COSMC-Regulated O-Glycosylation: A Bioinformatics-Driven Biomarker Identification for Stratifying Glioblastoma Stem Cell Subtypes by Sara Sadat Aghamiri, Rada Amin

“…High Cosmc expression also enriched immune-related pathways, including inflammatory response and antigen presentation, and was associated with presence of myeloid cells, T cells, and NK cells. …”
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CAR-T cell therapy in developing countries: how long should we wait? by Om P Kurmi, Ramila Shilpakar, Sanjivan Gautam, Balram Gautam, Sudhamshu K C

“…However, the survival rates for patients with cancer in these regions are notably lower than those in high-income countries, primarily due to late diagnosis and limited access to advanced treatments. Chimeric antigen receptor (CAR) T-cell therapy has demonstrated promising outcomes in certain terminally ill patients with cancer, yet access to this treatment remains limited in LMICs, including Nepal.The Center for Regenerative Medicine in Nepal has initiated efforts to make CAR-T cell therapy accessible to patients with cancer at a substantially reduced cost. …”
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Immunodiffusion assay as a method of bovine leucosis post-mortem diagnosis by A. R. Mustafayev

“…The proposed method allows for the detection of antibodies against bovine leukemia virus (BLV) antigen located in the muscle and tissue fluids (plasma and lymph) of meat and offal. …”
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An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation by Silvia Sedda, Irene Marafini, Michele M. Figliuzzi, Francesco Pallone, Giovanni Monteleone

“…Innate lymphoid cells (ILCs) are a group of hematopoietic cells devoid of antigen receptors that have important functions in lymphoid organogenesis, in the defense against extracellular pathogens, and in the maintenance of the epithelial barrier. …”
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Immunomodulatory Effects of Hemagglutinin- (HA-) Modified A20 B-Cell Lymphoma Expanded as a Brain Tumor on Adoptively Transferred HA-Specific CD4+ T Cells by Valentin P. Shichkin, Roman M. Moriev

“…Previously, the mouse A20 B-cell lymphoma engineered to express hemagglutinin (HA) antigen (A20HA) was used as a systemic tumor model. …”
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Potential and Limitation of HLA-Based Banking of Human Pluripotent Stem Cells for Cell Therapy by Casimir de Rham, Jean Villard

“…However, the main obstacle in transplantation is the rejection of tissues or organ by the receiver, due to the three main immunological barriers: the human leukocyte antigen (HLA), the ABO blood group, and minor antigens. …”
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Humoral Immune Response to Keyhole Limpet Haemocyanin, the Protein Carrier in Cancer Vaccines by A. Kantele, M. P. Häkkinen, J. Zivny, C. O. Elson, J. Mestecky, J. M. Kantele

“…Keyhole limpet haemocyanin (KLH) appears to be a promising protein carrier for tumor antigens in numerous cancer vaccine candidates. The humoral immune response to KLH was characterized at the single-cell level with ELISPOT combined with separations of cell populations according to their expression of homing receptors (HRs). …”
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Towards an HCV vaccine: an overview of the immunization strategies for eliciting an effective B-cell response by Gabriel L. Costa, Giuseppe A. Sautto

“…The protective role of the humoral response directed against the HCV E2 glycoprotein is well established, and broadly neutralizing antibodies play a crucial role in effective viral clearance.Areas covered This review explores the HCV targets and the different vaccination approaches, encompassing different expression systems, antigen selection strategies, and delivery methods, focusing on those aimed at eliciting a broad and effective humoral response. …”
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Escherichia coli O127 group 4 capsule proteins assemble at the outer membrane. by Matthew R Larson, Kassia Biddle, Adam Gorman, Sarah Boutom, Ilan Rosenshine, Mark A Saper

“…Enteropathogenic Escherichia coli O127 is encapsulated by a protective layer of polysaccharide made of the same strain specific O-antigen as the serotype lipopolysaccharide. Seven genes encoding capsule export functions comprise the group 4 capsule (gfc) operon. …”
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The South African Prostate Cancer Screening Guidelines by J John, A Adam, L Kaestner, P Spies, S Mutambirwa, J Lazarus

“…Several professional associations have developed guidelines on screening and early diagnosis of asymptomatic men with prostate-specific antigen testing. With recent updates from several large randomised prospective trials, the South African Urological Association and the Prostate Cancer Foundation of South Africa have developed these evidence-based recommendations to guide clinicians on PCa screening and early diagnosis for South African men. …”
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Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis by Joachim Sieper, Juergen Braun

