HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) by Aijaz Zeeshan Khan, Omer Sabir, Adnan Hussain Shahid, Muhammad Bilal Basit, Syeda Arzinda Fatima Shah, Qamar Sajad

“…Methodology: A total of 215 patients presenting with characteristic symptoms and NS1 antigen and IgM. Anti Dengue antibodies positivity were included in current study. …”
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Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis by He Cao, Zhi Cao, Yue Han, Jing Shan

“…Molecular docking simulations showed strong binding interactions between the vaccine and TLR-9, suggesting enhanced antigen presentation capabilities.ConclusionThis comprehensive immuno-informatics approach provides a precision immunotherapy strategy for uveitis by leveraging computational modeling and predictive analytics to design a multi-epitope vaccine for HSV-1. …”
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Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice by Dai Fukumura, Rakesh K Jain, Jun Ren, Xinyue Dong, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette

“…Chimeric antigen receptor (CAR)-T cells have revolutionized the treatment of multiple types of hematological malignancies, but have shown limited efficacy in patients with glioblastoma (GBM) or other solid tumors. …”
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The unique activity of the bone morphogenetic protein TGH4 affects the embryonic development of Trichinella spiralis and the establishment of vaccine protection by Wenjie Shi, Yi Liu, Yan Liu, Xue Bai, Yue Liang, Yaming Yang, Fangwei Wu, Mingyuan Liu, Ning Xu

“…Our findings demonstrate that the TGH4 mutant is an important vaccine candidate antigen that blocks embryonic development, kills larvae, and provides insight into parasite vaccine research.…”
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Coexistence of Rheumatoid Arthritis, Systemic Lupus Erythematosus, Sjogren Syndrome, Antiphospholipid Syndrome, and Ankylosing Spondylitis by Moshiur Rahman Khasru, Md Abu Bakar Siddiq, Kazi Mohammad Sayeeduzzaman, Tangila Marzen, Abul Khair Mohammad Salek

“…The patient was seropositive for rheumatoid factor (RF), antibodies against cyclic citrullinated peptides (anti-CCP), antinuclear antibody (ANA), anti-Sm antibody, anti-Sjögren’s-syndrome-related antigen A and B (anti-SSA/SSB), antiphospholipid (aPL-IgG/IgM), and HLA B27; however, serum complement (C3 and C4) levels were normal. …”
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The Evolving Roles of Macrophages in Organ Transplantation by Junhui Li, Cai Li, Quan Zhuang, Bo Peng, Yi Zhu, Qifa Ye, Yingzi Ming

“…In this process, macrophage-mediated mobilization of first-line defenses, particularly phagocytosis and the release of acute inflammatory mediators, is important, but macrophages also launch adaptive alloimmune reactions against grafts through antigen processing and presentation, as well as providing costimulation. …”
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Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans? by Daniel Y. Bargieri, Irene S. Soares, Fabio T. M. Costa, Catarina J. Braga, Luis C. S. Ferreira, Mauricio M. Rodrigues

“…In parallel, new means to increase the protective effects of antigens in general have been pursued and depicted, such as the use of bacterial flagellins as carriers/adjuvants. …”
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IgG4-Related Autoimmune Prostatitis: Is It an Unusual or Underdiagnosed Manifestation of IgG4-Related Disease? by María T. Bourlon, Mónica Sánchez-Ávila, Fredy Chablé-Montero, Ricardo Arceo-Olaiz

“…We present a 61-year-old Latin-American male with autoimmune pancreatitis (AIP) who presented with lower urinary tract symptoms (LUTS), normal prostate specific antigen (PSA) test, and prostate enlargement attributed to benign prostatic hyperplasia (BPH). …”
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Protein C deficiency with recurrent systemic thrombosis associated with compound heterozygous PROC missense variants by Mikio Shiba, Shuichiro Higo, Yu Morishita, Yasuhiro Ichibori, Yoshihiro Kin, Yasushi Sakata, Yoshiharu Higuchi

“…The patient's protein C activity and antigen levels were extremely low (<10 % and 5 %, respectively). …”
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Comparison of Biparametric and Multiparametric Prostate Magnetic Resonance Imaging in Predicting Oncologic Outcomes After Radical Prostatectomy by Ozgur EFILOGLU, Nesrin GUNDUZ, Ayberk IPLIKCI, Mahmut Bilal DOGAN, Mehmet Caglar CAKICI, Turgay TURAN, Asif YILDIRIM

“…Multivariate regression analysis was performed to determine the risk factors in predicting BCR, which revealed the positivity of seminal vesicle invasion and high pathological stage in the pathology report as significant factors. Prostate-specific antigen (PSA) and PSA density were higher in group 3 than in group 2, but without significance. …”
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Nucleos(t)ide Analog Treatment Discontinuation in Chronic Hepatitis B Virus Infection: A Systematic Literature Review by Robert Gish, Kosh Agarwal, Anadi Mahajan, Supriya Desai, Saifuddin Kharawala, Rob Elston, Joyeta Das, Stuart Kendrick, Vera Gielen

