Risk Factors and Outcome of Sepsis in Traumatic Patients and Pathogen Detection Using Metagenomic Next-Generation Sequencing by Yiqing Tong, Jianming Zhang, Yimu Fu, Xingxing He, Qiming Feng

“…Once diagnosed with sepsis, patients should be given an appropriate empiric antimicrobial treatment followed by the specific antibiotic therapy based on blood culture due to its rapid progression to tissue damage and organ failure. …”
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Vertical Transmission of Group B Streptococcus, Prevalence, Associated Factors, and Antimicrobial Susceptibility Profile among Newborns Delivered at Health Facilities in Jigjiga Ci... by Addisu Tesfaye, Mahlet Fekede, Fasil Getu, Surafel Mekuria, Tigist Abebe, Daniel Tollosa, Shamil Barsenga, Bawlah Tahir, Abdurahman Kedir Roble, Sara Tesfaye, Muluken Walle

“…GBS shows an increased resistance to commonly used antibiotics. Thus, we assessed the vertical transmission, contributing factors, and antimicrobial resistance patterns of GBS among newborns delivered at selected Hospitals in Jigjiga City. …”
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Antibacterial Activity of Traditional Medicinal Plants Used for the Treatment of Acute Diarrheal Diseases in Chiapas, Mexico by Jesús Mauricio Ernesto Hernández-Méndez, Israel Peña-Hernández, Mariela Tapia-Nazario, Gerardo Leyva-Padrón, Abumalé Cruz-Salomón, María Emperatriz Domínguez-Espinosa, Héctor Armando Esquinca-Avilés, Maritza del Carmen Hernández-Cruz, Rocío Magdalena Sánchez-Albores, Kelly del Carmen Cruz-Salomón, Rosa Isela Cruz-Rodríguez, Martha Guadalupe Gómez-Santos

“…The <i>Enterobacteriaceae</i> family poses health risks due to its role in gastrointestinal diseases like acute diarrhea. With rising antibiotic resistance, plants offer promising antibacterial compounds with low toxicity. …”
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Clinical Characteristics of COVID-19 in Neonates and Infants Younger Than 3 Months by Fatemeh Varshoei, Mohammad Sadegh Rezai, Roya Farhadi, Azin Hajialibeig, Saeid Mohammadi, Masoud Moradi, Fatemeh Hosseinzadeh

“…The median duration of antibiotic therapy did not differ among the groups (P=0.786). …”
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Can primary care research be conducted more efficiently using routinely reported practice-level data: a cluster randomised controlled trial conducted in England? by Jeremy Horwood, Alastair D Hay, Patricia Jane Lucas, Clare Clement, Peter S Blair, Jodi Taylor, Christie Cabral, Martin C Gulliford, Jenny Ingram, Padraig Dixon, Nick Francis, Athene Lane, Grace Young, Elizabeth Beech, Penny Seume, Scott Bevan, Sam T Creavin

“…We investigated barriers and facilitators to running a more efficient design.Design An RCT aiming to reduce antibiotic prescribing among children presenting with acute cough and a respiratory tract infection (RTI) with a clinician-focused intervention, embedded at the practice level. …”
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The microbiome of Total Suspended Particles and its influence on the respiratory microbiome of healthy office workers by Giulia Solazzo, Sabrina Rovelli, Simona Iodice, Matthew Chung, Michael Frimpong, Valentina Bollati, Luca Ferrari, Elodie Ghedin

“…Additionally, both indoor and outdoor TSP samples contained broad spectrum antibiotic resistance genes. Indoor TSP exposure was negatively associated with commensal bacteria and positively associated with Staphylococcus aureus relative abundance. …”
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Enhancing antibacterial photodynamic therapy with NIR‐activated gold nanoclusters: Atomic‐precision size effect on reducing bacterial biofilm formation and virulence by Chengyu Liu, Tenghui Tian, Yujia Shi, Meiqi Li, Le Hong, Jing Zhou, Jia Liu, Yuan Zhong, Xue Wang, Zhenyu Wang, Xue Bai, Lin Wang, Chunyan Li, Zhennan Wu

