A Revision on the Effectiveness of Omega-3 Polyunsaturated Fatty Acids as Monotherapy in the Treatment of Major Depressive Disorder by Tommaso Accinni, Matteo Panfili, Lorenzo Tarsitani, Massimo Biondi, Massimo Pasquini, Annalisa Maraone

“…Insufficient effectiveness and a difficult tolerability profile of antidepressant drugs for the treatment of major depressive disorder (MDD) have been reported, and polyunsaturated fatty acids (PUFAs) have been posited as reliable therapeutic alternatives. …”
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Therapeutic Potential of 5-HT2C Receptor Ligands by Nanna H. Jensen, Thomas I. Cremers, Florence Sotty

“…More precisely, blockade of serotonin 2C receptors has been suggested to provide antidepressant and anxiolytic benefit, while stimulation of these receptors may offer therapeutic benefit for the treatment of psychotic symptoms in schizophrenia and obesity. …”
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An Insight into Potential Pharmacotherapeutic Agents for Painful Diabetic Neuropathy by Zunaira Qureshi, Murtaza Najabat Ali, Minahil Khalid

“…Clinical studies have shown that anticonvulsant and antidepressant therapies have proven fruitful in management of pain associated with PDN. …”
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Bifidobacterium breve BB05 alleviates depressive symptoms in mice via the AKT/mTOR pathway by Yanni Pan, Qingling Huang, Yuan Liang, Yuwuqi Xie, Fang Tan, Xingyao Long

“…Mechanistic analysis revealed that BB05 exerts antidepressant effects by activating the AKT/mTOR signaling pathway in the prefrontal cortex, promoting neuroprotection, neurogenesis, and synaptic plasticity.DiscussionThese findings suggest that BB05, particularly at higher doses, effectively alleviates CUMS-induced depressive behaviors and improves physiological outcomes, supporting the use of probiotics as a potential treatment for depression by targeting the AKT/mTOR pathway.…”
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Possible Protective Effect of Sertraline against Cisplatin-Induced Ototoxicity: An Experimental Study by Murat Ozturk, Selcuk Ucar, Fatih Sarı, Selvet Erdogan, Murat Topdag, Mete Iseri

“…The aim of this study was to evaluate the otoprotective effect of sertraline, which is an antidepressant with neuroprotective effects, against cisplatin, in rats. …”
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A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male mice by Fangfang Wu, Chenxi Gu, Rui Xu, Junwei Ma, Lei Gao, Youjiao Zhang, Siyuan Bu, Qingbo Lu, Te Zhao, Yijun Han, Chen Guo, Yihui Cui, Jianhua Ding, Gang Hu, Zhijun Zhang

“…Overexpression of Gγ4 in the GluV1→LP neurons produced antidepressant-like effects, suggesting that Gγ4 is a crucial regulator of mood. …”
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Characteristics of Hydrogels as a Coating for Microneedle Transdermal Delivery Systems with Agomelatine by Monika Wojtyłko, Ariadna B. Nowicka, Anna Froelich, Mirosław Szybowicz, Tobiasz Banaszek, Dorota Tomczak, Wiesław Kuczko, Radosław Wichniarek, Irena Budnik, Barbara Jadach, Oliwia Kordyl, Antoni Białek, Julia Krysztofiak, Tomasz Osmałek, Dimitrios A. Lamprou

“…Agomelatine (AGM) is an effective antidepressant with low oral bioavailability due to intensive hepatic metabolism. …”
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The Role of Neurokinin-1 Receptor in the Microenvironment of Inflammation and Cancer by Marisa Rosso, Miguel Muñoz, Michael Berger

“…Antagonists against the NK-1 receptor are safe clinical drugs that are known to have anti-inflammatory, analgesic, anxiolytic, antidepressant, and antiemetic effects. Recently, it has become apparent that SP can induce tumor cell proliferation, angiogenesis, and migration via the NK-1 receptor, and that the SP/NK-1 receptor complex is an integral part of the microenvironment of inflammation and cancer. …”
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Maternal Characteristics of Women Exposed to Hypnotic Benzodiazepine Receptor Agonist during Pregnancy by Bjarke Askaa, Espen Jimenez-Solem, Henrik Enghusen Poulsen, Jon Traerup Andersen

