Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants by Christian C. Ndu, Wonder K. M. Abotsi, Priscilla K. Mante

“…Only about 60–70% of patients respond to antidepressant therapy. One of the factors causing patients to not attain therapeutic goals is herb-drug interactions. …”
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1,5-Dichloroethanoanthracene Derivatives As Antidepressant Maprotiline Analogs: Synthesis, DFT Computational Calculations, and Molecular Docking by Mujeeb A. Sultan, Renjith Raveendran Pillai, Eman Alzahrani, Ahmed A. Alsofi, Sadam A. Al-Qadhi, Rami Adel Pashameah

“…Molecular docking simulation showed that all the compounds (1, 2, 5, and 6) have high antidepressant activities and form stable complexes with LeuT by inhibiting the neurotransmitter reuptake at the synapse and hence are good candidates as antidepressant drugs.…”
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Anxiolytic, Antidepressant, and Anticholinesterase Effects of Essential Oil from <i>Myrcia sylvatica</i> (G.Mey.) DC by Antônio Quaresma da Silva Júnior, Mariana Maciel Garcia, Wanderson da Silva Farias, Deise Juliane dos Anjos de Sousa, Adenilson de Sousa Barroso, Pablo Luis Baia Figueiredo, Gabriela B. dos Santos, Ricardo Bezerra de Oliveira, Rosa Helena Veras Mourão

“…This study investigated the anxiolytic and antidepressant effects of <i>Myrcia sylvatica</i> essential oil (MsEO) through inhalation in an animal model and its in vitro anticholinesterase (AChE) activity. …”
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Drug-Drug interactions prediction calculations between cardiovascular drugs and antidepressants for discovering the potential co-medication risks. by Tie Hua Zhou, Tian Yu Jin, Xi Wei Wang, Ling Wang

“…These patients often need to use cardiovascular drugs and antidepressants for polypharmacy, but potential DDIs may compromise treatment effectiveness and patient safety. …”
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Trazodone Addition to Paroxetine and Mirtazapine in a Patient with Treatment-Resistant Depression: The Pros and Cons of Combining Three Antidepressants by Rui Lopes, José Carlos Alves, Raquel Garcia Rego

“…Dual antidepressant combination for treatment-resistant depression is a strategy well supported by literature and accepted in clinical practice. …”
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Retraction Note: Xiaoyaosan exerts antidepressant-like effects by regulating the functions of astrocytes and EAATs in the prefrontal cortex of mice by Yan Liu, Xiu-fang Ding, Xin-xing Wang, Xiao-juan Zou, Xiao-juan Li, Yue-yun Liu, Jie Li, Xiu-yun Qian, Jia-xu Chen

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Bidirectional relationship between sleep and depression by Shinnosuke Yasugaki, Hibiki Okamura, Ami Kaneko, Yu Hayashi

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The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases by Geordan J. Stukey, Matthew R. Breuer, Natalie Burchat, Ruta Jog, Kollin Schultz, Gil-Soo Han, Matthew S. Sachs, Harini Sampath, Ronen Marmorstein, George M. Carman

“…We identified that the antidepressant sertraline is a novel inhibitor of PAP. …”
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Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDD by Maojia Ran, Hang Zhang, Meijiang Jin, Yuanmei Tao, Hanmei Xu, Shoukang Zou, Zhujun Wang, Fang Deng, Lijuan Huang, Hong Zhang, Xiaowei Tang, Yanping Wang, Xia Fu, Li Yin, Li Yin, Li Yin

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Antidepressant- and Anxiolytic-like Effects in Mice of Alkaloids from Aerial Parts of <i>Argemone platyceras</i> Link & Otto by Mayra Beatriz Gómez-Patiño, Rosa Estrada-Reyes, Héctor Hugo Hernández-Mendoza, Ángela Suarez-Rojas, Daniel Arrieta-Baez

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Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies by Amani M. El Sisi, Essam M. Eissa, Ahmed H. E. Hassan, Marina A. Bekhet, Fatma I. Abo El-Ela, Eun Joo Roh, Rasha M. Kharshoum, Adel A. Ali

“…Ultimately, intranasal CS-MRZ-LPX can be considered a promising avenue for MRZ targeted brain delivery as an antidepressant.…”
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Evaluation of the Effectiveness of a Psychoeducational Intervention in Treatment-Naïve Patients with Antidepressant Medication in Primary Care: A Randomized Controlled Trial by R. Casañas, R. Catalán, R. Penadés, J. Real, S. Valero, MA. Muñoz, LL. Lalucat-Jo, M. Casas

“…There is evidence supporting the effectiveness of psychoeducation (PE) in patients with symptoms of depression in primary care (PC), but very few studies have assessed this intervention in antidepressant-naïve patients. The aim of this study is to assess the effectiveness of a PE program in these patients, since the use of antidepressant (AD) medication may interfere with the effects of the intervention. …”
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Treatment of Anxiety Disorders and Comorbid Alcohol Abuse with Buspirone in a Patient with Antidepressant-Induced Platelet Dysfunction: A Case Report by Mir Mazhar, Tariq Hassan, Tariq Munshi

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Safety of Rimegepant in Adults with Migraine and Anxiety, Depression, or Using Antidepressants: Analysis of a Multicenter, Long-Term, Open-Label Study by David Kudrow, Susan Hutchinson, Glenn C. Pixton, Terence Fullerton

“…Abstract Introduction Anxiety and depression are frequently associated with migraine, and antidepressant use can complicate treatment. These analyses assessed the safety and tolerability of rimegepant in participants with migraine and anxiety and/or depression, or using selective serotonin reuptake inhibitors (SSRIs) and/or other antidepressants. …”
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The anti-depression effect and mechanism of harmonious rosemary essential oil and its application in microcapsules by Yunwei Niu, Liyang Xu, Mengdong Qiao, Yamei Wang

Subjects: “…Antidepressant…”
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Emulating a randomized clinical trial with real-world data to evaluate the effect of antidepressant use in PTSD patients with high suicide risk by Oshin Miranda, Xiguang Qi, M. Daniel Brannock, Ryan Whitworth, Thomas Kosten, Neal David Ryan, Gretchen L. Haas, Gretchen L. Haas, Gretchen L. Haas, Levent Kirisci, LiRong Wang

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The risks of adverse events with mirtazapine for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis by Caroline Barkholt Kamp, Johanne Juul Petersen, Pascal Faltermeier, Sophie Juul, Christina Dam Bjerregaard Sillassen, Faiza Siddiqui, Rebecca Kjaer Andersen, Joanna Moncrieff, Mark Abie Horowitz, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud, Janus Christian Jakobsen

Subjects: “…Antidepressants…”
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Insomnia: definition, pathophysiological models, diagnosis, and treatment by E. Sakalauskaitė-Juodeikienė, R. Masaitienė

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Synthesis and Antidepressant Activity of Some New 5-(1H-Indol-3-yl)-3-(substituted aryl)-4,5-dihydroisoxazoline Derivatives by Pravin O. Patil, Sanjay B. Bari

“…The present study refers to the synthesis of new antidepressant candidates using the indole scaffold. In an attempt to identify potential lead antidepressant agents, a number of indole molecules, incorporating isoxazoline, were synthesized by microwave-assisted synthesis. …”
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The epidemiology and phenomenology of non-antipsychotic-induced dystonia: a hybrid systematic-narrative review by Catthoor Kirsten, Detraux Johan, Marc De Hert

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