Chemical Stabilisation of Collagen as a Biomimetic by R. Gordon Paul, Allen J. Bailey

“…Collagen is the most abundant protein in animals and because of its high mechanical strength and good resistance to degradation has been utilized in a wide range of products in industry whilst its low antigenicity has resulted in its widespread use in medicine. …”
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Linking Innate and Adaptive Immunity: Human Vγ9Vδ2 T Cells Enhance CD40 Expression and HMGB-1 Secretion by Shirin Kalyan, Anthony W. Chow

“…The main subset of human peripheral blood γδ T cells responds to nonpeptidic antigens, such as isopentylpyrophosphate (IPP), a metabolite in the mevalonate pathway for both eukaryote and prokaryote cells. …”
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Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins by Alison Smith, Hugh Manoli, Stacey Jaw, Kimberley Frutoz, Alan L. Epstein, Leslie A. Khawli, Frank-Peter Theil

“…We set out to describe what is known and unknown about the mechanisms underlying the interplay between antigenicity and immune response and their effect on the safety, efficacy, pharmacokinetics, and pharmacodynamics of these therapeutic agents.…”
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Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions by Kerry J. Welsh, Semyon A. Risin, Jeffrey K. Actor, Robert L. Hunter

“…Sections of characteristic lesions of caseating granulomas, lipid pneumonia, and cavitary stages of postprimary disease were selected for immunohistochemical studies of macrophages, lymphocytes, endothelial cells, and mycobacterial antigens. A higher percentage of cells in lipid pneumonia (36.1%) and cavitary lesions (27.8%) were positive for the dendritic cell marker DEC-205, compared to granulomas (9.0%, P<.05). …”
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Optimization of amino acid-stabilized erythropoietin parenteral formulation: In vitro and in vivo assessment by Fayed Bahgat E., Tawfik Abdulkader F., Yassin Alaa Eldeen B.

“…The aim of this study was to optimize the formulation of erythropoietin (EPO) using amino acids instead of human serum albumin (HSA) and to evaluate its in vivo stability in order to avoid the risk of viral contamination and antigenicity. Different EPO formulations were developed in such a way as to allow studying the effects of amino acids and surfactants on the EPO stability profile. …”
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A Case of Rituximab Use as an Induction and Maintenance of Remission in ANCA-Associated Vasculitis by Neveen Awad, Shahd Hafiz, Abdurahman Albeity, Hani Almoallim

“…Antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is a multisystem autoimmune disease affecting mainly microscopic blood vessels due to circulating autoantibodies against neutrophil cytoplasmic antigens. We report a case of a 57-year-old female patient presenting with hemoptysis, sinusitis, and conjunctivitis. …”
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Leukoreduction in a dog with acute leukemia by Brenna Hanratty, Anna Hauck, Amanda Foskett, J. D. Foster

“…Flow cytometry identified CD34+ leukocytosis with cells that did not express lineage antigens, suggesting the most likely diagnosis of either acute lymphoid or myeloid leukemia. …”
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Revolutionizing acute myeloid leukemia treatment: a systematic review of immune-based therapies by Ugochi Ebinama, Binsah George

“…The review focuses on targeting specific antigens in AML, including FLT3/CD125, CLL-1, CD33, CD38, CD47, CD70, and CD123.…”
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Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor... by Christopher L. Felten, Joel A. Chan, Dulce R. DeCastro, Jean Lopategui, Swapnil P. Rajurkar

“…Expression of multiple aberrant antigens and concurrent lymphomas of different classifications can cause a diagnostic challenge. …”
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Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I by Pan Qiong-Hua, Zheng Zhong-Yi, Yang Jun, Wen Yan, Yuan Lian-Chao, Li Huan-Ying, Steven G. Reed, Malcolm S. Duthie

