Development of a Novel Rapid Immunodiagnostic Kit Based on Flagellar 40 kDa Antigen Epitope for the Detection of Typhoid Fever in Indian Patients by Rahul Mitra, Surya Bhan, Gopal Nath, Narender Kumar, Ziledar Ali

“…To overcome the problem of cross reactivity specific epitope of the flagellar H antigen was immobilised on the testing kit strip eliminating chances of cross reactivity and false positive results thereby increasing the specificity of the test. …”
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Anti-SARS-CoV-2 serology based on ancestral RBD antigens does not correlate with the presence of neutralizing antibodies against Omicron variants by Léa Dépéry, Isabelle Bally, Axelle Amen, Benjamin Némoz, Marlyse Buisson, Laurence Grossi, Aurélie Truffot, Raphaële Germi, Delphine Guilligay, Mélanie Veloso, Antoine Vilotitch, Olivier Epaulard, Patrice Morand, Winfried Weissenhorn, Pascal Poignard, Julien Lupo

“…Serological tests based on receptor-binding domain antigens from the ancestral virus fail to predict neutralizing activity against the latest circulating Omicron variants. …”
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Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…Background Successful development of chimeric antigen receptor (CAR) T cell immunotherapy for children and adults with relapsed/refractory acute myeloid leukemia (AML) is highly desired given their poor clinical prognosis and frequent inability to achieve cure with conventional chemotherapy. …”
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Textural Analysis of Nuclear Mitotic Apparatus Antigen (NuMA) Spatial Distribution in Interphase Nuclei from Human Drug-Resistant CEM Lymphoblasts by Naima Rafki‐Beljebbar, Françoise Liautaud‐Roger, Dominique Ploton, Jean Dufer

“…Therefore, we have compared the textural features observed in G0/G1 nuclei from human leukemic CEM cells and their MDR variant CEM‐VLB, after staining of either DNA by Feulgen method or nuclear matrix by immunodetection of NuMA antigen on DNase treated samples. Chromatin or NuMA distributions within the nucleus were evaluated by image cytometry. …”
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CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens by Sara W. Feigelson, Tali Dadosh, Nehora Levi, Anita Sapoznikov, Hadas Weinstein-Marom, Hadas Weinstein-Marom, Dayana Blokon-Kogan, Dayana Blokon-Kogan, Yahel Avraham, Tamar Unger, Gideon Gross, Gideon Gross, Rony Dahan, Ronen Alon

“…Targeting cytotoxic T lymphocytes (CTLs), as chimeric antigen T cells (CAR-T), T cell receptor-engineered (TCR)-T cells or adoptive cell transfer of tumor infiltrating T cells (TILs) to solid tumors is a major therapeutic challenge. …”
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Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation by Xiaosu Zhao, Xiangyu Zhao, Mingrui Huo, Qiaozhen Fan, Xuying Pei, Yu Wang, Xiaohui Zhang, Lanping Xu, Xiaojun Huang, Kaiyan Liu, Yingjun Chang

“…In this study, we performed a retrospective analysis to investigate the association of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) with PT in 394 patients who underwent unmanipulated haploidentical blood and marrow transplantation (HBMT). …”
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Immune checkpoint inhibitor associated lichenoid dermatitis mimicking erythema multiforme major with a germline variant in human leukocyte antigen-B15 by Sach Thakker, BS, Alexis Antonucci, BS, Amin Benyounes, MD, Blair S. Allais, MD

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Neutralization of omicron subvariants and antigenic cartography following multiple COVID 19 vaccinations and repeated omicron non JN.1 or JN.1 infections by Nungruthai Suntronwong, Sitthichai Kanokudom, Thaneeya Duangchinda, Warangkana Chantima, Pattarakul Pakchotanon, Sirapa Klinfueng, Jiratchaya Puenpa, Thaksaporn Thatsanathorn, Nasamon Wanlapakorn, Yong Poovorawan

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Codon optimized influenza H1 HA sequence but not CTLA-4 targeting of HA antigen to enhance the efficacy of DNA vaccines in an animal model by Dito Anurogo, Chia-Yuan Chen, Chu-Chi Lin, Jeanne Adiwinata Pawitan, Daniel W. Qiu, J. Timothy Qiu

“…In the investigation here, protein expression was enhanced via codon optimization and then mouse cytotoxic T-lymphocyte antigen 4 (CTLA-4) was harnessed as a modulatory adjunct to bind directly to antigen-presenting cells. …”
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An MRI radiomics model for predicting a prostate-specific antigen response following abiraterone treatment in patients with metastatic castration-resistant prostate cancer by Yi Wu, Xiang Liu, Shaoxian Chen, Fen Fang, Feng Shi, Yuwei Xia, Zehong Yang, Daiying Lin