“…Abstract Persistent biofilm infections pose a critical health threat with their relentless presence and amplified antibiotic resistance. Traditional antibacterial photodynamic therapy can inhibit bacteria extracellularly but struggles to control biofilm formation and virulence. …”
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The Tools for Integrated Management of Childhood Illness (TIMCI) study protocol: a multi-country mixed-method evaluation of pulse oximetry and clinical decision support algorithms by Fenella Beynon, Hélène Langet, Leah F. Bohle, Shally Awasthi, Ousmane Ndiaye, James Machoki M’Imunya, Honorati Masanja, Susan Horton, Maymouna Ba, Silvia Cicconi, Mira Emmanuel-Fabula, Papa Moctar Faye, Tracy R. Glass, Kristina Keitel, Divas Kumar, Gaurav Kumar, Gillian A. Levine, Lena Matata, Grace Mhalu, Andolo Miheso, Deusdedit Mjungu, Francis Njiri, Elisabeth Reus, Michael Ruffo, Fabian Schär, Kovid Sharma, Helen L. Storey, Irene Masanja, Kaspar Wyss, Valérie D’Acremont, TIMCI Collaborator Group

“…The primary outcomes assessed for the RCT are severe complications (mortality and secondary hospitalisations) by Day 7 and primary hospitalisations (within 24 hours and with referral); and, for the pre-post study, referrals and antibiotic. Secondary outcomes on other aspects of health status, hypoxaemia, referral, follow-up and antimicrobial prescription are also evaluated. …”
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Comprehensive safety and toxicity analysis of 2,2’-Bipyridine derivatives in combating MRSA biofilm formation and persistence by Priyanka, Priyanka, Mohini Sharma, Bhavna Vaid, Bhavna Vaid, Ram Bharti, Ram Bharti, Sachin Raut, Sachin Raut, R. S. Jolly, Neeraj Khatri, Neeraj Khatri

“…They inhibited biofilm formation and eradicated biofilms in a dose-dependent manner against MTCC 737 and MRSA 831, and they effectively eliminated MRSA persister cells, outperforming the reference antibiotic vancomycin. These derivatives were found to depolarize the mitochondrial membrane and accumulate intracellular reactive oxygen species. …”
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The Complete Blood Count Sepsis Index Using Monocyte Distribution Width for Early Detection of Sepsis in Patients Without Obvious Signs by Scott Levin, PhD, Nima Sarani, MD, Jeremiah Hinson, MD, PhD, Melissa Naiman, PhD, Chad Cannon, MD, Aria Smith, MS, Benjamin Steinhart, MS, Arnaud DeBraine, BS, Sarah Kehoe, PhD, Bryan Immhoff, MD, Yasir Taribichi, MD, Alexandra Malinovska, MD, Kemi Badaki-Makun, MD

“…Septic patients without obvious signs exhibited delays in antibiotic administration from arrival (median 4.7 vs. 3.4 hr; p < 0.001) and higher rates of ICU admission (43.8% vs. 27.9%; p < 0.001) and in-hospital mortality (14.7% vs. 9.8%; p = 0.011) compared with the septic subgroup presenting with obvious signs. …”
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Clostridium difficile-associated disease in versatile hospital patient population and risk factors for its development by Ya. N. Yarushina, G. B. Kolotova, V. A. Rudnov, V. A. Bagin

“…Following risk factors for C. difficile-associated diarrhea were determined: age over 65 years, presence of several associated diseases (Charlson score >2), chronic renal failure that require hemodialysis, anemia, admission to intensive care unit and surgical departments, surgical treatment, PPI administration for over 7 days, more than one course of antibiotic treatment and duration of antibacterial therapy for more than 5 days, administration of 3rd generation cephalosporins.…”
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Omics-Based Comparison of Fungal Virulence Genes, Biosynthetic Gene Clusters, and Small Molecules in <i>Penicillium expansum</i> and <i>Penicillium chrysogenum</i> by Holly P. Bartholomew, Christopher Gottschalk, Bret Cooper, Michael R. Bukowski, Ronghui Yang, Verneta L. Gaskins, Dianiris Luciano-Rosario, Jorge M. Fonseca, Wayne M. Jurick

“…Molecules with varying biological activities, and phytohormone-like compounds were detected for the first time in <i>P. expansum</i> while antibiotics like penicillin G and other biologically active molecules were discovered in <i>P. chrysogenum</i> culture supernatants. …”
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Synthesis, characterization and biological profile of some new dihydropyrimidinone derivaties by Madiha Kanwal, Humaira Nadeem, Sumra Malik, Saima Maqsood

