Trazodone effectiveness in depression: impacts of trazodone extended release vs SSRIs on the health status and quality of life of patients with major depressive disorder by Marcin Siwek, Adrian Andrzej Chrobak, Anna Julia Krupa, Aleksandra Gorostowicz, Andrzej Juryk, Dominika Dudek

“…Studies have confirmed that antidepressants generally improve the functional outcomes in MDD, but very few works have compared the efficacies of specific drugs. …”
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Physicians’ and patients’ perceived risks of chronic pain medication and co-medications in Quebec, Canada: a cross-sectional study by Gwenaëlle De Clifford-Faugère, Anaïs Lacasse, Hermine Lore Nguena Nguefack, Marimée Godbout-Parent, Aline Boulanger, Nancy Julien

“…For eight subclasses, the difference in the mean perceived risk score was > 2 points and statistically significant (p < 0.05): non-specific oral NSAIDs, acetaminophen in combination with an opioid, short-acting opioids, long-acting opioids, tricyclic antidepressants, antipsychotics, benzodiazepines, and medical cannabis. …”
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Indian Psychiatric Society multicentre study: Diagnostic patterns, comorbidity and prescription practices for patients with Dementia by CT Sudhir Kumar, Mathew Varghese, Venugopal Duddu, Sridhar Vaitheswaran, Shrikant Srivastava, KS Shaji, Sanju George, Narendra Kumar Singh, Nishant Goyal, Ajay Bakhla, S Shaji, Vikas Menon, Tajamul Hussain, Sandeep Grover, Aseem Mehra, Lokesh Kumar Singh, A Purushotham, Avinash Desousa, Nilesh Shah, Sagar Karia, I Anand, Shafana Afroon, Ritambhara Mehta, Gargi Kukreja, Dimple Dadarwala, KL Vidya, PT Sivakumar, Preeti Sinha, Shivashankar Reddy, Thomas Isaac, Mina Chandra

“…Overall, 113 (19.3%) patients were on antidepressants, 80 (13.7%) patients were on sedatives/hypnotics, and 16 (2.7%) patients were on mood stabilizers. …”
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Reduction of depressive symptoms among patients with inflammatory bowel disease treated with biological therapy: a quantitative comparative incision study by J. Zinkevičiūtė, S. Ambrasas, A. Kiziela, R. Strumila, S. Brašiškienė, E. Dlugauskas

“…Patients diagnosed with active ulcerative colitis or Crohn’s disease and not using antidepressants were included in the study. Participants were divided into an experimental group (receiving tumor necrosis factor-alpha inhibitors) and control group (receiving treatment with other drugs). …”
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INTENSITY OF OXIDATIVE STRESS DEVELOPMENT IN RAT MAJOR CEREBRAL HEMISPHERES UNDER COMBINED CONDITIONS OF SYSTEMIC INFLAMMATORY RESPONSE, CHANGES IN THE NORMAL LIGHT-DARK CYCLE, AN... by O.A. Volkova, V.O. Kostenko

“…At present, the relevance of examining changes to the normal light-dark cycle is increasing, and the connection between the development of the systemic inflammatory response (SIR) and circadian rhythm disorders has been confirmed. The effects of antidepressants on the human body are also actively studied. …”
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Suicidality and Illness Course Worsening in a Male Patient with Bipolar Disorder during Tamoxifen Treatment for ER+/HER2+ Breast Cancer by Claudia Carmassi, Francesco Pardini, Valerio Dell’Oste, Annalisa Cordone, Virginia Pedrinelli, Marly Simoncini, Liliana Dell’Osso

“…The clinical picture showed poor response to treatment trials based on various associations of mood-stabilising, antidepressants, and antipsychotic drugs. During the second hospitalization, after a multidisciplinary evaluation, the oncologists agreed on Tamoxifen discontinuation upon the severity of the psychiatric condition. …”
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Patterns of self-harm presentations at a Tertiary Urban Hospital in Kenya: A retrospective 5-year study (2018-2022). by Willie Njoroge, Catherine Gitau, Everline Onchari, Linnet Ongeri, Linda Khakali, Murad Khan, Zul Merali, Lukoye Atwoli, Jasmit Shah

