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721
Approximate smooth solutions of a mathematical model for the activation and clonal expansion of T cells
Published 2012-11-01“…In a previous paper a mathematical model was developed for thedynamics of activation and clonal expansion of T cells during theimmune response to a single type of antigen challenge, constructedphenomenologically in the macroscopic framework of a thermodynamictheory of continuum mechanicsfor reacting and proliferatingfluid mixtures. …”
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722
Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies
Published 2016-01-01“…The antigen-presenting dendritic cells (DCs) are key to the immunological response, with different functions ascribed ranging from cellular immune activation to induction of tolerance. …”
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723
Clinical Outcomes of Specific Immunotherapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis
Published 2017-01-01“…Specific immunotherapies, including vaccines with autologous tumor cells and tumor antigen-specific monoclonal antibodies, are important treatments for PC patients. …”
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724
Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome.
Published 2011-03-01“…This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. …”
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725
The Role of Bacteria and Pattern Recognition Receptors in GvHD
Published 2010-01-01“…Graft-versus-Host Disease (GvHD) is the most serious complication of allogeneic stem cell transplantation (SCT) and results from an activation of donor lymphocytes by recipient antigen-presenting cells (APCs). For a long time, it has been postulated that the intestinal microflora and endotoxin exert a crucial step in this APC activation, as there is early and severe gastrointestinal damage induced by pretransplant conditioning. …”
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726
Improving CD3 bispecific antibody therapy in solid tumors using combination strategies
Published 2025-02-01“…Furthermore, tumor surface antigen selection for an optimal therapeutic window and acceptable collateral damage to normal tissues is challenging. …”
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727
Obesity and Cancer Screening according to Race and Gender
Published 2011-01-01“…In contrast, obese/overweight men reported higher rates of prostate-specific antigen (PSA) testing. Comparison of prostate cancer screening, mammography, and Pap smears implies a gender difference in the relationship between screening behavior and weight. …”
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728
Role of CEACAM1, ECM, and Mesenchymal Stem Cells in an Orthotopic Model of Human Breast Cancer
Published 2011-01-01“…Carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) is a morphogen in an in vitro model for lumen formation and plays a similar role in breast epithelial cells implanted in humanized mammary fat pads in NOD-SCID mice. …”
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729
Histopathological and Immunohistochemical Evaluation of African Swine Fever Pigs in Bali Province
Published 2024-12-01“…Immunohistochemistry consistently showed p54 viral antigen distribution in mononuclear cells/macrophages across various organs, with the spleen and lymph nodes being dominant sites in 12 pigs (100%). …”
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730
Genetic Associations in Acquired Immune-Mediated Bone Marrow Failure Syndromes: Insights in Aplastic Anemia and Chronic Idiopathic Neutropenia
Published 2012-01-01“…Various alleles and haplotypes of human leucocyte antigen (HLA) molecules have been implicated in the predisposition of developing the above diseases, as well as polymorphisms of inhibitory cytokines such as interferon-γ, tumor necrosis factor-α, and transforming growth factor-β1 along with polymorphisms on molecules of the immune system including the T-bet transcription factor and signal transducers and activators of transcription. …”
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731
Is platelet activating factor (PAF) an important mediator in bronchial asthma?
Published 1992-01-01“…In preclinical animal models of human asthma, PAF receptor antagonists have been found to be efficacious in blocking antigen-induced changes in lung function. However, the majority of these models involve acute inflammatory events and transient changes in lung function and, therefore, their relevance to human asthma is questionable. …”
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732
A critical review of the limitations of current diagnostic techniques for schistosomiasis
Published 2024-12-01“…This review summarizes the published literature on the diagnostics of schistosomiasis based on the techniques of microscopy, serology, molecular, antigen-based and aptamer-based assays. The limitations of each technique were summarized to encourage future research. …”
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733
A Case of Malaria Predisposing to Salmonella Bacteremia in a Returning Traveler from Nigeria
Published 2018-01-01“…Malaria was diagnosed by rapid antigen testing, but recognition of invasive nontyphoidal Salmonella disease was delayed. …”
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734
Genetic Factors in Animal Models of Intestinal Inflammation
Published 1995-01-01“…The dominant role of genetic background in induction of intestinal inflammation is further documented by spontaneous colitis which develops in spontaneously mutant mice, cotton-top tamarins, human leukocyte antigen-B27/ β2 microglobulin transgenic rats and mice with targeted deletions of certain immunoregulatory cytokine and T lymphocyte genes. …”
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735
Prevalence of canine heartworm disease in the gemlik area, bursa
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736
New Antibody Conjugates in Cancer Therapy
Published 2010-01-01“…Importantly, the advantages of combining RAIT with radiation sensitizers, with immunotherapy, or a drug conjugate targeting a different antigen are being studied clinically and preclinically. …”
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737
γδ T Cells Cross-Link Innate and Adaptive Immunity in Mycobacterium tuberculosis Infection
Published 2011-01-01“…Protective immunity against mycobacterial infections such as Mycobacterium tuberculosis is mediated by interactions between specific T cells and activated antigen presenting cells. To date, many aspects of mycobacterial immunity have shown that innate cells could be the key elements that substantially may influence the subsequent adaptive host response. …”
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738
Polypoid Carcinoma of the Oropharynx with Stromal Ossifying Myofibroblastic Proliferation: A Case Report and Literature Review
Published 2016-01-01“…Immunohistochemistry documented positivity for cytokeratins, epithelial membrane antigen, and P63 in the globoid elements beneath the necrotic rim; strong and diffuse expression of vimentin, smooth muscle actin, and CD99 and BCL2 in the spindle elements; and complete negativity for cytokeratin 5/6, high molecular weight cytokeratin (clone 34βE12), S100, muscle-specific actin, desmin, CD117, and anaplastic lymphoma kinase. …”
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739
Protective Immunity against SARS Subunit Vaccine Candidates Based on Spike Protein: Lessons for Coronavirus Vaccine Development
Published 2020-01-01“…In general, coronavirus spike protein is the major antigen for the vaccine design as it can induce neutralizing antibodies and protective immunity. …”
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740
Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells
Published 2024-04-01“…Dendritic cells (DCs) are professional antigen-presenting cells (APCs) and link the innate and adaptive immune systems. …”
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