Identification of anti-c, E alloantibodies with autoantibodies mimicking anti-c, E alloantibodies by Kangle Feng, Xinyu Huang, Xianguo Xu, Xiaodi Shi

“…Objectives: Autoantibodies mimicking alloantibodies (referred to as mimicking antibodies) are a type of specific antibody that reacts with all red blood cells, but exhibits a stronger reaction with red blood cells expressing the target antigens. This study aimed to explore immunohematologic methods for identifying mimicking antibodies, autoantibodies and alloantibodies, and to formulate safe transfusion strategies based on the results. …”
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Immunotherapy for Hepatocellular Carcinoma: Current Advances and Future Expectations by Yingjun Xie, Yien Xiang, Jiyao Sheng, Dan Zhang, Xiaoxiao Yao, Yongsheng Yang, Xuewen Zhang

“…Cancer vaccination is performed using antigenic substances to activate tumor-specific immune responses. …”
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Intelligence algorithm for the treatment of gastrointestinal diseases based on immune monitoring and neuroscience: A revolutionary tool for translational medicine by Liangyu Li, Xuewen Qin, Guangwei Wang, Siyi Li, Xudong Li, Lizhong Guo, Javier Santos, Ana María Gonzalez-Castro, Yanyang Tu, Yi Qin

“…A multi universe optimized BP neural network model was implemented based on TCGA data of common immune antigens in clinical laboratories. The working mechanism of this model is to assign values to the parameters of the BP neural network by using the process of searching for the best fitness in multiple universes. …”
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Temperature Depended Role of Shigella flexneri Invasion Plasmid on the Interaction with Acanthamoeba castellanii by Amir Saeed, David Johansson, Gunnar Sandström, Hadi Abd

“…The virulence genes required for invasion are clustered on a large 220 kb plasmid encoding type three secretion system (TTSS) apparatus and virulence factors such as adhesions and invasion plasmid antigens (Ipa). The bacterium is transmitted by contaminated food, water, or from person to person. …”
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Multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumor by Xiaoqing Han, Xingbo Wang, Jiao Yan, Panpan Song, Yanjing Wang, Yaqing Kang, Abdur Rauf, Haiyuan Zhang

“…The large recruitment of tumor-associated macrophages and low exposure of tumor-associated antigens in tumor microenvironment have severely suppress the efficacy of anti-tumor immunotherapy. …”
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Antibodies from a Patient with Type 1 Diabetes and Celiac Disease Bind to Macrophages that Express the Scavenger Receptor CD163 by Brigitte Sonier, Alexander Strom, Gen-Sheng Wang, Christopher Patrick, Jennifer A Crookshank, Majid Mojibian, Amanda J MacFarlane, Fraser W Scott

“…Antibodies against the wheat storage globulin Glo-3A from a patient with both type 1 diabetes (T1D) and celiac disease were enriched to identify potential molecular mimicry between wheat antigens and T1D target tissues. Recombinant Glo-3A was used to enrich anti-Glo-3A immunoglobulin G antibodies from plasma by batch affinity chromatography. …”
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Molecular dynamics simulation based prediction of T-cell epitopes for the production of effector molecules for liver cancer immunotherapy. by Sidra Zafar, Yuhe Bai, Syed Aun Muhammad, Jinlei Guo, Haris Khurram, Saba Zafar, Iraj Muqaddas, Rehan Sadiq Shaikh, Baogang Bai

“…In this study, machine learning and MD simulation-based approach are effectively used to design T-cell epitopes that aid the immune system against liver cancer. Antigenicity, molecular weight, subcellular localization and expression site predictions were used to shortlist liver cancer associated proteins including AMBP, CFB, CDHR5, VTN, APOBR, AFP, SERPINA1 and APOE. …”
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Ways to improve the gene pool of pigs of the Russian Federation by V. A. Bekenеv

“…The positive effect of breeding pigs in a closed mode in the form of a “line-population”, using such genetic markers as erythrocyte antigens, erythrocyte enzymes, lipoproteins, allowing intensifcation of the selection process, has been experimentally proved. …”
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Effectiveness of bovine immunoglobulin g against salmonella infections in mice by Hasan Hüseyin Hadimli, Gökçenur Sanioğlu Gölen, Zafer Sayın

“…Immunized cattle blood samples were collected at 10 days after last vaccination and titres of IgG to Salmonella antigens were measured micro Serum Agglutination Test. …”
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The clinical and immunological profiles of systemic lupus erythematosus patients from Assam, North-East India by Debashree Talukdar, Akash Protim Gogoi, Daisy Doley, Rebecca R Marak, Sanjeeb Kakati, Vandana Pradhan, Anita H Nadkarni, Shashi Baruah

“…A combination of high titers of anti-dsDNA, anti-Nuc, and anti-Rib-P antibodies showed association with disease complexity but not the combinations of autoantibodies against extractable nuclear antigens.…”
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Correlation between Ki-67 labeling index and mitotic index in Head and neck squamous cell carcinoma by Das C. K Deepa, Sunitha Balakrishnan

