Trypanosoma cruzi: Seroprevalence Detection in Suburban Population of Santiago de Querétaro (Mexico) by Ángeles López-Céspedes, Elena Villagrán, Kervin Briceño Álvarez, José Antonio de Diego, Hebert Luís Hernández-Montiel, Carlos Saldaña, Manuel Sānchez-Moreno, Clotilde Marín

“…These preliminary data reveal the degree of infection of nonrural areas of Mexico and demonstrated that SODeCRU is an antigen useful to diagnose Chagas disease.…”
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OK-432 Acts as Adjuvant to Modulate T Helper 2 Inflammatory Responses in a Murine Model of Asthma by Cheng-Jang Wu, Pin-Hsun Tseng, Cheng-Chi Chan, Sara Quon, Li-Chen Chen, Ming-Ling Kuo

“…Enhanced type 2 helper T (Th2) cell responses to inhaled harmless allergens are strongly associated with the development of allergic diseases. Antigen formulated with an appropriate adjuvant can elicit suitable systemic immunity to protect individuals from disease. …”
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Understanding Delayed T-Cell Priming, Lung Recruitment, and Airway Luminal T-Cell Responses in Host Defense against Pulmonary Tuberculosis by Christopher R. Shaler, Carly Horvath, Rocky Lai, Zhou Xing

“…However, in the case of M.tb, this may be impaired, thus delaying the recruitment of antigen-presenting cells (APCs) to the lung. Upon uptake by APC populations, M.tb is able to subvert and delay the processing of antigen, MHC class II loading, and the priming of effector T cell populations. …”
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Strong immune responses and robust protection following a novel protein in adjuvant tuberculosis vaccine candidate by Marcellus Korompis, Christopher J De Voss, Shuailin Li, Alexandre Richard, Salem Salman Almujri, Alberta Ateere, Géraldine Frank, Céline Lemoine, Helen McShane, Elena Stylianou

“…Vaccinated mice had enriched lung parenchymal antigen-specific CD4 + CXCR3 + KLRG1− T cells previously associated with TB protection. …”
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Potential and development of cellular vesicle vaccines in cancer immunotherapy by Wenxi Zhao, Xianjun Li, Jialu Guan, Shuai Yan, Lizhi Teng, Xitong Sun, Yuhan Dong, Hongyue Wang, Weiyang Tao

“…Tumor exosomes carry antigens and MHC-peptide complexes, which can provide tumor antigens to antigen-processing cells and increase the chances of recognition of tumor antigens by immune cells. …”
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Truncated SPAG9 as a novel candidate gene for a new syndrome: Coarse facial features, albinism, cataract and developmental delay (CACD syndrome) by Majid Alfadhel, Bashayr S. Alhubayshi, Muhammad Umair, Ahmed Alfaidi, Deemah Alwadaani, Essra Aloyouni, Safdar Abbas, Abdulkareem Al Abdulrahman, Mohammed Aldrees, Abeer Al Tuwaijri, Ruaa S. Alharithy, Abdulaziz Alajlan, Abdulrahman Alswaid, Saad Almohrij, Sultan Al-Khenaizan

“…Abstract Sperm-associated antigen 9 (SPAG9) is a member of cancer-testis antigen, having characteristics of a scaffold protein, which is involved in the c-Jun N-terminal kinase JNK signaling pathway, suggesting its key involvement in different physiological processes, such as survival, apoptosis, tumorigenesis, and cell proliferation. …”
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Key Insights into Respiratory Virus Testing: Sensitivity and Clinical Implications by Julio Garcia-Rodriguez, Frédéric Janvier, Clemens Kill

“…With the increasing availability of rapid antigen tests (RATS), it is tempting to prefer them over polymerase chain reaction (PCR) tests. …”
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Genome-wide association study of the antibody response to <i>Corynebacterium pseudotuberculosis</i> in sheep by J. Kyselová, L. Tichý, J. Marková, A. Gurgul, Z. Sztankóová, K. Vališ, S. Šlosárková, K. Kavanová, M. Beinhauerová, T. Szmatola, T. Szmatola

