High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance by Masanori Nakata, Boyang Zhang, Yifei Yang, Takashi Okada, Norihito Shintani, Hitoshi Hashimoto, Toshihiko Yada

“…Using GeneFishing method, HFD increased the leukocyte common antigen-related (LAR) protein tyrosine phosphatase in the liver in wild type mice. …”
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Clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone-sensitive prostate cancer by Feng Qi, Yihang Xu, Zicheng Xu, Qing Zou

“…No significant differences were detected between the two groups regarding prostate-specific antigen (PSA) at the initial diagnosis (P = 0.194), the International Society of Urological Pathology (ISUP) grade group (P = 0.158), the treatment options during omHSPC (P = 0.090), common comorbidities (P = 0.649) and the number of metastases (P = 0.291). …”
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High Serum Alkaline Phosphatase Flare after First-Line Androgen Deprivation Therapy Predicts Poor Prognosis in Metastatic Prostate Cancer Patients Treated with Second-Generation An... by Satoko Kojima, Hiroshi Masuda, Takahito Suyama, Kyokushin Hou, Kousuke Mikami, Kazuhiro Araki, Yukio Naya

“…The association of the ALP flare ratio with the prostate-specific antigen (PSA) response to CRPC treatment (second-generation androgen receptor targeted therapy (ART) or docetaxel), time to CRPC, and overall survival (OS) were investigated. …”
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Modified CD15/CD16-CLL1 inhibitory CAR-T cells for mitigating granulocytopenia toxicities in the treatment of acute myeloid leukemia by Rui Zhang, Yifan Zhao, Xiao Chai, Yingshuai Wang, Mohan Zhao, Shujing Guo, Yu Zhang, Mingfeng Zhao

“…CLL1 Chimeric antigen receptor T-cell (CAR-T) therapy, as a promising immunotherapeutic approach, has demonstrated its potential to enhance the prognosis of patients diagnosed with acute myeloid leukemia (AML). …”
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Optimization of Conditions for Expression of Dengue Serotype 2 EDIII Protein in <i>Escherichia coli</i> and Immune Responses of Adjuvant-Free EDIII Ferritin Nanoparticles Against D... by M.S.B.W.T.M. Nipuna Sudaraka Tennakoon, Kyoung-Ho Lee, Hye-Mi Lee, Jae-Yeon Park, Hyun-Jin Shin

“…Self-assembling ferritin nanoparticle technology is a widely used vaccine development platform for enhancing the efficacy of subunit vaccines by displaying multiple antigens on nanocages. The dengue virus (DENV) envelope domain III (EDIII) protein, the most promising antigen for DENV, has been applied in vaccine development, and it is essential to evaluate the relative immunogenicity of the EDIII protein and EDIII-conjugated ferritin to show the efficiency of the ferritin delivery system compared with EDIII. …”
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Second-hand Smoke Increases Nitric Oxide and Alters the IgE Response in a Murine Model of Allergic Aspergillosis by Brian W. P. Seymour, Janice L. Peake, Kent E. Pinkerton, Viswanath P. Kurup, Laurel J. Gershwin

“…During exposure, mice were sensitized to soluble Aspergillus fumigatus (Af) antigen intranasally between day 14 and 24. …”
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Selection of specific nanobodies against peanut allergen through unbiased immunization strategy and the developed immuno-assay by Yaozhong Hu, Chuan Zhang, Jing Lin, Yi Wang, Sihao Wu, Ying Sun, Bowei Zhang, Huan Lv, Xuemeng Ji, Yang Lu, Shuo Wang

“…In this study, nanobodies (Nbs) derived from the Heavy-Chain only Antibodies (HCAbs) were selected against the general peanut protein extract through the unbiased strategy to facilitate the development of the sandwich ELISA for the detection and surveillance of peanut allergen contamination. The target antigen of the selected Nb was identified as peanut allergen Ara h 3, and a cross-reaction was observed with the member of Gly 1 from the Ara h 3 family. …”
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Improving the N-glycosylation occupancy of plant-produced IgG1 by engineering the amino acid environment at Asn297 by Kathrin Göritzer, Valentina Ruocco, Ulrike Vavra, Shiva Izadi, Omayra C. Bolaños-Martínez, Thareeya Phetphoung, Nuttapat Pisuttinusart, Waranyoo Phoolcharoen, Richard Strasser

“…Furthermore, functional assays showed that antigen binding and human hFcRn interaction were unaffected, while FcγRIIIa binding affinity increased. …”
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Downmodulation of Vaccine-Induced Immunity and Protection against the Intracellular Bacterium Francisella tularensis by the Inhibitory Receptor FcγRIIB by Brian J. Franz, Ying Li, Constantine Bitsaktsis, Bibiana V. Iglesias, Giang Pham, Raju Sunagar, Sudeep Kumar, Edmund J. Gosselin

“…Fc gamma receptor IIB (FcγRIIB) is the only Fc gamma receptor (FcγR) which negatively regulates the immune response, when engaged by antigen- (Ag-) antibody (Ab) complexes. Thus, the generation of Ag-specific IgG in response to infection or immunization has the potential to downmodulate immune protection against infection. …”
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Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT by Kerstin Muders, Christian Pilat, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Frank-Christoph Mooren

