Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospectiv... by Yuqian Zhang, Chenglei Su, Yang Zhang, Shuo Ding, Xianliang Yan, Jianguo Zhang, Zhimin Tao

“…Concurrently, the post-COVID group was administered with fewer antibiotics but more corticosteroids for effective treatment than the pre-COVID group. …”
Get full text

Antimicrobial photodynamic inactivation of Pseudomonas aeruginosa persister cells and biofilms by Mona Mahmoud, Peter Richter, Philipp Arnold, Michael Lebert, Andreas Burkovski

“…P. aeruginosa is known for forming biofilms, a complex aggregate of bacteria embedded in a self-generated protective matrix that enhance its resistance to antibiotics and the immune system. Within the biofilm, persister cells, sub-populations of slow-growing or growth-arrested cells, are associated with recalcitrance of infections and antibiotic treatment failure. …”
Get full text

Multi-platform diagnostic strategy and biosecurity as basis of contagious agalactia control programs in endemic areas by Christian De la Fe, Ana Grau, Olga Minguez, Antonio Sánchez, Rosario Esquivel, Juan C. Corrales

“…Abstract Background Control strategies against contagious agalactia (CA), considered one of the most important diseases affecting small ruminants in countries surrounding the Mediterranean, are mainly based on traditional strategies considered suboptimal such as the use of inactivated vaccines and antibiotics. This manuscript analysed the efficacy of an alternative non-mandatory official control programme based on a multi-platform diagnostic panel and biosecurity developed and started in 185 herds placed in a contagious agalactia endemic area of Spain, using the data of 74,080 samples collected and analysed during a 4 years-period (2018–2021). …”
Get full text

Technologies of suspension cultivation in bioreactor of the Chlamydophila abortus strain on McCoy cell culture by Yerkin Krykbayev, Nurtas Tyrsynbayev, Nurlan Akhmetsadykov, Damir Khussainov, Zhanat Batanova

“…Isolated pathological material was grown in McCoy cell cultures that were suspended in a bioreactor in Dulbecco’s Modified Eagle’s Medium (DMEM) nutrient medium with 10% foetal bovine serum and antibiotics at a concentration of 2×105 cells/mL. Enzyme immunoassay was a confirmation of the successful result of cultivation. …”
Get full text

Discovery of 15-deoxynaphthomycins activating the antioxidant NRF2-ARE pathway from Streptomyces sp. N50 via genome mining, global regulator introduction, and molecular networking by Min-Seon Kim, Baskar Selvaraj, Hee-Tae Yeo, Jun-Su Park, Jae Wook Lee, Jin-Soo Park

“…Subsequent genome mining revealed that the new 15-deoxynaphthomycin could be produced due to the presence of an enoyl reductase domain, which is absent in the known BGC of naphthomycin, a type of ansamycin antibiotics. In addition, the engineered strain with the introduction of the global regulatory gene afsR2 into N50 successfully produced 15-deoxynaphthomycins. …”
Get full text

Immunogenicity of Type IV Pilin Proteins from <i>Clostridium perfringens</i> in Chickens by Audrey Charlebois, Nicolas Deslauriers, Lila Maduro, Martine Boulianne

“…<i>Clostridium perfringens</i>, the causative agent of necrotic enteritis in chickens, is controlled by in-feed antibiotics. With increasing pressure to reduce antimicrobial use, the development of alternative preventive tools is needed. …”
Get full text

Multidrug resistance of Pseudomonas aeruginosa: do virulence properties impact on resistance patterns? by Poulomi Saha, Rubaiya Binte Kabir, Chowdhury Rafiqul Ahsan, Mahmuda Yasmin

“…An antibiogram was performed to investigate the pathogen’s antibiotic sensitivity pattern against 14 widely used antibiotics in Bangladesh. …”
Get full text

Regional insights on the prevalence and antimicrobial susceptibility pattern of carbapenem and colistin-resistant gram-negative bacteria: an observational cross-sectional study fro... by Nazia Khursheed, Fareeha Adnan, Moiz Ahmed Khan, Ramlla Hatif

“…Tigecycline was the most susceptible antibiotic among isolates (96%) while, fosfomycin (53%), minocycline (50%), doxycycline (45%) and tetracycline (42%) exhibited moderate susceptibility. …”
Get full text

Phenotypic identification of Metallo-ß- lactamase resistance Gram negative bacteria from a clinical specimen in Sidama, Ethiopia. by Tsegaye Alemayehu, Wondwesson Abera, Musa Mohammed Ali, Bethelihem Jimma, Henok Ayalew, Limenih Habte, Frezer Teka, Demissie Asegu

“…Kirby disc diffusion technique was used to determine the susceptibility of antibiotics. Statistical Software for Social Science (SPSS) version 21 is used for data entry and analysis. …”
Get full text

Mid-term to long-term outcome and risk factors for failure of 158 hips with two-stage revision for periprosthetic hip joint infection by M. Abuelnour, C. McNamee, A. B. Rafi, W. Hohlbein, W. Hohlbein, P. Keogh, J. Cashman

“…The mean Western Ontario and McMaster Universities Arthritis Index (WOMAC) hip score significantly improved from 68.3 at the pre-operative stage to 35.9 at 2.1 (2 to 3.3) years, 35.3 at 5.3 (5 to 8.4) years, 38.3 at 11.3 (10–15) years and 43.8 at 18.7 (16.5 to 21.7) years (<span class="inline-formula"><i>p</i>&lt;0.01</span>). Duration of antibiotics and gram-negative infection were the only predictive risk factors for re-infection. …”
Get full text

