Therapeutic Approaches for Peripheral and Central Neuropathic Pain by Délia Szok, János Tajti, Aliz Nyári, László Vécsei

“…As first-line pharmacological treatment options, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, and gabapentinoids are recommended. …”
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Selective activation of SIGMAR1 in anterior cingulate cortex glutamatergic neurons facilitates comorbid pain in depression in male mice by Xianlei Wang, Shulin Wu, Junsheng Zuo, Keying Li, Yutong Chen, Zhijie Fan, Zhou Wu, Jun-Xia Yang, Weiyi Song, Jun-Li Cao, Mengqiao Cui

“…These results revealed a previously unknown neural mechanism for depression and pain comorbidity and provided new mechanistic insights into the antidepressive and analgesic effects of the disease.…”
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Putative Mechanism of Action of Trazodone-Related Oromandibular Dyskinesia by Alan L. Schneider

“…As opposed to other antidepressants, trazodone has a mechanism of action which can account for both the development and treatment of dyskinetic movements. …”
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A Look at Commonly Utilized Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) in Chronic Pain by Christopher Robinson, Suhani Dalal, Ahish Chitneni, Anand Patil, Amnon A. Berger, Syed Mahmood, Vwaire Orhurhu, Alan D. Kaye, Jamal Hasoon

“…Pain medications have been the mainstay of treatment for chronic pain conditions with an increasing use of membrane stabilizers and antidepressants to treat neuropathic pain conditions. …”
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Eagle Syndrome: Pathophysiology, Differential Diagnosis and Treatment Options by Daniel Swanson, Cole H. Evensky, Shadman Yusuf, Hannah Long, Jamal Hasoon, Mustafa Mohamed, Bruce M. Dixon, Tomasina Parker-Actlis, Michael A. Alvarado, Jaehong Song, Adam M. Kaye, Giustino Varrassi, Alan D. Kaye, Latha Ganti

“…Medical treatment options include steroids, antidepressants, and anticonvulsants however not all cases of Eagle Syndrome can be managed medically. …”
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Koro Syndrome: Epidemiology, Psychiatric and Physical Risk Factors, Clinical Presentation, Diagnosis, and Treatment Options by Yukino N. Strong, David Y. Cao, Jessica Zhou, Maya A. Guenther, Danyon J. Anderson, Alan D. Kaye, Brian E. Blick, Prathima R. Anandi, Hirni Y. Patel, Ivan Urits

“…In sporadic Koro, it is believed that if the primary psychiatric disorder is treated with anxiolytics, antidepressants, sedatives, or psychotics, the secondary Koro-like symptoms will also fade. …”
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Central Neuropathic Pain in a Patient with Multiple Sclerosis Treated Successfully with Topical Amitriptyline by David J. Kopsky, Remko Liebregts, Jan M. Keppel Hesselink

“…Central neuropathic pain in patients with multiple sclerosis (MS) is a common debilitating symptom, which is mostly treated with tricyclic antidepressants or antiepileptics. Unfortunately, the use of these drugs is often limited due to adverse events. …”
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Fibromyalgia: Presentation and Management with a Focus on Pharmacological Treatment by Janice E Sumpton, Dwight E Moulin

“…Controlled trials of antidepressants, gabapentinoids, tramadol, zopiclone and sodium oxybate have shown effectiveness in fibromyalgia patients. …”
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A Comprehensive Review of Celecoxib Oral Solution for the Acute Treatment of Migraine by Nazir Noor, Courtney LaChute, Mathew Root, Jasmine Rogers, Madeleine Richard, Giustino Varrassi, Ivan Urits, Omar Viswanath, Nazih Khater, Alan D. Kaye

“…Preventative therapies include tricyclic antidepressants, calcium channel blockers, beta-blockers, and anticonvulsants. …”
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Pain at chronic pancreatitis: origin and treatment options by V. T. Ivashkin, K. V. Ivashkin, A. V. Okhlobystin

“…Efficacy of analgetics can be increased by coadministration of psychotropic agents, most often — tricyclic antidepressants. In severe cases intractable pain at a chronic pancreatitis itself can become indication to surgical intervention.Conclusion. …”
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Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis by Giulia Di Stefano, Andrea Di Lionardo, Giuseppe Di Pietro, Giorgio Cruccu, Andrea Truini