“…Analgesics were the most frequently reported type of overdose, followed by tricyclic antidepressants. In context of self-injury, cutting emerged as the predominant form of self-harm. …”
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Polypharmacy and anticholinergic burden scales in older adults: a cross-sectional study among psychiatric outpatients in a tertiary care hospital by Manjunath Bidarolli, Biswadeep Das, Vikram Singh Rawat, Sachin Manocha, Hannah Theresa Sony, Akash Agnihotri, Mahima Gupta, Franklin Agera

“…All psychotropic medications, including antidepressants, antipsychotics, mood stabilizers, and hypnotics, were evaluated. …”
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Rural–urban and age differences in association between depression and suicidal attempt: a large retrospective clinical sample study in China by Yong Xia, Dandan Ge, Zhonghua Zhang

“…Notably, the predominant methods of suicide among individuals with depression were the utilisation of sleeping pills or antidepressants.Conclusion Our study found individuals with depression are at higher risk of SA, especially juveniles and urban individuals. …”
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Pharmacological Management of Chronic Neuropathic Pain – Consensus Statement and Guidelines from the Canadian Pain Society by DE Moulin, AJ Clark, I Gilron, MA Ware, CPN Watson, BJ Sessle, T Coderre, PK Morley-Forster, J Stinson, A Boulanger, P Peng, GA Finley, P Taenzer, P Squire, D Dion, A Cholkan, A Gilani, A Gordon, J Henry, R Jovey, M Lynch, A Mailis-Gagnon, A Panju, GB Rollman, A Velly

“…Analgesic agents recommended for first-line treatments are certain antidepressants (tricyclics) and anticonvulsants (gabapentin and pregabalin). …”
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S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study by Domenico De Berardis, Stefano Marini, Nicola Serroni, Gabriella Rapini, Felice Iasevoli, Alessandro Valchera, Maria Signorelli, Eugenio Aguglia, Giampaolo Perna, Anatolia Salone, Giuseppe Di Iorio, Giovanni Martinotti, Massimo Di Giannantonio

“…Thirty-three outpatients with major depressive episode who failed to respond to at least 8 weeks of treatment with two adequate and stable doses of antidepressants were treated openly with fixed dose of SAMe (800 mg) for 8 weeks, added to existing medication. …”
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Focus on Depression in Parkinson’s Disease: A Delphi Consensus of Experts in Psychiatry, Neurology, and Geriatrics by Luis Agüera-Ortiz, Rocío García-Ramos, Francisco J. Grandas Pérez, Jorge López-Álvarez, José Manuel Montes Rodríguez, F. Javier Olazarán Rodríguez, Javier Olivera Pueyo, Carmelo Pelegrín Valero, Jesús Porta-Etessam

“…Efficacious and well-tolerated pharmacological options for Parkinson’s comorbid depression were selective serotonin reuptake inhibitors (especially sertraline), dual-action serotonin and norepinephrine reuptake inhibitors (venlafaxine, desvenlafaxine, and duloxetine), multimodal (vortioxetine, bupropion, mirtazapine, and tianeptine), and anti-Parkinsonian dopamine agonists (pramipexole, ropinirole, and rotigotine). Tricyclic antidepressants and combining type B monoamine oxidase inhibitors with serotonergic drugs have serious side effects in these patients and therefore should not be prescribed. …”
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Effects of physical activity on depressive and anxiety symptoms of women in the menopausal transition and menopause: a comprehensive systematic review and meta-analysis of randomiz... by Hongyu Yue, Yijiao Yang, Fangfang Xie, Jiahe Cui, Yang Li, Mengran Si, Shanshan Li, Fei Yao

“…In addition to traditional treatment strategies such as hormone therapy, antidepressants, and psychotherapy, physical activity (PA) have been increasingly studied, but there is no consensus about their role in menopausal women with depression and anxiety. …”
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Electroacupuncture and Tongbian decoction ameliorate CUMS-induced depression and constipation in mice via TPH2/5-HT pathway of the gut-brain axis by Yi Chen, Peihua Shen, Qi Li, Shun Seng Ong, Yunzhi Qian, Hai Lu, Ming Li, Tianshu Xu