“…A case–control GWAS including 143 seropositive and 178 seronegative sheep was conducted to assess the relationship between the sheep genome and the antibody response to a phospholipase D antigen of <i>C. pseudotuberculosis</i> using GCTA software. …”
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Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases by Luca Perico, Federica Casiraghi, Fabiane Sônego, Marta Todeschini, Daniela Corna, Domenico Cerullo, Anna Pezzotta, Patricia Isnard-Petit, Silvia Faravelli, Federico Forneris, Kader Thiam, Ariela Benigni, Giuseppe Remuzzi

“…To test this approach, we focused on a prototype autoimmune disease of the kidney, membranous nephropathy (MN), in which phospholipase A2 receptor (PLA2R) serves as primary nephritogenic antigen. Specifically, we developed a BiAATE consisting of the immunodominant Cysteine-Rich (CysR) domain of PLA2R and the single-chain variable fragment (scFv) of an antibody against the T cell antigen CD3, connected by a small flexible linker.ResultsBiAATE creates an immunological synapse between autoreactive B cells bearing an CysR-specific surface Ig+ and T cells. …”
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Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism by Felix Pfister, Lucas R. Carnell, Lisa Löffler, Philipp Boosz, Niels Schaft, Jan Dörrie, René Stein, Malte Lenz, Erdmann Spiecker, Christian M. Huber, Sami Haddadin, Carola Berking, Christoph Alexiou, Christina Janko

“…Abstract Therapies against hematological malignancies using chimeric antigen receptors (CAR)‐T cells have shown great potential; however, therapeutic success in solid tumors has been constrained due to limited tumor trafficking and infiltration, as well as the scarcity of cancer‐specific solid tumor antigens. …”
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The guided fire from within: intratumoral administration of mRNA-based vaccines to mobilize memory immunity and direct immune responses against pathogen to target solid tumors by Renhao Li, Jing-Chu Hu, Li Rong, Yige He, Xiaolei Wang, Xuansheng Lin, Wenjun Li, Yangfan Wu, Chaiyaporn Kuwentrai, Canhui Su, Thomas Yau, Ivan Fan-Ngai Hung, Xiang Gao, Jian-Dong Huang

“…The pre-existing immunity against the pathogen antigen can significantly enhance the efficacy of this approach. …”
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A clinical efficacy analysis of single-port thoracoscopic lung resection in the treatment of male patients with non-small cell lung cancer using surface localization and CT-guided... by Qinghua Wang, Yujie He, Xiaowei Xie, Qinghua Wu

“…Results: Postoperatively, the study group had shorter operation time (124.15 ± 12.52 minutes), hospital stay (7.38 ± 0.73 days), drainage tube removal time (5.75 ± 0.57 days), and lower levels of Cytokeratin 19 fragment (CYFRA21-1) (3.03 ± 0.51 ng/mL), Carcino-Embryonic Antigen (CEA) (9.77 ± 0.96 ng/mL), Cancer Antigen 19-9 (CA199) (45.57 ± 4.86 U/mL), Squamous Cell Carcinoma Antigen (SCC) (21.29 ± 2.38 g/L), Epinephrine (E) (60.87 ± 6.41 pg/mL), Norepinephrine (NE) (185.32 ± 18.53 pg/mL), and Cortisol (Cor) (97.63 ± 9.76 ng/mL) compared to the control group (operation time: 136.85 ± 13.77 minutes; hospital stay: 9.67 ± 0.91 days; drainage tube removal time: 7.23 ± 0.69 days; CYFRA21-1: 4.87 ± 0.55 ng/mL; CEA: 12.68 ± 1.32 ng/mL; CA199: 16.38 ± 1.59 U/mL; SCC: 10.58 ± 1.12 g/L; E: 77.86 ± 7.86 pg/mL; NE: 226.76 ± 22.66 pg/mL; Cor: 119.87 ± 11.89 ng/mL). …”
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Vaccination techniques in fish by Kürşat Kav, Osman Erganiş

