Vacuum-Assisted Closure and Muscle Flap as An Alternative Modality for Infected Wound After Orif of Tibial Fracture: Case Report by OK Ilham Abdullah Irsyam, Saraswati Hastika, Hendra Hendra, Andrew Budiartha Budisantoso, Tesar Akbar Nugraha

“…Discussion: SSI can be treated by applicating of appropriate antibiotic and surgical procedures. In this case, the infection was treated using third-generation cephalosporin antibiotic, debridement, dissection, and re-elevation of gastrocnemius muscle flap covering the exposed plate area in inferior, split skin graft above the muscle flap and VAC above skin graft with 75 mmHg pressure. …”
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Management outcome of knee septic arthritis in neonates and infants:A systematic review by Hilmi Muhammad, Rahadyan Magetsari, Alfin Ihza Trimahendra, Paramita Ayu Saraswati

“…Conclusion: Detailed patient outcomes and specific data regarding the patient's demographics including risk factors are needed to construct the guidelines for infantile knee SA for more uniform management consisting of surgical intervention and antibiotic administration with its duration.…”
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The mutational landscape of Staphylococcus aureus during colonisation by Francesc Coll, Beth Blane, Katherine L. Bellis, Marta Matuszewska, Toska Wonfor, Dorota Jamrozy, Michelle S. Toleman, Joan A. Geoghegan, Julian Parkhill, Ruth C. Massey, Sharon J. Peacock, Ewan M. Harrison

“…Despite limited within-host genetic diversity, we observed an excess of protein-altering mutations in metabolic genes, in regulators of quorum-sensing (agrA and agrC) and in known antibiotic targets (fusA, pbp2, dfrA and ileS). We demonstrated the phenotypic effect of multiple adaptive mutations in vitro, including changes in haemolytic activity, antibiotic susceptibility, and metabolite utilisation. …”
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Antibacterial Activity of Rationally Designed Antimicrobial Peptides by Marius B. Tincho, Thureyah Morris, Mervin Meyer, Ashley Pretorius

“…The reasons may either be the antibiotic resistance towards the available therapeutic molecules or the slow rate of producing adequate therapeutic regimens to tackle the rapid growth of new infectious diseases, as well as the toxicity of current treatment regimens. …”
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Current Perspectives on Treatment of Gram-Positive Infections in India: What Is the Way Forward? by Atul P. Kulkarni, Vasant C. Nagvekar, Balaji Veeraraghavan, Anup R. Warrier, Deepak TS, Jaishid Ahdal, Rishi Jain

“…Judicious prescription of antimicrobial agents, implementation of antibiotic stewardship programmes, and antibiotic policies in hospitals are essential to reduce the problem of drug-resistant infections in India. …”
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Evidence of vancomycin-resistant Staphylococcus aureus, multidrug-resistant S. aureus, and Enterococcus faecium-causing mastitis in Thailand and Cambodia by Sambo Na, Montira Intanon, Anyaphat Srithanasuwan, Wasana Chaisri, Witaya Suriyasathaporn

“…Disk diffusion tests were conducted for antibiotic susceptibility, and polymerase chain reaction was employed to detect AMR genes. …”
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Multisite Infection with Mycobacterium abscessus after Replacement of Breast Implants and Gluteal Lipofilling by Eva Rüegg, Alexandre Cheretakis, Ali Modarressi, Stephan Harbarth, Brigitte Pittet-Cuénod

“…Three months postoperatively, implants were removed for NTM-infection in Switzerland. Adequate antibiotic treatment was stopped after seven days for drug-related hepatitis. …”
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Association between guidelines and medical practitioners’ perception of best management for patients attending with an apparently uncomplicated acute sore throat: a cross-sectional... by Alastair D Hay, Mark H Ebell, Ronny Gunnarsson, Pär-Daniel Sundvall, Katarina Hedin, Hannelore Wächtler, Naveen Manchal, Lynne Reid, Stefan Malmberg, Sean Hawkey

“…Hence, compared with the USA (reference), a throat swab showing no pathogenic bacteria increased the probability of antibiotic prescribing in the UK with OR 3.2 (95% CI 1.7 to 6.1) for adults, whereas it reduced the probability in Sweden for adults OR 0.35 (95% CI 0.13 to 0.96) and children 0.19 (95% CI 0.069 to 0.50).Conclusions The differences between practitioners’ perceptions of best management were associated with their guidelines. …”
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Urbanization enhances consumer protist-driven ARGs dissemination in riverine ecosystems by Bob Adyari, Lanping Zhang, Ana Maravić, Jiaxin Chen, Laiyi Li, Mahmoud Gad, Chang-Ping Yu, Anyi Hu

