Adaptive Treatment of Metastatic Prostate Cancer Using Generative Artificial Intelligence by Youcef Derbal

“…Testosterone and prostate-specific antigen (PSA) are assumed to be repeatedly monitored while treatment may involve a combination of androgen deprivation therapy (ADT), androgen receptor-signalling inhibitors (ARSI), chemotherapy, and radiotherapy. …”
Get full text

Is platelet activating factor (PAF) an important mediator in bronchial asthma? by R. H. Gundel, H. O. Heuer, L. G. Letts

“…In preclinical animal models of human asthma, PAF receptor antagonists have been found to be efficacious in blocking antigen-induced changes in lung function. However, the majority of these models involve acute inflammatory events and transient changes in lung function and, therefore, their relevance to human asthma is questionable. …”
Get full text

A critical review of the limitations of current diagnostic techniques for schistosomiasis by Ilemobayo Victor Fasogbon, Erick Nyakundi Ondari, Deusdedit Tusubira, Egwu Chinedu Ogbonnia, Jon Ashley, Swamiappan Sasikumar, Patrick Maduabuchi Aja

“…This review summarizes the published literature on the diagnostics of schistosomiasis based on the techniques of microscopy, serology, molecular, antigen-based and aptamer-based assays. The limitations of each technique were summarized to encourage future research. …”
Get full text

A Case of Malaria Predisposing to Salmonella Bacteremia in a Returning Traveler from Nigeria by Robert Jakubowski, Lisa L. Steed, Susan E. Dorman, Camelia Marculescu

“…Malaria was diagnosed by rapid antigen testing, but recognition of invasive nontyphoidal Salmonella disease was delayed. …”
Get full text

Genetic Factors in Animal Models of Intestinal Inflammation by R Balfour Sartor

“…The dominant role of genetic background in induction of intestinal inflammation is further documented by spontaneous colitis which develops in spontaneously mutant mice, cotton-top tamarins, human leukocyte antigen-B27/ β2 microglobulin transgenic rats and mice with targeted deletions of certain immunoregulatory cytokine and T lymphocyte genes. …”
Get full text

Prevalence of canine heartworm disease in the gemlik area, bursa by Turan Civelek, Alparslan Yıldırım, Anıl Iça

“…Heparinized blood specimens obtained from dogs were separately examined with native and Modified Knott techniques for the presence of circulating microfilariae while sera were examined with commercial test kit for the presence of circulating antigen. No circulating microfilaria was found in peripheral blood of examined dogs by native and modified Knott techniques whereas parasite antigens were determined in the sera of two male dogs one of which was aged between 3-6 years and the second was over 7 years. …”
Get full text

LFA-1: A potential key player in microglia-mediated neuroprotection against oxygen-glucose deprivation in vitro. by Robin Jansen, Marc Pawlitzki, Michael Gliem, Sven G Meuth, Stefanie Schreiber, Michael-W Görtler, Jens Neumann

“…Our present study reveals the relevance of a β2 integrin, lymphocyte function-associated antigen-1 (LFA-1), as a potential key player in protecting neuronal cell death after oxygen-glucose deprivation in organotypic hippocampal cell cultures. …”
Get full text

New Antibody Conjugates in Cancer Therapy by Serengulam V. Govindan, David M. Goldenberg

“…Importantly, the advantages of combining RAIT with radiation sensitizers, with immunotherapy, or a drug conjugate targeting a different antigen are being studied clinically and preclinically. …”
Get full text

γδ T Cells Cross-Link Innate and Adaptive Immunity in Mycobacterium tuberculosis Infection by Serena Meraviglia, Sary El Daker, Francesco Dieli, Federico Martini, Angelo Martino

“…Protective immunity against mycobacterial infections such as Mycobacterium tuberculosis is mediated by interactions between specific T cells and activated antigen presenting cells. To date, many aspects of mycobacterial immunity have shown that innate cells could be the key elements that substantially may influence the subsequent adaptive host response. …”
Get full text

Polypoid Carcinoma of the Oropharynx with Stromal Ossifying Myofibroblastic Proliferation: A Case Report and Literature Review by Marcello Filotico, Alessandro D’Amuri

