Defective production of interferon-γ and tumour necrosis factor-α by AIDS mononuclear cells after in vitro exposure to Rhodococcus equi by S. Delia, C. M. Mastroianni, M. Lichtner, F. Mengoni, S. Moretti, V. Vullo

“…We conclude that the failure of IFN-γ generation in AIDS patients in response to R. equi is not antigen-specific but it may reflect the global impairment of T-cell function. …”
Get full text

Combination Immunotherapy with 4-1BBL and CTLA-4 Blockade for the Treatment of Prostate Cancer by Kuang Youlin, Zhang Li, Weng Xiaodong, Liu Xiuheng, Zhu Hengchen

“…Interruption of immune regulatory pathways via activation of 4-1BB or cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) blockade appears to be a promising strategy for cancer immunotherapy. …”
Get full text

Vulval Elephantiasis: A Case Report by Harsh Mohan, Bhumika Bisht, Poonam Goel, Geeta Garg

“…Identification of microfilariae in night samples of peripheral blood or seropositivity for filarial antigen is requisite for the correct diagnosis. Case Presentation. …”
Get full text

Association of age, race, and ethnicity with access, response, and toxicities from CAR-T therapy in children and adults with B-cell malignancies: a review by Marco Ruella, Guido Ghilardi, Zainul S. Hasanali, Sandra P. Susanibar-Adaniya, Lena E. Winestone, Alfred L. Garfall

“…Chimeric antigen receptor T cell (CAR-T) therapies are now standard-of-care for several B-cell malignancies, and additional indications are being evaluated. …”
Get full text

Fundamentals and Methods for T- and B-Cell Epitope Prediction by Jose L. Sanchez-Trincado, Marta Gomez-Perosanz, Pedro A. Reche

“…Memory and effector functions of B- and T-cells are predicated on the recognition through specialized receptors of specific targets (antigens) in pathogens. More specifically, B- and T-cells recognize portions within their cognate antigens known as epitopes. …”
Get full text

Precision medicine using molecular-target drugs in psoriatic arthritis by Ippei Miyagawa, Yoshiya Tanaka

“…As the pathology of PsA has been clarified, molecular-targeted drugs targeting tumor necrosis factor-α, interleukin (IL)-17A, IL-17A/F, IL-17 receptor, IL-12/23(p40), IL-23p19, Cytotoxic T-lymphocyte Antigen-4 (CTLA-4), Janus kinase, and phosphodiesterase-4 have been developed and are widely used in clinical practice. …”
Get full text

Role of Macrophages in the Pathogenesis of Atopic Dermatitis by Sadaf Kasraie, Thomas Werfel

“…During the early and short inflammatory phase, macrophages exert proinflammatory functions like antigen-presenting phagocytosis and the production of inflammatory cytokines and growth factors that facilitate the resolution of inflammation. …”
Get full text

Isatuximab for Delayed Red Cell Engraftment after Allogeneic Hematopoietic Cell Transplantation by Mary Nauffal, Stephen Eng, Andrew Lin, Alexander Chan, Kathryn Mazzerella, Sergio Giralt, Miguel-Angel Perales, Boglarka Gyurkocza

“…Our patient was a 75-year-old female with acute myeloid leukemia who received an HLA-B antigen mismatched, unrelated peripheral blood stem cell transplant with a major ABO incompatibility (blood group A+ in the donor and blood group O+ in the recipient). …”
Get full text

Enhanced antibody responses in CD19-Cre mice by Diogo M. Cunha, Sara Hernández-Pérez, Pieta K. Mattila

“…Mice carrying one allele of CD19-Cre are, at the same time, rendered heterozygote for CD19, a crucial coreceptor of the B cell antigen receptor (BCR). As a result, CD19-Cre mice exhibit diminished expression levels of CD19, with potential, yet insufficiently examined, consequences in B cell activation. …”
Get full text

High Grade Glioma Mimicking Voltage Gated Potassium Channel Complex Associated Antibody Limbic Encephalitis by Dilan Athauda, R. S. Delamont, E. De Pablo-Fernandez

“…Further studies to elucidate a possible association between VGKC complex and other surface antigen antibodies with primary brain tumours should be carried out.…”
Get full text

