Current trends in antimicrobial use and the role of antimicrobial stewardship in palliative oncology: a narrative review by Bassem Awada, Aref Zribi, Ahmad Al Ghoche, Souha S. Kanj

“…Effective antimicrobial stewardship strategies, such as integrating infection management into goals-of-care discussions, early referrals to specialized palliative care teams, and implementing early intravenous-to-oral antimicrobial switches, are critical for balancing patient comfort and minimizing unnecessary antibiotic exposure. Conclusion Optimizing antimicrobial use in palliative oncology care requires a multidisciplinary approach that prioritizes patient-centered goals, minimizes harm, and addresses misconceptions about antibiotic efficacy in end-of-life care. …”
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Analysis of Risk Factors of Gastric Low-Grade Intraepithelial Neoplasia in Asymptomatic Subjects Undergoing Physical Examination by Yingling Liu, Yuli Cai, Si Chen, Yawen Gou, Qiaomin Wang, Mingli Zhang, Yetao Wang, Haiou Hong, Kaiguang Zhang

“…Risk factors including age, H. pylori infection, history of antibiotic misuse, and spicy and high-fat diet (all P<0.05) were further verified by multivariate analysis as independent risk factors. …”
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A Case of Cerebral Granuloma and Optic Papillitis due to Brucella sp. by A. Chiappe-Gonzalez, A Solano-Loza

“…We document a case of a 24-year-old woman who presented with cerebral granuloma and optic papillitis associated to Brucella sp. infection, whose diagnosis was made with a brain biopsy and serology tests, with clinical improvement following specific antibiotic therapy. The patient was followed up for over a year without evidence of relapse.…”
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Management of Necrotising Fasciitis

“…Fasciotomy and surgical debridment was done in these cases under antibiotic cover but antibiotics failed to prove as effective mode of treatment …”
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A Research-Based Summary on Trace Minerals for Cattle by João H. Jabur Bittar, Roberto A. Palomares

“… Producers can utilize mineral supplementation to improve cattle production and herd health, which has the potential to reduce antibiotic usage. This publication presents a summary on trace minerals for cattle. …”
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Translocation of Clostridium difficile Toxin B across Polarized Caco-2 Cell Monolayers Is Enhanced by Toxin A by Tim Du, Michelle J Alfa

“…Clostridium difficile is the etiological agent of antibiotic-associated diarrhea; the most common form of nosocomial infectious diarrhea. …”
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Comparison of Nasal Colonization of Methicillin-Resistant Staphylococcus aureus in HIV-Infected and Non-HIV Patients Attending the National Public Health Laboratory of Central Nepa... by Kalash Neupane, Binod Rayamajhee, Jyoti Acharya, Nisha Rijal, Dipendra Shrestha, Binod G C, Mahesh Raj Pant, Pradeep Kumar Shah

“…Intrinsically developed antibiotic resistance has sharply increased the burden of MRSA which is often associated with morbidity and mortality of the patients. …”
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Exogenous cystine increases susceptibility of drug-resistant Salmonella to gentamicin by promoting oxidation of glutathione metabolism and imbalance of intracellular redox levels by Junyuan Du, Junyuan Du, Zhiyi Wu, Zhiyi Wu, Chunyang Zhu, Chunyang Zhu, Heng Yang, Heng Yang, Feike Zhao, Feike Zhao, Binghu Fang, Binghu Fang

“…IntroductionAntibiotic overuse has caused the development of bacterial resistance, which is a major threat to public health. …”
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Characterization of Listeria monocytogenes strains isolated from soil under organic carrot farming by Maciej Nowak, Zbigniew Paluszak, Natalia Wiktorczyk-Kapischke, Katarzyna Grudlewska-Buda, Anna Budzyńska, Joanna Skonieczna-Kurpiel, Ewa Wałecka-Zacharska, Monika Huse-Kutowska, Krzysztof Skowron

“…Antibiotic resistance was demonstrated in two strains (strain 11 – resistant to penicillin and cotrimoxazole, strain 22 – resistant to penicillin). …”
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Toxicological assessment of citral and geraniol: Efflux pump inhibition in Staphylococcus aureus and invertebrate toxicity by Gildênia Alves de Araújo, Cícera Datiane de Morais Oliveira Tintino, Raimundo Luíz Silva Pereira, Isaac Moura Araújo, Cícera Laura Roque Paulo, João Arthur de Oliveira Borges, Ewerton Yago de Sousa Rodrigues, Ângella Eduarda da Silva, Francisco Assis Bezerra da Cunha, Zildene de Sousa Silveira, Nair Silva Macedo, Henrique Douglas Melo Coutinho, José Maria Barbosa Filho, Daniela Maria do Amaral Ferraz Navarro, Francisco Roberto de Azevedo, Saulo Relison Tintino

