A next-generation Fab library platform directly yielding drug-like antibodies with high affinity, diversity, and developability by Fortunato Ferrara, Adeline Fanni, Andre A. R. Teixeira, Esteban Molina, Camila Leal-Lopes, Ashley DeAguero, Sara D’Angelo, M. Frank Erasmus, Laura Spector, Luis Antonio Rodriguez Carnero, Jianquan Li, Thomas J. Pohl, Nikolai Suslov, Klervi Desrumeaux, Conor McMahon, Sagar Kathuria, Andrew R. M. Bradbury

Subjects: “…Recombinant antibody libraries…”
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Anti-Tn Monoclonal Antibody Ameliorates Hyperoxia-Induced Kidney Injury by Suppressing Oxidative Stress and Inflammation in Neonatal Mice by Julie Chi Chow, Hsiu-Chu Chou, Jaulang Hwang, Chung-Ming Chen

“…The Tn antigen, an N-acetylgalactosamine structure linked to serine or threonine, has been shown to induce high-specificity, high-affinity anti-Tn antibodies in mice. Maternal immunization with the Tn vaccine increases serum anti-Tn antibody titers and attenuates hyperoxia-induced kidney injury in neonatal rats. …”
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Increased Kappa/Lambda Hybrid Antibody in Serum Is a Novel Biomarker Related to Disease Activity and Inflammation in Rheumatoid Arthritis by Lang Yi, Mingju Hao, Tian Lu, Guigao Lin, Lida Chen, Ming Gao, Gaowei Fan, Dong Zhang, Guojing Wang, Xin Yang, Yulong Li, Kuo Zhang, Rui Zhang, Yanxi Han, Lunan Wang, Jinming Li

“…The κ/λ hybrid antibodies in normal human serum were reported recently, but their clinical relevance has not yet been explored. …”
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Neurosarcoidosis Presentation as Adipsic Diabetes Insipidus Secondary to a Pituitary Stalk Lesion and Association with Anti-NMDA Receptor Antibodies by Jose Gabriel Solis, Arturo Olascoaga Lugo, Marco Antonio Rodríguez Florido, Bayron Alexander Sandoval Bonilla, Jose Malagón Rangel

“…Also, we report the first proven association between anti-NMDA receptor antibodies and sarcoidosis.…”
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USE OF AN INDIRECT ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA) TO DETECT ANTIBODIES IN AYU (Plecogiossus altivelis) VACCINATED BY IMMERSION ADMINISTRATION by . Sukenda, Hisatsugu Wakabayashi

“… ABSTRACT An indirect enzyme-linked immunosorbent assay (ELISA) was used to detect serum antibody in ayu, Plecoglossus altivelis, immunized against Pseudomonasplecoglossicida by immersion vaccination.  …”
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Illuminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations by Melanie Maier, Linus Weiß, Nikolas Zeh, Valerie Schmieder-Todtenhaupt, Alireza Dehghani, Marius Nicolaus Felix, Daniel Heinzelmann, Benjamin Lindner, Moritz Schmidt, Joey Studts, Patrick Schulz, Bernd Reisinger, Kerstin Otte, Matthias Franzreb, Daniel Lakatos, Simon Fischer

“…Monoclonal antibodies (mAb) and other biological drugs are affected by enzymatic polysorbate (PS) degradation that reduces product stability and jeopardizes the supply of innovative medicines. …”
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Trypanosoma cruzi Infection in Genetically Selected Mouse Lines: Genetic Linkage with Quantitative Trait Locus Controlling Antibody Response by Francisca Vorraro, Wafa H. K. Cabrera, Orlando G. Ribeiro, José Ricardo Jensen, Marcelo De Franco, Olga M. Ibañez, Nancy Starobinas

“…Trypanosoma cruzi infection was studied in mouse lines selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reaction and for high (HIII) or low (LIII) antibody (Ab) responses to complex antigens. Resistance was associated with gender (females) and strain—the high responder lines AIRmax and HIII were resistant. …”
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IL-6 and PD-1 antibody blockade combination therapy regulate inflammation and T lymphocyte apoptosis in murine model of sepsis by Song I Lee, Na Young Kim, Chaeuk Chung, Dongil Park, Da Hyun Kang, Duk Ki Kim, Min-Kyung Yeo, Pureum Sun, Jeong Eun Lee