Monoclonal Antibodies Conjugated with Superparamagnetic Iron Oxide Particles Allow Magnetic Resonance Imaging Detection of Lymphocytes in the Mouse Brain by Alessandro Luchetti, Davide Milani, Francesca Ruffini, Rossella Galli, Andrea Falini, Angelo Quattrini, Giuseppe Scotti, Giancarlo Comi, Gianvito Martino, Roberto Furlan, Letterio S. Politi

“…The particle is the contrast agent, by means of its T 2 * relaxation properties; the antibody is the targeting vector, responsible for homing the particle to target a surface antigen. To investigate the efficiency of particle vectorialization by these antibodies, we compared two types of antibody-vectorialized CD3-specific particles in vivo. …”
Get full text

PURITY TESTING OF ARRIAH FMD VACCINES by D. A. Lozovoy, D. V. Mikhalishin, V. A. Starikov, M. I. Doronin, A. S. Sharypov

“…Subtype A, O, Asia-1 and SAT-2 cultural FMD virus replicated in baby hamster kidney suspension culture (ВНК-21/2-17) was used for vaccine production. FMDV antigen was inactivated with aminoethyl ethylenimine solution, and the suspension was subsequently purified. …”
Get full text

CAR-T CELL THERAPY FOR T-CELL MALIGNANCIES by Ugo Testa, Patrizia Chiusolo, Elvira Pelosi, Germana Castelli, Giuseppe Leone

“… Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of B-cell lymphoid neoplasia and, in some instances, improved disease outcomes. …”
Get full text

Defensive Driving: Directing HIV-1 Vaccine-Induced Humoral Immunity to the Mucosa with Chemokine Adjuvants by Ebony N. Gary, Michele A. Kutzler

“…Unfortunately, parenteral vaccination rarely induces the production of an antigen-specific antibody at mucosal surfaces and thus relies on transudation of systemically generated antibody to mucosal surfaces to mediate protection. …”
Get full text

Increased Cell Proliferation in Chronic Helicobacter pylori Positive Gastritis and Gastric Carcinoma – Correlation between Immuno-Histochemistry and Tv Image Cytometry by Erika Szaleczky, László Prónai, Béla Molnár, Lajos Berczi, János Fehér, Zsolt Tulassay

“…We compared the cell proliferation activity of H. pylori positive and negative gastric epithelial biopsies in chronic gastritis with and without intestinal metaplasia (IM) and gastric cancer by the expression of proliferation cell nuclear antigen (PCNA) and Tv image cytometry, and assessed the effect of H. pylori eradication on the cell proliferation rate in the gastric epithelium.…”
Get full text

Rapid and Selective Determination of Folate Receptor α with Sensitive Resonance Rayleigh Scattering Signal by Liping Wu, Yue Liu, Rong Huang, Huawen Zhao, Weiqun Shu

“…The antibody-modified Au NPs would aggregate when FRα was added to the probe for the specific interaction between antibody and antigen, resulting in the enhancement of resonance Rayleigh scattering (RRS) intensity. …”
Get full text

Understanding HLA-DQ in renal transplantation: a mini-review by Rajdeep Das, Neil S. Greenspan

“…Human leukocyte antigen (HLA) mismatching, particularly with HLA-DQ, significantly impacts the development of donor-specific antibodies (DSA) and transplant outcomes. …”
Get full text

Effector, Memory, and Dysfunctional CD8+ T Cell Fates in the Antitumor Immune Response by John Reiser, Arnob Banerjee

“…The adaptive immune system plays a pivotal role in the host’s ability to mount an effective, antigen-specific immune response against tumors. CD8+ tumor-infiltrating lymphocytes (TILs) mediate tumor rejection through recognition of tumor antigens and direct killing of transformed cells. …”
Get full text

Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern by Rowan L. Grigoropoulos, Penny Wright, Mars B. van t'Veer, Mike A. Scott, George A. Follows

“…In this report, we describe our diagnostic work-up for one such case using blood, lymph node, and bone marrow aspirate samples, highlighting the variability of antigen expression seen in different sample types and methodologies. …”
Get full text

Cytokine Profile of Mouse Vaginal and Uterus Lymphocytes at Estrus and Diestrus by Maria C. Lopez, Margaret A. Stanley

“…It is known that sex hormones regulate IgA and IgG levels in the female reproductive tract. Moreover, antigen presentation by uterine and vaginal epithelial cells is also under strict hormonal control. …”
Get full text