Agonistic anti-NKG2D antibody structure reveals unique stoichiometry and epitope compared to natural ligands by Daniel Fallon, Ching-Shin Huang, Jingya Ma, Christopher Morgan, Zhaohui Sunny Zhou

“…In contrast, as we report herein, the agonistic antibody 2D3 binds NKG2D with a 2:1 stoichiometry of its antigen binding fragments to homodimeric NKG2D and a largely distinct epitope. …”
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Tissue Factor Expression in Obese Type 2 Diabetic Subjects and Its Regulation by Antidiabetic Agents by Jing Wang, Theodore P. Ciaraldi, Fahumiya Samad

“…For the intervention study, subjects were randomized into treatment groups with rosiglitazone or metformin for 4 months. Results. Plasma TF antigen, activity, and adipose TF mRNA were greater in obese T2D subjects compared with obese nondiabetics. …”
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Regulatory Role of CD4+ T Cells in Myocarditis by Daria Vdovenko, Urs Eriksson

“…In the presence of tissue damage and innate immune activation, however, activated self-antigen-loaded dendritic cells promote CD4+ effector T cell expansion and myocarditis. …”
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Seroprevalence Study of Human Brucellosis by Conventional Tests and Indigenous Indirect Enzyme-Linked Immunosorbent Assay by Annapurna S. Agasthya, Srikrishna Isloor, Prabhudas Krishnamsetty

“…The focus of this work was to develop a highly sensitive and specific indirect ELISA by using smooth lipopolysaccharide antigen of Brucella abortus 99 to detect anti-Brucella antibodies at Project Directorate on Animal Disease Monitoring and Surveillance. …”
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Clinical utility of anti-cyclic citrullinated peptid and rheumatoid factor in chronic hepatitis B virus infection by Gokhan Sargin, Altay Kandemir

“…HBV-DNA, hepatitis B e antigen, anti-HBe, RF, and anti-CCP were evaluated. …”
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Differential Circulating Fungal Microbiome in Prostate Cancer Patients Compared to Healthy Control Individuals by Xu Wang, Zejun Zhou, David Turner, Michael Lilly, Tongwen Ou, Wei Jiang

“…The increased Bipolaris genus was associated with low prostate-specific antigen (PSA) levels, increased Sordariomycetes class was associated with severe pathological stage, and decreased Phoma herbarum species was associated with disease relapse, compared to corresponding controls. …”
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Predicting cytomegalovirus infection and graft-versus-host disease using QuantiFERON-CMV and Monitor in pediatric transplants: a proof-of-concept study by Lina Souan, Rawad Rihani, Maher A. Sughayer

“…Methods: The QF-CMV and QFM tests were used to predict CMV pp65 antigen and GvHD in 24 pediatric hematopoietic stem cell transplant recipients. …”
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Structure‐based computational design of antibody mimetics: challenges and perspectives by Elton J. F. Chaves, Danilo F. Coêlho, Carlos H. B. Cruz, Emerson G. Moreira, Júlio C. M. Simões, Manassés J. Nascimento‐Filho, Roberto D. Lins

“…This review covers the main classes of designed antigen‐binding motifs, as well as alternative strategies to develop tailored ones. …”
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Clinical Relevance of HLA Gene Variants in HBV Infection by Li Wang, Zhi-Qiang Zou, Kai Wang

“…Host gene variants may influence the natural history of hepatitis B virus (HBV) infection. The human leukocyte antigen (HLA) system, the major histocompatibility complex (MHC) in humans, is one of the most important host factors that are correlated with the clinical course of HBV infection. …”
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Familial Pemphigus Vulgaris Occured in a Father and Son as the First Confirmed Cases by Ali Haydar Eskiocak, Birgul Ozkesici, Soner Uzun

“…Although there is some evidence pointing towards a genetic predisposition by some human leukocyte antigen (HLA) genes, familial occurrence of PV is very rare. …”
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The Influence of Nanoparticle on Vaccine Responses against Bacterial Infection by Sareh Bagheri-Josheghani, Bita Bakhshi, Shahin Najar-peerayeh