“…Despite the emergence of antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARBs), how biological inter-trophic interactions, modulated by watershed urbanization, shape the resistome remains unexplored. …”
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Gemella morbillorum Endocarditis by Serap Ural, Sureyya Gul Yurtsever, Bahar Ormen, Nesrin Turker, Figen Kaptan, Sibel El, Zehra Ilke Akyildiz, Nejat Ali Coskun

“…The transthoracic echogram revealed 14 × 10 mm vegetation on the aortic noncoronary cuspis. After 4 weeks of antibiotic therapy, the case was referred to the clinic of cardiovascular surgery for valve surgery.…”
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Synthesis of trehalose-based chemical tools for the study of the mycobacterial membrane by Lesur, Emilie, Rollando, Paulin, Guianvarc’h, Dominique, Bourdreux, Yann

“…Corynebacteriales including the causative agent of many diseases such as tuberculosis are known to be extremely resistant against external stress as well as to antibiotic treatments which is believed to be related to the singular architecture of their mycomembrane. …”
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Drug-Induced Thrombocytopenia following a Transvaginal Oocyte Retrieval for In Vitro Fertilization by Ioanna A. Comstock, Michelle Longmire, Richard H. Aster, Amin A. Milki

“…We present a case of a healthy 33-year-old female undergoing in vitro fertilization who developed a severe drug-induced thrombocytopenia, petechiae, and a large hemoperitoneum after receiving Cefazolin antibiotic prophylaxis for a transvaginal oocyte retrieval. …”
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Relapsing Polychondritis and Artiritis in a Patient with Ulcerative Colitis: A Case Report by Dilara Turan Gökçe, Buket Karsavuranoğlu, Bahar Özdemir, Meral Akdoğan Kayhan, Yasemin Özderin Özin

“…Despite the initial antibiotic treatment, the patient’s symptoms persisted and worsened, necessitating the initiation of prednisolone therapy, which led to complete resolution of the chondritis and arthritis symptoms within 2 weeks. …”
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Bali Belly: Salmonella senftenberg Found in an Infected Ovarian Endometrioma by P. D. M. Pathiraja, Junaid Rafi, Emily Woolnough, Anna Clare

“…We present a case of a 30-year-old immunocompetent woman presenting with fevers and abdominal pain, on a background of prior endometriosis. Initial antibiotic treatment for pelvic inflammatory disease failed, and the patient progressed to septic shock requiring surgical evacuation of an infected ovarian endometrioma. …”
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Disseminated Nocardiosis: A Successful Blind Strategy of Treatment in an HIV Infected Patient by Ana C. Guerra, Dário Batista, Maria J. Aleixo, Paulo Saraiva, Maria J. Aguas

“…Diagnosis should be presumed early and microbiological conditions should be optimized, in order to identify the species and achieve antibiotic susceptibility testing. This is a very important step to choose an effective therapeutic regimen or alternative options.…”
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Nonodontogenic Cervical Necrotizing Fasciitis Caused by Sialadenitis by Alper Yenigun, Bayram Veyseller, Omer Vural, Orhan Ozturan

“…Factors affecting treatment success rates are early diagnosis, appropriate antibiotic treatment, and surgical debridement. We present a necrotizing fasciitis case located in the neck region that developed after sialoadenitis. …”
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A Giant Pseudoaneurysm of the Forearm as Unusual Complication of Bacterial Endocarditis by Michele Arcopinto, Teresa Russo, Antonio Ruvolo, Antonio Cittadini, Luigi Saccà, Raffaele Napoli

“…A 59-year-old man with fever was diagnosed with endocarditis due to Streptococcus bovis. Two weeks after antibiotic therapy was started, he presented with red and painful swelling of the forearm without any sign of systemic inflammation. …”
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Latent Syphilis Infection in Pregnancy: An Ultrasound Diagnosed Case of Penicillin Treatment Failure by Lucia Pasquini, Elena Rita Magro-Malosso, Adalgisa Cordisco, Michele Trotta, Mariarosaria Di Tommaso

“…Follow-up scans, in addiction to serial serological tests, have allowed the identification of fetal infection and therefore the failure of antibiotic therapy. We highlight the importance of ultrasound in suspecting fetal infection and in evaluation of the fetal response after penicillin treatment.…”
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Chromobacterium violaceum: A Rare Cause of Urinary Tract Infection by Ujjwal Laghu, Manami Yanagawa, Konosuke Morimoto, Bhim Gopal Dhoubhadel

“…Clinicians should be aware of this rare cause of urinary tract infection (UTI), the choice of antibiotic, length of treatment, and necessity of prompt treatment in SCI patients.…”
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Life-Threatening Manifestation of Diarrhea by Haritha Chelimilla, David Widjaja, Simeon Carvajal, Kavitha Kumbum

“…Further stool test revealed offending bacteria, which led to appropriate antibiotic use. This paper emphasizes the importance of complete history and correlation between clinical data and laboratory tests.…”
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