Comparison of the efficacy and safety of bupropion versus aripiprazole augmentation in adults with treatment-resistant depression: a nationwide cohort study in South Korea by Dong Yun Lee, Rae Woong Park, Soo Min Jeon

Subjects: “…antidepressants…”
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Neuropharmacological profile of new thiazepinone and thiazolidinone compounds designed by virtual screening by Juan Sebastian Carrero-Sandoval, Paola Andrea Cuervo-Prado, Fabian Orozco-Lopez, Christian Alonso Becerra-Rivas, Estefany Arias-Quiroz, Mario Francisco Guerrero-Pabón

Subjects: “…Antidepressant…”
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Disturbed Pitch Perception during Antidepressant Therapy of a Combination of Lithium, Nortriptyline, and Oxazepam: A Rare Unexpected and Undesirable Side Effect for a Violinist by Siwert de Groot

“…This observation is unique as no other examples of this side effect are found in the literature in relation to antidepressants.…”
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Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression by Daniël G. Aynekulu Mersha, Sarah E. Fromme, Frank van Boven, Gara Arteaga-Henríquez, Annemarie Wijkhuijs, Marianne van der Ent, Raf Berghmans, Bernard T. Baune, Hemmo A. Drexhage, Virgil Dalm

“…Conclusion: This preliminary small study suggests thymus hormone treatment to have antidepressive and related immune correcting effects. …”
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A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorder by Didakamiwan Khonglah, Arghya Pal, Nitu Mallik, Debes Ray, Malay Ghosal, Rudraprasad Acharya

“…Aims: This study was conducted to determine the relationship between the level of CRP to remission rates after antidepressant therapy. Methods: Fifty patients of first episode MDD with no past history of antidepressant exposure and other medical comorbidity were recruited after obtaining consent for Escitalopram therapy. …”
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Bidirectional relationship between sleep and depression by Shinnosuke Yasugaki, Hibiki Okamura, Ami Kaneko, Yu Hayashi

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Rutin via Increase in the CA3 Diameter of the Hippocampus Exerted Antidepressant-Like Effect in Mouse Model of Maternal Separation Stress: Possible Involvement of NMDA Receptors by Maryam Anjomshoa, Shakiba Nasiri Boroujeni, Sorayya Ghasemi, Zahra Lorigooini, Ahmad Amiri, Shima Balali-dehkordi, Hossein Amini-khoei

“…The aim of the present study is to investigate the role of the glutamatergic system in the antidepressant-like effect of rutin in a mouse model of maternal separation (MS) stress focusing on histological changes in the CA3 area of the hippocampus. …”
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Major Depressive Disorder as a Condition Negatively Impacting Both Mental and Physical Functioning. What to Do When There Is Treatment Resistance? by Monika Makar, Daria Michałka, Zuzanna Gałuszka, Natalie Papachristoforou, Justyna Głowacka, Aleksandra Kocjan, Emilia Bąk, Natalia Tekiela, Radosław Chmiel, Tomasz Bartuś

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Neural Plasticity Associated with Hippocampal PKA-CREB and NMDA Signaling Is Involved in the Antidepressant Effect of Repeated Low Dose of Yueju Pill on Chronic Mouse Model of Learned Helplessness by Zhilu Zou, Yin Chen, Qinqin Shen, Xiaoyan Guo, Yuxuan Zhang, Gang Chen

“…We showed that a single low dose of Yueju demonstrated antidepressant effects in tests of tail suspension, forced swim, and novelty-suppressed feeding. …”
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Antidepressant Prophylaxis Reduces Depression Risk but Does Not Improve Sustained Virological Response in Hepatitis C Patients Receiving Interferon Without Depression at Baseline: A Systematic Review and Meta-Analysis by Awad Al-Omari, Juthaporn Cowan, Lucy Turner, Curtis Cooper

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The risks of adverse events with mirtazapine for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis by Caroline Barkholt Kamp, Johanne Juul Petersen, Pascal Faltermeier, Sophie Juul, Christina Dam Bjerregaard Sillassen, Faiza Siddiqui, Rebecca Kjaer Andersen, Joanna Moncrieff, Mark Abie Horowitz, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud, Janus Christian Jakobsen

Subjects: “…Antidepressants…”
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Insomnia: definition, pathophysiological models, diagnosis, and treatment by E. Sakalauskaitė-Juodeikienė, R. Masaitienė

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MORE ATTENTION TO QUALITY OF PHARMACOTHERAPY IN PSYCHIATRY by ERKKI ISOMETSÄ

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Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility by Careen A. Schroeter, Anna Gorlova, Michael Sicker, Aleksei Umriukhin, Alisa Burova, Boris Shulgin, Sergey Morozov, Joao P. Costa-Nunes, Tatyana Strekalova

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Depression Following Thrombotic Cardiovascular Events in Elderly Medicare Beneficiaries: Risk of Morbidity and Mortality by Christopher M. Blanchette, Linda Simoni-Wastila, Fadia T. Shaya, Denise Orwig, Jason Noel, Bruce Stuart

“…Purpose. Depression and antidepressant use may independently increase the risk of acute myocardial infarction and mortality in adults. …”
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Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression by Juan Du, Ruyun Liu, Lin Ma, Yue Liu, Wei Wei, Ning Liu, Qiuhua Cao, Jianqiang Yu

“…Abstract Histone deacetylase-5 (HDAC5) is implicated in the pathogenesis of depression and the mechanistic pathways underlying the effects of antidepressant medications. We previously identified a novel HDAC5 inhibitor, T2943, with antidepressant properties that promote histone 3 lysine-14 acetylation (H3K14ac) by inhibiting HDAC5 activity. …”
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Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway by Yanqin Wu, Fusheng Sun, Yujin Guo, Yumao Zhang, Li Li, Ruili Dang, Pei Jiang

“…Of note, the PGC-1α inhibitor SR18292 remarkably reversed the beneficial effects of CUR on depressed rats, indicating an important role of PGC-1α in the antidepressant-like effects of CUR. Conclusion. Collectively, our data evaluating the neuroprotective action of CUR in the CUMS rats highlights the involvement of the PGC-1α/FNDC5/BDNF pathway in the antidepressant-like effects of CUR.…”
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C-Reactive Protein As A Response Indicator In Drug-Naïve Patients With Major Depressive Disorder: A Hospital-Based Study by Ather Muneer, Nargis Munir, Nadia Shams, Mirza Inam, Usman Ghani, Neelam Ayub

“…Patients with first-episode MDD with no history of antidepressant exposure and other medical comorbidity were recruited for pharmacotherapy with escitalopram, a first-line antidepressant. …”
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Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers by Shahzad M. Alikhan, Jessica A. Lee, Luiz Dratcu

“…This observation adds to the evidence that changes in inflammatory responses may be implicated in the mode of action of antidepressants. Further studies of antidepressant responses to mirtazapine and levels of inflammatory markers in depressed patients without medical comorbidity can help elucidate the role of the immune system in the pathophysiology of depression, and hence contribute to the development of novel antidepressant therapies.…”
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Treatment Options for Psychotic Depression in Adolescents: A Comprehensive Review by Perez-Rodriguez V, Aymerich C, Catalan A, Jauhar S, Salazar de Pablo G

“…In severe presentations, antidepressant-antipsychotic combination would be the treatment of choice. …”
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