“…Immunohistochemistry documented positivity for cytokeratins, epithelial membrane antigen, and P63 in the globoid elements beneath the necrotic rim; strong and diffuse expression of vimentin, smooth muscle actin, and CD99 and BCL2 in the spindle elements; and complete negativity for cytokeratin 5/6, high molecular weight cytokeratin (clone 34βE12), S100, muscle-specific actin, desmin, CD117, and anaplastic lymphoma kinase. …”
Get full text

Protective Immunity against SARS Subunit Vaccine Candidates Based on Spike Protein: Lessons for Coronavirus Vaccine Development by Atin Khalaj-Hedayati

“…In general, coronavirus spike protein is the major antigen for the vaccine design as it can induce neutralizing antibodies and protective immunity. …”
Get full text

Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells by Seulah Choi, Tae Sung Kim, Hui Xuan Lim

“…Dendritic cells (DCs) are professional antigen-presenting cells (APCs) and link the innate and adaptive immune systems. …”
Get full text

Bioluminescence Imaging of Vascular Endothelial Growth Factor Promoter Activity in Murine Mammary Tumorigenesis by Shannon L. Faley, Keiko Takahashi, Cornelia E. Crooke, Joshua T. Beckham, Takuya Tomemori, Scott B. Shappell, E. Duco Jansen, Takamune Takahashi

“…In contrast, the VEGF-GL mice, which were crossed with mouse mammary tumor virus-polyoma virus middle T antigen transgenic mammary tumor mice, exhibited prominent bioluminescence in the tumors, correlating with VEGF transcription. …”
Get full text

Immunoregulatory programs in anti‐N‐methyl‐D‐aspartate receptor encephalitis identified by single‐cell multi‐omics analysis by Xinhui Li, Yicong Xu, Weixing Zhang, Zihao Chen, Dongjie Peng, Wenxu Ren, Zhongjie Tang, Huilu Li, Jin Xu, Yaqing Shu

“…In parallel, single‐cell B cell receptor sequencing (scBCR‐seq) and repertoire analysis were conducted to assess antigen‐driven clonal expansion within the B cell population. …”
Get full text

Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells by Anthony M. Battram, Joan Mañé-Pujol, David F. Moreno, Aina Oliver-Caldés, Judit Carpio, Oriol Cardus, Luis Gerardo Rodríguez-Lobato, Álvaro Urbano-Ispizua, Carlos Fernández de Larrea

“…Abstract: Chimeric antigen receptor (CAR) T cells directed against B-cell maturation antigen (BCMA) are an effective treatment for multiple myeloma (MM), but short persistence and frequent relapses are challenges for this immunotherapy. …”
Get full text

Carbon Material Hybrid Construction on an Aptasensor for Monitoring Surgical Tumors by Renyuan Ma, Subash C. B. Gopinath, Thangavel Lakshmipriya, Yeng Chen

“…Carcinoembryonic antigen (CEA) is a glycoprotein, one of the common tumor biomarkers, found at low levels in body fluids. …”
Get full text

Establishment of a Rapid and Convenient Fluoroimmunoassay Platform Using Antibodies Against PDL1 and HER2 by Ji Eun Choi, Hanool Yun, Hee-Jin Jeong

“…This robust platform can be readily adapted for various fluoroimmunoassays targeting other antigens of interest.…”
Get full text

Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy by Shishengnan Song, Chong Wang, Yangchao Chen, Xiaorong Zhou, Yi Han, Haijian Zhang

“…Naive B cells present the initial antigen, germinal center B cell subsets enhance antibody affinity, and immunoglobulin subtypes exert multiple immune effects, while regulatory B cells establish immune tolerance. …”
Get full text

Transverse Myelitis Associated with Cryptococcus neoformans in an Immunocompetent Patient by David B. Villafuerte, Marco F. Passeri, Rayan Qazi, Moulika Baireddy, Fernando L. Sanchez

“…Analysis of cerebral spinal fluid (CSF) obtained via lumbar puncture was positive for the Streptococcus antigen with cultures also growing Cryptococcus neoformans. …”
Get full text

T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer by A. E. Albers, L. Strauss, T. Liao, T. K. Hoffmann, A. M. Kaufmann

“…Another important tumor-escape mechanism is to avoid recognition by dysregulation of antigen processing and presentation. Thus, both induction of functional CTL and susceptibility of the tumor and its microenvironment to become T cell targets should be considered in CTL-based immunotherapy.…”
Get full text