Roles of retinoic acid-related orphan receptor α in high glucose-induced cardiac fibroblasts proliferation by Wenqing San, Qianyou Zhou, Danning Shen, Danyi Cao, Yun Chen, Guoliang Meng

“…Expressions of Collagen I, Collagen III, proliferating cell nuclear antigen (PCNA), α-smooth muscle actin (α-SMA), receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3) were evaluated. …”
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Integrative analysis of Ewing’s sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy by Fangzhou He, Jiuhui Xu, Fanwei Zeng, Boyang Wang, Yi Yang, Jie Xu, Xin Sun, Tingting Ren, Xiaodong Tang

“…A comparative analysis of paired samples revealed that in tumors with a good chemotherapeutic response, macrophages presented increased antigen presentation and reduced release of protumor cytokines, whereas CD8+ T cells presented increased cytotoxicity and reduced exhaustion. …”
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Rapid isolation and recovery of Salmonella using hollow glass microspheres coated with multilayered nanofilms by Rutwik Joshi, Hesaneh Ahmadi, Md Nayeem Hasan Kashem, Fariha Afnan, Siva Parameswaran, Chau-Chyun Chen, Gizem Levent, Wei Li

“…In this study, we demonstrate that Salmonella can be captured due to antigen-antibody interactions on the surface of HGMS, allowing them to float to the top. …”
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The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression by Yu-Lei Gao, Bin Lu, Jian-Hua Zhai, Yan-Cun Liu, Hai-Xia Qi, Ying Yao, Yan-Fen Chai, Song-Tao Shou

“…The negative immunoregulation of Tregs was inhibited, mainly including inhibiting the expression of forkhead helix transcription factor- (Foxp-) 3, cytotoxic T lymphocyte associated antigen- (CTLA-) 4, membrane associated transforming growth factor-β (TGF-βm+), and the secretion of inhibitory cytokines [including TGF-β and interleukin- (IL-) 10], as well as CD4+ T cells-mediated cellular immunosuppression which was improved by parenteral Vit C in WT and Gulo−/− septic mice. …”
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Vaccinomics Approach for Designing Potential Peptide Vaccine by Targeting Shigella spp. Serine Protease Autotransporter Subfamily Protein SigA by Arafat Rahman Oany, Tahmina Pervin, Mamun Mia, Motaher Hossain, Mohammad Shahnaij, Shahin Mahmud, K. M. Kaderi Kibria

“…At first, 44 SigA proteins from different variants of S. flexneri, S. dysenteriae, S. boydii, and S. sonnei were assessed to find the most antigenic protein. We retrieved 12 peptides based on the highest score for human leukocyte antigen (HLA) supertypes analysed by NetCTL. …”
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Global progress, challenges and strategies in eliminating public threat of viral hepatitis by Sihui Zhang, Fuqiang Cui

“…Main text The updated World Health Organization guidelines for the prevention, diagnosis, care and treatment for people with chronic hepatitis B infection (2024 edition) and Chinese guidelines for the prevention and treatment of chronic hepatitis B (version 2022) simplify clinical algorithms for the diagnosis, treatment, and monitoring of hepatitis B, expand treatment eligibility criteria, and provide alternative treatment options, which will cover a higher proportion of all hepatitis B surface antigen positive populations. These actions promote the global goal of eliminating the public health hazards of viral hepatitis by 2030. …”
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Immune-Mediated Cytotoxicity in Inflammatory Bowel Disease by Stephan R Targan, Richard L Deem, Fergus Shanahan

“…One is that the destruction of target cells is mediated by direct recognition of target antigens by cytotoxic cells which in turn triggers lysis. …”
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Epidemiology of dengue fever in Somaliland: clinical features, and serological patterns from a retrospective study by Dek Kahin Yosef, Ahmed Saeed Ismail, Barwaqo Saleban Awil, Halima Ahmed Hassan, Mohamed Ahmed Hassan

“…Demographic data, clinical symptoms, and results of rapid diagnostic tests for dengue NS1 antigen and IgM antibodies were analyzed. Results Of the 1,410 suspected cases, 175 (12.41%) tested positive for dengue. …”
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Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity by Jiaqi Ma, Cory M. Ayres, Chad A. Brambley, Smita S. Chandran, Tatiana J. Rosales, W. W. J. Gihan Perera, Bassant Eldaly, William T. Murray, Steven A. Corcelli, Evgenii L. Kovrigin, Christopher A. Klebanoff, Brian M. Baker

“…Abstract The inherent antigen cross-reactivity of the T cell receptor (TCR) is balanced by high specificity. …”
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Sp17 Protein Expression and Major Histocompatibility Class I and II Epitope Presentation in Diffuse Large B Cell Lymphoma Patients by Kamel Ait-Tahar, Amanda P. Anderson, Martin Barnardo, Graham P. Collins, Chris S. R. Hatton, Alison H. Banham, Karen Pulford

“…Success using immune checkpoint inhibitors and chimeric antigen receptor T cell technology has fuelled demand for validated cancer epitopes. …”
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Primary liver lymphoma: review of the literature and clinical case presentation by A. K. Smolyaninova, A. V. Gubkin, Ye. Ye. Zvonkov, Yu. A. Kucheryavy

