Recent advances in the biosynthesis of polysaccharide-based antimicrobial glycoconjugate vaccines by Yuhui Wang, Yuhui Wang, Yuhui Wang, Yuhui Wang, Haodi Liu, Haodi Liu, Haodi Liu, Haodi Liu, Baoying Wang, Baoying Wang, Baoying Wang, Baoying Wang, Gülzire Gheyret, Jingliang Qin, Hanlin Wang, Hanlin Wang, Hanlin Wang, Hanlin Wang, Yuhan Di, Yuhan Di, Yuhan Di, Yuhan Di, Yanling Wang, Juan Wang, Haining Tan, Haining Tan, Haining Tan, Haining Tan

“…These vaccines are synthesized by covalently linking bacterial polysaccharide antigens to a carrier protein. Given that they produce a stronger and longer-lasting immune response than pure polysaccharides that activate only B cells, glycoconjugate vaccines have become one of the most promising vaccine types. …”
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Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology by Arthur Wickenhagen, Meaghan Flagg, Julia R. Port, Claude Kwe Yinda, Kerry Goldin, Shane Gallogly, Jonathan E. Schulz, Tessa Lutterman, Brandi N. Williamson, Franziska Kaiser, Reshma K. Mukesh, Sarah van Tol, Brian Smith, Neeltje van Doremalen, Colin A. Russell, Emmie de Wit, Vincent J. Munster

“…We compare in vivo infection in Syrian hamsters with infection in primary human nasal and lung epithelium cells and assess differences in transmissibility, antigenicity, and innate immune activation. Omicron variants replicate efficiently in the URT but display limited pathology in the lungs compared to previous variants and fail to replicate in human lung organoids. …”
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Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics Approach by Riska Ayu Sutriyansyah, Muhamad Hilmi Ihsanul Iman, Cahya Ajeng Valenta Tresna Sulung, Nelly Indira Kusuma Wardani, Arif Nur Muhammad Ansori

“…This peptide is predicted to have high antigenicity, non-allergenicity and non-toxicity. This study concluded that peptide 6E is a promising vaccine candidate. …”
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Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting by Iukary Takenami, Brook Finkmoore, Almério Machado, Krisztina Emodi, Lee W. Riley, Sérgio Arruda

“…The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. …”
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Development of an in vitro triculture model of intestine inflammation to assess the immunomodulatory properties of cassava and roselle, two African green leafy vegetables by Nelly Fioroni, Maria Del Carmen Ponce de León Rodríguez, Nicolas Leconte, Claire Mouquet-Rivier, Caroline Guzman, Frédéric Boudard, Claudie Dhuique-Mayer, Myriam Collin, Anaïs Deglos, Emmanuelle Reboul, Ángela Bravo-Núñez, Caroline Laurent-Babot

“…The intestine integrity and function are crucial for nutrient absorption and to prevent the entry of harmful antigens. In sub-Saharan Africa, frequent infections and enteric dysfunction can cause intestinal inflammation that is associated with stunting. …”
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The Origins, Specificity, and Potential Biological Relevance of Human Anti-IgG Hinge Autoantibodies by Randall J. Brezski, David M. Knight, Robert E. Jordan

“…Detailed molecular characterizations of HAH autoantibodies suggest that they are, in some cases, distinct from natural autoantibodies that arise independent of antigenic challenge. Multiple studies have attempted to define the specificity of HAH autoantibodies, which were originally detected as binding to fragments possessing C-terminal amino acid residues exposed in either the upper or lower hinge regions of IgGs. …”
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An Evaluation of MAPIA in Michigan as an Ante-Mortem Supplemental Test for Use in Suspect Tuberculosis Cattle by Scott D. Fitzgerald, Heather A. Grodi, John B. Kaneene

“…This study indicates that an interpretation criterion which includes 3 or more positive reactions to the 11 different mycobacteria antigens utilized provided both an acceptable sensitivity (69.39%) and a high specificity (90.27%). …”
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Current status of recombinant duck enteritis virus vector vaccine research by Wen-Feng Jia, An-Ping Wang, Zhi Wu, Xin-Nuo Lei, Yu-Ting Cheng, Shan-Yuan Zhu

“…It is suitable as a live virus vector for inserting and expressing antigenic genes from other pathogens to develop multivalent vaccines. …”
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Production and development of vaccines for ornithobacterium rhinotracheale infection in turkeys by Osman Erganis, Hasan Hüseyin Hadimli, Kursat Kav, Zafer Sayin, Zeki Aras

“…<b>Aim:</b> The purpose of this study was to prepare bivalent inactive Ornithobacterium rhinotracheale bacterin vaccines to measure the levels of antibodies against antigens in blood sera and to determine the efficacies of different O. rhinotracheale vaccines on turkeys.…”
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Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract by Kaei Nasu, Hisashi Narahara