“…The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex whose name goes back to its discovery in studies of transplanted tissue compatibility. …”
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Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study by Kiyoshi Shingu, Tokiko Ito, Gengo Kaneko, Nobuo Itoh

“…The immunohistochemical profile of the tumor was also similar to that of salivary gland acinic cell carcinoma: the tumor cells were positive for amylase, lysozyme, α-1-antichymotrypsin, S-100 protein, and epithelial membrane antigen and negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. …”
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Bacteria as Precision Tools for Cancer Therapy by Carmen Michán, José Prados, Juan‐Luis Ramos

“…Engineered S. typhimurium strains can generate adjuvant flagellin‐antigen complexes that function as in situ vaccines, hence increasing the immunogenic responses within tumour environment. …”
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Impact of Point-of-Care Testing on Diagnosis, Treatment, and Surveillance of Vaccine-Preventable Viral Infections by Kirthika Lakshmanan, Benjamin M. Liu

“…This review delves into the advancements in POC testing, including antigen/antibody detection and molecular assays, while focusing on their impact on the diagnosis, treatment, and surveillance of VPVIs such as mpox, viral hepatitis, influenza, flaviviruses (dengue, Zika, and yellow fever virus), and COVID-19. …”
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Detection of antibodies to non-structural proteins of foot-and-mouth disease virus (review) by A. S. Yakovleva, A. V. Scherbakov

“…RecombinantFMD virus non-structuralproteins, mostly 3АВС or 3АВ, areusedasan antigen for such assay. In ashort time, recombinant FMD virusantigen-basedELISA hasevolvedfrom an in-houselaboratory methodtocommonlyavailablecommercial test systems, mostof which have high diagnostic specificityandsensitivity. …”
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MAGEB2-Mediated Degradation of EGR1 Regulates the Proliferation and Apoptosis of Human Spermatogonial Stem Cell Lines by Xueheng Zhao, Zenghui Huang, Yongzhe Chen, Qianyin Zhou, Fang Zhu, Huan Zhang, Dai Zhou

“…Here, we analyzed normal human testis single-cell sequencing data from the GEO dataset (GSE149512 and GSE112013). Melanoma antigen gene B2 (MAGEB2) was found to be predominantly expressed in human SSCs and further validated by immunohistology. …”
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Henoch-Schonlein Purpura—A Case Report and Review of the Literature by Amit B. Sohagia, Srinivas Guptha Gunturu, Tommy R. Tong, Hilary I. Hertan

“…It is a systemic disease where antigen-antibody (IgA) complexes activate the alternate complement pathway, resulting in inflammation and small vessel vasculitis. …”
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A novel label-free method to determine equilibrium dissociation constants of antibodies binding to cell surface proteins by Eilyn R. Lacy, Rupesh Nanjunda, Scott L. Klakamp, Deborah Kwok, Jennifer F. Nemeth, Gordon D. Powers, H. Hugo Caicedo, Steven A. Jacobs

“…The data showed that MSD-CAT can be successfully applied to determine binding affinity on cells in a label free format and without the need for laborious solubilization procedures to generate recombinant antigen. In addition, this method has the potential for high-throughput application while enabling simultaneous determination of equilibrium dissociation constant (KD) and receptor density within the same experiment.…”
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Acquired von Willebrand Disease Associated with Monoclonal Gammopathy of Unknown Significance by Sijan Basnet, Catherine Lin, Rashmi Dhital, Izza Mir, Elan Mohanty, Biswaraj Tharu, Sushil Ghimire, Dilli Ram Poudel

“…Further workup with coagulation studies showed decreased factor VIII, vWF antigen, and vWF:ristocetin cofactor assay, and negative Bethesda assay, indicating acquired von Willebrand disease. …”
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Vulnerabilities of Prostate Glandular Concretions Considered as Artefacts: A Cross-sectional Biopsy Slide Study by Surraj SUSAI, Rohini MOTWANI, Mrudula CHANDRUPATLA

“…Methods: Fifty hematoxylin and eosin slides that were prepared from procured transrectal biopsy specimens of normal prostate glands from asymptomatic patients suspected of having a prostatic disease but later found to be normal were retrospectively observed for the staining, contour, and positioning of the aggregated masses or concretions within their prostatic lumina and were then compared with the blood prostate specific antigen (PSA) levels. Results: Although significant associations highlighting the utility of these masses in presumed pathological states of the gland were drawn by comparing their staining parameters and contours to those of their respective PSA levels, their interluminal contour variations and vivid staining appearances did not necessarily rule out the possibility of some of them being artefacts, provided they were assessed in totality with the surrounding acini. …”
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