Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL-15 by Xin Xu, Shantan Reddy, Saleh Bhar, Frederic D Bushman, Amy N Courtney, Gabriel A Barragán, Gengwen Tian, Erica J Di Pierro, Leonid S Metelitsa, Antonino Montalbano, Hangjin Yu, Claudia Martinez Amador, Nisha Ghatwai, Michael S Wood, Deborah Schady, Aoife M Roche, David de la Cerda, Donald Williams Parsons, Andras Heczey

“…Here, we describe a case of lethal hyperleukocytosis in a patient with neuroblastoma treated on phase 1 clinical trial (NCT03294954) with autologous natural killer T cells (NKTs) expressing a GD2-specific chimeric antigen receptor and cytokine interleukin 15 (GD2-CAR.15). …”
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Phages adapt to recognize an O-antigen polysaccharide site by mutating the “backup” tail protein ORF59, enabling reinfection of phage-resistant Klebsiella pneumoniae by Ping Li, Wenjie Ma, Jun Cheng, Cuixing Zhan, Hongzhou Lu, Jiayin Shen, Xin Zhou

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Peer Review of “Safety and Efficacy of Chimeric Antigen Receptor T-Cell Therapy for Recurrent Glioblastoma: An Augmented Meta-Analysis of Phase 1 Clinical Trials (Preprint)” by Vanessa Fairhurst, Randa Salah Gomaa Mahmoud, Toba Olatoye, Sylvester Sakilay

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Serum B-cell maturation antigen could be a simple and accurate biomarker to identify and prognosticate monoclonal gammopathy of undetermined significance and smoldering multiple myeloma by Masanori Toho, Daisuke Ikeda, Shuichi Aikawa, Chiho Misono, Mitsuaki Oura, Fuminari Fujii, Hajime Sakuma, Atsushi Uehara, R ikako Tabata, Kentaro Narita, Masami Takeuchi, Tomohisa Watari, Yoshihito Otsuka, Kosei Matsue

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Plant-Based Antigen Production Strategy for SARS-CoV-2 Nucleoprotein and RBD and Its Application for Detection of Antibody Responses in COVID-19 Patients by Katerina Takova, Valeria Tonova, Ivan Minkov, Eugenia S. Mardanova, Nikolai V. Ravin, Stanislav Kotsev, Maria Pishmisheva, Gergana Zahmanova

“…In this regard, low-cost and fast production of immunogenic antigens is essential for the rapid development of diagnostic serological kits. …”
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Prognostic importance of human leukocyte antigen DRβ1 gene and protein tyrosine phosphatase nonreceptor Type 22 gene polymorphism in rheumatoid arthritis by Pramod Kumar Verma, Usha Singh, Shyam Kumar Saraf, Narendra Kumar Singh

“…Background: Major histocompatibility complex (MHC) or human leukocyte antigen (HLA) gene and some of the non-MHC genes are associated with genetic predisposition in rheumatoid arthritis (RA). …”
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Bacterial Toxin Fusion Proteins Elicit Mucosal Immunity against a Foot-and-Mouth Disease Virus Antigen When Administered Intranasally to Guinea Pigs by Sreerupa Challa, Steven M. Szczepanek, Debra Rood, Roger W. Barrette, Lawrence K. Silbart

“…These were also the only groups that exhibited G-H loop-specific antigen-secreting cells in the nasal mucosa. These data demonstrate that fusion of nonreplicating antigens to LTA2B and ntPE-LTA2B has the potential to be used as carriers/adjuvants to induce mucosal immune responses against infectious diseases.…”
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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…VSIG4 deficiency recovered the antigen presentation (B2m, H2-k1, H2-d1) of TAMs and activated antigen-specific CD8+ T cells by promoting their in vivo proliferation and intratumoral infiltration. …”
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Piloting an external quality assurance program (QAP) for COVID-19 antigen rapid diagnostic tests (Ag-RDTs): findings and lessons learned from Cambodia by Vonthanak Saphonn, John Kaldor, Deborah Williamson, Sothavireak Bory, Philip Cunningham, Jessica Markby, Kennarey Seang, Jacqueline Prestedge, Chan Leakhena Phoeung, Marilyn Ninan, Kanika Heng, Andrew Valley

