J. Cowan, Richard Burchmore, David R. Cavanagh, David W. Taylor, Takafira Mduluza, Francisca Mutapi

“…The increase in IgE responses directed against adult worm antigens was accompanied by enhanced antigen recognition by sera from the children. …”
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Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C by Roberta C. Araújo, Fabricio C. Dias, Bruna C. Bertol, Deisy M. Silva, Patrícia H. Almeida, Andreza C. Teixeira, Fernanda F. Souza, Marcia G. Villanova, Leandra N. Z. Ramalho, Eduardo A. Donadi, Ana L. C. Martinelli

“…Hepatitis C virus (HCV) can escape from innate and adaptive immunity, making the immune response ineffective. Human leukocyte antigen E (HLA-E) might regulate the antiviral function of immune response and contribute to the persistence of HCV and the severity of liver disease. …”
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Mycobacterium avium subsp. paratuberculosis in an Italian Cohort of Type 1 Diabetes Pediatric Patients by Maria Luisa Manca Bitti, Speranza Masala, Francesca Capasso, Novella Rapini, Simona Piccinini, Federica Angelini, Andrea Pierantozzi, Roberta Lidano, Silvia Pietrosanti, Daniela Paccagnini, Leonardo A. Sechi

“…The presence of antibodies towards a MAP antigen, heparin binding hemoagglutinin (HBHA), was detected by ELISA. …”
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Constructing a potential HLA haplo-homozygous induced pluripotent stem cell haplobank using data from an umbilical cord blood bank by Ji He, Yanmin He, Qigang Zhan, Zhipan Wu, Qi Sheng, Wei Zhang, Faming Zhu

“…Methods To study the feasibility of constructing an HLA (human leukocyte antigen)-matched induced pluripotent stem cell haplobank in China, 5421 umbilical cord blood samples were randomly collected from the Umbilical Cord Blood Bank of Zhejiang Province, China. …”
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A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Dia... by Hidetoshi Akimoto, Emi Fukuda-Kawaguchi, Omar Duramad, Yasuyuki Ishii, Kazunari Tanabe

“…Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of pancreatic β cells by autoantigen-reactive diabetogenic cells. Antigen-specific therapies using islet autoantigens for restoring immune tolerance have emerged as promising approaches for the treatment of T1D but have been unsuccessful in humans. …”
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