Recent advances in immunotherapy targeting CETP proteins for atherosclerosis prevention by Wenhui Hu, Han Feng, Ying Liu, Xiaoshuang Xu, Ping Zhou, Zhonghua Sun, Xinyu Tao, Jiahui Yang, Jun Wu, Chen Qu, Zhengxia Liu

“…In addition, CETP vaccines are being explored as a novel strategy for the prevention and treatment of ASCVD by inducing the body to produce antibodies against CETP, which is expected to reduce CETP activity, thereby increasing high-density lipoproteins (HDL) levels. …”
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Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown by Susan Yung, Tak Mao Chan

“…Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface proteins of resident kidney cells, thereby triggering the downstream activation of signaling pathways and the release of mediators of inflammation and fibrosis. …”
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Research Progress on Tumor Treatment Strategies Targeting TGF-β by Jian ZHANG, Binyue LYU, Xiao ZHAO

“…Combination therapies that show promising results include combination with PD-1 antibodies, and combination with radiotherapy and chemotherapy. …”
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The Big Yawning: Pathological Yawning as a Symptom of Neuromyelitis Optica Spectrum Disorders by Veronika Spahlinger, Annette Niessen, Sebastian Rauer, Stefan Krämer, Matthias Reinhard

“…MRI showed a cervical myelitis over more than three vertebral segments up to the lower medulla and Aquaporin-4-antibodies were positive (diagnostic criteria for a Neuromyelitis optica spectrum disorder were fulfilled). …”
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A Presentation of Cerebritis Secondary to Granulomatosis with Polyangiitis (Wegener) by James Norman, Ira Pande, Timothy Taylor, Bruno Gran

“…An MRI of her brain showed bilateral signal abnormalities in the cingulate and superior sagittal gyrus while a staging CT revealed a mass in the right upper lobe of the patient’s lung with a satellite nodule. C-ANCA antibodies specific for PR3 at high titres were positive and a diagnosis of GPA was made. …”
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Ehrlichiosis in a Recent Liver Transplant Recipient Leading to Multiorgan Failure by Fawwaz Almajali, Catherine Oleary, Taylor Hallcox, Justin Lok, Daniela Hermelin, Alexis Guenette, Mustafa Nazzal

“…Our liver transplant patient presented with fever, persistent headaches, and negative Ehrlichia antibodies. Empiric antibiotic therapy was started and along with knowledge of prior tick infection, doxycycline was added. …”
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Clinical Outcomes of Specific Immunotherapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis by Jiang Chen, Guo Xiao-Zhong, Xing-Shun Qi

“…Specific immunotherapies, including vaccines with autologous tumor cells and tumor antigen-specific monoclonal antibodies, are important treatments for PC patients. …”
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Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis by Satoru Joshita, Takeji Umemura, Eiji Tanaka, Masao Ota

“…Formerly termed primary biliary cirrhosis, primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease characterized by the presence of antimitochondrial antibodies. Ursodeoxycholic acid (UDCA) therapy is the most effective and approved treatment for PBC and leads to a favorable outcome in the vast majority of cases. …”
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Immunotherapy in the Treatment of Metastatic Melanoma: Current Knowledge and Future Directions by Massimo Ralli, Andrea Botticelli, Irene Claudia Visconti, Diletta Angeletti, Marco Fiore, Paolo Marchetti, Alessandro Lambiase, Marco de Vincentiis, Antonio Greco

“…Future directions in the treatment of metastatic melanoma include immunotherapy with anti-PD1 antibodies or targeted therapy with BRAF and MEK inhibitors.…”
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RP105-Negative B Cells in Systemic Lupus Erythematosus by Syuichi Koarada, Yoshifumi Tada

“…Systemic lupus erythematosus (SLE) is a multisystem disease characterized by B cells producing autoantibodies against nuclear proteins and DNA, especially anti-double-strand DNA (dsDNA) antibodies. RP105 (CD180), the toll-like receptor- (TLR-) associated molecule, is expressed on normal B cells. …”
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Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management by Danielle Neuman, Russ Kuker, Francesco Vendrame

“…Here, we present a case of hyperthyroidism characterized by the presence of stimulating TSH receptor antibodies and severe bilateral exophthalmos. A thyroid uptake and scan revealed an elevated 24-hour iodine-131 uptake and a discrete hot nodule in the upper pole of the right lobe which was also observed with a thyroid ultrasound. …”
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Protocol for the visualization of pRps6-positive cells in larval zebrafish brains using whole-mount immunofluorescence and light-sheet microscopy by Olga Doszyn, Tomasz Dulski, Justyna Zmorzynska