“…Compared to unexposed women, exposed women were characterized by being older, with higher BMI, in their third or fourth parity, of lower income and education level, more frequently smokers, and more likely to be comedicated with antipsychotic, anxiolytic, or antidepressant drugs (P<0.0001). Conclusion. Women using HBRAs during their pregnancy differ from unexposed women in socioeconomic factors and were more likely to receive comedication. …”
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Adult-Onset Idiopathic Cervical Dystonia by Shameer Rafee, Mahmood Al-Hinai, Michael Hutchinson

“…Comprehensive modern management of patients with AOICD requires recognition of presence of mood disorders, and actively treating the endogenous mood disorder with antidepressant therapy. Botulinum toxin injections alone, no matter how expertly given, will not provide optimal therapy and improved health-related quality of life without an holistic approach to patient management. …”
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Cannabidiol Modulates Neuroinflammatory and Estrogen-Related Pathways in a Sex-Specific Manner in a Chronic Stress Model of Depression by Uri Bright, Irit Akirav

“…These findings highlight the sex-specific mechanisms of CBD’s antidepressant effect, with hippocampal neuroinflammatory and estrogenic pathways playing a key role in males.…”
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Agomelatine Efficacy in the Night Eating Syndrome by Walter Milano, Michele De Rosa, Luca Milano, Anna Capasso

“…This paper describes a case report of an NES patient treated with agomelatine, an antidepressant analogue of melatonin, which acts by improving not only the mood but also by regulating sleep cycles and appetite. …”
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Magnetic Seizure Therapy for Unipolar and Bipolar Depression: A Systematic Review by Eric Cretaz, André R. Brunoni, Beny Lafer

“…The studies found reported significant antidepressant effects, with remission rates ranging from 30% to 40%. …”
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Curcumin Alters Neural Plasticity and Viability of Intact Hippocampal Circuits and Attenuates Behavioral Despair and COX-2 Expression in Chronically Stressed Rats by Ga-Young Choi, Hyun-Bum Kim, Eun-Sang Hwang, Seok Lee, Min-Ji Kim, Ji-Young Choi, Sung-Ok Lee, Sang-Seong Kim, Ji-Ho Park

“…These findings indicate that curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects, possibly through the upregulation of BDNF and reduction of inflammatory factors in the brain.…”
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Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents by Frank Mazza, Alexandre Guet-McCreight, Thomas D. Prevot, Taufik Valiante, Etienne Sibille, Etay Hay

“…A novel positive allosteric modulator that specifically targets the α5-GABAA receptor subunit (α5-PAM), ligand GL-II-73 shows anxiolytic, antidepressant, and procognitive effects without the common side effects associated with nonspecific modulation by benzodiazepines such as diazepam, thus suggesting novel therapeutic potential. …”
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Comparison of Different Machine Learning Methodologies for Predicting the Non‐Specific Treatment Response in Placebo Controlled Major Depressive Disorder Clinical Trials by Roberto Gomeni, Françoise Bressolle‐Gomeni

“…ABSTRACT Placebo effect represents a serious confounder for the assessment of treatment effect to the extent that it has become increasingly difficult to develop antidepressant medications appropriate for outperforming placebo. …”
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Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation by M. A. Tikhonova, T. G. Amstislavskaya

“…The main gene for a high predisposition to catalepsy was shown to be associated with the expression of sexual motivation, but not with the hormonal component of sexual arousal (increase in plasma testosterone levels following exposure to a receptive female). ASC (Antidepressant Sensitive Catalepsy) mice, proposed as a model of depression, had a decreased manifestation of sexual motivation, while male GC (Genetic Catalepsy) strain rats had enhanced sexual motivation. …”
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Aspects of improving metrological characteristics of a sensor based on palladium nanoparticles for methionine determination by Eduard V. Gorchakov, Darya O. Perevezentseva, Elena A. Vaitulevich, Oksana V. Dubinina

“…It enhances the synthesis of phospholipids, choline, and lecithin, as well as having an antidepressant effect due to its s-adenosylmethionine content. …”
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Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism by E. R. de Kloet, M. L. Molendijk

“…In this test, a compound qualifies as a potential antidepressant if it prevents or delays the transition to this passive (energy conserving) behavioural style. …”
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Fluoxetine attenuates stress-induced depression-like behavior due to decrease in pro-inflammatory cytokines in male rats. by Nabirumbi, Ritah, Onohuean, Hope, Kato, Charles Drago, Alagbonsi, Abdullateef Isiaka, Adedeji1, Ahmed A.

“…We also investigated the effect of prior administration of the antidepressant drug fluoxetine on cytokines in animals exposed to both models of DLB. …”
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