The application of pigment-protein fraction from Nannochloropsis oculata on β-actin response of Cromileptes altivelis infected with viral nervous necrosis by Uun Yanuhar, Achmad Khumaidi

“…An outcome from gene transcription, the protein protects against pathogen infection, such as receptor clustering, antigen internalization, and regulating vesicle for antigen processing. ß - actin expression will determine the success of immune response of the organism. …”
Get full text

Isolation and Characterization of Coronavirus and Rotavirus Associated with Calves in Central Part of Oromia, Ethiopia by Umer Seid, Fufa Dawo, Asamino Tesfaye, Munera Ahmednur

“…Of the 83 diarrheic samples, 1 sample (1.2%) was positive for coronavirus antigen and 6 samples (7.2%) were found to be positive for rotavirus antigen by Ag-ELISA. …”
Get full text

DDO-adjuvanted influenza A virus nucleoprotein mRNA vaccine induces robust humoral and cellular type 1 immune responses and protects mice from challenge by Victoria Gnazzo, Hanaa Saleh, Ítalo A. Castro, Adrianus C. M. Boon, Amelia K. Pinto, James D. Brien, Carolina B. López

“…In addition, the adjuvant activity of DDO268 allows for the use of lower antigen doses during vaccination.…”
Get full text

Identification of nuclear valosin-containing-protein-like as a target of anti-nuclear autoantibodies in systemic sclerosis by Zitao Zeng, Ramona Miske, Madeleine Scharf, Yvonne Denno, Anthonina Ott, Stefanie Brakopp, Bianca Teegen, Winfried Stöcker, Elise Siegert, Elise Siegert, Sandra Saschenbrecker, Christian Probst, Lars Komorowski

“…ObjectiveTo identify the target antigen of an anti-nuclear autoantibody (ANA) from a patient with a suspected systemic autoimmune disease and to study the autoantibody’s clinical association.MethodsThe index patient serum was screened for autoantibodies using indirect immunofluorescence assay (IFA) and line blots (membrane strips coated with parallel lines of different purified antigens). …”
Get full text

Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity by Congcong Zhang, Anja Waldmann, Winfried S Wels, Jasmin Röder, Anne Scherer, Malena Bodden, Jordi Pfeifer Serrahima, Anita Bhatti, Nina Müller, Pranav Oberoi

“…Such ligands are broadly expressed by cancer cells of various origins and serve as targets for adoptive immunotherapy with effector cells endogenously expressing NKG2D or carrying an NKG2D-based chimeric antigen receptor (CAR). However, shedding or downregulation of NKG2D ligands (NKG2DL) can prevent NKG2D activation, resulting in escape of cancer cells from NKG2D-dependent immune surveillance.Methods To enable tumor-specific targeting of NKG2D-expressing effector cells independent of membrane-anchored NKG2DLs, we generated a homodimeric recombinant antibody which harbors an N-terminal single-chain fragment variable (scFv) antibody domain for binding to NKG2D, linked via a human IgG4 Fc region to a second C-terminal scFv antibody domain for recognition of the tumor-associated antigen ErbB2 (HER2). …”
Get full text

Predictors of cytomegalovirus infection in patients with connective tissue disease treated by pulsed methylprednisolone therapy: a multicenter retrospective cohort study by Haruka Ito, Takahiko Yoshimoto, Akatsuki Kokaze, Kuninobu Wakabayashi, Kazuteru Noguchi, Kiyoshi Matsui, Bunki Natsumoto, Keishi Fujio, Yutaro Hayashi, Yuko Kaneko, Takahisa Gono, Koh Okamoto, Shu Okugawa, Kyoji Moriya, Hirohiko Sueki

“…Logistic regression analysis was used to explore the factors associated with CMV antigen positivity. Receiver operating characteristic curve analysis was used to identify the cut-off values for the factors associated with CMV antigen sensitivity. …”
Get full text

Programmable Macrophage Vesicle Based Bionic Self‐Adjuvanting Vaccine for Immunization against Monkeypox Virus by Weiqiang Lin, Chenguang Shen, Mengjun Li, Shengchao Ma, Chenxin Liu, Jialin Huang, Zuning Ren, Yuechao Yang, Minghai Zhao, Qiulin Xie, Shuang Guo, Wei Wang, Kaiyuan Wang, Qiang Ma, Yideng Jiang, Judun Zheng, Yuhui Liao

“…Based on MPV‐related antigen‐stimulated macrophage‐derived vesicles, the nanovaccine is constructed by loading the mature virion (MV)‐related intracellular protein (A29L/M1R) and simultaneously modifying with the enveloped virion (EV) antigen (B6R), enabling them to effectively promote antigen presentation and enhance adaptive immune through self‐adjuvant strategy. …”
Get full text

Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases by Qiaolin Huang, Xiaojian Zhu, Yicheng Zhang

“…Abstract Adoptive immunotherapy using engineered T cells expressing chimeric antigen receptors has shown remarkable success in treating patients with hematological malignancies. …”
Get full text

A case report on weak subgroup of A: Aend by Saurabh Lahare, Ramesh Chandrakar, Minal Wasnik

