Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity by Said Mougari, Valérie Favède, Camilla Predella, Olivier Reynard, Stephanie Durand, Magalie Mazelier, Edoardo Pizzioli, Didier Decimo, Francesca T. Bovier, Lauren M. Lapsley, Candace Castagna, Nicole A. P. Lieberman, Guillaume Noel, Cyrille Mathieu, Bernard Malissen, Thomas Briese, Alexander L. Greninger, Christopher A. Alabi, N. Valerio Dorrello, Stéphane Marot, Anne-Geneviève Marcelin, Ana Zarubica, Anne Moscona, Matteo Porotto, Branka Horvat

“…The peptide-protected mice develop cross-reactive neutralizing antibodies against both SARS-CoV-2 used for the initial infection and recently circulating variants, and are completely protected from a second lethal infection, suggesting that they developed SARS-CoV-2-specific immunity. …”
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Busting the Breast Cancer with AstraZeneca’s Gefitinib by S. Chemmalar, A. R. Intan Shameha, Che Azurahanim Che Abdullah, Nor Asma Ab Razak, Loqman Mohamad Yusof, Mokrish Ajat, Kim Wei Chan, Md Zuki Abu Bakar Zakaria

“…With EGFR having four homologues: EGFR1, EGFR2, EGFR3, and EGFR4, in-depth understanding of EGFR biology led to the discovery of small-molecule inhibitors and antibodies against this receptor. Gefitinib (GEF), a tyrosine kinase inhibitor of EGFR1, possesses a vast potential for treatment against breast cancer and is supported by a multiplicity of experiments. …”
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Measles Outbreak among Previously Immunized Adult Healthcare Workers, China, 2015 by Zhengyi Zhang, Yuan Zhao, Lili Yang, Changhong Lu, Ying Meng, Xiaoli Guan, Hongjin An, Meizhong Zhang, Wenqin Guo, Bo Shang, Jing Yu

“…Fifty-one patients (85%) tested positive for IgM antibodies against the measles virus and 50 patients (83.3%) tested positive for measles virus RNA. …”
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Cells in Dengue Virus Infection In Vivo by Sansanee Noisakran, Nattawat Onlamoon, Pucharee Songprakhon, Hui-Mien Hsiao, Kulkanya Chokephaibulkit, Guey Chuen Perng

“…Studies in the endemic regions suggest that the preexisting antibodies are a risk factor for DHF/DSS. Viremia and thrombocytopenia are the key clinical features of dengue virus infection in patients. …”
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Rhabdomyolysis: An Unusual Presentation of Mycoplasma pneumoniae Infection in an Adult—A Case Report and Literature Review by Jaspreet Kaler, Osama Mukhtar, Bilal Khan, Binav Shrestha, Ravinder Kaler, Brandon Ting, Mazin Khalid

“…We report a case of a 30-year-old male who came in with complaints of fever and myalgia for three days. Immunoglobulin M antibodies for Mycoplasma pneumoniae were positive and trending up, despite having no radiographic evidence of pneumonia on chest X-ray or CT scan. …”
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Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies by Venkata Lokesh Battula, Abhishek Maiti, Adishwar Rao, Akriti Agrawal, Gautam Borthakur

“…Clinical trials leveraging γδ T cell biology have used unmodified and modified allogeneic cells as well as bispecific engagers and monoclonal antibodies. In this review, we discuss γδ T cells’ biology, roles in cancer and AML, and mechanisms of immune escape and antileukemia effect; we also discuss recent clinical advances related to γδ T cells in the field of AML therapeutics.…”
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Staphylococcal SSL5 Binding to Human Leukemia Cells Inhibits Cell Adhesion to Endothelial Cells and Platelets by Annemiek M. E. Walenkamp, Jovanka Bestebroer, Ingrid G. J. Boer, Roeline Kruizinga, Henk M. Verheul, Jos A. G. van Strijp, Carla J. C. de Haas

“…Competition of SSL5 with the binding of three anti-PSGL-1 antibodies and P-selectin to HL-60 cells identified PSGL-1 as the ligand on HL-60 cells. …”
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Cloning and Characterization of Immunological Properties of Haemophilus influenzae Enolase by Yesenia Osorio-Aguilar, Maria Cristina Gonzalez-Vazquez, Patricia Lozano-Zarain, Ygnacio Martinez-Laguna, Alejandro Carabarin-Lima, Rosa del Carmen Rocha-Gracia

“…Both in silico and experimental results showed that recombinant enolase from H. influenzae is immunogenic that could induce a humoral immune response; this was observed mediating the generation of specific polyclonal antibodies anti-rNTHiENO that recognize typeable and nontypeable H. influenzae strains. …”
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Parameters of Somatosensory Evoked Potentials in Patients with Primary Sjӧgren’s Syndrome: Preliminary Results by Edyta Dziadkowiak, Agata Sebastian, Małgorzata Wieczorek, Elżbieta Kusińska, Marta Waliszewska-Prosół, Piotr Wiland, Maria Ejma

“…In patients with pSS, significant differences in SEP parameters depending on the duration of the disease and presence of SSA and SSB antibodies were noted. The authors confirmed CNS involvement often observed in patients with pSS. …”
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HOXB8 mediates resistance to cetuximab in colorectal cancer cells through activation of the STAT3 pathway by Yunan Liang, Han Lin, Zongsheng Jiang, Qi Zhao, Ri Cui, Shaotang Li

