Abscess and aneurysm: A case of tuberculous abscess causing an aortic pseudo-aneurysm by Anjalie Gulati, BS, Steven Esses, MD

“…The patient underwent endovascular repair of the aortic aneurysm, followed by drainage and biopsy of the epidural abscess and antibiotic therapy for the underlying infection. This case demonstrates the rare occurrence of a mycotic aneurysm caused by tuberculous infection, and the importance of early diagnosis and prompt surgical intervention to prevent catastrophic complications such as rupture, sepsis, or neurological impairment.…”
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Challenges of Diagnosing Severe Ehrlichiosis in Orthotopic Liver Transplant Recipients by Melissa Parkinson, Spandana Vuyyuru, Jay Patel, Chinelo Animalu

“…Subsequently, E. chaffeensis polymerase chain reaction (PCR) was positive, and the antibiotic regimen was de-escalated to only doxycycline with complete resolution of his symptoms and progressive improvement in previously abnormal biochemical indices.…”
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Amoeba plate test with Acanthamoeba castellanii as an innovative tool for Nocardia recovery from sputum samples: a proof-of-concept study by Coralie Espinasse, Ghislaine Descours, Marine Ibranosyan, Laetitia Beraud, Christophe Ginevra, Joelle Chastang, Oana Dumitrescu, Frédéric Laurent, Verónica Rodriguez Nava, Sophie Jarraud, Camille Allam

“…However, the isolation of Nocardia strains remains necessary to perform antibiotic susceptibility testing and adapt the antibiotic regimen of the patients. …”
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The effect of the number of endometrial CD138+ cells on the pregnancy outcomes of infertile patients in the proliferative phase by Yuye Li, Yuye Li, Shuyi Yu, Shuyi Yu, Wenjuan Liu, Yawen Chen, Xiaobing Yang, Juanhua Wu, Mingjuan Xu, Guanying You, Ruochun Lian, Chunyu Huang, Chunyu Huang, Wanru Chen, Yong Zeng, Yong Zeng, Fenghua Liu, Lianghui Diao

“…A total of 664 infertile women who were not diagnosed with chronic endometritis (CE) and who had not received the respective antibiotic treatment were studied. Immunostaining was performed for the plasmacyte marker CD138. …”
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High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period by W. Louis Cleveland, Robert L. DeLaPaz, Rashid A. Fawwaz, Roger S. Challop

“…At age 22, another severe exacerbation followed antibiotic treatment for H. pylori. This led to a hypothesis that postulates deficient signal transduction by the N-methyl-D-aspartate receptor (NMDAR). …”
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A Case of Acute Budd-Chiari Syndrome Complicating Primary Antiphospholipid Syndrome Presenting as Acute Abdomen and Responding to Tight Anticoagulant Therapy by Naofumi Chinen, Yasushi Koyama, Shinji Sato, Yasuo Suzuki

“…Acute gastroenteritis was suspected and an antibiotic was administered, but symptoms progressed. …”
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Emergence of Non-Serotype b Encapsulated Haemophilus influenzae as a Cause of Pediatric Meningitis in Northwestern Ontario by Pouya Sadeghi-Aval, Raymond SW Tsang, Frances B Jamieson, Marina Ulanova

“…The present article describes these cases along with the characteristics of recent H influenzae isolates from the region, (ie, their genetic background and antibiotic sensitivity). The findings point to the clonal nature of circulating Hia strains as well as to an increase in frequency and severity of pediatric invasive H influenzae infections in northwestern Ontario.…”
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Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis by A. Nese Citak Kurt, A. Denizmen Aygun, Ahmet Godekmerdan, Abdullah Kurt, Yasar Dogan, Erdal Yilmaz

“…At the time of diagnosis, IL-1β, IL-6, IL-8, and TNF-α levels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment. Conclusion. Serum IL-1β, IL-6, IL-8, and TNF-α are mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis.…”
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Duodenal Aspirates for Small Intestine Bacterial Overgrowth: Yield, PPIs, and Outcomes after Treatment at a Tertiary Academic Medical Center by Diana L. Franco, Molly B. Disbrow, Allon Kahn, Laura M. Koepke, Lucinda A. Harris, M. Edwyn Harrison, Michael D. Crowell, Francisco C. Ramirez

“…Similar proportions of patients with SIBO improved whether or not they received antibiotic treatment, calling into question the use of this expensive therapy for this disorder.…”
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Early tolerance and late persistence as alternative drug responses in cancer by Simona Punzi, Davide Cittaro, Guido Gatti, Gemma Crupi, Oronza A. Botrugno, Antonino Alex Cartalemi, Alon Gutfreund, Caterina Oneto, Valentina Giansanti, Chiara Battistini, Giovanni Santacatterina, Lucrezia Patruno, Ilaria Villanti, Martina Palumbo, Daniel J. Laverty, Francesca Giannese, Alex Graudenzi, Giulio Caravagna, Marco Antoniotti, Zachary Nagel, Ugo Cavallaro, Luisa Lanfrancone, Timothy A. Yap, Giulio Draetta, Nathalie Balaban, Giovanni Tonon

“…Abstract Bacteria withstand antibiotic treatment through three alternative mechanisms: resistance, persistence or tolerance. …”
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Could Proteomic Research Deliver the Next Generation of Treatments for Pneumococcal Meningitis? by U. R. Goonetilleke, S. A. Ward, S. B. Gordon