“…Less pronounced lymphopenia (p=0.02), a trend towards a lower expression of CD69 count (p=0.07), and antigen-stimulated ICAM-1 (p=0.01) were found in the verum group. …”
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PMA Induces Vaccine Adjuvant Activity by the Modulation of TLR Signaling Pathway by Dool-Ri Oh, Hu Won Kang, Jong-Ro Kim, Sunoh Kim, In-Kyu Park, Joon Haeng Rhee, Won Keun Oh, Young Ran Kim

“…In in vivo mouse vaccination model, PMA induced antigen-specific IgG and IgA antibody responses and increased IL-12 production corresponding to T cell responses in spleen lymphocytes. …”
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Leishmania spp. Epidemiology of Canine Leishmaniasis in the Yucatan Peninsula by A. López-Céspedes, S. S. Longoni, C. H. Sauri-Arceo, M. Sánchez-Moreno, R. I. Rodríguez-Vivas, F. J. Escobedo-Ortegón, M. A. Barrera-Pérez, M. E. Bolio-González, C. Marín

“…The results obtained with ELISA using iron superoxide dismutase as the antigen were confirmed by western blot analysis with its greater sensitivity, and the agreement between the two techniques was very high.…”
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Ghrelin Protects Lipopolysaccharide-Induced Acute Lung Injury Rats against Pulmonary Vascular Dysfunction by Inhibiting Inflammation by Guang Li, Chen-Liang Zhou, Wen-Fang Xia, Di Zhang, Hui-Qing Lin

“…Immunohistochemical staining to detect alpha-smooth muscle actin (α-SMA) and proliferating cell nuclear antigen (PCNA) expression was performed to assess the intrapulmonary arterial wall thickness and the proliferation of smooth muscle cells, respectively. …”
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Immune status improvement in piglets through the use of interferon-containing products during specific prevention of porcine pleuropneumonia by A. G. Shakhov, L. Yu. Sashnina, V. A. Prokulevich, Yu. Yu. Vladimirova, M. I. Adodina

“…Tests for post-vaccination immunity levels in piglets showed a 3.8-fold increase in the levels of specific antibodies against the antigen of porcine pleuropneumonia agent, and in case of the vaccine administration in combination with biferon-S and prostimul – a 4.0-fold and 4.9-fold increase, respectively. …”
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Taurine Alleviated the Negative Effects of an Oxidized Lipid Diet on Growth Performance, Antioxidant Properties, and Muscle Quality of the Common Carp (Cyprinus carpio L.) by Dan Liu, Jiali Mi, Xiao Yan, Chaobin Qin, Junli Wang, Guoxing Nie

“…Moreover, taurine supplementation significantly reduced myofiber diameter and increased myofiber density (P<0.05) and enhanced the expression levels of paired box 7 (pax7), myogenic factor 5 (myf5), myogenic differentiation antigen (myod), and myogenic regulatory factor 4 (mrf4) compared with that of the OFO group (P<0.05). …”
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Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status by Keita Kai, Atsushi Miyoshi, Kenji Kitahara, Masanori Masuda, Yukari Takase, Kohji Miyazaki, Hirokazu Noshiro, Osamu Tokunaga

“…Viral infection was evaluated by serum HBV surface antigen (HBs Ag) and HCV antibody (HCV Ab). Sixty-eight (16.5%) patients had one or more EHPM. …”
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Molecular Mechanisms and Therapeutic Prospects of Immunotherapy and Targeted Therapy in Primary Central Nervous System Lymphoma by Lin Zhong MM, Anqing Lu MB, Xiyue Lu MM, Xiaoyin Liu MD, Lujia Cao MM, Shihong Zhu MM, SiJun Diao MM, Xu Cheng MM, Hongwei Wu MB, Jing Chen MD

“…With a deeper understanding of the pathophysiology of PCNSL, various therapies, including CD20 monoclonal antibodies, Bruton's tyrosine kinase (BTK) inhibitors, immunomodulatory drugs, immune checkpoint inhibitors, phosphoinositide 3-kinase (PI3 K)/mammalian target of rapamycin(mTOR) inhibitors, and chimeric antigen receptor (CAR) -T cells are increasingly being applied and have demonstrated considerable efficacy. …”
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Mast Cell-Derived Exosomes Promote Th2 Cell Differentiation via OX40L-OX40 Ligation by Fei Li, Yuping Wang, Lihui Lin, Juan Wang, Hui Xiao, Jia Li, Xia Peng, Huirong Dai, Li Li

“…Exosomes of different origin play a role in antigen presentation and modulation of immune response to infectious disease. …”
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Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B by Ashraf Mohamadkhani, Elnaz Naderi, Masoud Sotoudeh, Aezam Katoonizadeh, Ghodratollah Montazeri, Hossein Poustchi

“…In this study, fifty seven hepatitis B surface antigen (HBsAg) positive and HBeAg negative patients were studied to determine the expression of CD20, a cell surface marker expressed on B-cells, in liver biopsy sections using immunohistochemistry. …”
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Absence of Rejection in a Facial Allograft Recipient with a Positive Flow Crossmatch 24 Months after Induction with Rabbit Anti-Thymocyte Globulin and Anti-CD20 Monoclonal Antibody by Bruce E. Gelb, J. Rodrigo Diaz-Siso, Natalie M. Plana, Adam Jacoby, William J. Rifkin, Kimberly S. Khouri, Daniel J. Ceradini, Eduardo D. Rodriguez

“…Donor-specific antibodies (DSA) to human leukocyte antigen increase the risk of accelerated rejection and allograft damage and reduce the likelihood of successful transplantation. …”
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