Genomic insights on cgMLST markers, drug resistance, and urease cluster of Proteus mirabilis strains by Shitao Lian, Yadong Liu, Songnian Hu, Chen Shen, Yinping Ma, Peng Yin, Zilong He

“…Our findings underscore significant challenges posed by P. mirabilis in terms of antibiotic resistance, with widespread resistance observed particularly against beta-lactams and an increasing trend in resistance to carbapenems and quinolones. …”
Get full text

The transcriptional regulator Lrp activates the expression of genes involved in the biosynthesis of tilimycin and tilivalline enterotoxins in Klebsiella oxytoca by Miguel A. De la Cruz, Hilda A. Valdez-Salazar, Diana Rodríguez-Valverde, Santa Mejia-Ventura, Nayely Robles-Leyva, Tania Siqueiros-Cendón, Quintín Rascón-Cruz, Nancy León-Montes, Jorge Soria-Bustos, Fernando Chimal-Cázares, Roberto Rosales-Reyes, María L. Cedillo, Jorge A. Yañez-Santos, J. Antonio Ibarra, Javier Torres, Jorge A. Girón, James G. Fox, Miguel A. Ares

“…ABSTRACT The toxigenic Klebsiella oxytoca strains secrete tilymicin and tilivalline enterotoxins, which cause antibiotic-associated hemorrhagic colitis. Both enterotoxins are non-ribosomal peptides synthesized by enzymes encoded in two divergent operons clustered in a pathogenicity island. …”
Get full text

Severe pneumonia caused by Nocardia otitidiscaviarum in a patient with bronchiectasis and IgA nephropathy: a case report by Yi Lin, Zhao-Zhao Jiang, Xiao-Qian Chi, Jian-Sheng Chen, Chao Wen, Chao Zhang, Ying-Ying Wang, Guang-Liang Xie

“…Appropriate bacterial culture methods and efficient identification techniques should be adopted to promptly identify pathogens, and personalized treatment plans should be developed based on antibiotic sensitivity tests to save patients’ lives.…”
Get full text

Complete Genome Sequence of Photobacterium damselae Subsp. damselae Strain SSPD1601 Isolated from Deep-Sea Cage-Cultured Sebastes schlegelii with Septic Skin Ulcer by Yongxiang Yu, Zheng Zhang, Yingeng Wang, Meijie Liao, Xiaojun Rong, Bin Li, Kai Wang, Jing Chen, Hao Zhang

“…The phylogenetic analysis revealed SSPD1601 to be most closely related to Phdp Wu-1. In addition, the antibiotic resistance phenotype indicated that SSPD1601 was not sensitive to ceftazidime, pipemidic, streptomycin, cefalexin, bacitracin, cefoperazone sodium, acetylspiramycin, clarithromycin, amikacin, gentamycin, kanamycin, oxacillin, ampicillin, and trimethoprim-sulfamethoxazole, but only the bacitracin resistance gene bacA was detected based on Antibiotic Resistance Genes Database. …”
Get full text

Pneumonia, an Unusual Initial Presentation of Neonatal Herpes Infection by Franck Kouadio, Gil Klinger

“…Sepsis work-up and antibiotic treatment were immediately initiated; however, antiviral treatment was not given until the infant’s death. …”
Get full text

Diagnosis of Cellulitis in the Immunocompromised Host by Charles F Carey, Lawrence Dall

“…This study indicates that in the immunocompromised population with cellulitis, fine needle aspiration and blood cultures should be obtained, and the antibiotic regimen should cover Gram-positive cocci and Gram-negative bacilli pending the results of cultures.…”
Get full text

First Pediatric Case of Tularemia after a Coyote Bite by Bruno B. Chomel, Jane A. Morton, Rickie W. Kasten, Chao-chin Chang

“…Pediatricians should be aware of this risk after a carnivore bite and implement appropriate antibiotic therapy, as amoxicillin/clavulanate potassium (Augmentin) may have prolonged the typical two to three days’ incubation period commonly observed for tularemia after an animal bite and was not effective in preventing clinical signs in this child. …”
Get full text

Diabetic Foot Care Plan by Gordon Dow, The Diabetic Foot Care Plan Working Group

“…The care plan has been divided into three basic sections: assessment, general management and antibiotic therapy. Each of these sections is described in detail and borrows heavily from previous Canadian position papers. …”
Get full text

Isolated Abdominal Wall Actinomycosis Associated with an Intrauterine Contraceptive Device: A Case Report and Review of the Relevant Literature by Sinan Carkman, Volkan Ozben, Haydar Durak, Kagan Karabulut, Turgut Ipek