“…Streptococcus pneumoniae is the most common bacterial cause of community-acquired meningitis worldwide. Despite optimal antibiotic therapy and supportive care, the mortality of this condition remains very high at 20–30% in the developed world and over 60% in under-resourced hospitals. …”
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Identifying Risk Factors for Secondary Infection Post-SARS-CoV-2 Infection in Patients With Severe and Critical COVID-19 by Mingquan Guo, Mingquan Guo, Menglu Gao, Jing Gao, Tengfei Zhang, Xin Jin, Jian Fan, Qianying Wang, Xin Li, Jian Chen, Zhaoqin Zhu

“…By clinical examination index analysis of patients, combined with the integrative analysis with RNA-seq analysis in the peripheral blood mononuclear cell isolated shortly from initial infection, this study showed that the antibiotic catabolic process and myeloid cell homeostasis were activated while the T-cell response were relatively repressed in those with the risk of secondary infection. …”
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Developing a framework for tracking antimicrobial resistance gene movement in a persistent environmental reservoir by Amy J. Mathers, Thomas J. X. Li, Qijun He, Sharvari Narendra, Nicole Stoesser, David W. Eyre, A. Sarah Walker, Katie E. Barry, Salvador Castañeda-Barba, Fenix W. Huang, Hardik Parikh, Shireen Kotay, Derrick W. Crook, Christian Reidys

“…Abstract Mobile genetic elements are key to the global emergence of antibiotic resistance. We successfully reconstructed the complete bacterial genome and plasmid assemblies of isolates sharing the same bla KPC carbapenemase gene to understand evolution over time in six confined hospital drains over five years. …”
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Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus Infection by Fumihiro Ochi, Hisamichi Tauchi, Toshihiro Jogamoto, Hiromitsu Miura, Tomozo Moritani, Kozo Nagai, Eiichi Ishii

“…Here, we report the case of a 4-year-old boy who presented with pleural empyema due to GAS after influenza A virus infection. With intravenous antibiotic administration and continuous chest-tube drainage, followed by video-assisted thoracoscopic surgery, his condition improved. …”
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Kounis Syndrome as First Manifestation of Allergic Sensitization by D. Forlani, G. Scarano, A. D’Alleva, M. Di Marco, L. Paloscia, A. Gatta, L. Della Valle, A. Farinelli, A. Lumaca, C. Petrarca, R. Paganelli, L. Di Giampaolo, M. Di Gioacchino

“…In Cases 1 and 2, the association of intense chest pain with acute urticaria after an allergenic contact (wasp sting and betalactam antibiotic administration, respectively) was suspected to be an attack of angina related to an allergic reaction. …”
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The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis by Andreas Römpp, Axel Treu, Julia Kokesch-Himmelreich, Franziska Marwitz, Julia Dreisbach, Nadine Aboutara, Doris Hillemann, Moritz Garrelts, Paul J. Converse, Sandeep Tyagi, Sina Gerbach, Luzia Gyr, Ann-Kathrin Lemm, Johanna Volz, Alexandra Hölscher, Leon Gröschel, Eva-Maria Stemp, Norbert Heinrich, Florian Kloss, Eric L. Nuermberger, Dominik Schwudke, Michael Hoelscher, Christoph Hölscher, Kerstin Walter

“…BTZ-043 is a novel antibiotic showing good bactericidal activity in humans in a phase IIa trial. …”
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When a sore throat turns into deadly multiple serous cavity effusions: the role of Prevotella oris in rapidly progressing infection—a case report by Fangqi Zhang, Juan-Li Wang, Jian Zhu, Shaokui Si, Hao Guo, Xiang Yue, Wei Wen

“…After multiple cultures of the patient’s sputum yielded no identifiable pathogenic bacteria, the metagenomic next-generation sequencing (mNGS) revealed Prevotella oris as the predominant pathogen present in both the patient’s peripheral blood and the pericardial drainage fluid. The subsequent antibiotic treatment, guided by the mNGS results, along with surgical drainage and mediastinal irrigation, effectively controlled and ultimately cured the patient’s condition. …”
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Therapeutic potential of probiotic Lactobacillus spp. Fermented Talinum triangulare on Helicobacter pylori associated gastrointestinal infectious disorders by En-Su Chang, Cheng-Yi Hsu, Jui-Chen Li, Rajni Dubey, Wei-Chih Kan, Ming-Jen Sheu, Chia-Hui Cheng, Chia-Yu Chang, Chin-Chia Hsu, Jiunn-Jye Chuu

“…Considering the inadequacies and adverse impacts of antibiotic therapies, a potential treatment for H. pylori infection is the need of the hour. …”
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A Rare Case of Pylephlebitis as a Complication of Cholecystocolonic Fistula by Kouki Imaoka, Saburo Fukuda, Hirofumi Tazawa, Sotaro Fukuhara, Yuzo Hirata, Seiji Fujisaki, Mamoru Takahashi, Hideto Sakimoto

“…A diagnosis of thrombophlebitis of the portal vein associated with CCF was made, and the patient was immediately managed with an intravenous broad-spectrum antibiotic and anticoagulation. After the portal vein thrombosis (PVT) propagation and inflammation had subsided, cholecystectomy and partial resection of the transverse colon were performed. …”
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Exploring the interactions of rapamycin with target receptors in A549 cancer cells: insights from molecular docking analysis by Sanjeev K. Ganesh, C. Subathra Devi

“…Abstract Rapamycin, a macrocyclic antibiotic derived from the actinomycetes Streptomyces hygroscopicus, is a widely used immunosuppressant and anticancer drug. …”
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