New insights into anti-depression effects of bioactive phytochemicals by Ruohan Zhao, Jingwen Wang, Sookja Kim Chung, Baojun Xu

“…Therefore, this review aims to provide robust evidence for subsequent research into developing phytochemical resources as effective antidepressant agents.…”
Get full text

Overlapping of Serotonin Syndrome with Neuroleptic Malignant Syndrome due to Linezolid-Fluoxetine and Olanzapine-Metoclopramide Interactions: A Case Report of Two Serious Adverse D... by Faizan Mazhar, Shahzad Akram, Nafis Haider, Rafeeque Ahmed

“…Antipsychotic and antidepressant are often used in combination for the treatment of neuropsychiatric disorders. …”
Get full text

Exercise‐Activated mPFC Tri‐Synaptic Pathway Ameliorates Depression‐Like Behaviors in Mouse by Tian Lan, Ye Li, Xiao Chen, Wenjing Wang, Changmin Wang, Haiyan Lou, Shihong Chen, Shuyan Yu

“…In addition, it is found that exercise may exert antidepressant effects through regulating synaptic plasticity within this tri‐synaptic pathway. …”
Get full text

Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density? by Kim Chau, Stephanie A. Atkinson, Valerie H. Taylor

“…Both depression and antidepressant use have been identified as secondary causes of osteoporosis. …”
Get full text

Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice by Si Xiao-Ming, Tian Yu-Hua, Zhang Sha-Sha, Gao Hua, Liu Kun, Jin Jing-Yu

“…The present study is aimed at testing the antidepressant--like effects and probable mechanisms of action of low molecular mass chondroitin sulfate (LMMCS) on depression induced by chronic unpredictable mild stress (CUMS) in mice. …”
Get full text

The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex by Wei Liu, Tongtong Ge, Yashu Leng, Zhenxiang Pan, Jie Fan, Wei Yang, Ranji Cui

“…The changes in neural plasticity induced by stress and other negative stimuli play a significant role in the onset and development of depression. Antidepressant treatments have also been found to exert their antidepressant effects through regulatory effects on neural plasticity. …”
Get full text

A Comparative Study on the Effectiveness of Electroconvulsive Therapy and Ketamine in Persons Suffering from Treatment-resistant Depressive Disorder by Vikhram Ramasubramanian, S. Mathumathi, Gautami Thirumalaisamy, Sugaparaneetharan Ayyanar, Gopi Rajendhiran, M. Kannan

“…Patients with major depression respond to antidepressant treatment, but 10%–20% of them do not improve or show a partial response. …”
Get full text

Suicide Research and Adolescent Suicide Trends in New Zealand by Said Shahtahmasebi

“…In recent years, there have been a number of claims and counterclaims from suicide research using time series and longitudinal data; in particular, the linkage of increased antidepressant prescriptions to a decrease in suicide rates. …”
Get full text

Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression by Nicole R. Silva, Shokouh Arjmand, Luana B. Domingos, Adriano M. Chaves-Filho, Melina Mottin, Caroline C. Real, Anna L. Waszkiewicz, Pedro H. Gobira, Alessio Nicola Ferraro, Anne M. Landau, Carolina H. Andrade, Heidi K. Müller, Gregers Wegener, Sâmia R.L. Joca

“…Ketamine (KET) is recognized as rapid-acting antidepressant, but its mechanisms of action remain elusive. …”
Get full text

Muscle Relaxant and Sedative-Hypnotic Activities of Extract of Viola betonicifolia in Animal Models Supported by Its Isolated Compound, 4-Hydroxy Coumarin by Naveed Muhammad, Mohammad Saeed, Haroon Khan, Achyut Adhikari, Khalid Mohammed Khan

“…The crude methanolic extract of the whole plant of Viola betonicifolia (VBME) was investigated for anxiolytic, muscle relaxant, sleep induction, antidepressant, and sedative activities) to ascertain its scientific values. …”
Get full text

Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes by Wenbo Xu, Xiaoxiao Yao, Fangyi Zhao, Haisheng Zhao, Ziqian Cheng, Wei Yang, Ranji Cui, Songbai Xu, Bingjin Li