“…Among the prevalent monoclonal antibodies for treating RAS/BRAF wild-type metastatic colorectal cancer (mCRC) patients, cetuximab stands out, but resistance to cetuximab frequently arises in targeted treatments. …”
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Kidney Expression of Toll Like Receptors in Lupus Nephritis: Quantification and Clinicopathological Correlations by Fabrizio Conti, Francesca Romana Spinelli, Simona Truglia, Francesca Miranda, Cristiano Alessandri, Fulvia Ceccarelli, Michele Bombardieri, Konstantinos Giannakakis, Guido Valesini

“…Kidney sections from 26 LN patients and 4 controls were analyzed by immunohistochemistry using anti-human TLR3, TLR7, TLR8, and TLR9 polyclonal antibodies; the number of TLR-positive nuclei/mm2 was evaluated on digitalized images. …”
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An Innovative Method to Identify Autoantigens Expressed on the Endothelial Cell Surface: Serological Identification System for Autoantigens Using a Retroviral Vector and Flow Cytom... by Tsuyoshi Shirai, Hiroshi Fujii, Masao Ono, Ryu Watanabe, Tomonori Ishii, Hideo Harigae

“…Although anti-endothelial cell antibodies (AECAs) are considered to be critical, especially for vascular lesions in collagen diseases, most molecules identified as autoantigens for AECAs are localized within the cell and not expressed on the cell surface. …”
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Concomitant Treatment with Etanercept and Tacrolimus Synergistically Attenuates Arthritis Progression via Inhibition of Matrix Metalloproteinase-3 Production and Osteoclastogenesis... by Iwao Seki, Miwa Takai-Imamura, Tomomi Kohara-Tanaka, Satoshi Shirae, Minoru Sasano, Hiroaki Matsuno, Hiroyuki Aono

“…Interestingly, tacrolimus did not inhibit the production of antidrug antibodies (ADAs) against etanercept in the hTNF-Tg mice. …”
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Modern Trends in Imaging IX: Biophotonics Techniques for Structural and Functional Imaging, In Vivo by Yasaman Ardeshirpour, Amir H. Gandjbakhche, Laleh Najafizadeh

“…Recent advances in drugs targeting specific tumor receptors, such as AntiBodies (MAB), has created a new demand for developing non-invasive in vivo imaging techniques for detection of cancer biomarkers, and for monitoring their down regulations during therapy. …”
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When herpes zoster is not herpes: A case of statin-induced myopathy complicated by drug allergies by Hira Khalid Kareem, Muhammad Fawad Ashraf, Muhammad Shehryar, Hafsa Fayyaz, Shreyas Patil

“…After discontinuing atorvastatin and clindamycin, her CK levels improved, and subsequent testing confirmed the presence of anti-HMG-CoA reductase antibodies, establishing a diagnosis of statin-induced autoimmune necrotizing myopathy. …”
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Origin of Circulating Free DNA in Sepsis: Analysis of the CLP Mouse Model by Shigeto Hamaguchi, Yukihiro Akeda, Norihisa Yamamoto, Masafumi Seki, Kouji Yamamoto, Kazunori Oishi, Kazunori Tomono

“…In addition, neutrophil depletion using anti-Ly6G antibodies was performed to assess the association between neutrophils and cf-DNA. …”
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Prepartum Vaccination Against Neonatal Calf Diarrhea and Its Effect on Mammary Health and Milk Yield of Dairy Cows: A Retrospective Study Addressing Non-Specific Effects of Vaccina... by Caroline Kuhn, Holm Zerbe, Hans-Joachim Schuberth, Anke Römer, Debby Kraatz-van Egmond, Claudia Wesenauer, Martina Resch, Alexander Stoll, Yury Zablotski

“…Prepartum vaccinations against neonatal calf diarrhea pathogens are administered in late pregnancy to provide passive immunity to calves through protective colostral antibodies. Potential non-specific effects of the vaccine on maternal innate immune responses and disease susceptibility during the sensitive transition period have not been addressed so far. …”
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Disseminated Histoplasmosis as an AIDS-Defining Illness Presenting as Fever of Unknown Origin in an 11-Year-Old Female by Kathryn E. Kalata, Christina Osborne, Amy Willis, Kacey Navarro, Laura Z. Fenton, Christiana Smith

“…Initial laboratory studies revealed leukopenia, anemia, elevated inflammatory markers, and antibodies to HIV-1 in the patient’s serum and cerebrospinal fluid. …”
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Successful treatment of generalized myasthenia gravis with telitacicept: a Chinese case series and literature review by Xiaodong Song, Xiaodong Song, Yang He, Hong Jiang, Yao Yu, Yue Sun, Zhaoxu Zhang

“…Additionally, immunological assessments revealed a decrease in CD19+B lymphocyte counts and acetylcholine receptor (AChR) antibodies. Only one patient reported a mild, transient injection reaction.ConclusionFavorable clinical improvement and mild adverse events for gMG in treated with telitacicept were observed. …”
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Targeting T-Cell Activation for Malaria Immunotherapy: Scoping Review by Balsa Nobility Gustifante, Shafia Khairani, Nisa Fauziah, Silvita Fitri Riswari, Afiat Berbudi

“…The findings underscore the potential of T cells, particularly CD8+ T cells, in liver-stage defense and advocate for the exploration of advanced vaccine platforms and novel therapies, such as mRNA-based vectors and monoclonal antibodies.…”
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