“…ObjectiveTo establish a combined radiomics-clinical model for the early prediction of a prostate-specific antigen(PSA) response in patients with metastatic castration-resistant prostate cancer(mCRPC) after treatment with abiraterone acetate(AA).MethodsThe data of a total of 60 mCRPC patients from two hospitals were retrospectively analyzed and randomized into a training group(n=48) or a validation group(n=12). …”
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Effect of Advanced Glycation End Products on Human Thyroglobulin’s Antigenicity as Identified by the Use of Sera from Patients with Hashimoto’s Thyroiditis and Gestational Diabetes Mellitus by A. Hatzioannou, I. Kanistras, E. Mantzou, E. Anastasiou, M. Peppa, V. Sarantopoulou, P. Lymberi, M. Alevizaki

“…Herein, we investigated whether the modification of thyroglobulin (Tg) by AGEs influences its antigenicity and immunogenicity. Human Tg was incubated in vitro with increasing concentrations of D-glucose-6-phosphate in order to produce Tgs with different AGE content (AGE-Tg). …”
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Implementation of Antigen-Based Diagnostic Assays for Detection of Histoplasmosis and Cryptococcosis among Patients with Advanced HIV in Trinidad and Tobago: A Cross-Sectional Study by Ayanna Sebro, Jonathan Edwards, Omar Sued, Leon-Omari Lavia, Tricia Elder, Robert Jeffrey Edwards, Patrick Eberechi Akpaka, Nadia Ram-Bhola, Roanna Morton-Williams Bynoe, Yanink Caro-Vega, Isshad John, Freddy Perez

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Design and expression of a chimeric recombinant antigen (SsIR-Ss1a) for the serodiagnosis of human strongyloidiasis: Evaluation of performance, sensitivity, and specificity. by Mostafa Omidian, Zohreh Mostafavi-Pour, Marzieh Asadi, Meysam Sharifdini, Navid Nezafat, Ali Pouryousef, Amir Savardashtaki, Mortaza Taheri-Anganeh, Fattaneh Mikaeili, Bahador Sarkari

“…The present study aimed to design and produce a chimeric recombinant antigen from Strongyloides stercoralis immunoreactive antigen (SsIR) and Ss1a antigens, using immune-informatics approaches, and evaluated its diagnostic performance in an ELISA system for the diagnosis of human strongyloidiasis.…”
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Diagnostic Accuracy of Serum Prostate Specific Antigen and Gleason Score in Determining the Presence of Skeletal Metastasis in Prostate Cancer Patients: a Pakistani Perspective by Taimoor Nasir, Syeda Neha Aamer, Saman Waqar, Wafa Omer

Subjects: “…Bone metastasis, bone scan, Gleason score, prostate cancer, prostate specific antigen…”
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Negative Association of Gulf War Illness Symptomatology with Predicted Binding Affinity of Anthrax Vaccine Antigen to Human Leukocyte (HLA) Class II Molecules by Lisa M. James, Apostolos P. Georgopoulos

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MergeReference: A Tool for Merging Reference Panels for HLA Imputation by Seungho Cook, Buhm Han

Subjects: “…human leukocyte antigens…”
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Significance of immune factors in Crohn's disease development by D. S. Stavtsev, T. A. Astrelina, O. V. Knyazev, T. V. Pukhlikova

Subjects: “…hla-system antigens…”
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The effect of HLA genotype on disease onset and severity in CTLA-4 insufficiency by Sara Posadas-Cantera, Sara Posadas-Cantera, Noriko Mitsuiki, Florian Emmerich, Virginia Patiño, Hanns-Martin Lorenz, Olaf Neth, Ingunn Dybedal, Kjetil Taskén, Alejandro A. Schäffer, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Laura Gámez-Díaz, Laura Gámez-Díaz

Subjects: “…cytotoxic T-lymphocyte antigen 4 (CTLA-4)…”
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Influence of Regular Statin Intake on Prostate‐Specific Antigen Values, Prostate Cancer Incidence and Overall Survival in a Prospective Screening Trial (ERSPC Aarau) by Alkiviadis Papagiannakis, Maciej Kwiatkowski, Stephen F. Wyler, Ashkan Mortezavi, Lukas Manka, Marian S. Wettstein, Rainer Grobholz, Angelika Hammerer‐Lercher, Daniel Eberli, Lukas Werner Prause

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Hubungan Usia dan Kadar Prostate Specific Antigen (PSA) dengan Derajat Histopatologi Adenokarsinoma Prostat di RSUD Abdoel Wahab Sjahranie Samarinda by Novita Eka Tyas Pratiwi, Yudanti Riastiti, Hadi Irawiraman, Danial Danial

“…Adenocarcinoma prostate generally occurs in older adults and maybe because of increase in prostate-specific antigen (PSA) levels.  It is essential to know the relationship between age and PSA levels with histopathological grade to determine the appropriate management in cases of prostate adenocarcinoma. …”
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