“…Our data confirm that Chinese multibacillary (MB) leprosy patients have strong antibody responses against Mycobacterium leprae antigens ND-O-BSA and LID-1. Contacts of clinically diagnosed patients were then monitored at regular intervals by both physical examinations and the laboratory determination of antibody responses in sera collected during these examinations. …”
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Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis by Miao-Yan Xu, Jie Zeng, Xin-Hao Han, Duo-Duo Wei, Bing Fan, Xin‑Hui Qu, Shaorong Huang, Xiao-Jian Han

“…Moreover, JNC NPs + Laser can induce immunogenic cell death (ICD) to improve the maturation of dendritic cells (DCs) and present antigens to T cells, which high-effectively eliminate tumor lung metastasis. …”
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Current Mathematical Models for Analyzing Anti-Malarial Antibody Data with an Eye to Malaria Elimination and Eradication by Nuno Sepúlveda, Gillian Stresman, Michael T. White, Chris J. Drakeley

“…To overcome such problem, alternative measures based on antibodies against specific malaria antigens have gained recent interest in malaria epidemiology due to the possibility of estimating past disease exposure in absence of infected individuals. …”
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Peyer's Patches: The Immune Sensors of the Intestine by Camille Jung, Jean-Pierre Hugot, Frédérick Barreau

“…By their ability to transport luminal antigens and bacteria, PPs can be considered as the immune sensors of the intestine. …”
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A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists by Yu‐an Li, Yi Feng, Wenjing Li, Yuqin Zhang, Yanni Sun, Shifeng Wang, Roy Curtiss III, Huoying Shi

“…By leveraging the comprehensive biosynthetic capabilities of bacterial cells, this system can efficiently combine various adjuvant‐active modular components and antigenic cargo, thereby providing a highly diversified and potent vaccine platform.…”
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Elusive modes of Foxp3 activity in versatile regulatory T cells by Minghong He, Yongqiang Feng

“…Foxp3-expressing CD4 regulatory T (Treg) cells play a crucial role in suppressing autoimmunity, tolerating food antigens and commensal microbiota, and maintaining tissue integrity. …”
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A review of gut microbiota as a therapeutic approach for Parkinson’s disease by Debosree Ghosh, Suvendu Ghosh, Madhurima Sharma, Sutapa Datta

“…This, in turn, activates the innate immune system, leading to systemic inflammation, whereas the adaptive immune system responds to bacterial proteins through cross-reactivity with human antigens. The altered GM promotes the accumulation of alpha-synuclein fibrils in the intestinal neural plexus, which are then transported to the central nervous system, driving the core pathological process of PD. …”
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Potential of Peptides as Inhibitors and Mimotopes: Selection of Carbohydrate-Mimetic Peptides from Phage Display Libraries by Teruhiko Matsubara

“…In addition, the pathogenic capsular polysaccharides of bacteria are carbohydrate antigens, for which a safe and efficacious method of vaccination is required. …”
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Allergen-Induced Asthma by Donald W Cockcroft

“…It was only in the late 19th century that specific allergens, pollen, animal antigens and, later, house dust mite, were identified to cause upper and lower airway disease. …”
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Identification of Specific Cell Surface Markers on Immune Cells of Squirrel Monkeys (Saimiri sciureus) by Bharti P. Nehete, Ashley DeLise, Pramod N. Nehete

“…However, there are very few antibody reagents relevant for delineating the different immune cell subsets based on nonhuman primate antigens directly or with cross-reactivity to those in humans. …”
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DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells by Ignacio Melero, Ruth Conde-Garrosa, David Sancho, Santos Mañes, Alfonso R Sanchez-Paulete, Francisco J Cueto, Carlos del Fresno, Paola Brandi, Alexis J. Combes, Elena Hernández-García, Michel Enamorado, Christian P Bromley, Manuel J Gomez, Santiago Zelenay, Salvador Iborra, Matthew F. Krummel

“…To characterize the immune response, we performed flow cytometry and RNA-Seq of tumor-infiltrating cDC1s.Results Here, we found that cross-presentation of tumor antigens in the steady state was DNGR-1-independent. …”
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