“…Only geraniol reduced the antibiotic MIC when combined, reducing from 64 µg/mL to 16 µg/mL in the 1199B strain of S. aureus. …”
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Pharmacophore-based approach for the identification of prospective UDP-2,3-diacylglucosamine hydrolase (LpxH) inhibitor from natural product database against Salmonella Typhi by Divyapriya Karthikeyan, Sanjit Kumar, NS Jayaprakash

“…Antibiotics are essential for the treatment of typhoid fever, which is caused by Salmonella Typhi. …”
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Reducing the effective dose of doxycycline using chitosan silver nanocomposite as a carriers on gram positive and gram-negative bacteria by Elham M. Mostafa, Y. Badr, M. M. Hashem, K. Abo-EL-Sooud, Amna H. Faid

“…Abstract Doxycycline (Doxy) is a tetracycline antibiotic with a potent antibacterial activity against a broad range of bacteria. …”
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Airborne Escherichia coli bacteria biosynthesize lipids in response to aerosolization stress by Brooke L. Smith, Meiyi Zhang, Maria D. King

“…Abstract Gram-negative bacteria pose an increased threat to public health because of their ability to evade the effects of many antimicrobials with growing antibiotic resistance globally. One key component of gram-negative bacteria resistance is the functionality and the cells’ ability to repair the outer membrane (OM) which acts as a barrier for the cell to the external environment. …”
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Spore-Derived Isolates from a Single Basidiocarp of Bioluminescent <i>Omphalotus olivascens</i> Reveal Multifaceted Phenotypic and Physiological Variations by Rudy Diaz, David Bermudes

“…None of this subset produced an antibiotic effective against <i>Staphylococcus aureus</i>, and only the haploids, but not the parental heterokaryon, produced an antibiotic consistent with illudin M effective against <i>Mycobacterium smegmatis</i>. …”
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Ultrasound evaluation of gallbladder wall thickness for predicting severe dengue: a systematic review and meta-analysis by Amirhossein Shahsavand Davoudi, Hamid Harandi, Reza Samiee, Shayan Forghani, Keyhan Mohammadi, Maryam Shafaati

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Yersinia Infection with Clostridium Difficile Colitis by M.J. Fishman, M.A. Noble, H.J. Freeman

“…All patients seen during a two year period with diarrhea within four weeks of antibiotic therapy, a positive tool culture for C difficile and a positive stool cytotoxin assay specific for C difficile were investigated. …”
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Orlistat ameliorates lipid dysmetabolism in high-fat diet-induced mice via gut microbiota modulation by Chengyan Huang, Yuanhui He, Ping Chai, Zongxin Liu, Sirui Su, Yanhui Zhang, Yuelan Luo, Shuiping Fu

“…Specifically, it reduced α diversity and increased the relative abundance of Verrucomicrobia and Akkermansia. Notably, antibiotic-induced gut microbiota depletion significantly weakened Orlistat’s effect on improving metabolic disorders. …”
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Contributing factors to postoperative surgical site infections in pituitary neuroendocrine tumors undergoing endonasal transsphenoidal resection by Lei Wang, Shanxian Liu, Jie Zheng, Rui Li, Zhenyi Xing

“…Microbial analysis revealed Escherichia coli as the most prevalent pathogen in post-surgery infections, with notable antibiotic resistance patterns observed in key bacteria, necessitating careful antibiotic selection. …”
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The mutational landscape of Staphylococcus aureus during colonisation by Francesc Coll, Beth Blane, Katherine L. Bellis, Marta Matuszewska, Toska Wonfor, Dorota Jamrozy, Michelle S. Toleman, Joan A. Geoghegan, Julian Parkhill, Ruth C. Massey, Sharon J. Peacock, Ewan M. Harrison

“…Despite limited within-host genetic diversity, we observed an excess of protein-altering mutations in metabolic genes, in regulators of quorum-sensing (agrA and agrC) and in known antibiotic targets (fusA, pbp2, dfrA and ileS). We demonstrated the phenotypic effect of multiple adaptive mutations in vitro, including changes in haemolytic activity, antibiotic susceptibility, and metabolite utilisation. …”
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Antibacterial Activity of Rationally Designed Antimicrobial Peptides by Marius B. Tincho, Thureyah Morris, Mervin Meyer, Ashley Pretorius

“…The reasons may either be the antibiotic resistance towards the available therapeutic molecules or the slow rate of producing adequate therapeutic regimens to tackle the rapid growth of new infectious diseases, as well as the toxicity of current treatment regimens. …”
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