Pegloticase and Methotrexate Cotherapy in Patients With Uncontrolled Gout With Prior Pegloticase Monotherapy Failure: Findings of an Open‐Label Trial by Orrin M. Troum, John K. Botson, Katie Obermeyer, Bo Chao, Yang Song, Jennifer Zarzoso, Kjerstina Gutierrez, Supra Verma, Lissa Padnick‐Silver, Brian LaMoreaux

“…Pegloticase lowers serum urate (SU) levels, but antidrug antibodies limit SU‐lowering response and increase infusion reaction (IR) risk. …”
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Regulation of TXB2 and PGE2 production by TGF-β1 in in vitro silica dust-exposed rat alveolar macrophage by Urszula Orlinska, Douglas C. Kuhn

“…In the presence of 5 μg of anti-TGF-β1 antibodies, TXB2 production decreased, but PGE2 production increased. …”
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Clinical Biology and Potential Use of Thrombopoietin by Russell Basser

“…In addition, subcutaneous administration of one of these agents, megakaryocyte growth and development factor, has been shown to induce the formation of antibodies that neutralize native thrombopoietin and cause thrombocytopenia. …”
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Plasmapheresis for Pembrolizumab-Induced Hepatitis in a Patient with Squamous Cell Carcinoma and Prior Orthotopic Liver Transplantation by Sanaa Al-Nattah, Kusum Lata Sharma, Matthew Caldis, Erin Spengler, William N. Rose

“…Checkpoint inhibitor therapy with monoclonal antibodies against programmed cell death protein 1 (PD1) has been implemented in the treatment of numerous malignancies. …”
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Severe Hemolytic Anemia Associated with Mild Pneumonia Caused by Mycoplasma pneumonia by Zafer Kurugol, Serife Sebnem Onen, Guldane Koturoglu

“…Diagnosis of M. pneumoniae infection was confirmed by elevated levels of M. pneumoniae IgG and IgM antibodies and a chest X-ray suggestive of atypical pneumonia. …”
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Polycystic Ovary Syndrome May Be an Autoimmune Disorder by Hifsa Mobeen, Nadeem Afzal, Muhammad Kashif

“…Different autoantibodies have been documented in PCOS, for example, anti-nuclear (ANA), anti-thyroid, anti-spermatic, anti-SM, anti-histone, anti-carbonic anhydrase, anti-ovarian, and anti-islet cell antibodies. There is an association between PCOS and autoimmune diseases such as ANA and anti-TPO that have been documented in systemic lupus erythematosus and Hashimoto thyroiditis, respectively, and it is suspected that there are autoantibodies that might affect the long term clinical management of these patients. …”
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Protective Immunity against SARS Subunit Vaccine Candidates Based on Spike Protein: Lessons for Coronavirus Vaccine Development by Atin Khalaj-Hedayati

“…In general, coronavirus spike protein is the major antigen for the vaccine design as it can induce neutralizing antibodies and protective immunity. By considering the high genetic similarity between SARS-CoV and SARS-CoV-2, here, protective immunity against SARS-CoV spike subunit vaccine candidates in animal models has been reviewed to gain advances that can facilitate coronavirus vaccine development in the near future.…”
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Geographic Distribution of Vaccinia Virus, Diagnosis and Demographic Aspects of Affected Populations, Minas Gerais, Brazil, 2000–2023 by Pedro H. B. e Silva, Maycon D. de Oliveira, Iara M. de Almeida, Iago J. S. Domingos, Ana G. Stoffella-Dutra, Galileu Barbosa Costa, Jaqueline S. de Oliveira, Felipe C. M. Iani, Márcio R. de Castro, Jonatas S. Abrahão, Erna G. Kroon, Giliane de S. Trindade

“…Laboratory findings indicate high levels of anti-OPXV antibodies in most individuals, with some showing acute infections confirmed by qPCR testing. …”
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Establishing endotoxin limits to enhance the reliability of in vitro immunogenicity risk assessments by Yun Hee Jeong, Gillian Lennon, Geertruida Veldman, Daniel M. Serna, Alexander Ibrahimov

“…Immunogenic responses to biotherapeutics often lead to termination of their development because the resulting anti-drug-antibodies (ADA) can negatively impact pharmacology, safety, and efficacy. …”
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Skin Findings in a Patient with Sjogren’s Syndrome by Prajwal Boddu, Abdul S. Mohammed, Sonali Khandelwal

“…Hypergammaglobulinemic purpura (HGP) is a syndrome constellating recurrent purpura, hypergammaglobulinemia, positive rheumatoid factor (RF), anti-Ro/La antibodies, and elevated erythrocyte sedimentation rate (ESR). …”
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Co-Amoxiclav Induced Immune Haemolytic Anaemia: A Case Report by H. G. C. S. Karunathilaka, D. P. Chandrasiri, P. Ranasinghe, V. Ratnamalala, A. H. N. Fernando

