-
501
Current Challenges in Prostate Cancer Management and the Rationale behind Targeted Focal Therapy
Published 2012-01-01“…In this effort, a review of major epidemiological and screening studies, cancer statistics from the advent of prostate-specific antigen screening to the present, and reports on patient concerns and treatment outcomes was conducted to present the dominant factors that underlie current challenges in prostate cancer treatment and illuminate potential solutions.…”
Get full text
Article -
502
Analysis of the IFN-γ-induced signal transduction pathway in fetal rejection
Published 1995-01-01“…In this work the in vitro and in vivo signal transduction pathways followed by IFN-γ or 5-azaC to induce class H antigen expression on placental cells by using specific pathway inhibitors has been studied. …”
Get full text
Article -
503
The Pathophysiological Impact of HLA Class Ia and HLA-G Expression and Regulatory T Cells in Malignant Melanoma: A Review
Published 2016-01-01“…The examination of the interaction between the human leucocyte antigen (HLA) system and prognostic outcome has shown interesting results, and a correlation between the down- or upregulation of these antigens and prognosis has been seen through many different types of cancer. …”
Get full text
Article -
504
Colitis in spondyloarthritis
Published 2020-01-01“…Apart from the strong Class I human leukocyte antigen B27 link for both diseases, several new shared genetic risk loci are identified from genome-wide association studies. …”
Get full text
Article -
505
The Role of Dendritic Cells in Adaptive Immune Response Induced by OVA/PDDA Nanoparticles
Published 2025-01-01“…Dendritic cells (DCs), as sentinels of foreign antigens, exert a crucial role in the antigen-specific immune response. …”
Get full text
Article -
506
Isolation of PCSK9-specific nanobodies from synthetic libraries using a combined protein selection strategy
Published 2025-01-01“…We have developed a reliable protein selection strategy that combines magnetic activated cell sorting (MACS)-based screening of yeast surface display (YSD) libraries and functional ligand-binding identification by Tat-based recognition of associating proteins (FLI-TRAP) to isolate antigen-specific Nbs from synthetic libraries. This combined process enabled isolation of three unique Nb clones (NbT15, NbT21, and NbT22) that all bound specifically to a target antigen, namely proprotein convertase subtilisin/kexin type 9 (PCSK9) as well as a gain-of-function PCSK9 mutant (D374Y). …”
Get full text
Article -
507
A cell-penetrating bispecific antibody suppresses hepatitis B virus replication and secretion
Published 2025-03-01“…The antibody could recognize preS1 and HBcAg and internalize into living cells efficiently, suppressing the extracellular hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen, and the intracellular HBsAg and HBcAg in vitro. …”
Get full text
Article -
508
Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment
Published 2023-03-01“…The viral etiology of these cancers provides the opportunity for antigen-directed therapies that are restricted in scope compared with cancers without viral components. …”
Get full text
Article -
509
CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma
Published 2022-03-01“…Targeting CD25 high, antigen-engaged Treg with a depleting anti-CD25 ICI, achieved complete cures in 100% of mice with triple therapy. …”
Get full text
Article -
510
Perbedaan Kadar Interferon Gamma dan Interleukin-10 pada Orang Dewasa Terinfeksi Ascaris Lumbricoides dengan Tidak Terinfeksi yang Diinduksi Vaksin Bacille Calmette-Guerin
Published 2016-01-01“…Vaksin BCG merupakan antigen yang dikenal sebagai penginduksi respon sel Th1. …”
Get full text
Article -
511
Analysis of Signals Leading to Differentiation of Immature HL-60 after Administration of IL-4
Published 1994-01-01“…For instance, induction of HLA-DR antigens on human promyelocytic leukaemia HL-60 cells by interleukin-4 (IL-4) is of pivotal importance in immunology not only because class II expression is prerequisite to antigen recognition and response but also because IL-4 participates in a plethora of inflammatory or non-inflammatory reactions. …”
Get full text
Article -
512
Recent Advances in Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms
Published 2018-01-01“…Recently, the pathogenic mechanism of T-cell activation triggered by human leukocyte antigen- (HLA-) restricted presentation of a drug or metabolites was elucidated. …”
Get full text
Article -
513
Treatment of end-stages of liver disease in outcome of persistent hepatitis C virus infection at deficiency of donor organs
Published 2011-03-01“…To study the role of serological markers of hepatitis B virus infection: antibodies to hepatitis B virus cor-antigen (anti-HВcor IgG) in progressing liver damage at patients with persistent hepatitis C virus infection.Material and methods. …”
Get full text
Article -
514
Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases
Published 2019-01-01“…Chimeric antigen receptor T (CAR-T) cells are T cells engineered to express specific synthetic antigen receptors that can recognize antigens expressed by tumor cells, which after the binding of these antigens to the receptors are eliminated, and have been adopted to treat several kinds of malignancies. …”
Get full text
Article -
515
Perianal Basal Cell Carcinoma Successfully Managed with Excisional Biopsy
Published 2019-01-01“…Immunohistochemical staining confirmed the diagnosis: it showed diffuse and strong positivity for smooth muscle actin (SMA) and monoclonal antibody BER-Ep4 and was negative for carcinoembryonic antigen (CEA), pancytokeratin (AE1/AE3), and epithelial membrane antigen (EMA). …”
Get full text
Article -
516
T-regulatory cells for the treatment of autoimmune diseases
Published 2025-02-01“…Adoptive transfer of Tregs includes polyclonal Tregs with non-specific effects and antigen-specific Tregs in the form of CAR-Treg and TCR-Treg. …”
Get full text
Article -
517
Immune Reactions Against Elongation Factor 2 Kinase: Specific Pathogenesis of Gastric Ulcer from Helicobacter pylori Infection
Published 2009-01-01“…This antigen was over-expressed by a stressful (heat-stressed) environment, and was identified as elongation factor 2 kinase (EF-2K) by western blotting. …”
Get full text
Article -
518
Optimizing Microneutralization and IFN-γ ELISPOT Assays to Evaluate Mpox Immunity
Published 2024-12-01“…In addition, assays to measure T cell responses require the use of specific antigens, which may not be the same for all pox viruses. …”
Get full text
Article -
519
Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus
Published 2016-01-01“…Elevated levels of INF-γ, VWF, ADAMTS13 antigen, D-Dimer, and reduced ADAMTS13 activity/antigen ratio were observed in patients with nephropathy as compared to those without nephropathy (P=0.001, P<0.001, P<0.001, P<0.001, and P<0.001, resp.). …”
Get full text
Article -
520
Construction of a prognostic prediction model for colorectal cancer based on 5-year clinical follow-up data
Published 2025-01-01“…SHAP analysis revealed that increased perioperative transfusion quantity, higher tumor AJCC stage, elevated carcinoembryonic antigen level, elevated carbohydrate antigen 19–9 (CA19-9) level, advanced age, and elevated carbohydrate antigen 125 (CA125) level were correlated with increased individual mortality risk. …”
Get full text
Article