“…Trial outcomes were generally modest even for first-line drugs such as tricyclic antidepressants, serotonin-noradrenaline reuptake inhibitors, and gabapentinoids. …”
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Current Evidence on Atypical Odontalgia: Diagnosis and Clinical Management by Yoshihiro Abiko, Hirofumi Matsuoka, Itsuo Chiba, Akira Toyofuku

“…(v) Are there any characteristic symptoms of AO other than spontaneous pain? (vi) Are antidepressants effective for treatment of AO? (vii) Are anticonvulsants effective for treatment of AO? …”
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Synaptic plasticity in fronto-insular circuits underlying stress susceptibility and resilience by Devin Rocks, Conor Liston

“…In this review, we examine how chronic stress and antidepressants modulate synaptic connectivity in stress-sensitive brain circuits. …”
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Recurrent Catatonia due to Episodic Obsessive-Compulsive Disorder by Soumitra Das, Sakshi Prasad, Palak Atul Fichadia, Abhigan Babu Shrestha, Ozge C. Amuk Williams, Anil Bachu

“…A combination of ECT and antidepressants with ERP therapy for recurrent catatonia with OCD could be effective as a therapeutic modality.…”
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Ketamine for the Treatment of Chronic Pain: A Comprehensive Review by Jacob E. Israel, Samantha St Pierre, Emily Ellis, Josephine S. Hanukaai, Nazir Noor, Giustino Varrassi, Markus Wells, Alan D. Kaye

“… # Conclusion First-line treatment for many chronic pain conditions includes NSAIDs, antidepressants, anticonvulsants, and opioids. However, these treatment methods are unsuccessful in a subset of patients. …”
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Effect of Intranasal Calcitonin in a Patient with McCune-Albright Syndrome, Fibrous Dysplasia, and Refractory Bone Pain by Tayane Muniz Fighera, Poli Mara Spritzer

“…She was diagnosed with MAS at 4 years of age and, during follow-up, she had multiple pathological fractures and bone pain refractory to treatment with bisphosphonates, tricyclic antidepressants, and opioids. The pain was incapacitating and the patient required a wheelchair. …”
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Recent advances in understanding and managing body dysmorphic disorder by David Mataix-Cols, Lorena Fernández de la Cruz, Georgina Krebs

“…The recommended treatments for BDD are outlined, namely cognitive behavioural therapy (CBT) and antidepressants, such as selective serotonin reuptake inhibitors. …”
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Zuranolone for postpartum depression: a systematic review and meta-analysis of two randomized studies by Juliana Almeida Oliveira, Karine Eskandar, Marcos Aurélio Araújo Freitas, Chris Elizabeth Philip

“…Zuranolone was significantly associated to an improvement of Clinical Global Impression response rate; Hamilton Depression Rating Scale 15 days and 45-day remission, 3-day, 15-day, and 45-day symptom remission, and reduction in the dose of antidepressants. As for safety outcomes, it was noticed that zuranolone increases sedation risk, which can be dose related. …”
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S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study by Domenico De Berardis, Stefano Marini, Nicola Serroni, Gabriella Rapini, Felice Iasevoli, Alessandro Valchera, Maria Signorelli, Eugenio Aguglia, Giampaolo Perna, Anatolia Salone, Giuseppe Di Iorio, Giovanni Martinotti, Massimo Di Giannantonio

“…Thirty-three outpatients with major depressive episode who failed to respond to at least 8 weeks of treatment with two adequate and stable doses of antidepressants were treated openly with fixed dose of SAMe (800 mg) for 8 weeks, added to existing medication. …”
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Narcolepsy treatment: from exorcism and bloodletting to modern therapy with histamine receptor inverse agonists by E. Sakalauskaitė-Juodeikienė, R. Masaitienė

“…Serotonin and noradrenaline reuptake inhibitors were also often prescribed to manage cataplexy, while low doses of tricyclic antidepressants were used as third-line treatment. In this paper, we also present new European management guidelines for narcolepsy presented in 17th European Narcolepsy Masterclass in Berlin in September 5, 2020. …”
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