“…As a result, the aim of this research was to synthesize various types of dihydropyrimidinones heterocyclic compounds and screened them for their antibiotic properties. Methodology: Newly synthesized dihydropyrimidinone derivatives were characterized spectroscopically using proton NMR (1HNMR), and FT-IR. …”
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Attenuation of acute kidney injury in a murine model of neonatal Escherichia coli sepsis by Esther M. Speer, Atilade A. Adedeji, Joyce Lin, Alexandra Khorasanchi, Asma Rasheed, Maya Bhat, Kelly Mackenzie, Randolph Hennigar, Kimberly J. Reidy, Robert P. Woroniecki

“…We hypothesized that addition of PTX to antibiotics may attenuate immune and histological AKI in a murine neonatal sepsis model.MethodsPostnatal (PN) day 1 C57BL/6J mice were injected with E. coli K1 strain at 105 colony forming units per gram weight or saline control. …”
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Genomic epidemiology of third-generation cephalosporin-resistant Escherichia coli from companion animals and human infections in Europe by Adrien Biguenet, Benoit Valot, Farid El Garch, Xavier Bertrand, Didier Hocquet

“…Although it cannot rule out occasional transmission of bacteria between pets and humans within a household, it suggests that dogs and cats are not a major source of human infection with this antibiotic-resistant pathogen.…”
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Outcome and Management of Sepsis at RozhHalat Emergency Hospital in Erbil –Kurdistan region of Iraq by Samir Qader Ahmad, Shakawan Muhamad Ismaeel, Dara Ahmed Mohammed Ahmed Mohammed, Halgurd Fathulla Ahmed

“…All patients received empirical antibiotic therapy however 46% of cases received the wrong antimicrobials. …”
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Surgical and Non-surgical Treatments in Pleural Empyema by Sami DENİZ, Nimet AKSEL, Özer ÖZDEMİR, Görkem VAYISOĞLU ŞAHİN, Ezgi ÇİMEN ÇELİK, Mutlu Onur GÜÇSAV, Filiz GÜLDAVAL, Ahmet Emin ERBAYCU, Ahmet ÜÇVET

“…The treatment results revealed no significant difference between three groups (recovered, sequelae changes, death), except for blood neutrophil count and antibiotic duration. Conclusion: Medical treatment plus therapeutic drainage therapy may be chosen as first treatment instead of open surgery in empyema.…”
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Guava Leaf Extract Exhibits Antimicrobial Activity in Extensively Drug-Resistant (XDR) <i>Acinetobacter baumannii</i> by Daniela Gutierrez-Montiel, Alma L. Guerrero-Barrera, Flor Y. Ramírez-Castillo, Fabiola Galindo-Guerrero, Ingrid G. Ornelas-García, Norma A. Chávez-Vela, Matheus de O. Costa, Francisco J. Avelar-Gonzalez, Adriana C. Moreno-Flores, Erick Vazquez-Pedroza, José M. Arreola-Guerra, Mario González-Gámez

“…Additionally, possible improvements in antimicrobial activity after the purification of polyphenolic compounds and potential synergy with the antibiotic gentamicin are examined in this research. …”
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Conglomerated Imiquimod and Metronidazole Incorporated Biodegradable Nanofibrous Mats for Potential Therapy of Cervical Cancer by Chen YP, Chiu CF, Wang CN, Lin CC, Shen CR, Yao YC, Kuo YH, Liu SJ

“…Metronidazole is the most commonly prescribed antibiotic for bacterial vaginosis. The study developed biodegradable imiquimod- and metronidazole-loaded nanofibrous mats and assessed their effectiveness for the topical treatment of cervical cancer, a type of HPV-related lesion.Methods: Nanofibers of two distinct poly[(d,l)-lactide-co-glycolide] (PLGA)-to-drug ratios (6:1 and 4:1) were manufactured through the electrospinning technology. …”
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Exploring New Delhi Metallo Beta Lactamases in Klebsiella pneumoniae and Escherichia coli: genotypic vs. phenotypic insights by Noor Ul Ain, Linzy Elton, Zahra Sadouki, Timothy D. McHugh, Saba Riaz

“…All CREK strains exhibited complete resistance (100%) to multiple antibiotics with 66% showing sensitivity to levofloxacin. …”
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