“…Background: Proliferative activity of any tissue or neoplasm can be determined by its growth rate by mitotic count or by using antibodies directed against specific antigens like Ki-67. The usefulness of Ki-67 in head and neck cancers has been debated for the past 20 years; however, no study has definitively resolved this controversy. …”
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A population model capturing dynamics of tuberculosis granulomas predicts host infection outcomes by Chang Gong, Jennifer J. Linderman, Denise Kirschner

“…The model also predicts a dual role for granuloma development in LNs during Mtb infection: in early phases of infection granulomas suppress infection by providing additional antigens to the site of immune priming; however, this induces a more rapid reactivation at later stages by disrupting immune responses. …”
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Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer by Pietro Parcesepe, Guido Giordano, Carmelo Laudanna, Antonio Febbraro, Massimo Pancione

“…Recent works reveal that expression of immune antigens (PDL1, CD47, CD73, CD14, CD68, MAC387, CD163, DAP12, and CD15) by tumor cells “immune resistance,” combined with prometastatic function of nonmalignant infiltrating cells, may represent a strategy to overcome the rate-limiting steps of metastatic cascade through (a) enhanced interactions with protumorigenic myeloid cells and escape from T-dependent immune response mediated by CD8+ and natural killer (NK) cells; (b) production of immune mediators that establish a local and systemic tumor-supportive environment (premetastatic niche); (c) ability to survive either in the peripheral blood as circulating tumor cells (CTCs) or at the metastatic site forming a cooperative prometastatic loop with foreign “myeloid” cells, macrophages, and neutrophils, respectively. …”
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STAPHYLOCOCCAL INFECTION IN DOGS (DIAGNOSIS, TREATMENT AND PREVENTION) by V. B. Rudenko, P. A. Rudenko, S. G. Semushina, I. A. Pakhomova

“…Treatment of dogs also requires a comprehensive approach including specific immunotherapy (active, with the use of anatoxins and antigens and passive with antistaphylococcal hyperimmune sera). …”
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Optically driven microtools with an antibody‐immobilised surface for on‐site cell assembly by Shuntaro Mori, Takumi Ito, Hidekuni Takao, Fusao Shimokawa, Kyohei Terao

“…The cells were captured by the microtool through the bindings between the antibodies on the microtool and the antigens on the cell membrane. Transmembrane proteins, CD51/61 and CD44 that facilitate cell adhesion, commonly found on the surface of cancer cells were targeted. …”
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Development of a broad-spectrum epitope-based vaccine against Streptococcus pneumoniae. by Md Nahian, Muhammad Shahab, Md Rasel Khan, Shopnil Akash, Tanjina Akhtar Banu, Murshed Hasan Sarkar, Barna Goswami, Sanjana Fatema Chowdhury, Mohammad Ariful Islam, Ahmed Abu Rus'd, Shamima Begum, Ahashan Habib, Aftab Ali Shaikh, Jonas Ivan Nobre Oliveira, Shahina Akter

“…The vaccine construct was found to be antigenic, non-toxic, non-allergenic, and soluble. …”
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Rotavirus in Calves and Its Zoonotic Importance by Umer Seid Geletu, Munera Ahmednur Usmael, Fufa Dawo Bari

“…As it was found that certain animal rotavirus strains had antigenic similarities to some human strains, this may be an indication for an animal to play a role as a source of rotavirus infection in humans. …”
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Radiotherapy for Melanoma: More than DNA Damage by Susanne J. Rogers, Emsad Puric, Brigitte Eberle, Niloy R. Datta, Stephan B. Bodis

“…It has long been known that radiation causes not only DNA strand breaks, apoptosis, and necrosis, but also immunogenic modulation and cell death through the induction of dendritic cells, cell adhesion molecules, death receptors, and tumour-associated antigens, effectively transforming the tumour into an individualised vaccine. …”
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Natural regulatory T cells increase significantly in pediatric patients with parasitic infections: Flow cytometry study by Nadeem Kizilbash, Nida Suhail, A. Khuzaim Alzahrani, W. Jamith Basha, Mohamed Soliman

“…The Tregs maintain tolerance to self-antigens and prevent autoimmune diseases. Aim: The purpose of this study was to determine the difference in natural Treg levels in Entamoeba histolytica, Schistosoma mansoni, Giardia lamblia, Enterobius vermicularis, and Hymenolepis nana infected patients. …”
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Immunopathogenesis of inflammatory bowel diseases by Ye. A. Konovich, I. L. Khalif, M. V. Shapina

“…The physiological state of intestine is characterized by balanced interaction of effector (Th1, Th2, Th17) and regulatory (Treg) cells determining presence of immune tolerance to resident microflora antigens. Innate immunity changes revealed in last years, related to mutations of genes of bacterial structures receptors (NOD2, toll-like receptors, autophagy), cause disorder of endocellular signal processes and pathological activation of cells of adaptive immunodefense of intestinal mucosa and conforming profile of cytokines with development of chronic inflammation which will be mediated: at Crohn's disease – by Th1-and Th17-cells, cytokines IL-12, interferon-γ etc., at ulcerative colitis – by Th2-and NKT-cells, cytokines IL-4 and IL-3 in combination to incompetence of suppressor function of regulatory Т-cells and their cytokines TGF-β (transforming growth factor) and IL-10.Conclusion. …”
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