“…Injection and/or immersion type vaccines that are used commonly are prepared by inactivation of antigen with formaldehite. Vaccines are used effectively against bacterial (Vibrio spp. …”
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Fungal biomarkers in HIV-associated disseminated histoplasmosis: a multicenter diagnostic accuracy study on the Guiana shield by Aurore Moussiegt, Sigrid Mac Donald, Marie Elisabeth Bougnoux, Marja Van Eer, Stephen Vreden, Tom Chiller, Diego H. Caceres, Beatriz L. Gomez, Mathieu Nacher, Olivier Lortholary, Antoine Adenis

“…Our objective was to compare the performances of (1→3)-β-D-Glucan (BDG) and aspergillus galactomannan (GM) antigen for the diagnosis of HIV-associated histoplasmosis. …”
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Aspergillus identification through bronchoscope in intensive care unit – a retrospective, databased cohort study by Hsin-I Cheng, Chun-Yu Lin, Chun-Yu Lin, Horng-Chyuan Lin, Horng-Chyuan Lin, Horng-Chyuan Lin, Shu-Min Lin, Shu-Min Lin, Shu-Min Lin, Shu-Min Lin, Meng-Heng Hsieh, Meng-Heng Hsieh, Yueh-Fu Fang, Yueh-Fu Fang, Po-Jui Chang, Po-Jui Chang, Wei-Syun Hung, Ko Cheng, Chung−Chi Huang, Chung−Chi Huang

“…Galactomannan antigen from bronchoalveolar lavage may provide higher diagnostic sensitivity.…”
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Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naï... by David J Diemert, Maria Zumer, Mark Bova, Christina Gibbs-Tewary, Elissa M Malkin, Doreen Campbell, Lara Hoeweler, Guangzhao Li, Maria Elena Bottazzi, Peter J Hotez, Jeffrey M Bethony

“…Both dose concentrations of Na-GST-1/Alhydrogel plus CpG 10104 had significantly higher post-vaccination levels of antigen-specific IgG antibody compared to Na-GST-1/Alhydrogel without CpG, starting after the second injection. …”
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Search for Anti-EA(D) Antibodies in Subjects with an “Isolated VCA IgG” Pattern by Massimo De Paschale, Debora Cagnin, Teresa Cerulli, Maria Teresa Manco, Carlo Agrappi, Paola Mirri, Arianna Gatti, Cristina Rescaldani, Pierangelo Clerici

“…The presence of an “isolated viral capsid antigen (VCA) IgG” pattern in serum is not easy to interpret without the aid of further tests, such as specific immunoblotting or a virus genome search, that often give rise to organisational and economic problems. …”
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T Cell Repertoire and Inflammatory Bowel Disease by Kenneth Croitoru, David KH Wong, Maria E Baca-Estrada

“…The possibility that inflammatory bowel disease (IBD) is an autoimmune disease has led to the search for an auto-antigen. In addition, studies are exploring the T cell receptor repertoire in IBD patients for changes that may provide clues regarding etiopathogenesis. …”
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Molecular Detection, Phylogenetic Analysis, and Identification of Transcription Motifs in Feline Leukemia Virus from Naturally Infected Cats in Malaysia by Faruku Bande, Siti Suri Arshad, Latiffah Hassan, Zunita Zakaria

“…Of the 39 samples that were positive for FeLV p27 antigen, 87.2% (34/39) were confirmed positive with nested PCR. …”
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Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy by Amelia C. McCue, Stephen J. Demarest, Karen J. Froning, Michael J. Hickey, Stephen Antonysamy, Brian Kuhlman

“…TCEs function by binding to cell surface receptors on T cells, frequently CD3, with one arm of the bispecific antibody while the other arm binds to cell surface antigens on cancer cells. On-target, off-tumor toxicity can arise when the target antigen is also present on healthy cells. …”
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