“…Current treatments, such as antidepressants and prokinetics, are often associated with side effects and high recurrence rates, highlighting the need for effective treatments targeting both depression and constipation. …”
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Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment by Sabrina Pistorio, Gianluca Scotto di Tella, Vittoria Canzanella, Raffaella Merenda, Gianluigi Cuomo, Paola Iacotucci, Vincenzo Carnovale, Leonardo Bencivenga, Maria Vargas, Annalaura Manes, Mauro Cataldi, Giuseppe Rengo, Giuseppe Rengo, Michela Zanetti, Grazia Daniela Femminella, Grazia Daniela Femminella

“…Being on antipsychotics, antidepressants and antidiabetic drugs was associated with increased risk of higher anticholinergic burden.ConclusionIn conclusion, the anticholinergic burden might play a significant role as a risk factor for developing more severe BPSD in patients with cognitive decline, independently from their degree of cognitive impairment.…”
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Parsing the heterogeneity of depression: a data-driven subgroup derived from cognitive function by Chenyang Xu, Yanbao Tao, Yunhan Lin, Jiahui Zhu, Zhuoran Li, Jiayi Li, Mingqia Wang, Tao Huang, Chuan Shi

“…Cognitive deficits in depression are associated with poor psychosocial functioning and worse response to conventional antidepressants. However, a consistent profile of neurocognitive abnormalities in depression remains unclear.ObjectiveWe used data-driven parsing of cognitive performance to reveal subgroups present across depressed individuals and then investigate the change pattern of cognitive subgroups across the course in follow-up.MethodWe assessed cognition in 163 patients with depression using The Chinese Brief Cognitive Test(C-BCT) and the scores were compared with those of 196 healthy controls (HCs). 58 patients were reassessed after 8 weeks. …”
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Occurrence of micropollutants in surface water and removal by catalytic wet peroxide oxidation enhanced filtration using polymeric membranes loaded with carbon nanotubes by Adriano S. Silva, Paulo Zadra Filho, Ana Paula Ferreira, Fernanda F. Roman, Arthur P. Baldo, Madeleine Rauhauser, Jose L. Diaz de Tuesta, Ana I. Pereira, Adrián M.T. Silva, Juliana M.T. Pietrobelli, Marzhan S. Kalmakhanova, Daniel D. Snow, Helder T. Gomes

“…The statistical analysis revealed the correlation between the pollutants, showed the oscillation in their amounts, and enabled the identification of specific pollutant groups that deserve attention for treatment, such as antibiotics and antidepressants. Moreover, an innovative catalytic wet peroxide oxidation (CWPO) intensified filtration process was investigated as a possible water treatment solution, using composite polymeric membranes loaded with carbon nanotubes (CNTs). …”
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Depression Following Thrombotic Cardiovascular Events in Elderly Medicare Beneficiaries: Risk of Morbidity and Mortality by Christopher M. Blanchette, Linda Simoni-Wastila, Fadia T. Shaya, Denise Orwig, Jason Noel, Bruce Stuart

“…Purpose. Depression and antidepressant use may independently increase the risk of acute myocardial infarction and mortality in adults. …”
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Exercise‐Activated mPFC Tri‐Synaptic Pathway Ameliorates Depression‐Like Behaviors in Mouse by Tian Lan, Ye Li, Xiao Chen, Wenjing Wang, Changmin Wang, Haiyan Lou, Shihong Chen, Shuyan Yu

“…In addition, it is found that exercise may exert antidepressant effects through regulating synaptic plasticity within this tri‐synaptic pathway. …”
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Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression by Juan Du, Ruyun Liu, Lin Ma, Yue Liu, Wei Wei, Ning Liu, Qiuhua Cao, Jianqiang Yu

“…Abstract Histone deacetylase-5 (HDAC5) is implicated in the pathogenesis of depression and the mechanistic pathways underlying the effects of antidepressant medications. We previously identified a novel HDAC5 inhibitor, T2943, with antidepressant properties that promote histone 3 lysine-14 acetylation (H3K14ac) by inhibiting HDAC5 activity. …”
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