“…Studies have shown that some antidepressants can treat depression by changing the plasticity of the hippocampus. …”
Get full text

Comparative Pharmacokinetic Study of Three Major Bioactive Components in the Normal and Different Courses of Liver-Stagnation and Spleen-Deficiency Syndrome Depressive Rats after I... by Kaiwen Luo, Mengdie Wang, Xiangxiang Pan, Yadong Xing

“…This study provided important information for the clinical rational use of ZZHPD in antidepressant treatment.…”
Get full text

Transient Serotonin Toxicity Evoked by Combination of Electroconvulsive Therapy and Fluoxetine by René Klysner, Birgitte Bjerg Bendsen, Maja Soon Hansen

“…The serotonin syndrome has been described only in rare instances for electroconvulsive therapy combined with an antidepressant medication. We describe a case of serotonin toxicity induced by electroconvulsive therapy in combination with fluoxetine.…”
Get full text

Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice by Mengjie He, Mengying Hu, Tingqiao Wang, Zeping Zuo, Hongkai Li, Zhiwei Zhao, Yunwen Hao, Xueling Dai, Jianfang Wang, Yaxuan Sun

“…MOO further confirmed that sexual dysfunction is closely related to the development of depression by improving the lack of sexual motivation and low sexual performance in CUMS-induced depressed mice, modulating the disruption of sex hormone secretion in serum, and alleviating sperm morphology and functional defects in the epididymis.ConclusionThese findings on MOO provide a basis for exploring its antidepressant mechanism, its use to improve hypogonadotropic symptoms, and for future development of new antidepressant drug to improves hypogonadotropic symptoms.…”
Get full text

Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study by O. Malkesman, T. Asaf, L. Shbiro, A. Goldstein, R. Maayan, A. Weizman, N. Kinor, E. Okun, B. Sredni, G. Yadid, A. Weller

“…In the second phase, we examined the responsiveness of prepubertal WKY rats to different types of chronic antidepressant treatments: Fluoxetine, Desipramine, and dehydroepiandrosterone sulfate (DHEAS). …”
Get full text

The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth by Erin Graves, David J. Hill, Susan Evers, Kristine Van Aarsen, Brie Yama, Su Yuan, M. Karen Campbell

“…High prepregnancy BM, height, antidepressant use, pregnancy weight-gain exceeding 40 pounds, and high blood sugar were associated with LGA birth, but not necessarily infant weight/length ratio. …”
Get full text

The promise and challenges of pharmacogenomics in psychiatry by Elaine Ah Gi Lo, Yi Min Wan, Cyrus Su Hui Ho

“…The remission rate for the initial antidepressant prescribed in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial was only approximately 30%, underscoring the need for more personalised approaches to prescribing.1 For psychiatric patients who may show resistance towards pharmacotherapy, PGx offers promise in reducing adverse effects and enhancing therapeutic efficacy. …”
Get full text

Radix Scutellariae Ameliorates Stress-Induced Depressive-Like Behaviors via Protecting Neurons through the TGFβ3-Smad2/3-Nedd9 Signaling Pathway by Fan Zhao, Chenyiyu Zhang, Dong Xiao, Weihua Zhang, Liping Zhou, Simeng Gu, Rong Qu

“…These results suggest that RS could exert antidepressant effects via protecting neurons. And the molecular mechanism might be related to the regulation of the TGFβ3-SMAD2/3-NEDD9 pathway.…”
Get full text

Citrus aurantium L. extract alleviate depression by inhibiting gut microbiota-mediated inflammation in mice by Tao Li, Guirong Zeng, Lingfeng Zhu, Yanyang Wu, Qun Zhang, Fuhua Fu, Donglin Su, Gaoyang Li, Qili Li, Yang Shan

“…This study aimed to explore the antidepressant effect of mature whole Citrus aurantium fruit extract (FEMC) in the chronic unpredictable mild stress (CUMS) model. …”
Get full text

Neurobiology of Major Depressive Disorder by Rosa Villanueva

“…Controversial issues, such as whether neurogenesis is the basis of the disease or whether it is a response induced by antidepressant treatments, are also discussed.…”
Get full text