“…Significant predictors with adequate evidence of clinical relapse included older age, male gender, and higher hepatitis B surface antigen (HBsAg) and hepatitis B virus DNA at baseline and end of treatment. …”
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Activation of FGD5-AS1 Promotes Progression of Cervical Cancer through Regulating BST2 to Inhibit Macrophage M1 Polarization by Guokun Liu, Xuan Du, Li Xiao, Qing Zeng, QianLing Liu

“…Bone marrow stromal cell antigen 2 (BST2) can play critical roles in immune response, and the roles of BST2 in cervical cancer was explored currently. …”
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Systemic Proteomic Analysis Reveals Distinct Exosomal Protein Profiles in Rheumatoid Arthritis by Qiu Qin, Ronghua Song, Peng Du, Chaoqun Gao, Qiuming Yao, Jin-an Zhang

“…Bioinformatics analysis revealed that transthyretin (TTR), angiotensinogen (AGT), lipopolysaccharide-binding protein (LBP), monocyte differentiation antigen CD14 (CD14), cartilage oligomeric matrix protein (COMP), serum amyloid P (SAP/APCS), and tenascin (TNC) can interact with each other. …”
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Value of dual-energy CT quantitative parameters combined with clinical features in diagnosis of stages T2 and T3 colorectal cancer by FANG Ni, WEI Xin, CHEN Weijuan

“…Results‍　‍Univariate analysis showed that carcinoembryonic antigen （CEA）， N stage， tumor location， tumor longest diameter （LD）， CT value of virtual noncontrast （CT-VNC）， fat fraction， electron density （Rho） and dual energy index （DEI） were significantly different between the T2 and T3 groups （P<0.05）. …”
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Role of Cholinergic Anti-Inflammatory Pathway in Protecting Sepsis-Induced Acute Lung Injury through Regulation of the Conventional Dendritic Cells by Ruiting Li, Xuemei Hu, Huibin Chen, Yue Zhao, Xuehui Gao, Yin Yuan, Huiling Guo, Haiyan Huang, Xiaojing Zou, Hong Qi, Hong Liu, You Shang

“…Dendritic cells (DCs), the important antigen-presenting cells, also express the α7nAChR. …”
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Knockout IL4I1 affects macrophages to improve poor efficacy of CD19 CAR-T combined with PD-1 inhibitor in relapsed/refractory diffuse large B-cell lymphoma by Rui Zhang, Yi Zhang, Hairong Xiao, Qingxi Liu, Mingfeng Zhao

“…Abstract Chimeric antigen receptor (CAR) T-cell therapy plays a critical role in the treatment of B-cell hematologic malignancies. …”
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Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children by Yang Zhuo, Yalan Yang, Mingjun Zhang, Ying Xu, Zhongping Chen, Lihong Mu, Xiaojun Tang, Zhaohui Zhong, Juan Chen, Li Zhou

“…Two hundred and seventy-four HBV-infected children defined as test positive for hepatitis B surface antigen (HBsAg) and 353 controls defined as negative for HBsAg in China were recruited from October 2013 to May 2015. …”
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Diagnostic Performance of Three ELISAs for Detection of Antibodies against SARS-CoV-2 in Human Samples by Cássio Meira, Dahara Silva, Ivanilson Santos, Breno Barreto, Vinícius Rocha, Emanuelle Santos, Bruna dos Reis, Afrânio Evangelista, Ricardo Ribeiro dos Santos, Bruna Machado, Guilherme Ribeiro, Roberto Badaró, Milena Soares

“…Based on this, we evaluated three enzyme-linked immunoassays (ELISAs) using different antigens from SARS-CoV-2 in a cohort of 161 patients. …”
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Persistence of the Immune Response to an Intramuscular Bivalent (GI.1/GII.4) Norovirus Vaccine in Adults by Geert Leroux-Roels, Robert L. Atmar, Jakob P. Cramer, Ian Escudero, Astrid Borkowski

“…Methods: In this study, 428 adult recipients of various compositions of the norovirus vaccine candidate, HIL-214, were followed for 5 years, to assess immune responses to its virus-like particle antigens, GI.1 and GII.4c. Serum antibodies and peripheral-blood antibody-secreting cells (ASCs) were measured. …”
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A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P[6]Rotavirus Infection by Tsuyoshi Matsuoka, Toshifumi Yodoshi, Misaki Sugai, Masato Hiyane, Takashi Matsuoka, Hideki Akeda, Masaharu Ohfu, Satoshi Komoto, Koki Taniguchi

“…On day 8 of admission, head MRI revealed that the splenial lesion had disappeared. RV antigen-positive stools suggested that RV had caused MERS. …”
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