Genomic and Metabolomic Analyses of <i>Streptomyces albulus</i> with Enhanced ε-Poly-<span style="font-variant: small-caps">l</span>-lysine Production Through Adaptive Laboratory E... by Xidong Ren, Xinjie Sun, Yan Chen, Xiangheng Xi, Yunzhe Ma, Xinyue Jiang, Xian Zhang, Chenying Wang, Deqiang Zhu, Xinli Liu

“…To address this issue, adaptive laboratory evolution (ALE) was successfully employed in this study, subjecting <i>S. albulus</i> CICC 11022 to environmental stresses such as acidic pH and antibiotics (rifampicin, gentamicin, and streptomycin). …”
Get full text

Sex differences in the time trends of sepsis biomarkers following polytrauma by Cédric Niggli, Philipp Vetter, Jan Hambrecht, Hans-Christoph Pape, Ladislav Mica

“…Abstract Sepsis is a major cause of death in polytrauma patients, with delayed antibiotics increasing mortality. Although biological sex influences immune function and disease outcomes, gender-specific differences in inflammatory response and sepsis progression remain underexplored. …”
Get full text

Temporary ectopic banking as a treatment option for mangled thumb: a case report by Meisam Jafari Kafiabadi, Adel Ebrahimpour, Seyyed Hamidreza Ayatizadeh, Reza Fereidooni, Amirhossein Kamalinia, Mehrdad Sadighi, Farsad Biglari, Seyed Arman Moein

“…After a 4 week period of antibiotics, irrigation, debridement, and vacuum dressing, the thumb and soft tissue reconstruction were performed, retrieving the viable first metacarpal. …”
Get full text

A Novel Wild-Type <i>Lacticaseibacillus paracasei</i> Strain Suitable for the Production of Functional Yoghurt and Ayran Products by Ioanna Prapa, Chrysoula Pavlatou, Vasiliki Kompoura, Anastasios Nikolaou, Electra Stylianopoulou, George Skavdis, Maria E. Grigoriou, Yiannis Kourkoutas

“…After testing hemolytic activity and resistance to antibiotics, specific functional properties were evaluated; <i>Lactococcus lactis</i> subsp. …”
Get full text

Genomic insights into a multidrug-resistant pandoraea apista clinical isolate carrying blaOXA-153 from China by Lirong Li, Yawen Zhang, Fang He, Ningjun wu

“…PA167 exhibited resistance to multiple antibiotics, including cephalosporins and carbapenems, and was susceptible only to sulfamethoxazole/trimethoprim. …”
Get full text

Synthesis and Characterization of Paclitaxel-Loaded Silver Nanoparticles: Evaluation of Cytotoxic Effects and Antimicrobial Activity by Tutku Tunç, Ceylan Hepokur, Afşin Kari̇per

“…Compared to standard antibiotics, AgNPs-PTX was highly effective against 4 microorganisms.…”
Get full text

Intestinal Organoids in Colitis Research: Focusing on Variability and Cryopreservation by Talke F. zur Bruegge, Andrea Liese, Sören Donath, Stefan Kalies, Maike Kosanke, Oliver Dittrich-Breiholz, Sandra Czech, Verena N. Bauer, André Bleich, Manuela Buettner

“…First, to analyze the impact of antibiotics/antimycotics, we performed kinetic experiments using ZellShield® and measured the gene expression levels of the tight junction markers Ocln, Zo-1, and Cldn4, the proliferation marker Ki67, and the proinflammatory cytokine Tnfα. …”
Get full text

The burden of group A Streptococcus (GAS) infections: The challenge continues in the twenty-first century by Aswin Thacharodi, Saqib Hassan, Avadh Vithlani, Tawfeeq Ahmed, Sanjana Kavish, Nicole-Mae Geli Blacknell, Ali Alqahtani, Arivalagan Pugazhendhi

“…GAS infection rates decreased gradually during the 20th century in Western countries, largely due to improved living conditions and access to antibiotics. However, post-COVID-19, the situation has led to a steep increase in GAS infection rates in Europe, the United States, Australia, and New Zealand, which triggers a global concern. …”
Get full text

Experience with the implementation of central venous catheters by medical oncologists in a non-surgical setting by Alfonso Revuelta, Luka Mihic, Alfredo Castillo, Axel Mariño, Lucía Mateos, Claudia Iglesias, Carmen Sáenz de Jubera, Cristina Fernández, David Rodríguez-Rubí, Paula Jiménez-Fonseca, José Pablo Berros, Emilio Esteban

“…A thorax X-ray was performed after each procedure and no prophylactic antibiotics were required. From January 2015 to March 2019, five hundred port systems were implanted, with a median age of 62 years (range 18–81), male 286/female 214. …”
Get full text

Dual mechanisms of G3 against Vibrio parahaemolyticus in shrimp aquaculture by Cuixia Chen, Yangyang Ge, Qilong Gu, Tianling Wang, Yanyan Yang, Jinpeng Hu, Kang Gao, Xing Zhou, Hui Li

“…The unfavorable side effects and emergence of superbugs in traditional antibiotic treatment makes development of excellent antibacterial agents especially urgent. …”
Get full text