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Azathioprine Hypersensitivity Syndrome during Treatment of Severe Interstitial Lung Disease with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis by Eri Nakano, Tomohiko Asakawa, Mea Asou, Eri Nohara, Tomoyuki Seki, Makoto Araki

“…Azathioprine is used to treat anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitis. Azathioprine hypersensitivity syndrome is often missed. …”
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Effectiveness of Sambiloto (Andrographis paniculata) Supplementation on Antibody Titers of Newcastle Disease, Avian Influenza and Infectious Bursal Disease in Broilers by Madi Hartono, Muhammad Mirandy Pratama Sirat, Purnama Edy Santosa, Ratna Ermawati

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A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab by Azusa Okude, Etsuko Tagaya, Mitsuko Kondo, Manabu Nonaka, Jun Tamaoki

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Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed Abortion by Alexandros Daponte, Efthimios Deligeoroglou, Spyros Pournaras, Christos Hadjichristodoulou, Antonios Garas, Foteini Anastasiadou, Ioannis E. Messinis

“…Our assumption was that C1q/anti-C1q antibody complexes and serum levels of interleukin-15 (IL-15) may play a role in differentiating abortions (MAs) and EPs and normal pregnancies. …”
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Applicability of the Filter Paper Technique for Detection of AntifilarialIgG4 Antibodies Using the Bm14 Filariasis CELISA by Hayley M. Joseph, Wayne Melrose

“…There has been interest in complementing available diagnostics with antibody serology testing in children, since negative serology would correspond with cessation of LF transmission. …”
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Antibody response against an inactive SARS-CoV-2 vaccine among healthcare workers occupied in different divisions by Feridun Gürlek, Eyyüp Taşdemir, Fatih Coşkun, Ayşe Ulusoy Karaca, Taşkın Erkinüresin, Öner Özdemir

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Tracking Immunity: An Increased Number of COVID-19 Boosters Increases the Longevity of Anti-RBD and Anti-RBD-Neutralizing Antibodies by Ching-Wen Hou, Stacy Williams, Veronica Boyle, Alexa Roeder, Bradley Bobbett, Izamar Garcia, Giavanna Caruth, Mitch Magee, Yunro Chung, Douglas F. Lake, Joshua LaBaer, Vel Murugan

Subjects: “…anti-RBD IgG antibodies…”
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Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry by Jing Xu, John E. Coughlin, Malgorzata Szyjka, Serene Jabary, Sonal Saluja, Zoran Sosic, Yunqiu Chen, Chong-Feng Xu

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Impact of Abdominal Obesity on Thyroid Auto-Antibody Positivity: Abdominal Obesity Can Enhance the Risk of Thyroid Autoimmunity in Men by Jazyra Zynat, Suli Li, Yanrong Ma, Li Han, Fuhui Ma, Yuyuan Zhang, Bei Xing, Xinling Wang, Yanying Guo

“…The prevalence of thyroid peroxidase antibody (TPOAb) and/or thyroglobulin antibody (TgAb) positive was 32.1% (21.2% in men and 37% in women, P<0.01). …”
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Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies by Armin Sepp, Morris Muliaditan

Subjects: “…Antibody…”
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Use of failure mode and effect analysis to improve the monoclonal antibody drugs management process in pharmacy intravenous admixture services by Jian Cai, Min-Xian Li, Shuai Lu, Dan Shen, Wei Xie, Jian-Jun Zhu, Guo-Jun Jiang, Chun-Xiao Lu

“…Abstract Monoclonal antibodies (mAbs) constitute a new form of immunotherapy that has shown great success in long-term tumour control. …”
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Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development by Gamze Isitman, Ivan Stratov, Stephen J. Kent

“…It has long been recognised that cytotoxic T lymphocytes and neutralising antibodies readily select for immune escape HIV variants. …”
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