Antibody Engineering Toward Enhancement of Teplizumab Anti-CD3 Binding Affinity in Type 1 Diabetes Prevention and Treatment by Fateme Sefid, Kimia Monshizadeh, Roya Ghenaatzadeh, Zahra Roodgarpour, Ghasem Azamirad, Hamid Mirhosseini

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Reduction of monoclonal antibody viscosity using interpretable machine learning by Emily K. Makowski, Hsin-Ting Chen, Tiexin Wang, Lina Wu, Jie Huang, Marissa Mock, Patrick Underhill, Emma Pelegri-O’Day, Erick Maglalang, Dwight Winters, Peter M. Tessier

Subjects: “…Antibody engineering…”
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Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET by Andreas Evers, Simon Krah, Deniz Demir, Ramona Gaa, Desislava Elter, Christian Schroeter, Stefan Zielonka, Nicolas Rasche, Julia Dotterweich, Christine Knuehl, Achim Doerner

Subjects: “…Antibody engineering…”
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A novel monoclonal antibody against human thymic stromal lymphopoietin for the treatment of TSLP-mediated diseases by Lihua Shi, Mingcan Yu, Ying Jin, Peng Chen, Guangmao Mu, Susan H. Tam, Minseon Cho, Mark Tornetta, Chao Han, Man-Cheong Fung, Mark L. Chiu, Di Zhang

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IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with lim... by John S. Schardt, Even Walseng, Kim Le, Chunning Yang, Pooja Shah, Ying Fu, Kausar Alam, Cathryn R. Kelton, Yu Gu, Fengying Huang, Jia Lin, Wenhai Liu, Andrew Dippel, Hanzhi Zhang, Kathy Mulgrew, Stacy Pryts, Vijaykumar Chennupati, Hung-Chang Chen, Jessica Denham, Xiaoru Chen, Pallab Pradhan, Yuling Wu, Colin Hardman, Chihao Zhao, Michael Kierny, Yang Song, Simon J. Dovedi, Saso Cemerski, Yariv Mazor

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Modulating ion channels with nanobodies by Sher Ali, Ashley Suris, Yun Huang, Yubin Zhou

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Electrostatic properties of human germlines and biodistribution of small biologics by Leticia Maria De Souza Cordeiro, Kelley Christine Atkinson, Argin Aivazian, Patrick Frank Joyce, Fang Jia, Alessandro Mascioni

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AlphaBind, a domain-specific model to predict and optimize antibody–antigen binding affinity by Aditya A. Agarwal, James Harrang, David Noble, Kerry L. McGowan, Adrian W. Lange, Emily Engelhart, Miranda C. Lahman, Jeffrey Adamo, Xin Yu, Oliver Serang, Kyle J. Minch, Kimberly Y. Wellman, David A. Younger, Randolph M. Lopez, Ryan O. Emerson

Subjects: “…Antibody engineering…”
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Targeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy by Vedran Vasic, Can Buldun, Manfred Ritz, Steffen Dickopf, Guy J. Georges, Christian Spick, Alessa Peuker, Thomas Meier, Klaus Mayer, Ulrich Brinkmann

Subjects: “…antibody engineering…”
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Prediction of protein biophysical traits from limited data: a case study on nanobody thermostability through NanoMelt by Aubin Ramon, Mingyang Ni, Olga Predeina, Rebecca Gaffey, Patrick Kunz, Shimobi Onuoha, Pietro Sormanni

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Single chain fragment variable, a new theranostic approach for cardiovascular diseases by Rukhshan Zahid, Juncheng Wang, Zecheng Cai, Ayesha Ishtiaq, Meng Liu, Dan Ma, Yan Liang, Yuekang Xu

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Editorial: Single-domain antibodies—biology, engineering and emerging applications, volume II by Kevin A. Henry, Kevin A. Henry, Greg Hussack, Jan Gettemans, Cory L. Brooks

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Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+ T cell interleukin-2 secretion by Yoshiyuki Arata, Shigeki Motoyama, Mariko Yano, Tatsuya Ikuno, Shunsuke Ito, Tomochika Matsushita, Akira Takeiri, Yukari Nishito, Nami Yabuki, Hideaki Mizuno, Zenjiro Sampei, Masayuki Mishima, Masaki Honda, Jumpei Kiyokawa, Hiromi Suzuki, Shuichi Chiba, Mitsuyasu Tabo, Chiyomi Kubo

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A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization by Paul Arras, Han Byul Yoo, Lukas Pekar, Christian Schröter, Thomas Clarke, Simon Krah, Daniel Klewinghaus, Vanessa Siegmund, Andreas Evers, Stefan Zielonka

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Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors by Geoff Hale, Jelle De Vos, Alastair Douglas Davy, Koen Sandra, Ian Wilkinson

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Editorial: Engineering antibodies and bacteriophages to manage and diagnose microbial infections by Jamshid Tanha, Jamshid Tanha, Kenneth K. S. Ng, Chang-Chun Ling

Subjects: “…antibody engineering…”
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Integrating Biochemical and Computational Approaches Reveal Structural Insights in Trastuzumab scFv-Fc Antibody Engineering by Olga Bednova, Jessica Pougoue Ketchemen, Hazem Mslati, Mark Barok, Heikki Joensuu, Natalie Zeytuni, Francesco Gentile, Leon Sanche, Humphrey Fonge, Jeffrey Victor Leyton

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Facilitating high throughput bispecific antibody production and potential applications within biopharmaceutical discovery workflows by Caitlin Fawcett, Joseph. R. Tickle, Charlotte. H. Coles

Subjects: “…Antibody engineering…”
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Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers by Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz

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Multivalent IgM scaffold enhances the therapeutic potential of variant-agnostic ACE2 decoys against SARS-CoV-2 by Meghan M. Verstraete, Florian Heinkel, Janessa Li, Siran Cao, Anh Tran, Elizabeth C. Halverson, Robert Gene, Elizabeth Stangle, Begonia Silva-Moreno, Sifa Arrafi, Jegarubee Bavananthasivam, Madeline Fung, Mariam Eji-Lasisi, Stephanie Masterman, Steve Xanthoudakis, Surjit Dixit, John Babcook, Brandon Clavette, Mark Fogg, Eric Escobar-Cabrera

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