Temperature-dependent toxicity and mechanisms of florfenicol on the embryonic development of marine medaka (Oryzias melastigma) by Xingying Guo, Xu Gong, Jinhui Wang, Tan-Duc Nguyen, Syed Shabi Ul Hassan Kazmi, Jiezhang Mo, Feng Hua, Wenhua Liu, Zhen Wang

“…The extensive use of antibiotics and their persistence in the environment have seriously threatened marine ecosystems in recent years. …”
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Comparison of demographic, clinical and laboratory characteristics between first and second COVID-19 waves in a secondary care hospital in Qatar: a retrospective study by Prem Chandra, Vamanjore A Naushad, Nishan K Purayil, Abazar Ahmad M Saeed, Pradeep Radhakrishnan, Irfan Varikkodan, Joe V Mathew, Jaseem Sirajudeen, Riyadh A Hammamy, Ahmad M Badi, Aasir M Suliman, Mohamed N Badawi, Saket Arya, Maryam AlMotawa, Aisha Al-Baker, Rania Alatom, Anand Kartha

“…More patients received hydroxychloroquine and antibiotics during the first wave and more received steroids, antivirals and interleukin-1 antagonist during the second wave. …”
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Non-carbapenem-producing carbapenem-resistant Pseudomonas aeruginosa in children: Risk factors, molecular epidemiology, and resistance mechanism by Lijun Yin, Lu Lu, Leiyan He, Gangfeng Yan, Guoping Lu, Xiaowen Zhai, Chuanqing Wang

“…Antimicrobial susceptibility testing identified that both CC244 + and HAI isolates demonstrated elevated resistance across all tested antibiotics. Furthermore, low oprD expression was observed in 77.9 % of HAI isolates and 67.2 % of non-HAI isolates, while increased ampC production and mexB gene overexpression were infrequently detected (all P > 0.05). …”
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A Retrospective Study on Amoxicillin Susceptibility in Severe Haemophilus influenzae Pneumonia by Pierre Danneels, Maria Concetta Postorino, Alessio Strazzulla, Nabil Belfeki, Aurelia Pitch, Frank Pourcine, Sebastien Jochmans, Vincent Dubée, Mehran Monchi, Sylvain Diamantis

“…Patients with Sp pneumonia had more frequently local complications than patients with Hi pneumonia (17% vs. 7%, p=0.03). De-escalation of antibiotics was more frequent in patients with Sp than in patients with Hi (67% vs. 53%, p=0.03). …”
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Assessment of the magnitude, economic impact, and factors associated with expired veterinary pharmaceuticals in animal health facilities in South Wollo, Ethiopia by Yesuneh Tefera Mekasha, Ermias Belay Mekonnen, Abebe Tesfaye Gessese, Kassahun Berrie, Achenef Melaku Beyene, Bereket Dessalegn

“…From Anatomical Therapeutic Classification (ATC), antibiotics accounted for 14.8% of the total financial loss. …”
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Comparative In vitro antibacterial activity of nemonoxacin and other fluoroquinolones in correlation with resistant mechanisms in contemporary methicillin-resistant Staphylococcus... by Pao -Yu Chen, Mao-Wang Ho, Po-Liang Lu, Hung-Jen Tang, Cheng Len Sy, Jann-Tay Wang, Taiwan Staphylococcus aureus Consortium (TSAC)

“…Antimicrobial susceptibility testing for all antibiotics was performing by using Sensititre standard panel, except nemonoxacin by using agar dilution method. …”
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Influencing factors of acute kidney injury in elderly patients with diabetic nephropathy and establishment of nomogram model by Ganlin Wu, Ganlin Wu, Yanli Ye, Meirong Xu, Yanxia Zhang, Zuopeng Lu, Lv Huang