“…This protocol can also be modified for staining with antibodies against other proteins.For complete details on the use and execution of this protocol, please refer to Doszyn et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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Influence of Maternal Immunization with Allergens on the Thymic Maturation of Lymphocytes with Regulatory Potential in Children: A Broad Field for Further Exploration by Jefferson Russo Victor

“…The passive transfer of antigens, antibodies, and cytokines, the induction of phenotypic alterations in offspring lymphocytes, and the induction of regulatory populations in offspring have been proposed, but these mechanisms remain incompletely understood. …”
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“Almost Bleeding to Death”: The Conundrum of Acquired Amegakaryocytic Thrombocytopenia by Gabrielle Elena Brown, Hani M. Babiker, Carlos L. Cantu, Andrew M. Yeager, Ravitharan Krishnadasan

“…Previous in vitro studies postulated both cell-mediated suppression of megakaryocytopoiesis in early megakaryocytic progenitor cells and humoral-mediated suppression by anti-thrombopoietin antibodies as possible etiologies of AAT. Patients with AAT usually present with severe bleeding and thrombocytopenia that is unresponsive to steroids and intravenous immunoglobulin (IVIG). …”
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Clinical Implications for the Timely Diagnosis of Mycobacterium marinum in the Age of Biologic Therapy: A Case Report and Review of the Literature by Chris J. Lata, Kelle Edgar, Stephen Vaughan

“…Initiation of chronic immunosuppressant therapy including biologic monoclonal antibodies resulted in the exacerbation of initially localized disease to broadly disseminated lymphatic, joint, and myotendinous granulomatous disease and led to delay in the correct diagnosis. …”
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Liver Injury Induced by Anticancer Chemotherapy and Radiation Therapy by Y. Maor, S. Malnick

“…Methods for reducing and treating the hepatotoxicity are discussed for specific agents including tamxifen and the newly introduced targeted antibodies.…”
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Severe Congenital Toxoplasmosis: A Case Report and Strain Characterization by Bahador Sarkari, Samaneh Abdolahi Khabisi

“…Serological testing of the mother’s serum revealed positive IgG and IgM anti-Toxoplasma antibodies. Amniotic fluid was taken and evaluated by polymerase chain reaction (PCR) assay with a direct amplification of the Toxoplasma URPT gene which was found to be positive. …”
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Serological Evidence of Infectious Laryngotracheitis Infection and Associated Risk Factors in Chickens in Northwestern Ethiopia by Mastewal Birhan, Ashenafi Syoum, Saddam Mohammed Ibrahim, Tewodros Fentahun, Addisu Mohammed, Nega Berhane, Molalegne Bitew, Esayas Gelaye, Malede Birhan Atanaw, Belayneh Getachew, Bereket Dessalegn, Anmaw Shite Abat, Kassahun Berrie, Kassaye Adamu, Takele Abayneh

“…A total of 768 serum samples were collected using multistage cluster sampling and assayed for anti-ILTV antibodies using indirect ELISA. A questionnaire survey was used to identify the potential risk factors. …”
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Hubungan Nilai Hematokrit Terhadap Jumlah Trombosit pada Penderita Demam Berdarah Dengue by Amrina Rasyada, Ellyza Nasrul, Zulkarnain Edward

“…Nilai hematokrit akan meningkat (hemokonsentrasi) karena penurunan volume plasma darah, sedangkan jumlah trombosit akan menurun (trombositopenia) akibat supresi sum-sum tulang dan munculnya antibodi terhadap trombosit. Penelitian ini bertujuan untuk mengetahui hubungan nilai hematokrit terhadap jumlah trombosit pada penderita demam berdarah dengue. …”
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Invited review: Improved control of Johne's disease in dairy cattle through advancements in diagnostics, testing, and management of young stock by Larissa Martins, Karin Orsel, Razieh Eshraghisamani, Jose Miguel Hernández-Agudelo, A. Caroline Pereira, Waseem Shaukat, Ad P. Koets, John P. Bannantine, Caroline Ritter, David F. Kelton, Richard J. Whittington, Maarten F. Weber, Antonio Facciuolo, Navneet K. Dhand, Karsten Donat, Susanne Eisenberg, Miguel A. Salgado, John P. Kastelic, Jeroen De Buck, Herman W. Barkema

“…Young stock can shed MAP in feces and can have detectable MAP-specific antibodies in blood, as confirmed in experimentally and naturally infected cattle. …”
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