“…A end is a weak subgroup of Blood group A, found rarely in general population, not detected by routine forward and reverse blood grouping, detected by Adsorption/Elution technique along with saliva testing for A, B and H antigens. Although it is subgroup of A but it lacks A antigen in saliva and contains only H antigen. …”
Get full text

Germinal center dynamics during acute and chronic infection by Samantha Erwin, Stanca M. Ciupe

“…We use the models to determine how B-cell selection and competition for T follicular helper cells and antigen influences the size and composition of germinal centers in acute and chronic infections. …”
Get full text

利用EB病毒特异性DNA酶检测鼻咽癌的研究 by 黄迪

“…近年来,文献资料一致指出Epstein—Barr病毒(EBV)与鼻咽癌(NPC)密切相关,尽管其病因学的地位尚未确定,但NPC病人血清中对抗EBV的某些抗原,如早期抗原(Early antigen,EA)、病毒壳抗原(Virus capsid antigen,VCA)的抗体(IgA或IgG型)的出现及其滴度高低可作为鼻癌咽早期发现、早期诊断、预后推测等的重要参考。…”
Get full text

Bronchioloalveolar carcinoma in a van cat by Zabid Yener, Mehmet Tütüncü, Hayati Yüksel, Hasan Akkan

“…Microscopically, the lumor cells were arranged as papillary and glandular slructure. immunohistochemically, some tumor markers, such as cytokeratin, vimentin, car-cinoembryonic antigen (CEA), alfa-1-antitripsin, and proliferative cell nuclear antigen (PCNA) was investigated From these, cytokeratin and PCNA were found to be positive.…”
Get full text

The protective duration of Streptococcus agalactiae vaccine in Nile Tilapia for the prevention of streptococcosis by , Sukenda, , Rusli, Sri Nuryati, Dendi Hidayatullah

“…Antigen-antibody reaction on day 42 after the vaccination was founded, but did not different significantly (P>0.05) with the control. …”
Get full text

Role of Helicobacter pylori Eradication Therapy on Platelet Recovery in Chronic Immune Thrombocytopenic Purpura by Khan Sheema, Ujjan Ikramdin, Naz Arshi, Naz Farah, Sheikh Imran

“…In this condition an autoantibody is generated against a platelet antigen. ITP affects women more often than men and is more common in children than adults. …”
Get full text

Serological Detection of Rh-Del Phenotype among Rh-Negative Blood Donors at National Blood Center, Yangon, Myanmar by Saw Thu Wah, Saung Nay Chi, Kyi Kyi Kyaing, Aye Aye Khin, Thida Aung

“…Red cell Rhesus (Rh) antigen expression is influenced by the genetic polymorphism of RHD and RHCE genes and reveals serologically different reactions of RhD variants such as partial D, weak D, and Rh-Del. …”
Get full text

A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade therapy for hepatocellular carcinoma by Xingyang Zhao, Feichao Xuan, Zirong Li, Xiangyi Yin, Xiaojun Zeng, Jiali Chen, Chihua Fang

“…This study confirmed KIF20A as a promising immunogenic antigen through transcriptomic mRNA sequencing analysis in the context of HCC. …”
Get full text

A comparative study evaluating three line immunoassays available for serodiagnosis of equine Lyme borreliosis: Detection of Borrelia burgdorferi sensu lato-specific antibodies in s... by Cornelia V Broeckl, Stephanie Hiereth, Reinhard K Straubinger

“…To improve functionality of available LIAs for equine serum samples it is advisable to adjust sensitivity and specificity of single test antigen signals and establish appropriate evaluation protocols.…”
Get full text

Targeted delivery of curcumin and CM11 peptide against hepatocellular carcinoma cells based on binding affinity of PreS1-coated chitosan nanoparticles to SB3 protein by Danial Rahmani, Ramezan Ali Taheri, Mehrdad Moosazadeh Moghaddam

“…In this study, the targeted release of curcumin (Cur) and CM11 peptide alone and together against hepatocellular carcinoma (HCC) was evaluated using chitosan nanoparticles (CS NPs) coated with Pres1 that target the SB3 antigen of HCC cells (PreS1-Cur-CM11-CS NPs). SB3 protein is the specific antigen of HCC and the PreS1 peptide is a part of the hepatitis B antigen, which can specifically bind to the SB3 protein. …”
Get full text

Ulcerative Colitis and Its Association with Salmonella Species by Manish Kumar Tripathi, Chandra Bhan Pratap, Vinod K. Dixit, Tej Bali Singh, Sunit K. Shukla, Ashok K. Jain, Gopal Nath

“…About 1.73% show positive agglutination for AH antigen including 3.4%, 3.6%, and 1.6%, UC, CC, and IBS. …”
Get full text

Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development. by Seung-Joo Lee, James B McLachlan, Jonathan R Kurtz, Danhua Fan, Sebastian E Winter, Andreas J Baumler, Marc K Jenkins, Stephen J McSorley

“…Thus, pathogen regulation of antigen expression plays a major role in orchestrating the expansion, differentiation, and location of antigen-specific CD4 T cells in vivo.…”
Get full text