“…The prevalence and predisposing factors of acute kidney injury in diabetic nephropathy were analyzed, multivariate logistic regression were used to analyze the influencing factors of acute kidney injury in patients, and a nomogram risk prediction model was established based on risk factors for verification.ResultsAnalysis of the factors of acute kidney injury in diabetic nephropathy found that severe infection was the main trigger, accounting for 40.00%, followed by nephrotoxic antibiotics and severe heart failure. The age, urine microalbumin-to-creatinine ratio (ACR), blood urea nitrogen (BUN), uric acid(UA), and cystatin C (CysC) levels of patients in the combined acute kidney injury group were significantly higher than those in the unmerge group (P<0.05), and the left ventricular ejection fraction (LVEF) and epidermal growth factor receptor (eGFR) levels were significantly lower than those in the unmerge group (P<0.05). …”
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CMV Pancreatitis in an Immunocompromised Patient by Jaffer Ahmad, Najia Sayedy, Raghavendra Sanivarapu, Jagadish Akella, Javed Iqbal

“…She tested positive for HIV with a severely depressed CD4 count (42 cells/McL) and high viral load (1,492,761 copies/ml) and started on appropriate prophylactic antibiotics and HAART therapy. The patient was moved to the Medical Intensive Care Unit (MICU) after acute respiratory failure secondary to ARDS requiring mechanical ventilation with initiation of ARDS protocol. …”
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Development of Evidence-Based COVID-19 Management Guidelines for Local Context: The Methodological Challenges by Sarah Nadeem, Salima Saleem Aamdani, Bushra Ayub, Nashia Ali Rizvi, Fatima Safi Arslan, Russell Seth Martins, Maria Khan, Syed Faisal Mahmood

“…Regarding the use of antibiotics and ivermectin use in treating COVID-19 hospitalized patients, data from our review and WHO v 7.1 recommend against their use. …”
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Use of Cesarean Birth among Robson Groups 2 and 4 at Mizan-Tepi University Hospital, Ethiopia by Margo S. Harrison, Tewodros Liyew, Ephrem Kirub, Biruk Teshome, Andrea Jimenez-Zambrano, Margaret Muldrow, Teklemariam Yarinbab

“…The odds of requiring maternal antibiotics was the only notable outcome with increased risk (RR 11.1, CI (1.9, 64.9)). …”
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Scrub typhus in pregnancy: A 10-year multicenter study in resource-limited settings in China. by Peilin Zhao, Tieyong Dong, Hongbin Lu, Rui Zhu, Shanshan Zhao, Wuqian Tao, Li Li, Chunmei Liu, Shuwei Pu, Ling Mo, Huanhuan Wang

“…Further studies are needed to investigate the correlation between antibiotics regimens for this population and fetal outcome.…”
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Prevalensi Kuman Multi Drug Resistance (MDR) di Laboratorium Mikrobiologi RSUP Dr. M. Djamil Padang Periode Januari 2010 - Desember 2012 by Novilla Rezka Sjahjadi, Roslaili Rasyid, Erlina Rustam, Lily Restusari

“…<br />Kata kunci: kuman multi drug resistance, prevalensi, kuman</p><p>Abstract<br />Multi Drug Resistance (MDR) bacteria, makes harder to choose the right antibiotics to use for the treatment and can cause the longer of hospitality days and the sudden decrease of medic, social and economics. …”
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CAM/TMA-DPH as a promising alternative to SYTO9/PI for cell viability assessment in bacterial biofilms by Tinatini Tchatchiashvili, Tinatini Tchatchiashvili, Mateusz Jundzill, Mateusz Jundzill, Mike Marquet, Kamran A. Mirza, Kamran A. Mirza, Mathias W. Pletz, Mathias W. Pletz, Oliwia Makarewicz, Oliwia Makarewicz, Lara Thieme, Lara Thieme

“…To address this limitation, we investigated an alternative staining method employing calcein acetoxymethyl (CAM) to detect viable cells based on esterase activity, and 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene p-toluenesulfonate (TMA-DPH) to assess the remaining biofilm population.MethodsBiofilms of Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and Enterococcus faecium were matured and exposed to varying concentrations of antibiotics or sterile medium. Biofilm viability was assessed using CAM/TMA-DPH or SYTO9/PIstaining, followed by analysis with confocal laser scanning microscopy (CLSM) and ImageJ-based biofilm surface coverage quantification. …”
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Informatization of the processes of administration of the quality of medical services in surgical hospitals by Ya.S. Bereznytskyi, V.Ya. Bereznytskyi, O.V. Hudoshyna, N.D. Chuhrienko, G.V. Bereznytska, Ye.V. Zalyhina, Yu.B. Dianova, E.A. Rynska, L.N. Ksykevich