“…Rapid antigen diagnostic tests (Ag-RDTs) that quickly and accurately identify SARS-CoV-2 are an essential part of the COVID-19 response, but multiple factors can affect the validity of Ag-RDTs results. …”
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Molecular Assessment of Domain I of Apical Membrane Antigen I Gene in Plasmodium falciparum: Implications in Plasmodium Invasion, Taxonomy, Vaccine Development, and Drug Discovery by Che Roland Achungu, Damian Nota Anong, Robert Adamu Shey, Cevie Jesenta Tabe

“…The conserved short peptide sequences found in Domain I of Plasmodium falciparum apical membrane antigen 1 (PfAMA1), which are exposed on the parasite cell surface and in charge of Plasmodium falciparum invasion of host cells, make PfAMA1 a promising vaccine candidate antigen. …”
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An assessment model for efficacy of autologous CD19 chimeric antigen receptor T-cell therapy and relapse or refractory diffuse large B-cell lymphoma risk by Bin Xue, Yifan Liu, Min Zhang, Gangfeng Xiao, Xiu Luo, Lili Zhou, Shiguang Ye, Yan Lu, Wenbin Qian, Li Wang, Ping Li, Aibin Liang, Sihan Zhou, Xiuyuan Hao

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Correction: Design and expression of a chimeric recombinant antigen (SsIR-Ss1a) for the serodiagnosis of human strongyloidiasis: Evaluation of performance, sensitivity, and specificity. by Mostafa Omidian, Zohreh Mostafavi-Pour, Marzieh Asadi, Meysam Sharifdini, Navid Nezafat, Ali Pouryousef, Amir Savardashtaki, Mortaza Taheri-Anganeh, Fattaneh Mikaeili, Bahador Sarkari

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Development and use of indirect liquid-phase ELISA test system for detection of PRRS virus antigen during in-process control of raw materials intended for vaccine production by Ye. P. Baborenko, O. P. Byadovskaya, D. A. Biryuchenkov, A. V. Konstantinov, R. V. Yashin

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Molecular Mechanism of VSV-Vectored ASFV Vaccine Activating Immune Response in DCs by Yunyun Ma, Junjun Shao, Wei Liu, Shandian Gao, Guangqing Zhou, Xuefeng Qi, Huiyun Chang

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Blood immunophenotyping of multiple sclerosis patients at diagnosis identifies a classical monocyte subset associated to disease evolution by Stéphane Rodriguez, Stéphane Rodriguez, Laura Couloume, Juliette Ferrant, Juliette Ferrant, Nicolas Vince, Marion Mandon, Marion Mandon, Rachel Jean, Rachel Jean, Celine Monvoisin, Simon Leonard, Simon Le Gallou, Simon Le Gallou, Nayane S. B. Silva, Nayane S. B. Silva, Sonia Bourguiba-Hachemi, David Laplaud, David Laplaud, Alexandra Garcia, Romain Casey, Romain Casey, Romain Casey, Romain Casey, Helene Zephir, Anne Kerbrat, Gilles Edan, Emmanuelle Lepage, Eric Thouvenot, Eric Thouvenot, Aurelie Ruet, Aurelie Ruet, Guillaume Mathey, Guillaume Mathey, Pierre-Antoine Gourraud, Pierre-Antoine Gourraud, Karin Tarte, Karin Tarte, Celine Delaloy, Patricia Amé, Patricia Amé, Mikael Roussel, Mikael Roussel, Laure Michel, Laure Michel, Laure Michel

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Establishment and Clinical Application of Rh Blood Group Bank in the East China Region by Jin Y, Fu X, Xie S, Liu Z, Xu Z, Wang M, Wang Y, Lu R, Wang L

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Development of novel nomograms for predicting prostate cancer in biopsy-naive patients with PSA < 10 ng/ml and PI-RADS ≤ 3 lesions by Jia-gui Chai, Yu-hang Li, Chang-xing Ke

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Genome‐wide association study of tuberculosis in the western Chinese Han and Tibetan population by Hao Bai, Mengyuan Song, Shikun Lei, Lin Jiao, Xuejiao Hu, Tao Wu, Jiajia Song, Tangyuheng Liu, Wu Peng, Zhenzhen Zhao, Zirui Meng, Binwu Ying

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Expression of Functional MHC Class II Molecules By aMouse Pro-B Cell Clone by Suzanne Lombard-Platet, Amanda G. Fisher, Val&amp;#233;rie Meyer, Rhodri Ceredig

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Research Progress of Crustacean Allergens and Allergens Specific Immunological Products by Mengsi LI, Fei XIA, Qingmei LIU, Sujie HUANG, Yibin LU, Fei HUAN, Meng LIU, Yixiang LIU, Guangming LIU

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