“…Laboratory tests revealed progressive signs of liver failure at normal level of alpha-fetoprotein and carcino-embryonic antigen; clinical signs included progressive manifestations of liver encephalopathy, skin hemorrhages, severe edema, ascites, pruritis and excoriations. …”
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Long-Term Follow-Up after Prostatectomy for Prostate Cancer and the Need for Active Monitoring by Gregory P. Swanson, Wencong Chen, Sean Trevathan, Michael Hermans

“…We excluded lymph node and seminal vesicle positive patients and an additional 47 patients that did not have baseline prostate-specific antigen (PSA). This left 581 patients for analysis. …”
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Cigarette Smoke Suppresses the Surface Expression of c-kit and FcεRI on Mast Cells by M. E. Givi, B. R. Blokhuis, C. A. Da Silva, I. Adcock, J. Garssen, G. Folkerts, F. A. Redegeld, E. Mortaz

“…Stimulation with IgE/antigen resulted in decreased degranulation and release of Th1 and Th2 cytokines. …”
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Immunogenic characteristics of <i>Avibacterium paragallinаrum</i> (serogroup B) isolates and strains by M. S. Firsova, V. A. Yevgrafova, A. V. Potekhin, R. V. Yashin, O. V. Pruntova, V. S. Russaleyev

“…The vaccine sample based on the antigen of the ApB08 isolate induced an insufficient immune response in poultry when infected with the ApB04 and ApB12 isolates. …”
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Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity by Leonore Raudszus, Farbod Bahreini, Susanne Allan, Kai-Uwe Kalies, Charles C. Caldwell, Kathrin Kalies

“…For example, neutrophils regulate ongoing inflammation by modulating macrophage function through efferocytosis, T cell responses by antigen presentation and the release of cytokines. …”
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Recent Advances in Our Understanding of Human Inflammatory Dendritic Cells in Human Immunodeficiency Virus Infection by Freja A. Warner van Dijk, Kirstie M. Bertram, Thomas R. O’Neil, Yuchen Li, Daniel J. Buffa, Andrew N. Harman, Anthony L. Cunningham, Najla Nasr

“…Dendritic cells (DCs), as potent antigen-presenting cells, are among the first to capture HIV upon its entry into the mucosa, and they subsequently transport the virus to CD4 T cells, the primary HIV target cells. …”
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Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis by Zhenzhen Su, Jie Chen, Junlong Zhang, Yunfei An, Yun Liao, Xiaojuan Wu, Chuanmin Tao, Lanlan Wang, Bei Cai

“…Here, we explored the effects of proinflammatory and anti-inflammatory effector molecules on HBV progression, e antigen seroconversion, and liver function. Our results showed that circulating interleukin (IL)-17 may be helpful in HBV spontaneous clearance [odds ratio OR=1.468, 95%confidence interval CI=1.080–1.995, P=0.014] and protective against HBV-related hepatoma development (OR=0.933, 95%CI=0.910–0.957, P<0.001). …”
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The Effect of Age on the Regenerative Potential of Human Eyelid Adipose-Derived Stem Cells by Mingqi Zhang, Zhuoshi Wang, Yan Zhao, Lirong Zhang, Ling Xu, Liu Cao, Wei He

“…However, the expression of CD90 antigen and the adipogenic differentiation showed an age-related increase in HEASCs. …”
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Characterizing temporal and global host innate immune responses against SARS-CoV-1 and -2 infection in pathologically relevant human lung epithelial cells. by Vivian Y Tat, Aleksandra K Drelich, Pinghan Huang, Kamil Khanipov, Jason C Hsu, Steven G Widen, Chien-Te Kent Tseng, George Golovko

“…., bone marrow stromal cell antigen 2 (BST2), Z-DNA Binding Protein 1 (ZBP1), C-X-C Motif Chemokine Ligand 11 (CXCL11), and Interferon Induced Transmembrane Protein 1 (IFITM1), were identified as potential drug targets against β-CoVs. …”
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Prevalence and methodologies for detection, characterization and subtyping of Listeria monocytogenes and L. ivanovii in foods and environmental sources by Jin-Qiang Chen, Patrick Regan, Pongpan Laksanalamai, Stephanie Healey, Zonglin Hu

“…In this review, we (A) described L. monocytogenes and L. ivanovii, world-wide incidence of listeriosis, and prevalence of various L. monocytogenes strains in food and environmental sources; (B) comprehensively reviewed different types of traditional and newly developed methodologies, including culture-based, antigen/antibody-based, LOOP-mediated isothermal amplification, matrix-assisted laser desorption ionization-time of flight-mass spectrometry, DNA microarray, and genomic sequencing for detection and characterization of L. monocytogenes in foods and environmental sources; (C) comprehensively summarized different subtyping methodologies, including pulsed-field gel electrophoresis, multi-locus sequence typing, ribotyping, and phage-typing, and whole genomic sequencing etc. for subtyping of L. monocytogenes strains from food and environmental sources; and (D) described the applications of these methodologies in detection and subtyping of L. monocytogenes in foods and food processing facilities.…”
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