“…The quality control of the use of antibiotics, the frequency of their use for preventive and therapeutic purposes is also carried out. …”
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Early results of primary total hip arthroplasty performed in young adults at a regional Saudi-Arabian orthopedics center: a prospective observational study by Walid M. Al-Shaer, Ali H. Al-Yami, Mokhtar Ahmed Al-Sayed, Ali Mohammed Al-Zaidan, Emad Ruddah Al-Sufyani, Ahmed A. Khalifa, Raad M. M. Al-Thaqafi, Abdulmohsen H. Al-Hamyani, Mohammed M. Al-Subaie

“…Two (8%) patients had superficial wound infections at the time of suture removal, which were treated successfully by daily dressing and antibiotics. None required revision. Conclusions. …”
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Bone Defect Repair Using a Bone Substitute Supported by Mesenchymal Stem Cells Derived from the Umbilical Cord by Michal Kosinski, Anna Figiel-Dabrowska, Wioletta Lech, Lukasz Wieprzowski, Ryszard Strzalkowski, Damian Strzemecki, Lukasz Cheda, Jacek Lenart, Krystyna Domanska-Janik, Anna Sarnowska

“…Mesenchymal stem cells derived from the umbilical cord (Wharton’s jelly (WJ-MSC)) were cultured in GMP-grade DMEM low glucose supplemented with heparin, 10% platelet lysate, glucose, and antibiotics. In vitro WJ-MSCs were seeded on the bone substitute Bio-Oss Collagen® and cultured in the StemPro® Osteogenesis Differentiation Kit. …”
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Impact of Flexor Tendon Traction Tenolysis on Clinical Outcomes in Open A1 Pulley Release for Trigger Finger by Shalimar Abdullah, BMBS, MS, Syed Jeffrey Syed Ahmad Kabeer, MBChB, MD, Lim Chia Hua, MD, Jamari Sapuan, MD, MS, Parminder Singh Gill, MBBS, MS, Elaine Soh Zi Fan, MBBS, MD

“…Two patients in group I experienced wound infections, which resolved with a week-long course of antibiotics. Conclusions: Open A1 pulley release with flexor tendon traction tenolysis resulted in better early postoperative (2 weeks) finger flexion range of motion and QuickDASH scores, albeit with a longer surgery duration. …”
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Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives by Basma T. Abd-Elhalim, Ghada G. El-Bana, Ahmed F. El-Sayed, Ghada E. Abdel-Ghani

“…Abstract Background Because of their many bioactivities, which include psychoanalytic, antifungal, antihypertensive, anti-inflammatory, and antiviral properties, pyrazoles and their derivatives are attracting interest in pharmacology and medicine, the pressing need for novel fungicides is increased for lessened by the growing microbiological resistance of illnesses to recognized antibiotics. Objective The current work validates the results and pyrazole binding sites as potent antifungals by investigating many pyrazole derivatives as antifungal agents. …”
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Molecular Detection of Carbapenemase-Encoding Genes in Multidrug-Resistant Acinetobacter baumannii Clinical Isolates in South Africa by Yaw Adjei Anane, Teke Apalata, Sandeep Vasaikar, Grace Emily Okuthe, Sandile Songca

“…Most strains showed high resistance rates (>80%) to the antibiotics tested. Resistance to amikacin, tetracycline, and tigecycline were 50%, 64%, and 48%, respectively. …”
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Prevalence of Site-Specific Mycoplasma genitalium Infection and Macrolide and Fluoroquinolone-Associated Mutations in Men Who Have Sex with Men in Shenzhen, China by Leng X, Zhu R, Ao X, Zhou Y, Zhang K, Hu T, Wu J, Chen Z, Huang L, Huang N, Li X, Ahmed Alnour R, Xue Z, Zhang X, Liu H, Axirejiang T, Ke W, Zou H

“…The high prevalence of macrolide and fluoroquinolone-resistant MG underscores the importance of implementing resistance-guided therapy, establishing surveillance networks, and exploring new antibiotics against MG.Keywords: antimicrobial resistance, Mycoplasma genitalium, MSM, macrolide, fluoroquinolone…”
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