“…He was found to have evidence of haemolysis with a positive Coombs test and IgG antibodies and C3d. Co-amoxiclav was identified as the probable culprit, using the Naranjo adverse drug reaction probability scale. …”
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An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters by Ryuta Uraki, Mutsumi Ito, Maki Kiso, Kiyoko Iwatsuki-Horimoto, Masafumi Endo, Seiya Yamayoshi, Yoshihiro Kawaoka

“…Immunization with the inactivated XBB.1.5 vaccine induced antigen-specific antibodies leading to protection from XBB.1.5 and antigenically distinct JN.1 strains in a hamster model. …”
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Molecular Typing of Dengue Virus Circulating in Kolkata, India in 2010 by Arindam Sarkar, Debjani Taraphdar, Shyamalendu Chatterjee

“…All the samples were tested for the detection of IgM antibodies by ELISA method, followed by RT-PCR test for the detection of serotypes. …”
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European distribution and intramuscular pathogenicity of divergent lyssaviruses West Caucasian bat virus and Lleida bat lyssavirus by Stefania Leopardi, Laurent Dacheux, Jordi Serra-Cobo, Ágota Ábrahám, Branka Bajić, Hervé Bourhy, Szilárd-Lehel Bücs, Ivana Budinski, Martina Castellan, Petra Drzewniokova, Heliana Dundarova, Francesca Festa, Lauriane Kergoat, Maxime Leuchtmann, Marc López-Roig, Dominique Pontier, Maria Francesca Priore, Emmanuelle Robardet, Dino Scaravelli, Barbara Zecchin, Zsófia Lanszki, Tamás Görföl, Gábor Kemenesi, Paola De Benedictis

“…Infected hamsters developed antibodies by day seven, regardless the virus and the clinical outcome. …”
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CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth. by Gina L Griffith, Kawthar Machmach, Ningbo Jian, Dohoon Kim, Margaret C Costanzo, Matthew Creegan, Isabella Swafford, Gautam Kundu, Lauren Yum, Jessica S Bolton, Lauren Smith, Bonnie M Slike, Elke S Bergmann-Leitner, Rasmi Thomas, Nelson L Michael, Julie A Ake, Leigh Anne Eller, Merlin L Robb, Samantha M Townsley, Shelly J Krebs, Dominic Paquin-Proulx, RV217 Study Group

“…New HIV vaccine approaches are focused on eliciting broadly neutralizing antibodies. We characterized early gamma-delta (γδ) T cell responses starting from pre-acquisition and during acute HIV infection (AHI) in participants previously characterized for neutralization breadth development. …”
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Analysis of KRAS Mutations of Exon 2 Codons 12 and 13 by SNaPshot Analysis in Comparison to Common DNA Sequencing by Rica Zinsky, Servet Bölükbas, Holger Bartsch, Joachim Schirren, Annette Fisseler-Eckhoff

“…Due to the call for fast KRAS mutation status analysis for treatment of patients with monoclonal antibodies for metastatic colorectal cancer, sensitive, economic, and easily feasible methods are required. …”
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Reidel’s Thyroiditis, a Diagnostic and Management Challenge: A Case Report and Review of the Literature by Yassine Er-Rahali, Mohammed Massine El Hammoumi, Jad Issouani, Colna Antonio Nfad, Souad El Moussaoui, El Hassane Kabiri, Ahmed Anass Guerboub

“…Pathological study confirmed Riedel's thyroiditis with the presence of IgG4 antibodies in immunohistochemistry. The patient was successfully treated with levothyroxine replacement and corticosteroid therapy with rapid resolution of obstructive symptoms. …”
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A review on surface modification of nanofibrous textiles for diverse applications: Focus on medical uses by Rasool Shabanloo, Majid Montazer, Ali Farahani, Nesa Karimi

“…Chemical modification includes functionalization with chemical groups, while biological modification involves coating with proteins, enzymes, or antibodies. Nanotreatment approaches use nanomaterials to modify the surface of nanofibers. …”
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Role of CFT and PCR in diagnosis of Chlamydia psittaci in experimentally infected rabbits by V. V. Evstifeev, F. M. Khusainov, S. I. Yakovlev, R. I. Shangaraev, V. I. Eremets

“…Specific antibodies against сhlamydia weredetectedusingcomplement fixation test and сhlamydiagenome wasdetectedusingpolymerase chain reaction in pregnant rabbits experimentally infected with Chlamydiapsittaci. …”
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Q Fever Presenting as Recurrent, Culture-Negative Endocarditis with Aortic Prosthetic Valve Failure: A Case Report and Review of the Literature by Abeer N AlShukairi, Muhammad G Morshed, Neil E Reiner

“…On the occasion of his most recent presentation, a detailed history of animal exposure -- including hunting and skinning deer, moose and other large animals with his bare hands -- was the only clue to his diagnosis. Serum antibodies against Coxiella burnetii were strongly positive, and C burnetii DNA was detected by polymerase chain reaction from his resected aortic valve tissue. …”
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