“…This mucosal compartment has adapted to a dynamic, non-sterile environment challenged by a variety of antigenic/inflammatory stimuli associated with sexual intercourse and endogenous vaginal microbiota. …”
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Identification of T and В lymphocytes in chickens and their subpopulations byflowcytofluorometric analysis using flow cytometer BD FACSVerse™ by M. A. Volkova, Ir. A. Chvala

“…Классификация CD {duster of differentiation antigens) основана на различиях между кластерами клеток в поверхностных дифферен-цировочных маркерах. …”
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A model for predicting birth defects of the fetus based on risk factors in mothers with a history of premature birth by G. Mammadzada

“…Statistical analysis found significant associations between BD and preterm delivery, intrauterine malformations, miscarriages, MTHFR polymorphism, and HLA antigens. The logistic model showed good predictive performance. …”
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Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties by Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai

“…Despite the progress of the bioinformatics approach to characterize cell-surface antigens and receptors on tumor cells, it remains difficult to generate novel cancer vaccines or neutralizing monoclonal antibody therapeutics. …”
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INSIHGT: an accessible multi-scale, multi-modal 3D spatial biology platform by Chun Ngo Yau, Jacky Tin Shing Hung, Robert A. A. Campbell, Thomas Chun Yip Wong, Bei Huang, Ben Tin Yan Wong, Nick King Ngai Chow, Lichun Zhang, Eldric Pui Lam Tsoi, Yuqi Tan, Joshua Jing Xi Li, Yun Kwok Wing, Hei Ming Lai

“…Here, we report the development of INSIHGT, a non-destructive, accessible three-dimensional (3D) spatial biology method utilizing superchaotropes and host-guest chemistry to achieve homogeneous, deep penetration of macromolecular probes up to centimeter scales, providing reliable semi-quantitative signals throughout the tissue volume. Diverse antigens, mRNAs, neurotransmitters, and post-translational modifications are well-preserved and simultaneously visualized. …”
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SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases by Minoru Fujimoto, Tetsuji Naka

“…As an immune organ, the liver contains various types of immune cells such as T cells, NK cells, NKT cells, and Kupffer cells and is continuously challenged with gut-derived bacterial and dietary antigens. SOCS1 may be implicated in pathophysiology of the liver. …”
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Efficient reduction of β-lactoglobulin allergenicity in milk using Clostridium tyrobutyricum Z816 by Qianru Zhao, Yuwei Wang, Zhengming Zhu, Quanyu Zhao, Liying Zhu, Ling Jiang

“…The hydrolyzed peptides were identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and analyzed by molecular modeling, which indicated that C. tyrobutyricum Z816 could effectively degrade the antigenic epitopes of β-LG. Finally, the concentration and digestibility of β-LG in actual samples was quantified using enzyme-linked immunosorbent assay (ELISA) and gastrointestinal digestion simulation experiments. …”
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Immune Vulnerability of Infants to Tuberculosis by Koen Vanden Driessche, Alexander Persson, Ben J. Marais, Pamela J. Fink, Kevin B. Urdahl

“…One of the challenges faced by the infant immune system is learning to distinguish the myriad of foreign but nonthreatening antigens encountered from those expressed by true pathogens. …”
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The survival of B cells is compromised in kidney disease by Doureradjou Peroumal, Chetan V. Jawale, Wonseok Choi, Hossein Rahimi, Danielle Antos, De-dong Li, Shuxia Wang, Godhev K. Manakkat Vijay, Isha Mehta, Raymond West, Muthusamy Thangaraju, Thomas D. Nolin, Jishnu Das, John F. Alcorn, Partha S. Biswas

“…Using multiple mouse models of kidney disease, we demonstrate that renal dysfunction inhibits germinal center (GC) response against T-dependent antigens. GC B cells exhibit increased apoptosis in kidney disease. …”
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Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis by Weiqian Chen, Qin Wang, Yini Ke, Jin Lin

“…Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by the presence of autoantibodies against citrullinated protein antigens and proinflammatory cytokines which cause chronic synovitis, bone erosion, and eventual deformity; however, the precise etiology of RA is unclear. …”
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Claudin-11 regulates immunological barrier formation and spermatogonial proliferation through stem cell factor by Taichi Sugawara, Kayoko Sonoda, Nattapran Chompusri, Kazuhiro Noguchi, Seiji Okada, Mikio Furuse, Tomohiko Wakayama

“…Here, we analyzed male mice lacking claudin-11 (Cldn11), which encodes a SCTJ component, and found autoantibodies against antigens of spermatocytes/spermatids in their sera. …”
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