“…Nanoparticles could function as a drug delivery tool, as an adjuvant to promote antigen processing, and as an immune modulator to induce immune responses. …”
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Immune Evasion Strategies of Trypanosoma cruzi by Ana Flávia Nardy, Célio Geraldo Freire-de-Lima, Alexandre Morrot

“…It interferes with the antigen presenting function of dendritic cells via an action on host sialic acid-binding Ig-like lectin receptors. …”
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Soy 11S Globulin Acid Subunits as the Novel Food Polymer Carrier by Lei Chen, Dahai Liu, Guohua Wu, Yuanyuan Ma

“…The results indicated that soy 11S globulin acid subunits were suitable novel carriers for aflatoxin antigen in immunization experiments and clone 4C5 could be used for simultaneous analysis of total aflatoxins.…”
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Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases by Georgy A. Nevinsky, Valentina N. Buneva

“…In human patients with autoimmune, viral, and bacterial diseases, the generation of antibodies (Abs) to foreign antigens and/or autoantibodies to self-antigens usually occurs. …”
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Detection of Islet Cell Immune Reactivity with Low Glycemic Index Foods: Is This a Concern for Type 1 Diabetes? by Datis Kharrazian, Martha Herbert, Aristo Vojdani

“…We measured the reactivity of either monoclonal or polyclonal affinity-purified antibodies to insulin, insulin receptor alpha, insulin receptor beta, zinc transporter 8 (ZnT8), tyrosine phosphatase-based islet antigen 2 (IA2), and glutamic acid decarboxylase (GAD) 65 and 67 against 204 dietary proteins that are commonly consumed. …”
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Antibodies Recognizing Yersinia enterocolitica Lipopolysaccharides of Various Chemotypes in Synovial Fluids From Patients With Juvenile Idiopathic Arthritis by Katarzyna Kasperkiewicz, Anna S. Świerzko, Mateusz Michalski, Łukasz Eppa, Mikael Skurnik, Zbigniew Żuber, Maciej Cedzyński

“…Western blot analysis revealed the presence of antibodies reacting with fast-migrating LPS fractions and enterobacterial common antigen (ECA) in synovial fluid samples. Our data also suggest the importance of LPS-associated ECA for the antigenicity of endotoxin. …”
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DETECTION SYSTEM OF A NEW-GENERATION BIOANALYTICAL DEVICE by E. V. Sysoev, A. K. Potashnikov, Y. V. Obidin, T. N. Goryachkovskaya, V. S. Bazin, V. M. Popik, S. E. Peltek, N. A. Kolchanov

“…We designed and manufactured a system for detection of antibodies/antigenes in biological fluids. This system records the kinetics of free immunodiffusion of fluorescent nanocomplexes inside the channels of a microfluid module of a new-generation bioanalytical device. …”
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The success of the tumor immunotherapy: neutrophils from bench to beside by Meng Zhu, Ru Jia, Xiaojie Zhang, Pingwei Xu

“…The present immune therapy was focused on the immune checkpoint blockade or Chimeric Antigen Receptor T-Cell Immunotherapy (CART) transfer, but how to activate the innate immune system to antitumor still lags out. …”
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Improved Clonal Selection Algorithm Based on Biological Forgetting Mechanism by Chao Yang, Bing-qiu Chen, Lin Jia, Hai-yang Wen

“…The antibody candidate set generated by the clonal selection algorithm has only a small number of antibodies with high antigen affinity to obtain high-frequency mutations. …”
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Dexamethasone reduces cell surface levels of CD11b on human eosinophils by A. M. Das, L. H. K. Lim, R. J. Flower, M. Perretti

“…Overnight incubation of human eosinophils (Eøs) with the glucocorticoid hormone dexamethasone (DEX; 0.1 μM) resulted in lower expression of the CD11b, but not CD49d, antigen on their plasma membrane, as assessed by flow cytometry. …”
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