“…Surgical excision of the actinomycotic pseudotumour and removal of the IUCD followed by antibiotic therapy resulted in the full recovery of the patient.…”
Get full text

Risks and Benefits of Helicobacter pylori Eradication: Current Status by Richard H Hunt, Carlo Fallone, Sander Veldhuyzen van Zanten, Phil Sherman, Fiona Smaill, Alan BR Thomson, the Canadian Helicobacter Study Group

“…This practice is not encouraged because of insufficient evidence of cost-benefit in gastric cancer prevention, the potential for increases in antibiotic resistance and the controversial hypothesis of potential negative effects of eradication in certain clinical entities. …”
Get full text

Subacute Brucellosis-induced Guillain-Barré Syndrome: a Case Report by Mehrdad MORADI-PORDANJANI, Ameneh MEHRI-GHAHFARROKHI, Sohrab MORADI-PORDANJANI, Fereidoun RAHMANI

“…The patients recovered after undergoing plasma exchange, intravenous immunoglobulin administration, and antibiotic therapy. Our findings indicate that physicians should consider brucellosis as a potential etiology of GBS and closely monitor the neurological symptoms of patients with brucellosis.…”
Get full text

Conservative Treatment of a Gossypiboma Causing Uterine Wound Dehiscence by Taner A. Usta, Dogukan Yildirim, Sefik E. Ozyurek, Elif C. Gundogdu

“…We performed repetitive wound debridements under broad-spectrum antibiotic cover and eventually resutured the incision. …”
Get full text

Systemic Steroid Treatment for Severe Expanding Pneumococcal Pneumonia by Eran Lavi, David Shoseyov, Natalia Simanovsky, Rebecca Brooks

“…The treatment of bacterial community-acquired pneumonia (CAP) is based on appropriate antibiotic therapy and supportive care such as intravenous fluids and supplemental oxygen. …”
Get full text

Glyphosate and Microbiota: controversies and truths by Stefania Colantuono, Maria Antonietta Zavarella, Gabriela Leonti, Ilaria Baglivo, Cristiano Caruso, Alfredo Papa

“…Moreover, if future evidence will confirm that glyphosate may act as one of the drivers for antibiotic resistance, its global impact on human health will need to be reassessed.…”
Get full text

Fleming's penicillin producing strain is not Penicillium chrysogenum but P. rubens by J. Houbraken, J.C. Frisvad, R.A. Samson

“…Penicillium chrysogenum is a commonly occurring mould in indoor environments and foods, and has gained much attention for its use in the production of the antibiotic penicillin. Phylogenetic analysis of the most important penicillin producing P. chrysogenum isolates revealed the presence of two highly supported clades, and we show here that these two clades represent two species, P. chrysogenum and P. rubens. …”
Get full text

When Ribonucleases Come into Play in Pathogens: A Survey of Gram-Positive Bacteria by Brian C. Jester, Pascale Romby, Efthimia Lioliou

“…The role of ribonucleases in emergence of antibiotic resistance and new concepts in drug design will additionally be discussed.…”
Get full text

Ehrlichiosis in a Recent Liver Transplant Recipient Leading to Multiorgan Failure by Fawwaz Almajali, Catherine Oleary, Taylor Hallcox, Justin Lok, Daniela Hermelin, Alexis Guenette, Mustafa Nazzal

“…Our liver transplant patient presented with fever, persistent headaches, and negative Ehrlichia antibodies. Empiric antibiotic therapy was started and along with knowledge of prior tick infection, doxycycline was added. …”
Get full text

Spontaneous Bacterial Peritonitis due to Lactobacillus paracasei in Cirrhosis by Emily Harding-Theobald, Bharat Maraj

“…Our case report addresses the challenges of Lactobacillus treatment and suggests antibiotic coverage of commensal organisms in patients who do not improve with standard management.…”
Get full text

Brucella-Induced Acute Psychosis: A Novel Cause of Acute Psychosis by Chi-Chi Obuaya, Gayathri Thivyaa Gangatharan, Efthimia Karra

“…Serological tests revealed that he had brucellosis. Following antibiotic treatment, the psychotic symptoms abated and he was discharged within ten days of hospitalisation. …”
Get full text

An Atypical Case of a Common Pregnancy Issue: Appendicitis-Like Hyperemesis Gravidarum by Janice Chung, Ryan P. Berryman

“…While her clinical picture and ultrasound findings were only mildly consistent with appendicitis, the only therapy that provided pain relief was empiric antibiotic treatment that was prescribed due to a mildly elevated procalcitonin of 0.61. …”
Get full text